T 세포 치료 시장 : 치료 유형별, 적응증별, 표적 항원별, 기업 규모별, 지역별, 주요 기업별, 치료제 매출 예측 : 업계 동향 및 세계 예측(-2035년)
T-Cell Therapy Market by Type of Therapy, Target Indication, Target Antigen, Company Size, Geographical Regions, Leading Players and Sales Forecast of Therapies, Industry Trends and Global Forecasts, Till 2035
상품코드:1677742
리서치사:Roots Analysis
발행일:2025년 03월
페이지 정보:영문 1040 Pages
라이선스 & 가격 (부가세 별도)
한글목차
세계 T 세포 치료 시장 규모는 2035년까지 예측 기간 동안 12%의 CAGR로 확대되어 현재 65억 달러에서 2035년까지 209억 달러로 성장할 것으로 예상됩니다.
백혈구의 하위 집합인 T 세포는 인체의 면역 체계에 필수적입니다. 외부의 알레르겐이나 감염에 대한 신체의 반응은 이 세포에 의해 엄격하게 제어되며, 신속하고 효율적인 면역 반응을 유발하는 첫 번째 상호 작용을 불러일으키면서 효율적으로 식별, 표적화 및 제거합니다. 과학자들은 19세기부터 다양한 질병을 치료하기 위해 이러한 세포를 활용하기 위해 활발히 연구해 왔습니다. 실제로 세포 치료(특히 T 세포 치료)는 암, 자가면역질환, 희귀유전성질환 등 치료가 어려운 질환의 관리/치료, 나아가 전 세계 질병부담 경감을 위해 최근 큰 주목을 받고 있습니다.
암은 주요 사망 원인 중 하나이며, 미국에서만 2022년 60만 명이 사망할 것으로 예상됩니다. 국제암연구소(IARC)에 따르면, 2040년까지 암 관련 신규 환자는 연간 2,750만 명, 사망자 수는 1,630만 명에 달할 것으로 예상됩니다. 암 치료제는 의약품 개발 측면에서 가장 활발한 분야 중 하나이지만, 이 분야에는 몇 가지 강력한 도전과제가 있습니다. 실제로 화학요법, 수술, 방사선 치료와 같은 전통적인 암 치료는 말기 암에서 매우 제한적인 효과를 보이고 있습니다.
보다 정밀하고 효과적인 항암제를 개발하기 위한 노력이 계속되고 있는 가운데, T 세포 치료는 체내 면역세포를 이용하여 종양세포를 선택적으로 제거하여 부작용을 최소화하는 유망한 면역요법으로 발전해 왔습니다. 기존 치료법과 달리 면역치료는 특이성, 잠재적인 표적 외 독성 감소, 치료 성적 향상 등 몇 가지 장점이 있으며, 2024년 미국 식품의약국(FDA)이 암을 표적으로 하는 여러 T 세포 치료를 승인한 것은 주목할 만합니다. 예를 들어, Obecabtagene autoleucel/Aucatzyl(재발성 또는 불응성 B세포 전구체 급성 림프아구성 백혈병, 2024년 11월), Afamitresgene autoleucel/TECELRA(전이성 또는 절제 불가능한 활막육종, 2024년 8월), Lifileucel/Amtogene autoleucel/Amtogene autoleucel/Amtogene autoleucel Lifileucel/Amtagvi(절제불능 또는 전이성 흑색종, 2024년 2월) 등이 있습니다.
기존 치료법 대비 면역치료의 장점에 힘입어 T 세포 기반 면역치료의 채택이 증가하고, 맞춤형 암 치료에 대한 수요가 급증하고 있으며, 규제 당국의 승인 속도가 빨라짐에 따라 T 세포 치료 시장이 크게 성장할 것으로 예상됩니다. 또한, 전 세계 암 분야가 계속 진화하고 있는 가운데, T세포공학과 차세대 제조기술의 발전은 이 분야의 기술 혁신을 촉진하여 향후 몇 년 동안 안정적인 성장을 이룰 것으로 예상됩니다.
