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Monocyte Activation Test Global Market Report 2025
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The monocyte activation test (MAT) is an in vitro method used to detect pyrogens by measuring cytokine release, particularly interleukin-6 (IL-6), from human monocytes. It more accurately replicates the human immune response compared to traditional animal-based tests. The primary objective of this test is to ensure pyrogen safety in pharmaceuticals, particularly in biologics and medical devices.

The main product types in the monocyte activation test market include reagents, test kits, assay systems, and software solutions. Reagents are specialized chemical or biological substances designed to stimulate or identify immune responses, facilitating the accurate detection of pyrogenic contaminants. The test employs various technologies, such as enzyme-linked immunosorbent assay (ELISA), flow cytometry, polymerase chain reaction (PCR), and Luminex technologies. It is distributed through multiple channels, including direct sales, distributors or third-party partners, online retailers, and institutional sales. MAT is applied in various areas such as drug development, vaccine development, medical device testing, and others, and serves a wide range of end-users, including pharmaceutical companies, biotechnology firms, research institutions, hospitals, and laboratories.

The monocyte activation test market research report is one of a series of new reports from The Business Research Company that provides monocyte activation test market statistics, including the monocyte activation test industry global market size, regional shares, competitors with the monocyte activation test market share, detailed monocyte activation test market segments, market trends, opportunities, and any further data you may need to thrive in the monocyte activation test industry. This monocyte activation test market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The monocyte activation test market size has grown rapidly in recent years. It will grow from $0.47 billion in 2024 to $0.54 billion in 2025 at a compound annual growth rate (CAGR) of 15.0%. The historical growth of the MAT market can be attributed to heightened concerns regarding animal welfare, increased regulatory acceptance, the expansion of pharmaceutical and biologics production, a stronger focus on detecting both endotoxin and non-endotoxin pyrogens, and a rising prevalence of chronic and infectious diseases.

The monocyte activation test market size is expected to see rapid growth in the next few years. It will grow to $0.94 billion in 2029 at a compound annual growth rate (CAGR) of 14.7%. Projected growth in the forecast period is expected to stem from increased support for the principles of replacement, reduction, and refinement (3Rs), higher investment in life sciences research and development, growing utilization of monoclonal antibodies and cell therapies, broader recognition of the limitations associated with traditional pyrogen testing methods, and a rise in collaborations and strategic partnerships. Key trends anticipated during this period include advancements in in vitro diagnostic technologies, the incorporation of automation into laboratory workflows, technological improvements in monocyte-based cell culture systems, progress in modeling human immune responses, and developments in cryopreserved monocyte technologies.

The increasing prevalence of autoimmune disorders is anticipated to drive the growth of the monocyte activation test market. Autoimmune disorders occur when the body's immune system mistakenly attacks healthy cells, tissues, or organs, rather than defending against infections and foreign substances. This rising prevalence is largely attributed to greater exposure to environmental pollutants, which can disrupt immune system regulation and provoke abnormal immune responses. The monocyte activation test (MAT) plays a key role in detecting autoimmune disorders by offering a reliable method to assess immune system activation. It enables the identification of irregular immune responses, which is critical for diagnosing conditions such as lupus and rheumatoid arthritis, thereby supporting early detection and better disease management. For example, according to a November 2024 survey by Versorgungsatlas.de, a Germany-based organization, among 73,241,305 insured individuals in 2022, 6,304,340 were diagnosed with at least one autoimmune disease, indicating a raw prevalence rate of 8.61%. As a result, the increasing incidence of autoimmune disorders is fueling the expansion of the monocyte activation test market.

