Genome Editing Market - Focus on Technology, Type of Therapy, Gene Editing Approach, Type of Gene Delivery Method, Gene Delivery Modality, Application Area, Type of End-User and Leading Industry Players: Industry Trends and Global Forecasts, till 2035
As per Roots Analysis, the global genome editing market size is currently valued at USD 3.41 billion in 2024, is projected to reach USD 4.25 billion in the current year and USD 13.36 billion by 2035, growing at a CAGR of 12.1% during the forecast period.
The opportunity for genome editing market has been distributed across the following segments:
Payment Method Employed
Upfront Payments
Milestone Payments
Type of Gene Editing Technique
CRISPR-Cas System
TALENs
Meganucleases
ZFNs
Other Techniques
Gene Editing Approach
Gene Knock-out
Gene Knock-in
Gene Delivery Methods
Ex vivo
In vivo
Gene Delivery Modality
Viral Vectors
Non-Viral Vectors
Type of Therapy
Cell Therapies
Gene Therapies
Other Therapies
Application Area
Drug Discovery and Development
Diagnostics
Type of End-User
Pharmaceutical and Biotechnology Companies
Academic and Research Institutes
Key Geographical Regions
North America (US, Canada)
Europe (Germany, France and Ireland)
Asia-Pacific (South Korea, China and Japan)
GENOME EDITING MARKET: GROWTH AND TRENDS
The human genome comprises nearly three billion nucleotide base pairs, which contain ~20,000-25,000 protein-coding genes. These genes act as a code that regulates and controls protein synthesis, thereby influencing gene expression. The ongoing advancements in the biotechnology domain have enabled various medical researchers to modify human genome expression through specialized techniques called genome editing or genome engineering. Genome editing, also known as gene editing, is a technique that allows genome modification by inserting, deleting or replacing a single gene or a set of genes in an organism, thereby altering the nucleotide composition. The growing need for genome editing at the desired site has led to the development of various genome editing tools by companies engaged in this domain. Key technologies include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and CRISPR technology. Notably, ZFN was the first genome engineering technique discovered in 1895, followed by TALENs (in 2011) and CRISPR, which emerged as a transformative breakthrough in the genome editing domain. These gene editing tools have been widely used for the treatment of various clinical conditions developed as a result of genetic abnormalities, such as sickle cell disease, Parkinson's disease, peripheral artery disease, spinal muscular atrophy, autoimmune diseases, and other genetic disorders.
Moreover, gene therapies have gained prominence as a promising approach to addressing the underlying genetic abnormalities by introducing therapeutic genes into the cells or by replacing mutated genes. As of April 2024, over 1,100 active clinical trials are investigating gene therapies at various stages of development. According to the WHO, 10 out of every 1,000 individuals suffer from genetic disorders, affecting more than 70 million people worldwide. Further, more than 40% of infant mortality globally is associated with various genetic disorders. Despite its potential, gene edited drug development requires substantial investment in drug discovery, development, and manufacturing. Therefore, in order to ensure the efficiency, precision and safe delivery of these drugs, pharmaceutical companies are increasingly adopting advanced genome editing technologies. As a result, there is a growing emphasis on integrating cutting-edge technologies to enhance clinical outcomes through precise genetic modifications.
The ongoing pace of innovation in the genome editing domain, coupled with the promising clinical trial results in cell and gene therapies are driving the industry forward. Additionally, the expanding applications of gene editing in agriculture and food security are further propelling the market growth.
GENOME EDITING MARKET: KEY INSIGHTS
The report delves into the current state of the genome editing market and identifies potential growth opportunities within the industry. The key takeaways of the report are:
Close to 85% of technologies use CRISPR-Cas technique; of these, nearly 30% enable the delivery of the CRISPR tool directly into the cells, primarily utilized for drug discovery and regenerative medicine.
A steady growth in partnership activity has been observed in recent years; technology licensing agreements have emerged as the most prominent type of partnership model.
Over 2,400 patents related to genome editing have been filed by / granted to various technology developers in order to protect the intellectual property generated within this field.
Foreseeing lucrative returns, many public and private investors have made investments worth USD 14.1 billion since 2018; the funding activity in this domain is well distributed across different geographical regions.
The genome editing technologies market is anticipated to witness an annualized growth rate of 12.1% over the next decade.
