한글목차

세계 녹아웃 마우스 모델 시장은 병원 및 연구소 시장에서의 기회를 배경으로 미래가 기대되는 시장입니다. 2025년부터 2031년까지 세계 녹아웃 마우스 모델 시장은 4.1%의 연평균 복합 성장률(CAGR)을 보일 것으로 예측됩니다. 이 시장의 주요 촉진요인은 개인 맞춤형 의료에 대한 수요 증가, 유전성 질환의 유병률 증가, 정밀 연구의 채택 확대 등입니다.

• Lucintel의 예측에 따르면, 유형별로는 조건부 녹아웃 마우스가 예측 기간 동안 가장 높은 성장률을 보일 것으로 예측됩니다.
• 용도별로는 실험실용도가 더 높은 성장률을 보일 것으로 예측됩니다.
• 지역별로는 아시아태평양(APAC)이 예측 기간 동안 가장 높은 성장률을 보일 것으로 예측됩니다.

녹아웃 마우스 모델 시장의 새로운 트렌드

녹아웃 마우스 모델 시장은 유전자 연구와 신약 개발의 본질을 근본적으로 변화시키는 몇 가지 주요 신흥 트렌드에 의해 변화하고 있습니다. 이러한 추세는 전임상시험의 정확성, 생산성, 생물학적 연관성 향상에 대한 요구에 부응하는 것입니다. 보다 진보된 모델과 통합된 워크플로우에 대한 추세는 질병 메커니즘에 대한 더 깊은 통찰력을 가져다 줄 것입니다. 이러한 새로운 트렌드는 녹아웃 마우스의 기능적 능력을 발전시킬 뿐만 아니라 더 많은 과학 분야로 응용 범위를 확장하고 있습니다.

• CRISPR-Cas9 유전자 편집 기술의 응용: 주요 동향 중 하나는 CRISPR-Cas9 기술을 이용한 녹아웃 마우스 모델의 대규모 생성입니다. 이 강력한 유전자 편집 기법은 기존 기술에 비해 빠르고 효율적이며 비용 효율성이 뛰어납니다. 그 결과, 신규 모델 개발에 소요되는 시간과 비용이 크게 절감되어 더 많은 연구자들이 쉽게 이용할 수 있게 되었습니다. 이 기술은 유전자 연구의 속도를 가속화하고 더 복잡하고 정확한 모델 개발을 가능하게 하고 있습니다.
• 조건부 및 인간화 모델 개발: 업계에서는 조건부 및 인간화 녹아웃 마우스 모델 구축이 증가하는 추세에 있습니다. 조건부 녹아웃 마우스는 특정 시기나 조직에서 유전자 결손을 일으켜 유전자 기능에 대한 보다 심층적인 연구를 가능하게 합니다. 인간 유전자 및 조직을 이용한 인간화 모델은 약물 시험에서 보다 생리적 관련성이 높은 시스템을 제공합니다. 그 결과, 인간에서의 약효와 안전성에 대한 예측 정확도가 향상되어 임상시험에서 약물의 실패율을 크게 낮출 수 있을 것으로 기대됩니다.
• 계산생물학과 AI의 통합: 주요 트렌드 중 하나는 계산생물학과 인공지능(AI)을 녹아웃 마우스 모델 연구에 결합하는 것입니다. AI는 이러한 모델에서 생성되는 방대한 표현형 데이터의 해석과 미확인 유전자의 기능 규명에 활용됩니다. 이를 통해 보다 효율적이고 데이터에 기반한 조사 접근 방식을 구현할 수 있습니다. 이러한 융합을 통해 과학자들은 새로운 약물 표적을 발견하고 복잡한 유전자형-표현형 연관성을 보다 효율적으로 해독할 수 있으며, 전체 연구 과정을 가속화할 수 있습니다.
• 아웃소싱 및 CRO 서비스로의 전환: 시장에서는 녹아웃 마우스 모델의 생산 및 개발을 전문 위탁연구기관(CRO)에 위탁하는 움직임이 나타나고 있습니다. 이를 통해 생명공학 기업이나 제약사들은 별도의 동물 사육 시설과 인력에 대한 막대한 비용 없이 핵심 연구 기능에 집중할 수 있게 됩니다. 이를 통해 효율성 향상, 비용 절감, 다양한 전문 지식 및 특수 모델에 대한 접근성을 확보할 수 있습니다. 이러한 추세는 녹아웃 마우스에 대한 접근성을 널리 보급하고 CRO 산업의 성장을 가속하고 있습니다.
• 맞춤형 의료로의 확장: 맞춤형 의료 분야에서 녹아웃 마우스 모델의 활용이 증가하고 있습니다. 연구진은 환자 유래 이종이식 모델(PDX) 및 기타 환자 특이적 모델을 개발하여 개별 종양 및 질병에 대한 다양한 치료법의 효과를 검증하고 있습니다. 이러한 기여는 환자의 고유한 유전체 구성에 따라 치료법을 맞춤화할 수 있는 정밀의료에 매우 유용한 도구가 될 수 있습니다. 이 방법은 암 치료를 비롯한 개인 맞춤형 치료의 변화를 가져올 수 있는 잠재력을 가지고 있습니다.