대부분의 TIL 기반 면역요법(58종)은 다양한 치료제와 함께 사용되고 있습니다.
CAR 구조를 개선하기 위해 scFv 영역의 변형, 다양한 유전자 도입 벡터의 사용 등 세대를 초월한 광범위한 노력이 계속되고 있습니다.
지난 몇 년 동안 CAR-T 치료와 관련된 임상시험은 지역별로 970건 이상 등록되었습니다.
이해관계자들의 관심이 높아진 것은 이 분야의 제휴 활동이 활발해지면서 전체 제휴 건수의 45% 가량이 북미에 기반을 둔 기업들 간에 체결되고 있는 것으로 나타났습니다.
암 면역치료라는 미래 사업 기회를 발견한 여러 투자자들이 지난 몇 년 동안 370개 이상의 펀딩 라운드를 통해 320억 달러 이상을 투자했습니다.
CAR-T 세포 치료 관련 특허는 11,900건 이상 출원되어 이 분야에서 탄생한 지적 재산을 보호하기 위해 특허가 부여되고 있습니다.
CAR-T, TCR, TIL 기반 제품 외에도 약 205종의 T 세포 면역치료제가 수많은 종양학적 및 비종양학적 적응증 치료를 위해 시판/개발되고 있습니다.
약 200개 기업이 다양한 유형의 세포 치료제를 제조하는 데 필요한 역량을 보유하고 있다고 주장하고 있으며, 이러한 기업들은 제품 개발의 다양한 단계에 걸쳐 광범위한 서비스를 제공하고 있습니다.
암 발병률 증가, 기술 개발, 승인 획득 진행 등을 고려할 때, T 세포 치료 시장은 앞으로도 안정적인 성장이 예상됩니다.
개발 파이프라인에 대한 관심이 높아지고 임상시험의 성과가 기대되는 만큼, 향후 10년간 시장은 연평균 12% 이상 성장할 것으로 예상됩니다.
세계의 T 세포 치료 시장에 대해 조사했으며, 시장 개요와 함께 치료 유형별, 적응증별, 표적 항원별, 기업 규모별, 지역별 동향, 시장 진출 기업 프로파일 등의 정보를 전해드립니다.
As per Roots Analysis, the global T-cell therapy market size is estimated to grow from USD 6.5 billion in the current year to USD 20.9 billion by 2035, at a CAGR of 12% during the forecast period, till 2035.
The opportunity for the T-cell therapy market has been distributed across the following segments:
Type of Therapy
CAR-T
TCR
TIL
Target Indication
Multiple Myeloma
Large B-Cell Lymphoma
Acute Lymphoblastic Leukemia
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma, Primary Mediastinal Large B-Cell Lymphoma, Transformed Follicular Lymphoma and High grade B-cell lymphoma
T cells, a subset of white blood cells, are essential to the immunological system of the human body. The body's reactions to external allergens and infections are tightly controlled by these cells, which efficiently identify, target, and eliminate them while recalling the first interactions to trigger a prompt and efficient immune response. Scientists have been actively researching these cells since the 19th century with an aim to leverage them to treat a wide range of medical conditions. In fact, cell therapies (specifically T cell therapies) have attracted a lot of attention lately for managing / treating hard-to-treat diseases, like cancer, autoimmune diseases, and uncommon genetic disorders, ultimately decreasing the global disease burden.
Cancer is one of the leading causes of mortality, accounting for 0.6 million deaths in 2022, in the US alone. As per the International Agency for Research on Cancer (IARC), by 2040, there are likely to be 27.5 million new cases and 16.3 million deaths related to cancer, annually. Although cancer therapeutics continue to be one of the most active areas, in terms of drug development, there are several persistent challenges in this domain. In fact, conventional cancer treatments, such as chemotherapy, surgery and radiation therapy, have demonstrated very limited efficacy in late-stage cancers.
