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Complement Inhibitors Global Market Report 2025
»óǰÄÚµå : 1720765
¸®¼­Ä¡»ç : The Business Research Company
¹ßÇàÀÏ : On Demand Report
ÆäÀÌÁö Á¤º¸ : ¿µ¹® 175 Pages
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Complement inhibitors are therapeutic agents designed to regulate or block the complement system, a crucial part of the immune response involved in inflammation, pathogen elimination, and cell lysis. These inhibitors target specific complement components, such as complement component 3 (C3) or complement component 5 (C5), to prevent overactivation and reduce tissue damage in conditions such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

The key product types in the complement inhibitors market include complement component 3 (C3) inhibitors, complement component 5 (C5) inhibitors, and complement factor D inhibitors. C3 inhibitors are therapeutic agents that block the activation of C3, a central protein in the complement cascade. The mechanisms of action for complement inhibitors involve alternative pathway inhibitors, classical pathway inhibitors, and lectin pathway inhibitors. These therapies are used to treat conditions such as aHUS, generalized myasthenia gravis (GMG), and PNH. Administration routes include intravenous (IV) and subcutaneous (SC) methods, serving a broad patient demographic, including adults, geriatrics, and pediatrics.

The complement inhibitors market research report is one of a series of new reports from The Business Research Company that provides complement inhibitors market statistics, including complement inhibitors industry global market size, regional shares, competitors with a complement inhibitors market share, detailed complement inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the complement inhibitors industry. This complement inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The complement inhibitors market size has grown exponentially in recent years. It will grow from $16.41 billion in 2024 to $21.43 billion in 2025 at a compound annual growth rate (CAGR) of 30.6%. The growth during the historic period can be attributed to the increasing prevalence of complement-mediated diseases, rising awareness of rare diseases, the emergence of biologics as effective therapies, growing healthcare expenditure, a stronger focus on personalized medicine, the availability of orphan drug incentives, regulatory support for rare disease treatments, and enhanced collaborations between pharmaceutical companies and research institutions.

The complement inhibitors market size is expected to see exponential growth in the next few years. It will grow to $61.74 billion in 2029 at a compound annual growth rate (CAGR) of 39.3%. The growth in the forecast period can be attributed to the rising incidence of autoimmune and inflammatory diseases, expansion of the biologics and biosimilars markets, an increasing number of clinical trials, the development of longer-acting complement inhibitors, improved healthcare infrastructure in emerging markets, greater adoption of targeted therapies, a growing geriatric population, and enhanced patient access to biologic treatments. Key trends expected during this period include the integration of artificial intelligence in drug discovery, advanced biomarker identification techniques, machine learning for predicting patient responses, long-acting drug formulations, next-generation sequencing for complement system analysis, high-throughput screening platforms, organ-on-a-chip models for complement inhibition testing, 3D bioprinting for complement inhibitor development, and real-time monitoring tools for assessing treatment efficacy.

The increasing focus on personalized medicine is expected to drive the growth of the complement inhibitors market in the coming years. Personalized medicine involves tailoring treatments to individual patients based on their genetic, environmental, and lifestyle factors to optimize outcomes and improve care. The rising adoption of personalized medicine is fueled by advancements in genomics, the growing availability of biomarker-based diagnostics, improved data analytics technologies, and a growing demand for more targeted and effective therapies. Complement inhibitors align with personalized medicine by targeting specific components of the complement system based on a patient's unique disease profile, genetic makeup, and complement activity levels. For instance, in February 2024, the Personalized Medicine Coalition (PMC), a US-based nonprofit organization, reported that the U.S. Food and Drug Administration (FDA) approved 26 new personalized medicines in 2023, a notable increase from 12 approvals in 2022. As a result, the expanding focus on personalized medicine is fueling the growth of the complement inhibitors market.

