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Anti-GPC3 Targeted Therapies - Target Population, Competitive Landscape, and Market Forecast - 2040
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¹ßÇàÀÏ : On Demand Report
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Key Highlights:

DelveInsight's "Anti-GPC3 Targeted Therapies - Target Population, Competitive Landscape, and Market Forecast - 2040" report delivers an in-depth understanding of the Anti-GPC3 Targeted Therapies, historical and competitive landscape as well as its market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

The Anti-GPC3 Targeted Therapies market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Anti-GPC3 Targeted Therapies market size from 2020 to 2040. The report also covers current Anti-GPC3 Targeted Therapies treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.

Geography Covered:

Study Period: 2020-2040

Anti-GPC3 Targeted Therapies Understanding and Treatment Algorithm

GPC3 Overview

Glypican-3 (GPC3) is a well-established molecular target for hepatocellular carcinoma (HCC). As a member of the heparan sulfate proteoglycan family, GPC3 is anchored to the cell membrane and plays a crucial role in tumor biology. Clinically, GPC3 has been observed to be highly expressed in malignant liver cells while demonstrating little to no expression in normal hepatic tissues. This differential expression profile positions GPC3 as an ideal candidate for HCC-specific therapeutic interventions, enabling targeted drug delivery and reducing off-target effects in non-cancerous liver tissue.

Anti-GPC3 Targeted Therapies Market Overview

In recent years, there has been a growing interest in the exploration of Anti-GPC3 Targeted Therapies for targeting indications such as HCC and NSCLC.

Anti-GPC3 Targeted Therapies Epidemiology

The epidemiology chapter of Anti-GPC3 Targeted Therapies in the report provides historical as well as forecasted epidemiology segmented as total cases in selected indications for Anti-GPC3 Targeted Therapies, total eligible patient pool in selected indications for Anti-GPC3 Targeted Therapies, and total treated cases in selected indications for Anti-GPC3 Targeted Therapies in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain), and the United Kingdom, and Japan from 2020 to 2040.

Anti-GPC3 Targeted Therapies Drug Chapters

The drug chapter segment of the Anti-GPC3 Targeted Therapies report encloses a detailed analysis of clinical trial details of Anti-GPC3 Targeted Therapies, expressive pharmacological action, agreements and collaborations, approval, and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Emerging Drugs

ECT204: Eureka Therapeutics

ECT204 is an investigational ARTEMIS T-cell therapy targeting GPC3, a promising HCC antigen found in more than 70% of HCC cells. ECT204 ARTEMIS T cells also incorporate Eureka's proprietary tumor infiltration technology demonstrating enhanced ability to infiltrate solid tumors in animal models, potentially leading to improved efficacy in patients.

ECT204 is currently being investigated in Eureka's ongoing ARYA-3 study, an open-label, dose-escalation, multi-center Phase I/II clinical trial in adult patients with GPC3-positive HCC. It has been granted Orphan drug designation (ODD) for the treatment of HCC.

AZD9793: AstraZeneca

AZD9793, a trispecific IgG1 monoclonal antibody, is a first-in-class CD8-targeted TCE that directly engages tumor-infiltrating T cells and GPC3+ tumors, forming a bridge that activates T cells leading to tumor cell lysis and T cell proliferation. AZD9793 promotes potent GPC3+ HCC cell killing through preferential engagement of CD8+ T cells while minimizing CD4+ T cell activation and unwanted cytokine release. The novel mechanism of action combines bivalent GPC3 binding, CD8-biased engagement, and low-affinity T cell receptor binding to improve cytotoxicity and reduce the risk of cytokine release syndrome compared with other TCEs.

225Ac-GPC3 (BAY 3547926): Bayer

225AC-GPC3 (BAY 3547926) is an investigational targeted alpha radiopharmaceutical being developed to treat tumors expressing Glypican-3 (GPC3) in patients with advanced HCC. It is composed of a GPC3 targeting high-affinity antibody radiolabeled with actinium-225 (225Ac). 225Ac-GPC3 delivers highly potent alpha-particles to the GPC3-expressing cancer cells, with the potential to induce DNA double-strand breaks, reducing cancer cell viability which may potentially cause anti-tumor activity.