Amidst the ongoing efforts to develop more precise and effective anti-cancer therapeutics, T-cell therapies have evolved as a promising immunotherapy that uses the body's own immune cells to selectively eliminate tumor cells with minimal side effects. Unlike conventional therapies, immunotherapies provide several advantages, including specificity, potential reduction in off-target toxicities and improving treatment outcomes. It is worth mentioning that in 2024, the US Food and Drug Administration approved multiple T cell therapies targeting cancer (in reverse chronological order), such as Obecabtagene autoleucel / Aucatzyl (relapsed or refractory B-cell precursor acute lymphoblastic leukemia, November 2024), Afamitresgene autoleucel / TECELRA (metastatic or unresectable synovial sarcoma, August 2024) and Lifileucel / Amtagvi (unresectable or metastatic melanoma, February 2024).
Driven by the advantages offered by immunotherapies over conventional therapies, the increasing adoption of T-cell-based immunotherapies and the surge in demand for personalized cancer treatment, coupled with the expedited regulatory approvals, is expected to drive significant growth in the T cell therapeutics market. Moreover, as the global oncology landscape continues to evolve, advancements in T cell engineering and next-generation manufacturing technologies would drive innovation in this domain and position the market for steady growth in the forthcoming years.
T-CELL THERAPY MARKET: KEY INSIGHTS
The report delves into the current state of the T cell therapy market and identifies potential growth opportunities within industry. Some key findings from the report include:
With over 10 approved therapies and more than 1,200 preclinical / clinical therapy candidates, CAR-T immunotherapies represent one of the most active segments of the pharmaceutical domain.
More than 75% of the therapy candidates, which are being developed to target a range of disease indications, are autologous in nature; notably, CD19 and BCMA have emerged as the most popular target antigens.
Presently, there are over 205 TCR-based therapies that are approved / under clinical stages of development; notably, the current landscape is dominated (38%) by mid-sized players based in Europe.
Close to 35% of the TCR immunotherapies in the clinical development pipeline are being developed to target oncological disorders in adults, children and senior citizens.
Over 85 TIL-based immunotherapies have been either approved or are currently under development; of these, most of the immunotherapies are being developed by players based in North America to target melanoma.
Majority (58) of the TIL-based therapies are being used in combination with various therapeutic agents; of these, more than 45% of the immunotherapies are being developed by non-industry players.
Extensive efforts are underway to improve the CAR constructs across successive generations, involving alterations in the scFv region and using different types of gene delivery vectors.
In the last few years, over 970 clinical trials have been registered across different geographies for CAR-T therapies; extensive efforts are underway to improve successive generations of therapies.
The growing interest of stakeholders is evident from the increasing partnership activity in this domain; close to 45% of the total number of partnerships have been signed between players based in North America.
Several investors, having realized the opportunity within this upcoming segment of cancer immunotherapy, have invested more than USD 32 billion, across 370+ funding rounds in the past few years.
More than 11,900 patents related to CAR-T cell therapies have been filed / granted to protect the intellectual property generated within this field.
Apart from CAR-T, TCR and TIL-based products, close to 205 other T-cell immunotherapies are marketed / under development for the treatment of a myriad of oncological and non-oncological indications.
Close to 200 players claim to have the required capabilities to manufacture different types of cell therapies; such firms also offer a wide range of services across different stages of product development.
Given the growing prevalence of cancer, technological developments and ongoing approvals, the market for T-cell therapies is poised to witness a steady growth in the foreseen future.
With a growing focus on the development pipeline and encouraging clinical trial outcomes, the market is expected to witness an annualized growth rate of over 12%, during the next decade.
