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Human Liver Model Global Market Report 2025
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The human liver model represents a dual-lobed model of the human liver, primarily responsible for filtering blood from the digestive tract. It is utilized to illustrate and assess the toxic effects of drug candidates on the liver.

The primary product types of human liver models include liver organoids, liver-on-a-chip, 2D models, animal models, and 3D bioprinting. Liver organoids are 3D structures generated from stem cells that self-organize through mechanisms similar to those in vivo. These models find applications in education, drug discovery, and other fields, and are employed by research institutes, pharmaceutical companies, and other entities.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sharp rise in U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the healthcare sector, especially in the supply of essential medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are grappling with higher costs for imported surgical tools, imaging systems, and consumables like syringes and catheters, many of which have limited domestic substitutes. These escalating expenses are putting pressure on healthcare budgets, prompting some providers to delay equipment upgrades or pass increased costs on to patients. Furthermore, tariffs on raw materials and components are disrupting the manufacturing of vital drugs and devices, leading to supply chain delays. In response, the industry is adopting diversified sourcing strategies, expanding local production where feasible, and pushing for tariff exemptions on critical medical products.

The human liver model market research report is one of a series of new reports from The Business Research Company that provides human liver model market statistics, including human liver model industry global market size, regional shares, competitors with a human liver model market share, detailed human liver model market segments, market trends and opportunities, and any further data you may need to thrive in the human liver model industry. This human liver model market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The human liver model market size has grown rapidly in recent years. It will grow from $2.34 billion in 2024 to $2.62 billion in 2025 at a compound annual growth rate (CAGR) of 11.9%. The growth in the historic period can be attributed to drug development needs, advancements in biotechnology, animal testing alternatives, rising liver diseases, regulatory demands.

The human liver model market size is expected to see rapid growth in the next few years. It will grow to $4.39 billion in 2029 at a compound annual growth rate (CAGR) of 13.7%. The growth in the forecast period can be attributed to ai and machine learning integration, patient-derived liver models, bioengineering breakthroughs, drug safety and toxicity testing requirements, virtual clinical trials. Major trends in the forecast period include multi-organ models integration, 3d bioprinting innovations, high-throughput screening capability, enhanced vascularization and blood flow, ethical and regulatory compliance.

The forecast of 13.7% growth over the next five years reflects a slight reduction of 0.1% from the previous projection. This reduction is primarily due to the impact of tariffs between the US and other countries. Trade tensions could hinder U.S. adoption of precision medicine by inflating prices of 3D bio-printed liver models and toxicity testing platforms developed in the UK and Japan, resulting in delayed drug development and higher pharmaceutical research and development (R&D) costs. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.

The growth of the human liver model market is anticipated to be driven by the increasing incidence of liver disease. Liver disease encompasses various disorders that affect the proper functioning of the liver. The emerging area of research involving human liver models holds the potential to enhance understanding of liver diseases and improve drug development. Consequently, the escalating cases of liver diseases are fostering the expansion of the human liver model market. For instance, in September 2022, Caner Australia reported approximately 2,905 new cases of liver cancer diagnosed in Australia in 2022, highlighting the significance of addressing liver-related health concerns. The rising prevalence of liver disease underscores the crucial role of human liver models in advancing medical research and therapeutic strategies.

The growth of the human liver model market is further expected to be propelled by the increasing number of clinical trials. Clinical trials, essential for evaluating the safety and efficacy of medical interventions, treatments, or drugs in humans, frequently employ human liver models to simulate drug metabolism and assess hepatotoxicity in the context of pharmaceutical development. As of May 2023, there are 452,604 registered clinical trials globally, signifying a substantial increase from previous counts. The surge in clinical trials emphasizes the growing demand for human liver models in facilitating robust research practices and advancing drug discovery initiatives.

A prominent trend in the human liver model market is the focus on product innovation by major companies. Companies operating in this market are actively engaged in developing innovative products to enhance their market positioning. In April 2023, LifeNet Health Life Sciences introduced TruVivo, a groundbreaking liver system composed entirely of human cells. TruVivo represents a 2D+ solution that combines the robust data associated with 3D models with the flexibility and simplicity of a 2D model, offering a significant advancement in liver research and drug development.

Major players in the human liver model market are directing their efforts toward the development of advanced systems, particularly single-organ higher throughput (HT) systems. These innovative systems aim to improve the adoption of predictive human liver models and provide a competitive advantage. For instance, in February 2023, UK-based organ-on-a-chip company CN Bio launched PhysioMimix with Liver-48 plate, a single-organ higher throughput (HT) system designed to overcome challenges in the adoption of predictive human liver models for drug discovery. The Liver-48 plate, a multi-chip consumable, facilitates larger-scale comparative studies on drug disposition, efficacy, and safety.

In April 2023, AnaBios Corporation, a biotechnology research firm, acquired Cell Systems for an undisclosed amount. This acquisition is designed to enhance AnaBios' capabilities in drug discovery and development by integrating Cell Systems' advanced cell-based technologies. As a result, this move strengthens AnaBios' portfolio in human-relevant models, allowing for more accurate predictions of drug efficacy and safety. Cell Systems is a biotechnology research company based in the US.

Major companies operating in the human liver model market include Corning Incorporated, EISCO Scientific LLC, BioIVT LLC, Cyprotex plc, Emulate Inc., Cellink AB, Nortis Inc., InSphero AG, CN Bio Innovations Ltd., TissUse GmbH, Ascendance Biotechnology Inc., HemoShear Therapeutics Inc., Cyfuse Biomedical, MIMETAS BV, Biopredic International Sarl, ZenBio, Hurel Corporation, Regenovo, Pandorum, Organovo Holdings Inc., BICO Group, Hepregen Corporation, Kirkstall Ltd., HepaLife Technologies Inc., Cellaion SA.

North America was the largest region in the human liver model market in 2024. The regions covered in the human liver model market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

The countries covered in the human liver model market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The human liver model market consists of sales of 3B scientific liver and prime baker fiber liver model. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Human Liver Model Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on human liver model market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for human liver model ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The human liver model market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.

Scope

Table of Contents

1. Executive Summary

2. Human Liver Model Market Characteristics

3. Human Liver Model Market Trends And Strategies

4. Human Liver Model Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market

5. Global Human Liver Model Growth Analysis And Strategic Analysis Framework

6. Human Liver Model Market Segmentation

7. Human Liver Model Market Regional And Country Analysis

8. Asia-Pacific Human Liver Model Market

9. China Human Liver Model Market

10. India Human Liver Model Market

11. Japan Human Liver Model Market

12. Australia Human Liver Model Market

13. Indonesia Human Liver Model Market

14. South Korea Human Liver Model Market

15. Western Europe Human Liver Model Market

16. UK Human Liver Model Market

17. Germany Human Liver Model Market

18. France Human Liver Model Market

19. Italy Human Liver Model Market

20. Spain Human Liver Model Market

21. Eastern Europe Human Liver Model Market

22. Russia Human Liver Model Market

23. North America Human Liver Model Market

24. USA Human Liver Model Market

25. Canada Human Liver Model Market

26. South America Human Liver Model Market

27. Brazil Human Liver Model Market

28. Middle East Human Liver Model Market

29. Africa Human Liver Model Market

30. Human Liver Model Market Competitive Landscape And Company Profiles

31. Human Liver Model Market Other Major And Innovative Companies

32. Global Human Liver Model Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Human Liver Model Market

34. Recent Developments In The Human Liver Model Market

35. Human Liver Model Market High Potential Countries, Segments and Strategies

36. Appendix

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