The market opportunity for technologies being developed for pharmaceutical and biotechnology companies is likely to be the highest; in terms of type of therapy, gene therapy segment is anticipated to grow substantially.
GENOME EDITING MARKET: KEY SEGMENTS
Based on the type of Payment Mode Employed, Upfront Payments Captures the Majority of the Current Market Share
Based on the type of payment method employed, the global genome editing market is segmented into upfront payments and milestone payments. Presently, the upfront payment segment occupies the highest share of the overall market. However, it is important to note that the milestone payment segment is anticipated to witness significant growth during the forecast period.
CRISPR-Cas System is Likely to Hold the Largest Share in the Genome Editing Market During the Forecast Period
Based on the type of gene editing techniques, the global genome editing market is segmented into CRISPR-Cas Systems, TALENs, Meganucleases, ZFNs, and others. Currently, CRISP-Case systems segment leads the genome editing market. Further, it is important to highlight that this trend is unlikely to change in the future as well. This trend can be attributed to the fact that next-generation CRISPR technologies have emerged as a promising technique to overcome the limitations associated with conventional gene editing techniques, by offering more customized and precise results.
Genome Editing Market for Gene Knock-out is Likely to Grow at a Relatively Faster Pace During the Forecast Period
Based on the type of gene editing approach, the global genome editing market is segmented across gene knock-in and gene knock-out approaches. Presently, the market is dominated by the revenues generated through gene knock-out approach. This can be attributed to the greater feasibility and accessibility of this approach, in comparison to knock-in approach, since knock-in approaches require a complex optimization process.
Genome Editing Market for In-vivo is Likely to Grow at a Higher CAGR During the Forecast Period
Based on the gene delivery method, the global genome editing market is segmented into ex-vivo and in-vivo. Currently, the ex-vivo segment captures the maximum share of the genome editing market. This can be attributed to the fact that in ex vivo gene delivery, cells are taken from the patient, modified in the lab and then reintroduced into the body. This allows precise control over the genetic modification in a lab setting, while minimizing the associated off-target effects. However, the in-vivo segment is likely to grow at a relatively higher CAGR during the forecast period.
Viral Vectors are Likely to Dominate the Genome Editing Market During the Forecast Period
Based on the gene delivery modality, the global genome editing market is distributed across viral vectors and non-viral vectors. Presently, the viral vector segment occupies the highest share of the genome editing market. However, due to various challenges associated with the use of viral vectors as gene modality (such as cytotoxicity, immunogenicity and scale-up issues), this trend is anticipated to change in the coming years, with non-viral vectors occupying an approximately equal market share in the overall market.
Cell Therapies Hold the Largest Share in the Genome Editing Market
Based on the type of therapy, the global genome editing market is segmented into cell therapies, gene therapies, and others. Presently, the cell therapies segment accounts for the largest market share. Additionally, owing to its wider applicability in treating a wide array of diseases this trend is unlikely to change in the future as well.
Drug Discovery and Development Hold the Largest Share in the Genome Editing Market
Based on the application area, the global genome editing market is segmented into drug discovery and development, and diagnostics. Currently, drug discovery and development segment capture the majority of the market share.
Revenues Generated from Pharmaceutical and Biotechnology Companies are Likely to Dominate the Genome Editing Market During the Forecast Period
Based on the end-user, the global genome editing market is distributed across pharmaceutical and biotechnology companies, and academic and research institutions. Notably, the pharmaceutical and biotechnology segment captures the majority of the genome editing market. This is due to the fact that pharmaceutical and biotechnology companies have signed maximum technology licensing / integration agreements in this domain, thus contributing to the majority of the revenue generated by industry players.
North America Accounts for the Largest Share in the Market
Based on key geographical regions, the market is segmented into North America, Europe, and Asia Pacific. In the current scenario, North America is likely to capture the largest market share. Further, it is worth highlighting that Europe is expected to grow at a relatively high CAGR during the forecast period.