T-CELL THERAPY MARKET: KEY SEGMENTS
CAR T-cell Therapy Market Holds the Largest Share of the T-Cell Therapy Market During the Forecast Period
Based on the type of therapy, the global market is segmented into CAR-T, TCR and TIL therapies. Currently, the CAR T-cell therapy market segment captures the majority of the overall market share and is likely to dominate and drive the overall market growth. This can be attributed to the precise targeting mechanism of CAR T cell therapies that use chimeric antigen receptors to target and kill malignant cells (while minimizing damage to healthy tissues). It is worth highlighting that the TIL therapy market segment is likely to flourish during the forecast period, owing to their versatility in targeting a wide range of cancers and encouraging clinical trial results.
Therapies Targeting Melanoma Hold the Largest Share of TCR Therapies Market
Based on the target indication, the T-cell therapy market is segmented into multiple myeloma, large B-cell lymphoma, acute lymphoblastic leukemia, diffuse large b-cell lymphoma, diffuse large b-cell lymphoma, primary mediastinal large B-Cell lymphoma, transformed follicular lymphoma and high grade B-cell lymphoma, acute lymphoblastic leukemia / B-cell Non-Hodgkin lymphoma, Non-Hodgkin lymphoma, mantle cell lymphoma, acute myeloid leukemia, generalized myasthenia gravis (MG), renal transplantation (HLA-A2), gastric adenocarcinoma, ovarian / endometrial cancer, chronic lymphocytic leukemia, follicular lymphoma, renal cell carcinoma, melanoma, basal cell carcinoma, lung cancer, sarcoma, head and neck cancer, cervical cancer, neuro gastro-intestinal (GI) Cancer, breast cancer, hepatocellular carcinoma, nasopharyngeal carcinoma and ovarian cancer.
Currently, the majority share of the TCR therapies market is captured by therapies targeting melanoma (over 95%). This can be attributed to the fact that melanoma has a high rate of genetic mutations, leading to the production of many unique neoantigens which makes it a prime target for TCR therapies. Recently, the FDA has approved a TCR therapy (Kimmtrak) which is used to treat adults with metastatic uveal melanoma (a type of intraocular melanoma).
Therapies Targeting CD19 Antigen are Likely to Dominate the CAR-T Therapy market During the Forecast Period
Based on the type of target antigens, the T-cell therapy market is segmented into BCMA, CD19, CD20, CD19 and CD22, HLA, MAGE, PRAME, NY-ESO-1 and LAGE, EBV, HBV and others. Currently, therapies targeting CD19 antigen dominate the CAR-T therapies market, accounting for more than 65% of the overall market share. This dominance is primarily driven by the essential role of CD19 as it is a highly specific antigen expressed on B-cells, making it an ideal target for treating B-cell malignancies like leukemia and lymphoma.
North America Accounts for the Largest Share of the overall TCR therapy Market
Based on geographical regions, the market is segmented into North America, Europe, Asia-Pacific, Latin America and Middle East and North Africa, and the rest of the world. In the current scenario, North America is likely to capture the largest market share owing to the robust research and development infrastructure, a strong commercial base for cell therapies, and a high number of clinical trials being conducted in the region.
However, it is worth noting that the market for TCR therapies in Asia-Pacific is expected to grow at a relatively faster pace (CAGR of more than 45%), during the forecast period. This is driven by the increasing cases of cancer in the region, supported by the demand for curative treatments. Notably, it has been highlighted by industry experts that the cell therapy industry in China has witnessed growing interest from investment firms, enabling faster clinical research for T-cell therapies.
