Exosome Therapy Market by Type of Therapeutic, Target Indication, Therapeutic Area, Route of Administration and Geography : Industry Trends and Global Forecasts, Till 2035
As per Roots Analysis, the global exosome therapy is estimated to grow from USD 0.03 billion in 2029 to USD 1.4 billion by 2040, at a CAGR of 41.1% during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Exosome Therapeutics
Allogenic
Autologous
Target Disease Indications
Degenerative Meniscal Injury
Dystrophic Epidermolysis Bullosa
Fistula Perianal
Retinitis Pigmentosa
Therapeutic Area
Dermatological Disorders
Musculoskeletal Disorders
Ophthalmic Disorders
Rectal Disorders
Route of Administration
Fistula Tract
Intra-articular
Intra-ocular
Key Geographical Regions
North America
Europe
Asia-Pacific
Rest of the World
EXOSOME THERAPY MARKET: GROWTH AND TRENDS
Owing to the various benefits, such as enhanced tissue regeneration, reduced inflammation and chronic pain, and target specificity, exosome therapies have garnered significant attention in the recent past. Various studies have demonstrated the high efficacy and therapeutic superiority of exosome therapeutics in disease diagnosis, drug delivery and therapeutic applications. It is worth highlighting that over 120 therapeutic candidates are currently being investigated for treating myriads of disease indications, across the globe. This depicts the extensive development efforts being undertaken by drug developers in this domain. More than 40% of the total number of drugs are in various phases of clinical development. Of the total candidates, seven exosome therapies, including EXOMSC-COV19 (Dermama Biotech Lab), Dex2 (Gustave Roussy Institute), SF-MSC-EX (Osmangazi University), are currently being tested in the advanced clinical stages of development.
At present, around 30% of exosome-based therapeutics are under development for the treatment of various cancers. This innovative approach uses exosomes as a means to deliver drugs specifically to cancer cells, and these therapies are still in the early phases of research. Notable types of cancer being investigated for exosome delivery systems include breast cancer, lung cancer, melanoma, and colon cancer. Considering the ongoing R&D efforts in this domain, promising clinical trial results and anticipated launch of late-stage exosome therapies, the market is anticipated to witness notable growth over the next decade.
EXOSOME THERAPY MARKET: KEY INSIGHTS
The report delves into the current state of the exosome therapy market and identifies potential growth opportunities within the industry. Some key findings from the report include:
Close to 60 players, worldwide, have taken initiatives to develop exosome therapeutics; the market is characterized by the presence of start-ups and small companies.
The current pipeline features more than 120 exosome therapeutics that are being evaluated across different phases of development; most of these are designed for intravenous administration.
3,000+ patients have been recruited / enrolled in clinical trials evaluating exosome related therapies and biomarkers across different geographies.
More than 530 grants have been awarded for the ongoing R&D efforts for exosome therapeutics; the University of California has been awarded the maximum grant amount of USD 21 million.
A variety of investors, having realized the benefits and future opportunities in this field, have invested more than USD 570 million across more than 30 instances.
The rising interest of stakeholders in exosome therapeutics is also reflected by the increasing number of partnerships established by various industry and non-industry players.
Stakeholders have participated in various global events to discuss the research outcomes, and affiliated challenges as well as opportunities existing in this domain.
At present, more than 30 start-ups are driving innovation in this domain; a variety of R&D initiatives have been undertaken by these players over the last few years for the development of exosome therapeutics.
Lack of efficacy, the COVID-19 pandemic, limited patient enrollment, and scarce funding are among the key reasons that have led to the discontinuation of studies sponsored by various industry and non-industry players.
With the rising demand for therapeutic advances in drug safety, the market for exosome therapeutics is expected to grow at an annualized rate of 41.1% between 2029-2040.
EXOSOME THERAPY MARKET: KEY SEGMENTS
Autologous Therapies are Likely to Capture Largest Share of the Exosome Therapy Market
Based on the type of therapy, the market is segmented into allogenic therapy and autologous therapy. It is anticipated that the autologous therapy segment will hold the maximum share of the exosome therapy market in 2029. However, it is worth highlighting that allogeneic therapy is likely to grow at a relatively higher CAGR.