Leading companies in the complement inhibitors market are increasingly developing monoclonal antibodies to effectively regulate the complement system in various autoimmune and inflammatory diseases. Monoclonal antibodies are lab-engineered proteins designed to specifically target and bind to antigens, aiding in the treatment of conditions such as cancer, autoimmune disorders, and infections. For example, in August 2024, F. Hoffmann-La Roche AG, a Switzerland-based pharmaceutical company, received approval from the European Commission for PiaSky (crovalimab), a monoclonal antibody designed for adults and adolescents with paroxysmal nocturnal hemoglobinuria (PNH) who are either new to or previously treated with C5 inhibitors. PiaSky (crovalimab) targets complement protein C5 to prevent its cleavage, thereby inhibiting the formation of the membrane attack complex (MAC) and reducing terminal complement-mediated intravascular hemolysis. This mechanism helps improve hemoglobin levels, decrease the need for blood transfusions, and alleviate symptoms such as fatigue and anemia, ultimately enhancing patients' quality of life.

In September 2023, Magenta Therapeutics Inc., a US-based clinical-stage biotechnology company, merged with Dianthus Therapeutics Inc. for an undisclosed amount. This merger enables the combined company to focus on advancing Dianthus' pipeline of next-generation complement inhibitors, including DNTH103, which is currently in a Phase I clinical trial. Dianthus Therapeutics Inc. is a US-based clinical-stage biotechnology company specializing in developing next-generation antibody complement therapeutics for severe autoimmune diseases.

Major players in the complement inhibitors market are F. Hoffmann-La Roche AG, Bayer AG, Sanofi S.A., AstraZeneca plc, Novartis AG, Amgen Inc., Regeneron Pharmaceuticals Inc., Astellas Pharma Inc., CSL Behring, UCB S.A., Takeda Pharmaceutical Company Limited, Alnylam Pharmaceuticals Inc., Innovent Biologics Inc., BioCryst Pharmaceuticals Inc., Pharming Group N.V., Apellis Pharmaceuticals Inc., Omeros Corporation, Akari Therapeutics Plc, InflaRx N.V., Kira Pharmaceuticals.

North America was the largest region in the complement inhibitors market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in complement inhibitors report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the complement inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The complement inhibitors market consists of sales of small molecule inhibitors, recombinant proteins and biologics designed to regulate the complement system and treat complement-mediated diseases. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Complement Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on complement inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for complement inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The complement inhibitors market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Complement Inhibitors Market Characteristics

3. Complement Inhibitors Market Trends And Strategies

4. Complement Inhibitors Market - Macro Economic Scenario Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics And Covid And Recovery On The Market

5. Global Complement Inhibitors Growth Analysis And Strategic Analysis Framework

6. Complement Inhibitors Market Segmentation

7. Complement Inhibitors Market Regional And Country Analysis

8. Asia-Pacific Complement Inhibitors Market

9. China Complement Inhibitors Market

10. India Complement Inhibitors Market

11. Japan Complement Inhibitors Market

12. Australia Complement Inhibitors Market

13. Indonesia Complement Inhibitors Market

14. South Korea Complement Inhibitors Market

15. Western Europe Complement Inhibitors Market

16. UK Complement Inhibitors Market

17. Germany Complement Inhibitors Market

18. France Complement Inhibitors Market

19. Italy Complement Inhibitors Market

20. Spain Complement Inhibitors Market

21. Eastern Europe Complement Inhibitors Market

22. Russia Complement Inhibitors Market

23. North America Complement Inhibitors Market

24. USA Complement Inhibitors Market

25. Canada Complement Inhibitors Market

26. South America Complement Inhibitors Market

27. Brazil Complement Inhibitors Market

28. Middle East Complement Inhibitors Market

29. Africa Complement Inhibitors Market

30. Complement Inhibitors Market Competitive Landscape And Company Profiles

31. Complement Inhibitors Market Other Major And Innovative Companies

32. Global Complement Inhibitors Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Complement Inhibitors Market

34. Recent Developments In The Complement Inhibitors Market

35. Complement Inhibitors Market High Potential Countries, Segments and Strategies

36. Appendix

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