Leading companies in the monocyte activation test market are prioritizing the development of advanced MAT products, including pyrogen and endotoxin tests, to improve test sensitivity and enhance immune response detection. Pyrogen and endotoxin tests are essential for identifying fever-inducing substances, particularly endotoxins produced by gram-negative bacteria. For instance, in June 2024, FUJIFILM Wako Pure Chemicals Corporation, a Japan-based chemical manufacturer, introduced the LumiMAT Pyrogen Detection Kit-a next-generation monocyte activation test for in vitro pyrogen screening-and PYROSTAR Neo+, a recombinant protein reagent designed for bacterial endotoxin detection. These innovations significantly enhance the precision, performance, and safety of pyrogen testing across pharmaceutical and biotechnology applications.

In October 2022, FUJIFILM Wako LAL, a division of FUJIFILM Wako Chemicals U.S.A. Corporation, partnered with Cotton Mouton Diagnostics Ltd. to advance patient safety through high-quality and dependable endotoxin testing solutions. The collaboration aims to integrate CMD's accredited testing capabilities with FUJIFILM Wako's PYROSTAR ES-F reagents, delivering sensitive and specific endotoxin testing services that support the pharmaceutical and medical device industries. Cotton Mouton Diagnostics Ltd. is a UK-based biotechnology firm recognized for its innovative approaches to monocyte activation tests (MAT).

Major players in the monocyte activation test market are Merck KGaA, Becton Dickinson and Company, Eurofins Scientific, Lonza Group, Charles River Laboratories, Nelson Laboratories LLC, Solvias AG, Labor LS SE and Co. KG, BMG Labtech, Cellular Technology Limited, Creative Biolabs, FUJIFILM Wako Chemicals, Microcoat Biotechnologie GmbH, MAT BioTech B.V., Sanquin Diagnostiek B.V., PyroDex LLC, MAT Research B.V., Minerva Biolabs GmbH, Wickham Micro Limited, and Rapid Test Methods Ltd.

North America was the largest region in the monocyte activation test market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in monocyte activation test report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the monocyte activation test market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The monocyte activation test market consists of revenues earned by entities by providing services such as pyrogen detection testing, batch release testing, medical device testing, vaccine and biologic testing, and customized test development. The market value includes the value of related goods sold by the service provider or included within the service offering. The monocyte activation test market also includes sales of cryopreserved human monocytes, cytokine detection kits, culture media and buffers, and pyrogen-free consumables. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Monocyte Activation Test Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on monocyte activation test market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for monocyte activation test ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The monocyte activation test market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Monocyte Activation Test Market Characteristics

3. Monocyte Activation Test Market Trends And Strategies

4. Monocyte Activation Test Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market

5. Global Monocyte Activation Test Growth Analysis And Strategic Analysis Framework

6. Monocyte Activation Test Market Segmentation

7. Monocyte Activation Test Market Regional And Country Analysis

8. Asia-Pacific Monocyte Activation Test Market

9. China Monocyte Activation Test Market

10. India Monocyte Activation Test Market

11. Japan Monocyte Activation Test Market

12. Australia Monocyte Activation Test Market

13. Indonesia Monocyte Activation Test Market

14. South Korea Monocyte Activation Test Market

15. Western Europe Monocyte Activation Test Market

16. UK Monocyte Activation Test Market

17. Germany Monocyte Activation Test Market

18. France Monocyte Activation Test Market

19. Italy Monocyte Activation Test Market

20. Spain Monocyte Activation Test Market

21. Eastern Europe Monocyte Activation Test Market

22. Russia Monocyte Activation Test Market

23. North America Monocyte Activation Test Market

24. USA Monocyte Activation Test Market

25. Canada Monocyte Activation Test Market

26. South America Monocyte Activation Test Market

27. Brazil Monocyte Activation Test Market

28. Middle East Monocyte Activation Test Market

29. Africa Monocyte Activation Test Market

30. Monocyte Activation Test Market Competitive Landscape And Company Profiles

31. Monocyte Activation Test Market Other Major And Innovative Companies

32. Global Monocyte Activation Test Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Monocyte Activation Test Market

34. Recent Developments In The Monocyte Activation Test Market

35. Monocyte Activation Test Market High Potential Countries, Segments and Strategies

36. Appendix

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