Retinitis Pigmentosa is Likely to be the Fastest Growing Segment of the Exosome Therapy Market During the Forecast Period
Based on the target disease indication, the market is segmented into degenerative meniscal injury, dystrophic epidermolysis bullosa, fistula perianal and retinitis pigmentosa. It is anticipated that fistula perianal will hold the maximum share of the exosome therapy market in 2029. However, it is worth highlighting that the exosome therapy market for retinitis pigmentosa is likely to grow at a relatively higher CAGR.
Rectal Disorders Segment is the Fastest Growing Segment of the Exosome Therapy Market
Based on the therapeutic area, the market is segmented into dermatological disorders, musculoskeletal disorders, ophthalmic disorders and rectal disorders. While the rectal disorders segment is likely to hold a relatively higher market share, it is worth highlighting that the ophthalmic diseases segment is expected to witness substantial market growth in the coming years.
Fistula Tract Segment is Likely to Capture Largest Share of the Exosome Therapy Market in 2029
Based on the route of administration, the market is segmented into fistula tract, intra-articular and intra-ocular. It is anticipated that the fistula tract segment will hold the maximum share of the exosome therapy market in 2029. However, it is worth highlighting that the intraocular segment is likely to grow at a relatively higher CAGR.
Asia-Pacific Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific and the Rest of the World. The majority share is expected to be captured by drug developers based in Asia-Pacific. It is worth highlighting that, over the years, the market in Europe is expected to grow at a higher CAGR.
Example Players in the Exosome Therapy Market
Coya Therapeutics
Evox Therapeutics
Curexsys
EV Therapeutics
SHIFTBIO
Primary Research Overview
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:
Chief Business Officer, Capricor Therapeutics
R&D and Innovation Manager, Exogenus Therapeutics
Chief Business Officer, ILIAS Biologics
EXOSOME THERAPY MARKET: RESEARCH COVERAGE
Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the exosome therapy market, focusing on key market segments, including [A] type of therapy, [B] target disease indications, [C] therapeutic area, [D] route of administration and [E] key geographical regions.
Market Landscape: A comprehensive evaluation of exosome therapeutics, considering various parameters, such as [A] phase of development, [B] technology platform, [C] type of payload, [D] target disease indication (s), [E] therapeutic area, [F] biological target, [G] route of administration, [H] type of therapy, [I] combination drug, [J] line of treatment and [K] dosing frequency. Further, it includes details on the exosome therapeutic developers, along with information on their [L] year of establishment, [M] company size and [N] location of headquarters.
Company Profiles: In-depth profiles of key industry players engaged in the development of exosome therapeutics, focusing on [A] company overviews, [B] financial information (if available), [C] product portfolio, [E] recent developments and [F] an informed future outlook.
Drug Profiles: In-depth profiles of key exosome therapies, focusing on [A] product portfolio and [B] clinical trial information.
Clinical Trials Analysis: Examination of completed, ongoing, and planned clinical studies of various exosome therapeutics, based on parameters like [A] trial status, [B] trial registration year, [C] type of sponsor / collaborator, [D] study design, [E] number of patients enrolled, [F] year-wise trend of completed and recruiting trials, [G] age group of the patients enrolled, [H] active industry and non-industry players and [I] location of the trials.
Academic Grant Analysis: A comprehensive examination of various academic grants that have been awarded to various research institutes for projects related to exosome therapeutics, based on several parameters, such as [A] year of grant awarded, [B] amount awarded, [C] type of funding institute center, [D] popular NIH departments, [E] support period, [F] emerging focus area, [G] purpose of grants, [H] grant activity code, [I] local recipients, [J] type of recipient organization study section, [K] type of grant application and [L] popular recipient organizations, (in terms of number of grants and amount awarded).
Global Event Analysis: An in-depth analysis of the global events attended by the exosome therapy developers, based on several relevant parameters, such as [A] year of event, [B] type of event platform, [C] location of event, [D] emerging focus areas, [E] active organizers (in terms of number of events), [F] active industry and non-industry participants, [G] designation of participants, [H] affiliated department of participants, and [I] active speakers (in terms of number of events).
Partnerships and Collaborations: An analysis of partnerships established in this sector, since 2017, covering research agreements, licensing agreements, manufacturing agreements, product development and commercialization agreements, mergers / acquisitions, and other relevant deals.
Funding and Investment Analysis: A detailed evaluation of the investments made in this domain, encompassing seed financing, venture capital financing, IPOs, secondary offering, debt financing and other equity.
