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Hepatic Fibrosis Biomarkers Market Size, Share & Trends Analysis Report By Product (Blood-based Kits, Saliva-based Kits), By Technology (Immunofiltration Assays, Lateral Flow Assays), By End Use, By Region, And Segment Forecasts, 2025 - 2033
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Hepatic Fibrosis Biomarkers Market Summary
The global hepatic fibrosis biomarkers market size was estimated at USD 423.51 million in 2024 and is projected to reach USD 2,291.73 million by 2033, growing at a CAGR of 20.01% from 2025 to 2033. The rising prevalence of NASH, a consequence of obesity, sedentary lifestyles, and metabolic syndrome, has led to a greater focus on hepatic fibrosis biomarkers.
According to the study published in the National Institutes of Diabetes and Digestive and Kidney Diseases, NAFLD affects one-third to two-thirds of individuals with type 2 diabetes. Studies also indicate that over 90% of individuals with extreme obesity and up to 75% of overweight individuals have NAFLD. One of the key drivers propelling the demand for NASH-specific hepatic fibrosis biomarkers is the clinical significance of fibrosis staging. The risks and limitations associated with liver biopsies and non-invasive biomarkers offer a safer and more patient-friendly approach to monitoring hepatic fibrosis progression in NASH patients.
As of the most recent estimates, approximately 3.3% of the global population is living with advanced hepatic fibrosis, with rates rising to around 3.5% when measured using vibration-controlled transient elastography (VCTE). Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), affects about 25% of the world's population, with prevalence increasing to 38% in certain regions between 2016 and 2019 due to rising obesity and type 2 diabetes rates.
The adoption of tests such as ELF, FIB-4, NAFLD fibrosis score, APRI, and FibroTest/FibroSure, alongside emerging multi-marker panels like IGFBP7/SSc5D/Sema4D, is enabling earlier detection, accurate staging, and reduced reliance on invasive liver biopsies. These advancements, combined with rising screening initiatives, are positioning hepatic fibrosis biomarkers as a central tool in tackling the global liver disease epidemic.
The dynamics of liver fibrosis are specifically targeted by noninvasive biomarkers of liver condition, such as NASH, which offer a novel tool to assess a patient's disease progression. Such indicators for liver illness could be applied to patient risk classification as well as prognostic enrichment of clinical trials aimed at the individuals with the highest risk, improving the likelihood of success. These blood biomarkers are also accurate indicators of the dynamics of liver fibrosis and can be used to gauge the success of a given treatment. Nordic Bioscience NASH specialists can examine a precise panel of liver fibrosis biomarkers, including the biomarker PRO-C3 NASH, which offers insight into the course of the illness.
Global Hepatic Fibrosis Biomarkers Market Report Segmentation
This report forecasts revenue growth and provides an analysis of the latest trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global hepatic fibrosis biomarkers market report based on product, technology, end use, and region:
Product Outlook (Revenue, USD Million, 2021 - 2033)
Kits and Reagents
Assays
Services
Technology Outlook (Revenue, USD Million, 2021 - 2033)
Immunoassay
Molecular Diagnostics
Proteomics/Metabolomics
Imaging-based Biomarker Assessment
End Use Outlook (Revenue, USD Million, 2021 - 2033)
Hospitals
Diagnostic Laboratories
Specialty Clinics
Academic & Research Institutes
Pharmaceutical & Biotechnology Companies
Regional Outlook (Revenue, USD Million, 2021 - 2033)
North America
Europe
UK
Germany
France
Italy
Spain
Denmark
Sweden
Norway
Asia Pacific
Japan
China
India
Australia
South Korea
Thailand
Latin America
Middle East & Africa
South Africa
Saudi Arabia
UAE
Kuwait
Table of Contents
Chapter 1. Hepatic Fibrosis Biomarkers Market: Methodology and Scope
1.1. Market Segmentation and Scope
1.1.1. Segment Definitions
1.1.1.1. Product Segment
1.1.1.2. Technology Segment
1.1.1.3. Sample Product segment
1.1.1.4. End Use Segment
1.2. Regional Scope
1.3. Estimates and Forecast Timeline
1.4. Objectives
1.4.1. Objective - 1
1.4.2. Objective - 2
1.4.3. Objective - 3
1.5. Research Methodology
1.6. Information Procurement
1.6.1. Purchased Database
1.6.2. GVR's Internal Database
1.6.3. Secondary Sources
1.6.4. Primary Research
1.7. Information or Data Analysis
1.7.1. Data Analysis Models