Example Players in the T-Cell Therapy Market
Adaptimmune Therapeutics
AbelZeta
Alaunos Therapeutics
Autolus Therapeutics
bluebird bio
Bristol Myers Squibb
CARsgen Therapeutics
Cellectis
Gilead Sciences
Immatics
Immunocore
Innovative Cellular Therapeutics
Iovance Biotherapeutics
Kuur Therapeutics
Lion TCR
Noile-Immune Biotech
Novartis
Takara Bio
Wellington Zhaotai Therapies
Zelluna immunotherapy
Primary Research Overview
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:
Chief Executive Officer, Mid-sized Company, China
Chief Operating Officer and Executive Vice President, Small Company, France
Former Co-Founder and Chief Executive Officer, Mid-sized Company, UK
Former Chief Executive Officer, Small Company, Netherlands
Former Chief Executive Officer, Mid-sized Company, Australia
Former Vice President, Immuno-Oncology, Mid-sized Company, Belgium
Director, Business Development, Small Company, US
Former Director, Process Development, Large Company, US
Former Research Head, Large Company, US
Former Competitive Intelligence Manager, Strategy & Business Development, Small Company, US
Professor of Medicine and Director, Department of Oncology, Hospital, China
Assistant Professor of Medicine, University, US
T-CELL THERAPY MARKET: RESEARCH COVERAGE
The report on T-cell therapy market features insights into various sections, including:
Market Sizing and Opportunity Analysis: An in-depth analysis of T-cell therapy market, focusing on key market segments, including [A] type of therapy, [B] target indication, [C] target antigen, [D] company size, [E] geographical regions, [F] leading players, and [G] sales forecast (of more than 55 T-cell therapies).
CAR-T cell therapies Market Landscape: A comprehensive evaluation of CAR-T cell therapies, based on several relevant parameters, such as [A] type of developer, [B] stage of development, [C] therapeutic area, [D] target indication, [E] target antigen, [F] source of T-cells, [G] route of administration, [H] dosing frequency, [I] patient segment, [J] type of therapy, [K] most active industry players, and [L] most active non-industry players.
CAR-T cell therapies Developer Landscape: The report features a list of players engaged in the development of CAR-T cell therapies offered, along with analyses based on [A] year of establishment, [B] company size, and [C] location of headquarters.
TCR-based therapies Market Landscape: A comprehensive evaluation of TCR-based therapies, based on several relevant parameters, such as [A] stage of development, [B] therapeutic area, [C] target indication, [D] target antigen, [E] source of T-cells, [F] route of administration, [G] dosing frequency, [H] target patient segment, [I] type of therapy, [J] most active industry players, and [K] most active non-industry players.
TCR-based therapies Developer Landscape: The report features a list of players engaged in the development of TCR-based therapies offered, along with analyses based on [A] year of establishment, [B] company size, and [C] location of headquarters.
TIL-based therapies Market Landscape: A comprehensive evaluation of TIL-based therapies, based on several relevant parameters, such as [A] type of developer, [B] stage of development, [C] route of administration, [D] dosing frequency, [E] patient segment, [F] type of therapy, [G] most active industry players, and [H] most active non-industry players.
TIL-based therapies Developer Landscape: The report features a list of players engaged in the development of TIL-based therapies offered, along with analyses based on [A] year of establishment, [B] company size, and [C] location of headquarters.
Key Insights Analysis: An in-depth analysis of key insights derived from the study featuring a competitive analysis, highlighting the popular target antigens related to hematological malignancies and solid tumors. Additionally, it includes CAR construct analysis of clinical-stage CAR-T therapies, based on various relevant parameters, such as [A] generation of CAR, [B] type of binding domain, [C] type of virus used, [D] type of gene transfer method used, and [E] type of co-stimulatory domain used.
Clinical Trial Analysis: A detailed analysis of completed, ongoing, and planned clinical studies related to CAR-Ts, TCRs, and TIL, based on several relevant parameters, such as [A] trial registration year, [B] enrolled patient population, [C] trial recruitment status, [D] trial phase, [E] target patient segment, [F] type of sponsor/collaborator, [G] most active players, and [H] regional distribution of trials.
Key Opinion Leaders (KOLs) Analysis: A comprehensive evaluation of various principal investigators (considered as key opinion leaders in this domain) involved in clinical trials related to CAR-Ts, TCRs and TILs. The section presents detailed analyses, comparing the relative expertise of KOLs based on a proprietary scoring criterion and that of a third party.