Start-Up Health Indexing: An analysis of start-ups / small companies engaged in the development of exosome therapeutics, based on parameters, such as [A] pipeline strength, [B] pipeline maturity, [C] financial support, [D] number of investors, [E] partnership activity and [F] start-up health indexing.
Case Study: A case study highlighting the companies offering development and manufacturing services for exosome therapeutics, along with the information on their [A] year of establishment, [B] company size, [C] location of headquarters, [D] types of service(s) offered, [E] method of isolation, [F] method of purification, [G] method of characterization, [H] method of exosome manufacturing, [I] scale of operation and [J] scalability.
Drug Failure Analysis: An in-depth analysis, focusing on exosome therapeutics that failed to progress to later stages of clinical development, based on various relevant parameters, such as [A] trial status of discontinuation, [B] target disease indication(s), [C] route of administration and [D] type of sponsor.
KEY QUESTIONS ANSWERED IN THIS REPORT
How many companies are currently engaged in this market?
Which are the leading companies in this market?
What kind of partnership models are commonly adopted by industry stakeholders?
What factors are likely to influence the evolution of this market?
What is the current and future market size?
What is the CAGR of this market?
How is the current and future market opportunity likely to be distributed across key market segments?
REASONS TO BUY THIS REPORT
The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
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TABLE OF CONTENTS
1. PREFACE
1.1. Scope of the Report
1.2. Market Segmentation
1.3. Research Methodology
1.4. Key Questions Answered
1.5. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Overview of Exosomes
3.1.1. Types of Extracellular Vesicles
3.1.2. Potential Sources of Exosomes
3.2. Exosome Biogenesis
3.2.1. Exosome Formation and Development Process
3.2.2. Secretion of Exosomes
3.3. Applications of Exosomes
3.4. Mechanism of Exosome Therapy
3.4.1. Exosome Drug Therapy
3.4.2. Exosome RNAi Therapy
3.4.3. Exosome Immunotherapy
3.5. Advantages of Exosome Therapies
3.6. Risks and Future Perspectives Associated with Exosome Therapeutics
4. EXOSOME THERAPEUTICS: MARKET LANDSCAPE
4.1. Analysis Methodology and Key Parameters
4.2. Exosome Therapeutics Market Landscape
4.2.1. Analysis by Phase of Development
4.2.2. Analysis by Technology Platform
4.2.3. Analysis by Type of Payload
4.2.4. Analysis by Type of Formulation
4.2.5. Analysis by Type of Therapy
4.2.6. Analysis by Derived Source
4.2.7. Analysis by Target Disease Indication(s)
4.2.8. Analysis by Therapeutic Area
4.2.9. Analysis by Phase of Development and Therapeutic Area
4.2.10. Analysis by Route of Administration
4.2.11. Analysis by Therapeutic Area and Route of Administration
4.2.12. Analysis by Type of Therapy (By Method of Composition)
4.2.13. Analysis by Line of Treatment
4.2.14. Analysis by Dosing Frequency
4.3. Exosome Therapeutics Developers
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters
4.3.4. Most Active Players: Analysis by Number of Therapeutics
5. EXOSOME THERAPEUTICS DEVELOPERS: COMPANY PROFILES
5.1. Codiak BioSciences
5.1.1. Company Overview
5.1.2. Product Portfolio
5.1.3. Clinical Trial Information
5.1.4. Recent Developments and Future Outlook
5.2. Coya Therapeutics
5.2.1. Company Overview
5.2.2. Product Portfolio
5.2.3. Recent Developments and Future Outlook
5.3. Curexsys
5.3.1. Company Overview
5.3.2. Product Portfolio
5.3.3. Recent Developments and Future Outlook
5.4. EV Therapeutics
5.4.1. Company Overview
5.4.2. Product Portfolio
5.4.3. Recent Developments and Future Outlook
5.5. Evox Therapeutics
5.5.1. Company Overview
5.5.2. Product Portfolio