1.8. Market Formulation & Validation
1.9. Model Details
1.9.1. Commodity Flow Analysis
1.10. List of Secondary Sources
1.11. List of Abbreviations
Chapter 2. Hepatic Fibrosis Biomarkers Market: Executive Summary
2.1. Market Snapshot
2.2. Product and Technology Snapshot
2.3. End Use Snapshot
2.4. Competitive Landscape Snapshot
Chapter 3. Hepatic Fibrosis Biomarkers Market Variables, Trends, & Scope
3.1. Market Segmentation and Scope
3.2. Market Lineage Outlook
3.2.1. Parent Market Outlook
3.2.2. Related/Ancillary Market Outlook
3.3. Market Dynamics
3.4. Market Drivers Analysis
3.5. Market Restraint Analysis
3.6. Porter's Five Forces Analysis
3.7. PESTLE Analysis
3.8. Pipeline Analysis
Chapter 4. Hepatic Fibrosis Biomarkers Market: Product Estimates & Trend Analysis
4.1. Hepatic Fibrosis Biomarkers Market: Product Movement Analysis
4.2. Kits and Reagents
4.2.1. Market Estimates and Forecasts, 2021 - 2033 (USD Million)
4.3. Assays
4.3.1. Market Estimates and Forecasts, 2021 - 2033 (USD Million)
4.4. Services
4.4.1. Market Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 5. Hepatic Fibrosis Biomarkers Market: Technology Estimates & Trend Analysis
5.1. Hepatic Fibrosis Biomarkers Market: Technology Movement Analysis
5.2. Immunoassays
5.2.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.3. Molecular Diagnostics
5.3.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.4. Proteomics/Metabolomics
5.4.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
5.5. Imaging-based Biomarker Assessment
5.5.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 6. Hepatic Fibrosis Biomarkers Market: End Use Estimates & Trend Analysis
6.1. Hepatic Fibrosis Biomarkers Market: End Use Movement Analysis
6.2. Hospitals
6.2.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.3. Diagnostics Laboratories
6.3.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.4. Specialty Clinics
6.4.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.5. Academic & Research Institutes
6.5.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
6.6. Pharmaceutical & Biotechnology Companies
6.6.1. Market Revenue Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 7. Hepatic Fibrosis Biomarkers Market: Regional Business Analysis
7.1. Regional Market Snapshot
7.2. North America
7.2.1. North America Hepatic Fibrosis Biomarkers Market Estimates And Forecast, 2021 - 2033 (USD Million)
7.2.2. U.S.
7.2.2.1. U.S. Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.2.2.2. Key Country Dynamics
7.2.2.3. Regulatory Framework
7.2.2.4. Reimbursement Scenario
7.2.2.5. Competitive Scenario
7.2.3. Canada
7.2.3.1. Canada Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.2.3.2. Key Country Dynamics
7.2.3.3. Regulatory Framework
7.2.3.4. Reimbursement Scenario
7.2.3.5. Competitive Scenario
7.2.4. Mexico
7.2.4.1. Mexico Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.2.4.2. Key Country Dynamics
7.2.4.3. Regulatory Framework
7.2.4.4. Reimbursement Scenario
7.2.4.5. Competitive Scenario
7.3. Europe
7.3.1. Europe Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.2. UK
7.3.2.1. UK Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.2.2. Key Country Dynamics
7.3.2.3. Regulatory Framework
7.3.2.4. Reimbursement Scenario
7.3.2.5. Competitive Scenario
7.3.3. Germany
7.3.3.1. Germany Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.3.2. Key Country Dynamics
7.3.3.3. Regulatory Framework
7.3.3.4. Reimbursement Scenario
7.3.3.5. Competitive Scenario
7.3.4. Spain
7.3.4.1. Spain Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.4.2. Key Country Dynamics
7.3.4.3. Regulatory Framework
7.3.4.4. Reimbursement Scenario
7.3.4.5. Competitive Scenario
7.3.5. France
7.3.5.1. France Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.5.2. Key Country Dynamics
7.3.5.3. Regulatory Framework
7.3.5.4. Reimbursement Scenario
7.3.5.5. Competitive Scenario
7.3.6. Italy
7.3.6.1. Italy Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.6.2. Key Country Dynamics
7.3.6.3. Regulatory Framework
7.3.6.4. Reimbursement Scenario
7.3.6.5. Competitive Scenario
7.3.7. Denmark
7.3.7.1. Denmark Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.7.2. Key Country Dynamics
7.3.7.3. Regulatory Framework
7.3.7.4. Reimbursement Scenario
7.3.7.5. Competitive Scenario
7.3.8. Sweden
7.3.8.1. Sweden Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.8.2. Key Country Dynamics
7.3.8.3. Regulatory Framework
7.3.8.4. Reimbursement Scenario
7.3.8.5. Competitive Scenario
7.3.9. Norway
7.3.9.1. Norway Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.3.9.2. Key Country Dynamics