전반적으로,이러한 새로운 발전은 녹아웃 마우스 모델 산업을 근본적으로 변화시키고 있습니다. CRISPR-Cas9 기술의 채택과 고도화된 모델 개발로 연구의 정확성과 생물학적 타당성이 향상되고 있습니다. AI의 통합과 아웃소싱은 효율성과 접근성을 높이고 있습니다. 개인 맞춤형 의료로의 전환은 이러한 모델에 새로운 고부가가치 용도를 부여하고 있습니다. 이러한 변화는 현대 생물의학 연구의 최첨단을 달리고, 보다 혁신적이고, 비용 효율적이며, 다양성이 풍부한 시장 형성에 기여하고 있습니다.

녹아웃 마우스 모델 시장의 최근 동향

현재 녹아웃 마우스 모델 시장의 발전은 모델 생성 및 활용의 속도, 정확도, 복잡성 향상에 초점을 맞추었습니다. 이러한 발전은 현대 신약개발의 기하급수적으로 증가하는 요구사항에 대응하고 보다 복잡한 생물학적 과제를 탐구해야 할 필요성에서 필연적으로 발생합니다. 이 분야는 기본적인 상시 녹아웃에 대한 의존에서 벗어나 첨단 기술을 활용한 보다 정교한 접근 방식으로 전환하고 있습니다. 이를 통해 인간 질병을 보다 충실하게 재현하는 모델을 개발하여 최종적으로 일관성 있는 전임상 데이터를 얻을 수 있게 되었습니다.