Therapy Profiles: Elaborate profiles of marketed and mid- to late-stage clinical therapies (phase I / II or above) related to CAR-Ts, TCRs and TILs, providing insights on [A] overview of the therapy, [B] mechanism of action of therapy, [C] dosage information, [D] details on the cost, and sales information (wherever available), [E] clinical development plan, and [F] key clinical trial results.
Emerging Technologies: A detailed discussion on innovative technology platforms that are being used for the development of T-cell therapies, along with profiles of key technology providers, and a relative competitiveness analysis of different gene editing platforms (used for the development of T-cell therapies), based on various parameters, such as [A] ease of system design, [B] cost of technology, [C] level of toxicity, and [D] efficiency of technology.
Partnerships and Collaborations: An insightful analysis of the deals inked by stakeholders in T-Cell therapy market, based on several parameters, such as [A] year of partnership, [B] type of product, [D] type of partner, [E] most popular products, [F] most active industry players, [G] most active non-industry players and [H] geographical distribution of partnership activity.
Funding and Investment Analysis: An in-depth analysis of the fundings raised by companies that have proprietary T-cell based products/technologies, based on relevant parameters, such as [A] year of funding, [B] type of funding, [C] amount invested (USD million), [D] type of therapy, [E] type of investor, [F] most active players, [G] most active investors, and [H] geography.
Patents Analysis: An in-depth analysis of patents filed / granted till 2022 related to CAR-Ts, TCRs and TILs, based on various relevant parameters, such as [A] type of patent, [B] publication year, [C] geographical distribution, [D] Cooperative Patent Classification (CPC) symbols, [E] emerging focus areas, [F] type of applicant, [G] leading players, [H] patent benchmarking, and [I] patent valuation analysis.
Other T-Cell Immunotherapies: An overview on other T-cell-based therapies, apart from CAR-Ts, TCRs and TILs, including a detailed analysis of approved / pipeline products, which are analyzed based on various parameters, such as [A] phase of development, [B] target therapeutic area(s), [C] type of T-cells used, [D] and source of T-cells.
Case Study: A detailed assessment of manufacturing cell therapy products, highlighting the key challenges, and a detailed list of contract service providers and in-house manufacturers involved in this space. It provides information about these manufacturers, focusing on details of [A] scale of operation, [B] compliance with cGMP standards, [C] location of the manufacturing facility, and [D] products being manufactured.
Cost-Price Analysis: A detailed analysis of various factors that form the basis for the pricing of cell-based therapies. It features different models / approaches that a pharmaceutical company may choose to adopt to decide the price of a T-cell based immunotherapy that is likely to be marketed in the coming years.
Promotional Analysis: A review of the key promotional strategies being adopted by the developers of the approved CAR-T cell therapies, namely Kymriah(R), Yescarta(R), Tecartus(TM), Breyanzi(R), Abecma(TM), Carvykti(TM) and TCR-based therapy (Kimmtrak(R)).
Company Profiles: In-depth profiles of several developers evaluating T-cell immunotherapy therapies for the treatment of various oncological and non-oncological indications, focusing on [A] company overviews, [B] financial information (if available), [C] T-cell therapy (CAR-T, TCR and TIL) specific portfolio, [D] technology portfolio (if available), [E] manufacturing capabilities (if available), [F] recent collaborations , and [G] funding and investments received by the company related to T-cell immunotherapies.
KEY QUESTIONS ANSWERED IN THIS REPORT
How many companies are currently engaged in this market?
Which are the leading companies in this market?
What factors are likely to influence the evolution of this market?
What is the current and future market size?
What is the CAGR of this market?
How is the current and future market opportunity likely to be distributed across key market segments?
What kind of partnership models are commonly adopted by industry stakeholders?
