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Pharmaceutical Intermediates Global Market Report 2025
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Pharmaceutical intermediates are chemical compounds or substances used in the synthesis and production of active pharmaceutical ingredients (APIs) or drug substances. These intermediates play a crucial role in the development and production of a wide range of drugs and therapeutic products, and they are utilized by pharmaceutical companies and research institutions.

The main types of pharmaceutical intermediates products include chemical intermediates, bulk drug intermediates, and other products. Chemical intermediates are compounds or substances produced during the manufacturing process of chemicals and find applications in various industries, including pharmaceuticals, agrochemicals, polymers, and specialty chemicals. Categories of pharmaceutical intermediates include branded drug intermediates and generic drug intermediates. The applications of pharmaceutical intermediates cover various drugs such as analgesics, anti-infective drugs, cardiovascular drugs, oral antidiabetic drugs, antimicrobial drugs, and others. The end-users of pharmaceutical intermediates include biotech and pharma companies, research institutions, and others.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The escalating U.S. tariffs and rising trade tensions in spring 2025 are expected to significantly affect the chemicals sector, which is facing a disproportionate impact-particularly from tariffs on petrochemicals and intermediates, where affordable domestic alternatives are limited. Specialty chemical producers, who rely heavily on Chinese raw materials, are encountering production disruptions. Meanwhile, fertilizer manufacturers are seeing their profit margins squeezed due to tariffs on phosphate imports. In response, companies are increasing investments in R&D for bio-based alternatives, forming procurement alliances to strengthen purchasing power, and relocating production to tariff-neutral countries like Saudi Arabia.

The pharmaceutical intermediates market research report is one of a series of new reports from The Business Research Company that provides pharmaceutical intermediates market statistics, including pharmaceutical intermediates industry global market size, regional shares, competitors with a pharmaceutical intermediates market share, detailed pharmaceutical intermediates market segments, market trends, and opportunities, and any further data you may need to thrive in the pharmaceutical intermediates industry. This pharmaceutical intermediate market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The pharmaceutical intermediates market size has grown steadily in recent years. It will grow from $33.37 billion in 2024 to $34.95 billion in 2025 at a compound annual growth rate (CAGR) of 4.7%. The growth in the historic period can be attributed to chemical synthesis advancements, drug development evolution, market demand and growth, research and development, regulatory compliance.

The pharmaceutical intermediates market size is expected to see strong growth in the next few years. It will grow to $46.04 billion in 2029 at a compound annual growth rate (CAGR) of 7.1%. The growth in the forecast period can be attributed to biopharmaceutical innovation, precision medicine development, green chemistry initiatives, customized intermediates, pharmaceutical outsourcing trends. Major trends in the forecast period include continuous flow chemistry, increased automation and robotics, application of nanotechnology, biocatalysis and enzyme engineering, and strategic supply chain management.

The forecast of 7.1% growth over the next five years reflects a modest reduction of 0.3% from the previous estimate for this market.This reduction is primarily due to the impact of tariffs between the US and other countries. This is likely to directly affect the US by disrupting drug manufacturing supply chains, as critical precursors from India and China encounter tariff-related delays, raising healthcare costs.The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.

The anticipated increase in the prevalence of chronic diseases is poised to drive the growth of the pharmaceutical intermediates market in the foreseeable future. Chronic diseases, characterized by lasting three months or longer and having the potential to worsen over time, are on the rise due to factors such as an aging population, lifestyle changes, rapid urbanization, and insufficient preventive measures. In March 2022, the National Institute of Health reported that chronic kidney disorders are expected to affect 13.4% of the population, with an estimated 4.902 to 7.083 million individuals requiring renal replacement therapy for end-stage kidney disease (ESKD). Pharmaceutical intermediates play a vital role in developing medications used to manage chronic diseases, mitigating the escalating prevalence of such conditions and consequently driving the pharmaceutical intermediates market's growth.

The anticipated increase in pharmaceutical drug production is expected to drive the growth of the pharmaceutical intermediates market moving forward. Drug production involves the manufacturing process of pharmaceutical substances, medications, or drugs. These pharmaceutical drugs are complex molecules that undergo multiple synthesis steps. Pharmaceutical intermediates are the chemical compounds generated during these intermediate stages of the manufacturing process, particularly as more complex and targeted drugs are developed. For example, in November 2023, the European Federation of Pharmaceutical Industries and Associations (EFPIA), a Belgium-based trade association representing the pharmaceutical industry in Europe, reported that total pharmaceutical production in Europe reached €390,000 million ($422,803 million) in 2023, an increase from €363,300 million ($393,857 million) in 2022. Consequently, the rise in pharmaceutical drug production is fueling the growth of the pharmaceutical intermediates market.