Example Players in the Genome Editing Market
Arcturus Therapeutics
ArsenalBio
Avectas
Beam Therapeutics
Bio-Sourcing
Caribou Biosciences
Century Therapeutics
CRISPR Therapeutics
Editas Medicine
Flash Biosolutions
Graphite Bio
Intellia Therapeutics
NTrans Technologies
OXGENE
Prime Medicine
Revvity
Vor Biopharma
GENOME EDITING MARKET: RESEARCH COVERAGE
The report on the genome editing market features insights into various sections, including:
Market Sizing and Opportunity Analysis: An in-depth analysis of current market opportunity and the future growth potential of genome editing market, focusing on key market segments, including [A] payment method employed, [B] type of gene editing technique, [C] gene editing approach, [D] gene delivery methods, [E] gene delivery modality, [F] type of therapy, [G] application area, [H] type of end-user, [I] key geographical regions, and [J] leading industry players.
Market Impact Analysis: A thorough analysis of various factors, such as [A] drivers, [B] restraints, [C] opportunities, and [D] existing challenges that are likely to impact market growth.
Market Landscape: A comprehensive evaluation of genome editing technologies, based on several relevant parameters, such as [A] type of gene editing technique, [B] type of gene editing approach, [C] type of gene delivery method, [D] type of gene delivery modality, [E] highest phase of drug development supported, [F] therapeutic area, and [G] application area.
Genome Editing Technology Providers Landscape: The report features a list of technology providers engaged in the genome editing domain, along with analyses based on [A] year of establishment, [B] company size, and [C] location of headquarters, [D] most active players, and [E] operational model.
Technology Competitiveness Analysis: An insightful competitiveness analysis of the genome technologies in this domain, based on various relevant parameters, such as [A] company strength, and [B] technology strength.
Company Profiles: Comprehensive profiles of key industry players in the genome editing domain based in regions, such as North America, Europe, and Asia-Pacific and rest of the world, featuring information on [A] company overview, [B] financial information (if available), [C] technology portfolio, [D] recent developments, and [E] future outlook statements.
Partnerships and Collaborations: A detailed analysis of partnerships inked between stakeholders in the genome editing market, since 2018, based on several relevant parameters, such as [A] year of partnership, [B] type of partnership, [C] purpose of partnership, [D] type of partner, [E] location of headquarters of partner, [F] most active players (in terms of number of partnerships), and [G] geography.
Patent Analysis: An in-depth analysis of various patents that have been filed / granted by various technology providers related to genome editing, since 2018, based on various relevant parameters, such as [A] type of patent, [B] publication year, [C] geography, [D] CPC symbols, [E] leading industry players (in terms of number of patents), [F] patent benchmarking, [G] patent characteristics, [H] leading industry players, and [I] patent valuation.
Funding and Investments Analysis: A detailed analysis of the various funding and investments raised in the genome editing domain, based on several relevant parameters, such as [A] year of funding, [B] amount of funding, [C] type of funding, [D] geography, [E] most active players (in terms of number of funding instances), and [F] leading investors.
KEY QUESTIONS ANSWERED IN THIS REPORT
How many companies are currently engaged in this market?
Which are the leading companies in this market?
What factors are likely to influence the evolution of this market?
What is the current and future market size?
What is the CAGR of this market?
How is the current and future market opportunity likely to be distributed across key market segments?
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The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
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TABLE OF CONTENTS
SECTION I: REPORT OVERVIEW
1. BACKGROUND
1.1. Context
1.2. Project Objectives