Anti-GPC3 Targeted Therapies Market Outlook

The global Anti-GPC3 Targeted Therapies market is expected to witness growth in the coming years, driven by the increasing incidences of cancer cases, clinical pipeline activity, and anticipated regulatory approvals.

Market players, including Bayer, Carisma Therapeutics, Moderna, Eureka Therapeutics, AstraZeneca, CRISPR Therapeutics, and others, are involved in developing drugs for Anti-GPC3 Targeted Therapies for the treatment of indications such as HCC, NSCLC, and others, respectively. Overall, this is an exciting new class with great potential for development. The maturation of current studies over the next few years will lead to a better understanding of anti-GPC3 targeted Therapies and define their role in cancer therapies.

Anti-GPC3 Targeted Therapies Drugs Uptake

This section focuses on the uptake rate of potential approved and emerging Anti-GPC3 Targeted Therapies expected to be launched in the market during 2025-2040.

Anti-GPC3 Targeted Therapies Pipeline Development Activities

The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I. It also analyzes key players involved in developing targeted therapeutics.

The presence of numerous drugs under different stages is expected to generate immense opportunity for Anti-GPC3 Targeted Therapies market growth over the forecast period.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Anti-GPC3 Targeted Therapies.

KOL Views

To keep up with current and future market trends, we take Industry Experts' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on Anti-GPC3 Targeted Therapies evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, drug uptake, along challenges related to accessibility.

DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 10+ KOLs in the 7MM. Centers such as the University of Miyazaki, University of Pittsburgh Medical Center, Ochsner Lafayette General Medical Center, National Cancer Center, Memorial Sloan Kettering Cancer Center, and others.

Their opinion helps understand and validate current and emerging therapy treatment patterns or Anti-GPC3 Targeted Therapies market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Market Access and Reimbursement

Reimbursement may be referred to as the negotiation of a price between a manufacturer and payer that allows the manufacturer access to the market. It is provided to reduce the high costs and make the essential drugs affordable. Health Technology Assessment (HTA) plays an important role in reimbursement decision-making and recommending the use of a drug. These recommendations vary widely throughout the seven major markets, even for the same drug.

In the US healthcare system, both Public and Private health insurance coverage are included. Also, Medicare and Medicaid are the largest government-funded programs in the US. The major healthcare programs including Medicare, Continuing Medical Education (CME) program, the Children's Health Insurance Program (CHIP), and the state and federal health insurance marketplaces are overseen by the Centers for Medicare & Medicaid Services (CMS). Other than these, Pharmacy Benefit Managers (PBMs), and third-party organizations that provide services, and educational programs to aid patients are also present.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Key Updates on Anti-GPC3 Targeted Therapies

The abstract list is not exhaustive, will be provided in the final report

Scope of the Report:

Anti-GPC3 Targeted Therapies Report Insights

Anti-GPC3 Targeted Therapies Report Key Strengths

Anti-GPC3 Targeted Therapies Report Assessment

Key Questions:

Reasons to buy:

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary of Anti-GPC3 Targeted Therapies

4. Key Events

5. Epidemiology Market Forecast Methodology of Anti-GPC3 Targeted Therapies

6. Anti-GPC3 Targeted Therapies Market Overview at a Glance in the 7MM

7. Anti-GPC3 Targeted Therapies: Background and Overview

8. Target Patient Pool of Anti-GPC3 Targeted Therapies

9. Emerging Anti-GPC3 Targeted Therapies

10. Anti-GPC3 Targeted Therapies: 7MM Analysis

11. SWOT Analysis

12. KOL Views

13. Unmet Needs

14. Market Access and Reimbursement

15. Appendix

16. DelveInsight Capabilities

17. Disclaimer

18. About DelveInsight

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