• CRISPR-Cas9 기술의 다학제적 활용: 가장 중요한 진전 중 하나는 녹아웃 마우스 모델 제작에 CRISPR-Cas9 기술의 다학제적 활용입니다. 이 유전자 편집 기술을 통해 녹아웃 모델을 비교할 수 없는 속도와 정확도로 생성할 수 있으며, 보통 몇 년이 아닌 몇 달 만에 실현할 수 있습니다. 이를 통해 신규 모델 생성 기간을 획기적으로 단축하고, 연구 파이프라인을 크게 가속화할 수 있게 되었습니다. 이 혁신은 커스텀 마우스 모델을 광범위하게 사용할 수 있게 하여 업계 전반의 혁신을 촉진하고 있습니다.
• 마우스 모델의 인간화 및 상용화: 인간화 마우스 모델의 상용화와 표준화가 눈에 띄게 진전되고 있습니다. 인간 유전자, 세포, 조직을 도입한 이들 모델은 특히 면역학 및 암 연구에서 인간 질병 연구의 보다 우수한 대표 모델이자 예측 모델로 자리 잡았습니다. 이를 통해 연구자들은 전임상 환경에서 인간 특이적 약물이나 치료법을 높은 정확도로 검증할 수 있으며, 임상시험 단계에서의 실패 위험을 최소화할 수 있습니다.
• 대규모 마우스 모델 리포지토리 개발: 중요한 진전 중 하나는 국제 마우스 표현형 분석 컨소시엄(IMPC)이 유지 관리하는 대규모 마우스 모델 리포지토리 구축입니다. 이 리포지토리에는 방대한 양의 녹아웃 마우스가 저장되어 있으며, 수천 종에 이르는 다양한 모델에 쉽게 접근할 수 있습니다. 이를 통해 연구 중복을 최소화하고 대규모 유전자 기능 연구를 위한 표준화된 자원을 제공하는 세계 공동연구를 실현하여 유전자와 질병의 연관성 규명을 가속화하고 있습니다.
• 조건부 녹아웃 시스템의 발전: 최근 연구 결과, 유전자 결손을 시공간적으로 제어할 수 있는 조건부 녹아웃 시스템이 비약적으로 발전했습니다. 예를 들어, Cre-Lox 시스템을 통해 특정 시기, 특정 조직에서 유전자를 켜고 끌 수 있게 되었습니다. 이를 통해 배아 치사성이나 유전자 전체 결손에 의한 혼동 요인을 제거하여 보다 민감하고 특이적인 유전자 기능 분석을 실현하여 보다 방향성 있고 일관성 있는 연구 결과를 얻을 수 있습니다.
• 코로나19 연구에서의 마우스 모델 활용 확대: 이러한 새로운 트렌드 중 하나로 코로나19 연구에서의 마우스 모델 활용이 눈에 띄게 증가하고 있습니다. 연구진은 인간 ACE2 수용체를 발현하는 녹아웃 마우스를 개발하여 바이러스의 병원성 규명 및 치료-백신 시험에 활용했습니다. 이를 통해 신종 병원체 연구를 위한 신속하고 효율적인 전임상 모델을 구현할 수 있게 되었습니다. 이는 공중보건 위기 대응에 있어 녹아웃 마우스 모델의 중요한 역할과 질병 모델링에 있어 그 다재다능함을 보여줍니다.

요약하면, 이러한 발전과 함께 녹아웃 마우스 모델 시장은 더욱 효율적이고 정확하며 진보된 모습으로 변화하고 있습니다. CRISPR-Cas9 기술의 대규모 도입과 인간화 모델의 상용화로 전임상시험의 질과 적용성이 향상되고 있습니다. 대규모 리포지토리 구축과 조건부 녹아웃 시스템 개발로 접근성과 정확성을 높이고 있습니다. 이러한 발전으로 시장은 바이오메디컬 분야의 혁신을 촉진하는 중요한 원동력이 되고 있으며, 혁신과 새로운 치료법 개발을 촉진하고 있습니다.

목차

제1장 주요 요약

제2장 시장 개요

• 배경과 분류
• 공급망

제3장 시장 동향과 예측 분석

• 업계 촉진요인과 과제
• PESTLE 분석
• 특허 분석
• 규제 환경

제4장 세계의 녹아웃 마우스 모델 시장 : 유형별

• 매력 분석 : 유형별
• 구성적 녹아웃 마우스
• 조건부 녹아웃 마우스
• 단백질 기능 녹아웃 마우스

제5장 세계의 녹아웃 마우스 모델 시장 : 용도별

• 매력 분석 : 용도별
• 병원
• 연구소
• 기타

제6장 지역 분석

제7장 북미의 녹아웃 마우스 모델 시장

• 북미 녹아웃 마우스 모델 시장 : 유형별
• 북미 녹아웃 마우스 모델 시장 : 용도별
• 미국 녹아웃 마우스 모델 시장
• 멕시코 녹아웃 마우스 모델 시장
• 캐나다 녹아웃 마우스 모델 시장

제8장 유럽의 녹아웃 마우스 모델 시장

• 유럽 녹아웃 마우스 모델 시장 : 유형별
• 유럽 녹아웃 마우스 모델 시장 : 용도별
• 독일 녹아웃 마우스 모델 시장
• 프랑스 녹아웃 마우스 모델 시장
• 스페인 녹아웃 마우스 모델 시장
• 이탈리아 녹아웃 마우스 모델 시장
• 영국 녹아웃 마우스 모델 시장