Leading companies in the pharmaceutical intermediates market are introducing new product lines, such as API Intermediates, to enhance their market position and profitability. API intermediates, which are chemical compounds used in the synthesis of active pharmaceutical ingredients (APIs), play a crucial role in producing medications for various therapeutic areas. In October 2023, Huateng Pharmaceutical Co. Ltd., a China-based pharmaceutical company, launched its Gastrointestinal API Intermediates product line. These intermediates serve as building blocks for pharmaceutical active ingredients used in medications treating gastrointestinal system disorders, including laxatives, 5-HT3 receptor antagonists, H2-receptor antagonists, and proton pump inhibitors.

Leading companies in the pharmaceutical intermediates market are concentrating on developing intermediates specifically for small-molecule drugs. These intermediates are essential in the synthesis of small-molecule drugs, acting as transitional products formed during various stages of the chemical manufacturing process before culminating in the final active pharmaceutical ingredient (API) or drug substance. For example, in March 2022, Sumitomo Chemical Co. Ltd., a Japan-based chemical firm, launched active pharmaceutical ingredients (APIs) and intermediates tailored for small-molecule drugs. This initiative aims to enhance the company's capacity to meet the increasing demand for small-molecule medications by offering a broader array of high-quality APIs and intermediates.

In March 2024, International Chemical Investors Group (ICIG), a Luxembourg-based chemical company, acquired Vasant Chemicals for an undisclosed sum. This acquisition is designed to strengthen WeylChem's foothold in the global specialty chemicals market. The strategic partnership aims to provide added value for customers and stakeholders by merging the technologies and resources of both companies, thus advancing Vasant Chemicals' global expansion efforts. Vasant Chemicals is an India-based producer of pharmaceutical intermediates.

Major companies operating in the pharmaceutical intermediates market include BASF SE, Sanofi SA, Thermo Fisher Scientific Inc, Meck KGaA, Dishman Carbogen Amcis Ltd, Evonik Industries AG, Arkema Inc., Lonza Group AG, Wuxi AppTec co. Ltd, Aurobindo Pharma Lmited., Lianhe Chemical Technology Co. Ltd., Cambrex Corporation, Vertellus Holdings LLC., Hovione LLC, Hikal Ltd., Codexis Inc., Aceto Corporation, Interchem Corporation, Midas Pharma GmbH, Arbiom, Dextra Laboratories Ltd., A. R. Life Sciences, Ingenza Ltd, Chiracon GmbH, Dyadic International Inc., Elam Pharma Pvt Ltd, Yin-sheng Bio-tech Co. Ltd., Green Vision Life Sciences, Sibylla Biotech s.r.l., Pfizer CentreOne

North America was the largest region in the pharmaceutical intermediates market in 2024. The regions covered in the pharmaceutical intermediates market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

The countries covered in the pharmaceutical intermediates market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The pharmaceutical intermediates market consists of sales of intermediates for API synthesis, API precursors, fine chemicals, and specialty chemicals. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Pharmaceutical Intermediates Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on pharmaceutical intermediates market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for pharmaceutical intermediates ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The pharmaceutical intermediates market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.

Scope

Table of Contents

1. Executive Summary

2. Pharmaceutical Intermediates Market Characteristics

3. Pharmaceutical Intermediates Market Trends And Strategies

4. Pharmaceutical Intermediates Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market

5. Global Pharmaceutical Intermediates Growth Analysis And Strategic Analysis Framework

6. Pharmaceutical Intermediates Market Segmentation

7. Pharmaceutical Intermediates Market Regional And Country Analysis

8. Asia-Pacific Pharmaceutical Intermediates Market

9. China Pharmaceutical Intermediates Market

10. India Pharmaceutical Intermediates Market

11. Japan Pharmaceutical Intermediates Market

12. Australia Pharmaceutical Intermediates Market

13. Indonesia Pharmaceutical Intermediates Market

14. South Korea Pharmaceutical Intermediates Market

15. Western Europe Pharmaceutical Intermediates Market

16. UK Pharmaceutical Intermediates Market

17. Germany Pharmaceutical Intermediates Market

18. France Pharmaceutical Intermediates Market

19. Italy Pharmaceutical Intermediates Market

20. Spain Pharmaceutical Intermediates Market

21. Eastern Europe Pharmaceutical Intermediates Market

22. Russia Pharmaceutical Intermediates Market

23. North America Pharmaceutical Intermediates Market

24. USA Pharmaceutical Intermediates Market

25. Canada Pharmaceutical Intermediates Market

26. South America Pharmaceutical Intermediates Market

27. Brazil Pharmaceutical Intermediates Market

28. Middle East Pharmaceutical Intermediates Market

29. Africa Pharmaceutical Intermediates Market

30. Pharmaceutical Intermediates Market Competitive Landscape And Company Profiles

31. Pharmaceutical Intermediates Market Other Major And Innovative Companies

32. Global Pharmaceutical Intermediates Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Pharmaceutical Intermediates Market

34. Recent Developments In The Pharmaceutical Intermediates Market

35. Pharmaceutical Intermediates Market High Potential Countries, Segments and Strategies

36. Appendix

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