5.5.3. Recent Developments and Future Outlook
5.6. SHIFTBIO
5.6.1. Company Overview
5.6.2. Product Portfolio
5.6.3. Recent Developments and Future Outlook
6. EXOSOME THERAPEUTICS: DRUG PROFILES
6.1. AEGLE Therapeutics
6.1.1. Company Overview
6.1.2. AGLE-102: Product Portfolio
6.1.2.1. AGLE-102: Clinical Trial Information
6.1.3. Recent Developments and Future Outlook
6.2. AVEM Healthcare
6.2.1. Company Overview
6.2.2. Ardoxso: Product Portfolio
6.2.2.1. Ardoxso: Clinical Trial Information
6.2.3. Recent Developments and Future Outlook
6.3. Cellular Biomedicine Group
6.3.1. Company Overview
6.3.2. Financial Information
6.3.3. haMPC-Exos: Product Portfolio
6.3.3.1. haMPC-Exos: Clinical Trial Information
6.3.4. hMSC-Exos: Product Portfolio
6.3.4.1. hMSC-Exos: Clinical Trial Information
6.3.5. Undisclosed Drug 1: Product Portfolio
6.3.5.1. Undisclosed Drug 1: Clinical Trial Information
6.3.6. Recent Developments and Future Outlook
6.4. OBCTCD24
6.4.1. Company Overview
6.4.2. CovenD24: Product Portfolio
6.4.2.1. CovenD24: Clinical Trial Information
6.4.3. Recent Developments and Future Outlook
6.5. ReNeuron
6.5.1. Company Overview
6.5.2. Financial Information
6.5.3. Undisclosed Drug 1: Product Portfolio
6.5.3.1. Undisclosed Drug 1: Clinical Trial Information
6.5.4. Recent Developments and Future Outlook
6.6. Stem Cell Medicine
6.6.1. Company Overview
6.6.2. Undisclosed Drug 1: Product Portfolio
6.6.3. Recent Developments and Future Outlook
7. CLINICAL TRIAL ANALYSIS
7.1. Analysis Methodology and Key Parameters
7.2. Exosome Therapeutics: List of Clinical Trials
7.2.1. Analysis by Trial Status
7.2.2. Analysis by Trial Registration Year
7.2.3. Analysis by Type of Sponsor / Collaborator
7.2.4. Analysis by Registration Year and Type of Study
7.2.5. Analysis by Registration Year and Status of Trial
7.2.6. Analysis by Study Design
7.2.7. Analysis by Patient Enrollment
7.2.8. Year-wise Trend of Completed and Recruiting Trials
7.2.9. Analysis by Age Category
7.2.10. Analysis by Phase of Development and Trial Status
7.2.11. Analysis by Phase of Development and Patient Enrollment
7.2.12. Most Active Industry Players: Analysis by Number of Registered Trials
7.2.13. Most Active Non-Industry Players: Analysis by Number of Registered Trials
7.2.14. Analysis by Trial Location
7.2.15. Analysis by Trial Status and Geography
8. ACADEMIC GRANT ANALYSIS
8.1. Analysis Methodology and Key Parameters
8.2. Exosome Therapeutics: List of Academic Grants
8.3. Analysis by Year of Grants Awarded
8.4. Analysis by Amount Awarded
8.5. Popular NIH Departments: Analysis by Number of Grants
8.6. Analysis by Type of Funding Institute Center
8.7. Analysis by Support Period
8.8. Analysis by Purpose of Grants
8.9. Word Cloud Analysis: Emerging Focus Area
8.10. Analysis by Grant Activity Code
8.11. Analysis by Local Recipients
8.12. Analysis by Type of Recipient Organization
8.13. Popular Recipient Organizations: Analysis by Amount Awarded
8.14. Popular Recipient Organizations: Analysis by Number of Grants
8.15. Analysis by Study Section Involved
8.16. Analysis by Type of Grant Application
8.17. Analysis by Funding Institute Center and Support Year
9. GLOBAL EVENT ANALYSIS
9.1. Chapter Overview
9.2. Scope and Methodology
9.3. List of Global Events Related to Exosomes
9.3.1. Analysis by Year of Event
9.3.2. Analysis by Event Platform
9.3.3. Analysis by Type of Event
9.3.4. Analysis by Location of Event
9.3.5. Word Cloud Analysis: Evolutionary Trends in Event Agenda / Key Focus Area
9.3.6. Most Active Organizers: Analysis by Number of Events
9.3.7. Most Active Industry Participants: Analysis by Number of Events
9.3.8. Most Active Non-Industry Participants: Analysis by Number of Events
9.3.9. Analysis by Designation of Participant
9.3.10. Analysis by Affiliated Department of Participant
9.3.11. Most Active Speakers: Analysis by Number of Events