What is the ongoing investment trend in this market?
What is the patent filing activity trend in the market?
REASONS TO BUY THIS REPORT
The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
ADDITIONAL BENEFITS
Complimentary PPT Insights Packs
Complimentary Excel Data Packs for all Analytical Modules in the Report
10% Free Content Customization
Detailed Report Walkthrough Session with Research Team
Free Updated report if the report is 6-12 months old or older
TABLE OF CONTENTS
1. PREFACE
1.1. Introduction
1.2. Market Share Insights
1.3. Key Market Insights
1.4. Report Coverage
1.5. Key Questions Answered
1.6. Chapter Outlines
2. RESEARCH METHODOLOGY
2.1. Chapter Overview
2.2. Research Assumptions
2.2.1. Market Landscape and Market Trends
2.2.2. Market Forecast and Opportunity Analysis
2.2.3. Comparative Analysis
2.3. Database Building
2.3.1. Data Collection
2.3.2. Data Validation
2.3.3. Data Analysis
2.4. Project Methodology
2.4.1. Secondary Research
2.4.1.1. Annual Reports
2.4.1.2. Academic Research Papers
2.4.1.3. Company Websites
2.4.1.4. Investor Presentations
2.4.1.5. Regulatory Filings
2.4.1.6. White Papers
2.4.1.7. Industry Publications
2.4.1.8. Conferences and Seminars
2.4.1.9. Government Portals
2.4.1.10. Media and Press Releases
2.4.1.11. Newsletters
2.4.1.12. Industry Databases
2.4.1.13. Roots Proprietary Databases
2.4.1.14. Paid Databases and Sources
2.4.1.15. Social Media Portals
2.4.1.16. Other Secondary Sources
2.4.2. Primary Research
2.4.2.1. Types of Primary Research
2.4.2.1.1. Qualitative Research
2.4.2.1.2. Quantitative Research
2.4.2.1.3. Hybrid Approach
2.4.2.2. Advantages of Primary Research
2.4.2.3. Techniques for Primary Research
2.4.2.3.1. Interviews
2.4.2.3.2. Surveys
2.4.2.3.3. Focus Groups
2.4.2.3.4. Observational Research
2.4.2.3.5. Social Media Interactions
2.4.2.4. Key Opinion Leaders Considered in Primary Research
2.4.2.4.1. Company Executives (CXOs)
2.4.2.4.2. Board of Directors
2.4.2.4.3. Company Presidents and Vice Presidents
2.4.2.4.4. Research and Development Heads
2.4.2.4.5. Technical Experts
2.4.2.4.6. Subject Matter Experts
2.4.2.4.7. Scientists
2.4.2.4.8. Doctors and Other Healthcare Providers
2.4.2.5. Ethics and Integrity
2.4.2.5.1. Research Ethics
2.4.2.5.2. Data Integrity
2.4.3. Analytical Tools and Databases
2.5. Robust Quality Control
3. MARKET DYNAMICS
3.1. Chapter Overview
3.2. Forecast Methodology
3.2.1. Top-down Approach
3.2.2. Bottom-up Approach
3.2.3. Hybrid Approach
3.3. Market Assessment Framework
3.3.1. Total Addressable Market (TAM)
3.3.2. Serviceable Addressable Market (SAM)
3.3.3. Serviceable Obtainable Market (SOM)
3.3.4. Currently Acquired Market (CAM)
3.4. Forecasting Tools and Techniques
3.4.1. Qualitative Forecasting
3.4.2. Correlation
3.4.3. Regression
3.4.4. Extrapolation
3.4.5. Convergence
3.4.6. Sensitivity Analysis
3.4.7. Scenario Planning
3.4.8. Data Visualization
3.4.9. Time Series Analysis
3.4.10. Forecast Error Analysis
3.5. Key Considerations