제9장 아시아태평양의 녹아웃 마우스 모델 시장

• 아시아태평양 녹아웃 마우스 모델 시장 : 유형별
• 아시아태평양 녹아웃 마우스 모델 시장 : 용도별
• 일본 녹아웃 마우스 모델 시장
• 인도 녹아웃 마우스 모델 시장
• 중국 녹아웃 마우스 모델 시장
• 한국 녹아웃 마우스 모델 시장
• 인도네시아 녹아웃 마우스 모델 시장

제10장 기타 지역(ROW)의 녹아웃 마우스 모델 시장

• 기타 지역 녹아웃 마우스 모델 시장 : 유형별
• 기타 지역 녹아웃 마우스 모델 시장 : 용도별
• 중동 녹아웃 마우스 모델 시장
• 남미 녹아웃 마우스 모델 시장
• 아프리카 녹아웃 마우스 모델 시장

제11장 경쟁 분석

• 제품 포트폴리오 분석
• 운영 통합
• Porter의 Five Forces 분석
• 시장 점유율 분석

제12장 기회와 전략 분석

• 밸류체인 분석
• 성장 기회 분석
• 세계 녹아웃 마우스 모델 시장의 새로운 동향
• 전략 분석

제13장 밸류체인 주요 기업 개요

• 경쟁 분석
• Envigo
• GenOway
• Cyagen Biosciences
• Charles River Laboratories International
• TransGenic

제14장 부록

영문목차

The future of the global knock out mouse model market looks promising with opportunities in the hospital and laboratory markets. The global knock out mouse model market is expected to grow with a CAGR of 4.1% from 2025 to 2031. The major drivers for this market are the increasing demand for personalized medicine, the rising prevalence of genetic disorders, and the growing adoption of precision research.

• Lucintel forecasts that, within the type category, conditional knockout mouse is expected to witness the highest growth over the forecast period.
• Within the application category, laboratory is expected to witness higher growth.
• In terms of region, APAC is expected to witness the highest growth over the forecast period.

Emerging Trends in the Knock Out Mouse Model Market

The knock out mouse model market is being transformed by some major emerging trends that are radically altering the nature of genetic research and drug discovery. These trends are responding to the imperative for increased precision, productivity, and biological relevance in preclinical studies. The trend is toward more advanced models and integrated workflows that yield richer insights into disease mechanisms. These new trends are not just advancing the functional capability of knock out mice but also broadening their applications across more scientific fields.

• CRISPR-Cas9 Gene Editing Application: One of the key trends is the use of CRISPR-Cas9 technology for creating knock out mouse models on a widespread scale. This powerful gene editing method is quicker, faster, and more efficient and cost-effective than conventional techniques. The effect is a substantial decrease in the time and cost involved to develop new models, which is more within the reach of a broad array of researchers. This technology is speeding up the pace of genetic studies and allowing the development of more complex and accurate models.
• Conditional and Humanized Model Development: The industry is witnessing an increasing trend towards the construction of conditional and humanized knock out mouse models. Conditional knock out mice enable gene deletion at a particular time or tissue, and this offers a closer study of gene function. Humanized models with human genes or tissues provide a more physiologically relevant system for drug testing. The outcome is a more reliable prediction of drug efficacy and safety in humans, which can really lower drug failure in clinical trials.
• Computational Biology-AI Integration: One of the major trends is the combination of computational biology and artificial intelligence (AI) with knock out mouse model studies. AI is utilized to interpret the huge amount of phenotypic data produced from these models and to determine the function of unidentified genes. The result is a more effective and data-oriented approach to research. This convergence assists scientists to discover new drug targets and decipher intricate genotype-phenotype associations more efficiently, speeding the whole discovery process.
• Movement towards Outsourcing and CRO Services: The market is observing a movement towards outsourcing the production and development of knock out mouse models to expert contract research organizations (CROs). This enables biotech and pharmaceutical firms to concentrate on their primary research functions without the exorbitant expense of a separate vivarium and personnel. The effect is improved efficiency, cost reduction, and access to more diversity of expertise and specialized models. This trend is democratizing access to knock out mice and facilitating growth in the CRO industry.
• Expansion into Personalized Medicine: There has been increased utilization of the knock out mouse model in personalized medicine. Scientists are developing patient-derived xenograft (PDX) and other patient-specific models on which they check the efficacy of various treatments on an individual's tumor or disease. The contribution is the creation of a very valuable tool for precision medicine, where therapies are customized based on a patient's unique genomic makeup. This method has the ability to transform cancer therapy and other therapies of a tailored nature.