10. PARTNERSHIPS AND COLLABORATIONS
10.1. Chapter Overview
10.2. Partnership Models
10.3. Exosome Therapeutics: List of Partnerships and Collaborations
10.3.1. Analysis by Year of Partnership
10.3.2. Analysis by Type of Partnership
10.3.3. Analysis by Year and Type of Partnership
10.3.4. Analysis by Company and Type of Partnership
10.3.5. Analysis by Type of Technology Platform
10.3.6. Analysis by Type of Partner
10.3.7. Word Cloud Analysis: Emerging Focus Areas
10.3.8. Analysis by Target Disease Indication(s)
10.3.9. Analysis by Therapeutic Area
10.3.10. Analysis by Therapeutic Area and Type of Partnership
10.3.11. Most Active Players: Analysis by Number of Partnerships
10.3.12. Regional Analysis
10.3.13. Intercontinental and Intracontinental Agreements
11. FUNDING AND INVESTMENT ANALYSIS
11.1. Analysis Methodology and Key Parameters
11.2. Type of Funding
11.3. Exosome Therapeutics: List of Funding Instances
11.4. Analysis by Year of Funding
11.5. Analysis by Amount Invested
11.6. Analysis by Type of Funding
11.7. Analysis by Type of Funding and Amount Invested
11.8. Analysis by Year, Type of Funding and Amount Invested
11.9. Analysis by Purpose of Funding
11.10. Analysis by Target Disease Indication(s)
11.11. Analysis by Therapeutic Area
11.12. Most Active Players: Analysis by Number of Funding Instances
11.13. Most Active Players: Analysis by Amount Invested
11.14. Key Investors: Analysis by Number of Funding Instances
11.15. Regional Analysis
11.16. Summary of Funding Instances
12. START-UP HEALTH INDEXING
12.1. Analysis Methodology and Key Parameters
12.2. Analysis by Pipeline Maturity
12.3. Analysis by Pipeline Strength
12.4. Analysis by Financial Support
12.5. Analysis by Number of Investors
12.6. Analysis by Partnership Activity
12.7. Start-up Health Indexing: Roots Analysis Perspective
13. CASE STUDY: EXOSOME DEVELOPMENT AND MANUFACTURING SERVICE PROVIDERS
13.1. Chapter Overview
13.2. Exosome Development and Manufacturing Service Providers Landscape
13.2.1. Analysis by Year of Establishment
13.2.2. Analysis by Company Size
13.2.3. Analysis by Location of Headquarters
13.2.4. Analysis by Location of Headquarters and Company Size
13.3. Analysis by Type of Service(s) Offered
13.3.1. Analysis by Method of Isolation
13.3.2. Analysis by Method of Purification
13.3.3. Analysis by Method of Characterization
13.3.4. Analysis by Method of Exosome Manufacturing
13.3.5. Analysis by Scale of Operation
13.3.6. Analysis by Scalability
14. DRUG FAILURE ANALYSIS
14.1. Methodology and Key Parameters
14.2. Exosome Therapeutics: List of Failed Drug Candidates
14.2.1. Analysis by Study Start Year and Year of Termination of the Clinical Trials
14.2.2. Analysis by Trial Status of Discontinuation
14.2.3. Analysis by Target Disease Indication(s)
14.2.4. Analysis by Route of Administration
14.2.5. Analysis by Type of Sponsor
14.2.6. Analysis by Reasons for Drug Failure
14.2.7. Word Cloud Analysis: Emerging Focus Area
15. MARKET SIZING AND OPPORTUNITY ANALYSIS
15.1. Forecast Methodology and Key Assumptions
15.2. Global Exosome Therapeutics Market, 2029-2040
15.3. Global Exosome Therapeutics Market, 2029-2040: Distribution by Target Disease Indication(s)
15.3.1. Exosome Therapeutics Market for COVID-19, 2029-2040
15.3.2. Exosome Therapeutics Market for Degenerative Meniscal Injury, 2029-2040
15.3.3. Exosome Therapeutics Market for Retinitis Pigmentosa, 2029-2040
15.4. Global Exosome Therapeutics Market, 2029-2040: Distribution by Therapeutic Area
15.4.1. Exosome Therapeutics Market for Infectious Diseases, 2029-2040
15.4.2. Exosome Therapeutics Market for Ophthalmic Diseases, 2029-2040
15.4.3. Exosome Therapeutics Market for Musculoskeletal Disorders, 2029-2040
15.5. Global Exosome Therapeutics Market, 2029-2040: Distribution by Route of Administration