3.5.1. Demographics
3.5.2. Government Regulations
3.5.3. Reimbursement Scenarios
3.5.4. Market Access
3.5.5. Supply Chain
3.5.6. Industry Consolidation
3.5.7. Pandemic / Unforeseen Disruptions Impact
3.6. Limitations
4. MACRO-ECONOMIC INDICATORS
4.1. Chapter Overview
4.2. Market Dynamics
4.2.1. Time Period
4.2.1.1. Historical Trends
4.2.1.2. Current and Forecasted Estimates
4.2.2. Currency Coverage
4.2.2.1. Major Currencies Affecting the Market
4.2.2.2. Factors Affecting Currency Fluctuations on the Industry
4.2.2.3. Impact of Currency Fluctuations on the Industry
4.2.3. Foreign Currency Exchange Rate
4.2.3.1. Impact of Foreign Exchange Rate Volatility on the Market
4.2.3.2. Strategies for Mitigating Foreign Exchange Risk
4.2.4. Recession
4.2.4.1. Assessment of Current Economic Conditions and Potential Impact on the Market
4.2.4.2. Historical Analysis of Past Recessions and Lessons Learnt
4.2.5. Inflation
4.2.5.1. Measurement and Analysis of Inflationary Pressures in the Economy
4.2.5.2. Potential Impact of Inflation on the Market Evolution
4.2.6. Interest Rates
4.2.6.1. Interest Rates and Their Impact on the Market
4.2.6.2. Strategies for Managing Interest Rate Risk
4.2.7. Commodity Flow Analysis
4.2.7.1. Type of Commodity
4.2.7.2. Origins and Destinations
4.2.7.3. Values and Weights
4.2.7.4. Modes of Transportation
4.2.8. Global Trade Dynamics
4.2.8.1. Import Scenario
4.2.8.2. Export Scenario
4.2.8.3. Trade Policies
4.2.8.4. Strategies for Mitigating the Risks Associated with Trade Barriers
4.2.8.5. Impact of Trade Barriers on the Market
4.2.9. War Impact Analysis
4.2.9.1. Russian-Ukraine War
4.2.9.2. Israel-Hamas War
4.2.10. COVID Impact / Related Factors
4.2.10.1. Global Economic Impact
4.2.10.2. Industry-specific Impact
4.2.10.3. Government Response and Stimulus Measures
4.2.10.4. Future Outlook and Adaptation Strategies
4.2.11. Other Indicators
4.2.11.1. Fiscal Policy
4.2.11.2. Consumer Spending
4.2.11.3. Gross Domestic Product
4.2.11.4. Employment
4.2.11.5. Taxes
4.2.11.6. Stock Market Performance
4.2.11.7. Cross Border Dynamics
4.3. Conclusion
5. EXECUTIVE SUMMARY
6. INTRODUCTION
6.1. Chapter Overview
6.2. Pillars of Cancer Therapy
6.3. Overview of Immunotherapies
6.4. Fundamentals of Cancer Immunotherapy
6.5. Classification of Cancer Immunotherapies
6.5.1. By Mechanism of Action
6.5.1.1. Active Immunotherapy
6.5.1.2. Passive Immunotherapy
6.5.2. By Type of Target
6.5.3. By Approach
6.5.3.1. Activation and Suppression Immunotherapy
6.5.4. By Product Class
6.5.4.1. Monoclonal Antibodies
6.5.4.2. Bispecific Antibodies
6.5.4.3. Cytokines
6.5.4.4. Oncolytic Virus Therapy
6.5.4.5. Therapeutic Cancer Vaccines
6.5.4.6. Cell-based Therapies
6.6. T-Cell Immunotherapies
6.6.1. Historical Evolution
6.6.2. Key Considerations for Developing T-Cell Immunotherapies
6.6.3. Strategies Employed for the Redirection of T-Cells
6.6.4. Manufacturing of Engineered T-Cells
6.6.5. T-Cell Transduction and Transfection Methods