Overall, these new developments are essentially transforming the knock out mouse model industry. Adoption of CRISPR-Cas9 and advanced model development are refining precision and biological validity of research. Integration of AI and outsourcing are enhancing efficiency and accessibility. The move into personalized medicine is establishing new, high-value applications for these models. These shifts are together contributing to a more innovative, cost-effective, and variable market that is cutting-edge for contemporary biomedical investigation.

Recent Developments in the Knock Out Mouse Model Market

Current advances in the knock out mouse model market are centered on enhancing the speed, accuracy, and complexity of model creation and use. The advances are necessitated by the need to keep up with the exponentially increasing requirements of contemporary drug discovery as well as explore more intricate biological questions. The field is shifting away from a dependence on basic, constitutive knock outs toward a more sophisticated approach that utilizes state-of-the-art technology to develop models that better simulate human disease, ultimately yielding more consistent preclinical information.

• Cross-Disciplinary Adoption of CRISPR-Cas9 Technology: One of the most important developments is the cross-disciplinary adoption of CRISPR-Cas9 technology for creating knock out mouse models. This gene editing technology makes it possible to produce knock outs with unrivaled speed and accuracy, frequently in a few months instead of years. The effect is a profound acceleration of the research pipeline, as it cuts dramatically the time to produce a new model. This innovation has made custom mouse models accessible to anyone and stimulated innovation across the industry.
• Humanization Commercialization of Mouse Models: Commercialization and standardization of mouse models with humanization have proceeded enormously. Such models are developed to contain human genes, cells, or tissues, and are now a better representative and predictive model for the study of human disease, notably in immunology and cancer. The benefit is the potential to have researchers test human-specific drugs and treatments in a preclinical environment with increased assurance, minimizing the risk of failure in follow-on clinical trials.
• Development of Large-Scale Mouse Model Repositories: One of the important developments is the creation of large-scale mouse model repositories, as preserved by the International Mouse Phenotyping Consortium. These repositories contain enormous collections of knock out mice, offering easy access to thousands of various models. The effect is a worldwide collaborative effort minimizing redundancy in research and offering a standardized resource for large-scale gene function study, hence speeding up the identification of gene-disease associations.
• Progress in Conditional Knock out Systems: Recent research has seen a major leap forward in conditional knock out systems that permit the spatiotemporal control of gene ablation. These systems, for example, Cre-Lox, make it possible for scientists to switch a gene on or off in a given time and tissue. The consequence is a more sensitive and specific investigation of gene function free from the confounding influences of embryonic lethality or ubiquitous gene deletion, resulting in more directed and consistent research findings.
• Enhanced Utilization of Mouse Models in COVID-19 Research: One such new trend has been the heightened utilization of mouse models in COVID-19 research. Researchers developed knock out mice that have the human ACE2 receptor to research the pathogenesis of the virus and test treatments and vaccines. The effect is a fast and efficient preclinical model for researching an emerging pathogen. It has shown the important function that knock out mouse models have in responding to public health crises and their versatility in modeling disease.

