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Phosphoramidite Global Market Report 2025
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Phosphoramidite is a chemical compound commonly used in the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) through solid-phase synthesis. It contains a phosphate group linked to an amine (-NR2) and is highly reactive, enabling the stepwise addition of nucleotide bases in oligonucleotide synthesis. Phosphoramidites play a vital role in producing synthetic nucleic acids for various applications in research, diagnostics, and therapy.

The primary types of phosphoramidites include deoxyribonucleic acid (DNA) phosphoramidites, ribonucleic acid (RNA) phosphoramidites, labeled phosphoramidites, modifier phosphoramidites, and others. DNA phosphoramidites are chemical building blocks used in solid-phase DNA synthesis to create custom sequences for applications such as gene synthesis, PCR, and molecular diagnostics. Various synthesis methods, including the h-phosphonate method, phosphoramidite method, and trivalent phosphorus compounds method, are employed for applications such as gene synthesis, DNA sequencing, and DNA amplification. Phosphoramidites are widely used by end-users in academic research, the pharmaceutical industry, and the biotechnology sector.

The phosphoramidite market research report is one of a series of new reports from The Business Research Company that provides phosphoramidite market statistics, including the phosphoramidite industry global market size, regional shares, competitors with the phosphoramidite market share, detailed phosphoramidite market segments, market trends, and opportunities, and any further data you may need to thrive in the phosphoramidite industry. This phosphoramidite market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The phosphoramidite market size has grown strongly in recent years. It will grow from $1.01 billion in 2024 to $1.09 billion in 2025 at a compound annual growth rate (CAGR) of 7.7%. The growth observed during the historical period can be attributed to factors such as the increasing demand for DNA and RNA synthesis, the rising adoption of mRNA-based therapeutics, the growing prevalence of genetic disorders, the expanding demand for synthetic biology, and increased investments in genomic research.

The phosphoramidite market size is expected to see strong growth in the next few years. It will grow to $1.44 billion in 2029 at a compound annual growth rate (CAGR) of 7.4%. The growth in the forecast period can be attributed to the increasing use of phosphoramidites, the rising demand for custom DNA and RNA synthesis, a growing need for high-purity phosphoramidites, the increasing focus on personalized medicine, and the rise of biopharmaceutical companies. Major trends expected in the forecast period include the expansion of synthetic biology, the development of novel phosphoramidite chemistries, advancements in genomic technologies, increased research activities in biotechnology, and the growth of personalized medicine.

The growth of the biopharmaceutical sector is expected to drive the expansion of the phosphoramidite market in the future. The biopharmaceutical sector encompasses industries involved in the research, development, production, and commercialization of biologically-derived medical products such as vaccines, gene therapies, monoclonal antibodies, and recombinant proteins. This sector's growth is fueled by advances in biotechnology, a rise in chronic diseases, and increasing investments in research and development. Breakthroughs in biotechnology, including gene editing and monoclonal antibody therapies, have enabled more precise and effective treatments. As the biopharmaceutical sector grows, so does the demand for phosphoramidites, which play a vital role in synthesizing DNA and RNA for gene therapies, mRNA vaccines, and oligonucleotide-based drugs. As these therapies become more widely adopted, the need for phosphoramidites to create synthetic nucleic acids will rise, increasing their use in biopharmaceutical research and production. For example, according to the UK government, the core biopharmaceutical sector generated £46.7 billion ($58.4 billion) in revenue in 2022, accounting for 43% of the life sciences industry's total turnover. Additionally, the sector supports over 126,000 jobs and has seen substantial growth in research and development investments. As such, the expansion of the biopharmaceutical sector is driving the phosphoramidite market's growth.

Companies in the phosphoramidite market are focusing on enhancing DNA synthesis technologies to improve accuracy, speed, and sustainability while reducing hazardous waste. DNA synthesis involves creating DNA sequences using enzymes instead of chemical reagents, offering higher precision, speed, and sustainability. For example, in April 2022, Ansa Biotechnologies Inc., a US-based biotechnology firm, closed an oversubscribed $68 million Series A financing round led by Northpond Ventures, with participation from new and existing investors. This funding is intended to accelerate the development of Ansa's next-generation enzymatic DNA synthesis technology, also known as phosphoramidite synthesis, expand its R&D and manufacturing capabilities, and launch a customizable DNA synthesis service. A spinout from the University of California, Berkeley, Ansa uses a patented method to rapidly and accurately synthesize long DNA sequences, addressing current challenges in the industry.

In May 2023, Actylis, a US-based chemicals and raw materials company, formed a partnership with Innovassynth India to address vulnerabilities in the nucleic acid supply chain. This collaboration aims to strengthen the phosphoramidite market by ensuring a stable, transparent, and diversified supply chain, improving global access to high-quality nucleosides and phosphoramidites for pharmaceutical and biotech applications. Innovassynth India is a manufacturer of protected nucleosides, phosphoramidites, and reagents based in India.

Major players in the phosphoramidite market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Aragen Life Sciences, Twist Bioscience, Innovassynth Technologies (I) Ltd., Tokyo Chemical Industry Co. Ltd. (TCI), Aurigene Services, Eurofins Genomics, LGC Biosearch Technologies, Link Technologies Ltd., Creative Biolabs, Biosynth Carbosynth, TriLink BioTechnologies, ChemGenes Corporation, Berry & Associates Inc., Lumiprobe Corporation, Hongene Biotech Corporation, Carbolink India Pvt. Ltd., PolyOrg Inc., Glen Research, Gene Link Inc., emp BIOTECH GmbH.

North America was the largest region in the phosphoramidite market in 2024. Europe is expected to be the fastest-growing region during the forecast period. The regions covered in phosphoramidite report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the phosphoramidite market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The phosphoramidite market consists of sales of spacer and linker phosphoramidites, fluorescent dye-Labeled phosphoramidites, biotinylated phosphoramidites, and structural phosphoramidites. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Phosphoramidite Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on phosphoramidite market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for phosphoramidite ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The phosphoramidite market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Phosphoramidite Market Characteristics

3. Phosphoramidite Market Trends And Strategies

4. Phosphoramidite Market - Macro Economic Scenario Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics And Covid And Recovery On The Market

5. Global Phosphoramidite Growth Analysis And Strategic Analysis Framework

6. Phosphoramidite Market Segmentation

7. Phosphoramidite Market Regional And Country Analysis

8. Asia-Pacific Phosphoramidite Market

9. China Phosphoramidite Market

10. India Phosphoramidite Market

11. Japan Phosphoramidite Market

12. Australia Phosphoramidite Market

13. Indonesia Phosphoramidite Market

14. South Korea Phosphoramidite Market

15. Western Europe Phosphoramidite Market

16. UK Phosphoramidite Market

17. Germany Phosphoramidite Market

18. France Phosphoramidite Market

19. Italy Phosphoramidite Market

20. Spain Phosphoramidite Market

21. Eastern Europe Phosphoramidite Market

22. Russia Phosphoramidite Market

23. North America Phosphoramidite Market

24. USA Phosphoramidite Market

25. Canada Phosphoramidite Market

26. South America Phosphoramidite Market

27. Brazil Phosphoramidite Market

28. Middle East Phosphoramidite Market

29. Africa Phosphoramidite Market

30. Phosphoramidite Market Competitive Landscape And Company Profiles

31. Phosphoramidite Market Other Major And Innovative Companies

32. Global Phosphoramidite Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Phosphoramidite Market

34. Recent Developments In The Phosphoramidite Market

35. Phosphoramidite Market High Potential Countries, Segments and Strategies

36. Appendix

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