2. RESEARCH METHODOLOGY
2.1. Chapter Overview
2.2. Research Assumptions
2.2.1. Market Landscape and Market Trends
2.2.2. Market Forecast and Opportunity Analysis
2.2.3. Comparative Analysis
2.3. Database Building
2.3.1. Data Collection
2.3.2. Data Validation
2.3.3. Data Analysis
2.4. Project Methodology
2.4.1. Secondary Research
2.4.1.1. Annual Reports
2.4.1.2. Academic Research Papers
2.4.1.3. Company Websites
2.4.1.4. Investor Presentations
2.4.1.5. Regulatory Filings
2.4.1.6. White Papers
2.4.1.7. Industry Publications
2.4.1.8. Conferences and Seminars
2.4.1.9. Government Portals
2.4.1.10. Media and Press Releases
2.4.1.11. Newsletters
2.4.1.12. Industry Databases
2.4.1.13. Roots Proprietary Databases
2.4.1.14. Paid Databases and Sources
2.4.1.15. Social Media Portals
2.4.1.16. Other Secondary Sources
2.4.2. Primary Research
2.4.2.1. Types of Primary Research
2.4.2.1.1. Qualitative Research
2.4.2.1.2. Quantitative Research
2.4.2.1.3. Hybrid Approach
2.4.2.2. Advantages of Primary Research
2.4.2.3. Techniques for Primary Research
2.4.2.3.1. Interviews
2.4.2.3.2. Surveys
2.4.2.3.3. Focus Groups
2.4.2.3.4. Observational Research
2.4.2.3.5. Social Media Interactions
2.4.2.4. Key Opinion Leaders Considered in Primary Research
2.4.2.4.1. Company Executives (CXOs)
2.4.2.4.2. Board of Directors
2.4.2.4.3. Company Presidents and Vice Presidents
2.4.2.4.4. Research and Development Heads
2.4.2.4.5. Technical Experts
2.4.2.4.6. Subject Matter Experts
2.4.2.4.7. Scientists
2.4.2.4.8. Doctors and Other Healthcare Providers
2.4.2.5. Ethics and Integrity
2.4.2.5.1. Research Ethics
2.4.2.5.2. Data Integrity
2.4.3. Analytical Tools and Databases
2.5. Robust Quality Control
3. MARKET DYNAMICS
3.1. Chapter Overview
3.2. Forecast Methodology
3.2.1. Top-down Approach
3.2.2. Bottom-up Approach
3.2.3. Hybrid Approach
3.3. Market Assessment Framework
3.3.1. Total Addressable Market (TAM)
3.3.2. Serviceable Addressable Market (SAM)
3.3.3. Serviceable Obtainable Market (SOM)
3.3.4. Currently Acquired Market (CAM)
3.4. Forecasting Tools and Techniques
3.4.1. Qualitative Forecasting
3.4.2. Correlation
3.4.3. Regression
3.4.4. Extrapolation
3.4.5. Convergence
3.4.6. Sensitivity Analysis
3.4.7. Scenario Planning
3.4.8. Data Visualization
3.4.9. Time Series Analysis
3.4.10. Forecast Error Analysis
3.5. Key Considerations
3.5.1. Demographics
3.5.2. Government Regulations
3.5.3. Reimbursement Scenarios
3.5.4. Market Access
3.5.5. Supply Chain
3.5.6. Industry Consolidation
3.5.7. Pandemic / Unforeseen Disruptions Impact
3.6. Limitations
4. MACRO-ECONOMIC INDICATORS
4.1. Chapter Overview
4.2. Market Dynamics
4.2.1. Time Period
4.2.1.1. Historical Trends
4.2.1.2. Current and Forecasted Estimates
4.2.2. Currency Coverage
4.2.2.1. Major Currencies Affecting the Market
4.2.2.2. Factors Affecting Currency Fluctuations on the Industry
4.2.2.3. Impact of Currency Fluctuations on the Industry
4.2.3. Foreign Currency Exchange Rate
4.2.3.1. Impact of Foreign Exchange Rate Volatility on the Market
4.2.3.2. Strategies for Mitigating Foreign Exchange Risk
4.2.4. Recession
4.2.4.1. Assessment of Current Economic Conditions and Potential Impact on the Market
4.2.4.2. Historical Analysis of Past Recessions and Lessons Learnt
4.2.5. Inflation
4.2.5.1. Measurement and Analysis of Inflationary Pressures in the Economy
4.2.5.2. Potential Impact of Inflation on the Market Evolution
4.2.6. Interest Rates
4.2.6.1. Interest Rates and Their Impact on the Market
4.2.6.2. Strategies for Managing Interest Rate Risk
4.2.7. Commodity Flow Analysis
4.2.7.1. Type of Commodity
4.2.7.2. Origins and Destinations
4.2.7.3. Values and Weights
4.2.7.4. Modes of Transportation
4.2.8. Global Trade Dynamics
4.2.8.1. Import Scenario
4.2.8.2. Export Scenario
4.2.8.3. Trade Policies
4.2.8.4. Strategies for Mitigating the Risks Associated with Trade Barriers
4.2.8.5. Impact of Trade Barriers on the Market
4.2.9. War Impact Analysis
4.2.9.1. Russian-Ukraine War
4.2.9.2. Israel-Hamas War
4.2.10. COVID Impact / Related Factors
4.2.10.1. Global Economic Impact
4.2.10.2. Industry-specific Impact
4.2.10.3. Government Response and Stimulus Measures
4.2.10.4. Future Outlook and Adaptation Strategies