7.3.9.3. Regulatory Framework
7.3.9.4. Reimbursement Scenario
7.3.9.5. Competitive Scenario
7.4. Asia Pacific
7.4.1. Asia-Pacific Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.2. Japan
7.4.2.1. Japan Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.2.2. Key Country Dynamics
7.4.2.3. Regulatory Framework
7.4.2.4. Reimbursement Scenario
7.4.2.5. Competitive Scenario
7.4.3. China
7.4.3.1. China Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.3.2. Key Country Dynamics
7.4.3.3. Regulatory Framework
7.4.3.4. Reimbursement Scenario
7.4.3.5. Competitive Scenario
7.4.4. India
7.4.4.1. India Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.4.2. Key Country Dynamics
7.4.4.3. Regulatory Framework
7.4.4.4. Reimbursement Scenario
7.4.4.5. Competitive Scenario
7.4.5. South Korea
7.4.5.1. South Korea Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.5.2. Key Country Dynamics
7.4.5.3. Regulatory Framework
7.4.5.4. Reimbursement Scenario
7.4.5.5. Competitive Scenario
7.4.6. Thailand
7.4.6.1. Thailand Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.6.2. Key Country Dynamics
7.4.6.3. Regulatory Framework
7.4.6.4. Reimbursement Scenario
7.4.6.5. Competitive Scenario
7.4.7. Australia
7.4.7.1. Australia Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.4.7.2. Key Country Dynamics
7.4.7.3. Regulatory Framework
7.4.7.4. Reimbursement Scenario
7.4.7.5. Competitive Scenario
7.5. Latin America
7.5.1. Latin America Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.5.2. Brazil
7.5.2.1. Brazil Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.5.2.2. Key Country Dynamics
7.5.2.3. Regulatory Framework
7.5.2.4. Reimbursement Scenario
7.5.2.5. Competitive Scenario
7.5.3. Argentina
7.5.3.1. Argentina Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.5.3.2. Key Country Dynamics
7.5.3.3. Regulatory Framework
7.5.3.4. Reimbursement Scenario
7.5.3.5. Competitive Scenario
7.6. MEA
7.6.1. MEA Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.6.2. South Africa
7.6.2.1. South Africa Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.6.2.2. Key Country Dynamics
7.6.2.3. Regulatory Framework
7.6.2.4. Reimbursement Scenario
7.6.2.5. Competitive Scenario
7.6.3. Saudi Arabia
7.6.3.1. Saudi Arabia Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.6.3.2. Key Country Dynamics
7.6.3.3. Regulatory Framework
7.6.3.4. Reimbursement Scenario
7.6.3.5. Competitive Scenario
7.6.4. UAE
7.6.4.1. UAE Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.6.4.2. Key Country Dynamics
7.6.4.3. Regulatory Framework
7.6.4.4. Reimbursement Scenario
7.6.4.5. Competitive Scenario
7.6.5. Kuwait
7.6.5.1. Kuwait Hepatic Fibrosis Biomarkers Market, 2021 - 2033 (USD Million)
7.6.5.2. Key Country Dynamics
7.6.5.3. Regulatory Framework
7.6.5.4. Reimbursement Scenario
7.6.5.5. Competitive Scenario
Chapter 8. Competitive Landscape
8.1. Company Categorization
8.2. Strategy Mapping
8.2.1. New Product Launch
8.2.2. Partnerships
8.2.3. Acquisition
8.2.4. Collaboration
8.2.5. Funding
8.3. Key Company Market Share Analysis, 2024
8.4. Company Heat Map Analysis
8.5. Company Profiles
8.5.1. GENFIT
8.5.1.1. Company Overview
8.5.1.2. Financial Performance
8.5.1.3. Product Benchmarking
8.5.1.4. Strategic Initiatives
8.5.2. Prometheus Laboratories
8.5.2.1. Company Overview
8.5.2.2. Financial Performance
8.5.2.3. Product Benchmarking
8.5.2.4. Strategic Initiatives
8.5.3. Siemens Healthineers AG
8.5.3.1. Company Overview
8.5.3.2. Financial Performance
8.5.3.3. Product Benchmarking
8.5.3.4. Strategic Initiatives
8.5.4. BioPredictive
8.5.4.1. Company Overview
8.5.4.2. Financial Performance
8.5.4.3. Product Benchmarking
8.5.4.4. Strategic Initiatives
8.5.5. Quest Diagnostics
8.5.5.1. Company Overview
8.5.5.2. Financial Performance
8.5.5.3. Product Benchmarking
8.5.5.4. Strategic Initiatives
8.5.6. AstraZeneca
8.5.6.1. Company Overview
8.5.6.2. Financial Performance
8.5.6.3. Product Benchmarking
8.5.6.4. Strategic Initiatives
8.5.7. Exalenz Bioscience Ltd (meridian bioscience)
8.5.7.1. Company Overview
8.5.7.2. Financial Performance
8.5.7.3. Product Benchmarking
8.5.7.4. Strategic Initiatives
8.5.8. Labcorp
8.5.8.1. Company Overview
8.5.8.2. Financial Performance
8.5.8.3. Product Benchmarking
8.5.8.4. Strategic Initiatives
8.5.9. Pfizer Inc.
8.5.9.1. Company Overview
8.5.9.2. Financial Performance
8.5.9.3. Product Benchmarking
8.5.9.4. Strategic Initiatives
8.5.10. Bristol-Myers Squibb Company
8.5.10.1. Company Overview
8.5.10.2. Financial Performance
8.5.10.3. Product Benchmarking
8.5.10.4. Strategic Initiatives
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