In summary, all these advances are collectively transforming the knock out mouse model market such that it is becoming more efficient, accurate, and advanced. The large-scale adoption of CRISPR-Cas9 and commercial availability of humanized models are improving the quality and applicability of preclinical studies. The organization of large repositories and development of conditional knock out systems are enhancing accessibility and accuracy. These developments are making the market a critical and active force for biomedical breakthrough, pushing innovation and new therapy development.

Strategic Growth Opportunities in the Knock Out Mouse Model Market

The knock out mouse model market has a number of strategic opportunities for growth across primary applications, fueled by its inevitability as a tool for deciphering gene function and disease. Through targeting such application-specific segments, firms can use their genetic engineering expertise to help meet some of the most critical needs in life sciences and achieve a competitive edge. The market is shifting toward increasing specialization and focus, generating new value propositions and new top-line streams beyond mere basic research into high-impact areas such as personalized medicine and therapeutic development.

• Business in Oncology and Cancer Research: A key strategic growth business opportunity exists in the use of knock out mouse models for cancer research and oncology. These models are critical to investigate tumor biology, discover novel drug targets, and to assay the effectiveness of new cancer drugs. The opportunity is to offer a broad spectrum of cancer-specific models, such as patient-derived xenografts (PDX), and to provide comprehensive preclinical services. The benefit is the potential to collaborate with biotechnology and pharmaceutical firms to speed up the development of life-saving cancer therapies.
• Expansion into Personalized Medicine: The market offers a tremendous growth potential in the use of knock out mouse models for personalized medicine. By developing patient-specific models with specific genetic mutations, scientists can try out the efficacy of various drugs and treatments prior to giving them to the patient. The market opportunity is to create and sell platforms to produce such highly customized models. The value is in having the ability to offer an enabling tool for precision medicine, resulting in improved and targeted therapies for individuals and a high-value application.
• Use in Neurodegenerative Disease Research: There is another tremendous growth opportunity in the use of knock out mouse models in research on neurodegenerative diseases like Alzheimer's and Parkinson's disease. These models are essential for examining the intricate genetic and molecular pathways of these diseases, for which there are at present few useful treatments. The potential is to supply specialized models accurately representing the human disease. The benefit is the potential to advance a field with huge unmet medical need, spurring innovation and potential breakthroughs in therapy.
• Immunology and Infectious Disease Research Growth: A strategic opportunity for growth exists in the use of knock out mouse models for infectious disease and immunology research. Humanized mouse models are especially useful here for research on the human immune response to pathogens as well as for the testing of vaccines and immunotherapies. The opportunity exists to develop and market a portfolio of humanized models. The effect is the potential to be a central contribution to global health initiatives, including the creation of vaccines for pandemics, and to enable the emerging industry of immunotherapy.
• Focusing on Academic and Government Research Institutions: One of the major growth possibilities is to focus on academic and government research institutions. Pharmaceutical corporations are large customers, but these institutions are a huge and steady market for knock out mouse models for basic research. The potential is to offer a broad variety of standardized, low-cost models and support services. The effect is extended market reach and the capability to establish long-term relationships with a wide variety of research teams, thus having an impact on future scientific breakthroughs.

Overall, these strategic opportunity growths are redefining the knock out mouse model market by emphasizing application-based requirements. By focusing on oncology, personalized medicine, neurodegenerative disorders, immunology, and the academic market, businesses are shifting towards a high-value and specialized model. This is promoting a market wherein an understanding of application needs and the provision of customized solutions are driving success, which places knock out mice as a core technology for a broad spectrum of life sciences applications.

Knock Out Mouse Model Market Driver and Challenges

The knock out mouse model market is dictated by a multifaceted interplay of key drivers propelling its growth and major pitfalls tempering its expansion. The growth of the markets is inherently driven by the escalating demand for cutting-edge tools for drug discovery and the worldwide bid to hasten biomedical research. Yet, such advancement is hampered by serious obstacles, such as ethical issues, the exorbitant cost of models, and the complexity of producing and characterizing them. The interplay between these drivers determines the direction and speed of market development.

The factors responsible for driving the knock out mouse model market include:

1. Growing Research and Development Expenditures: One major impetus is growing R&D expenditures in the biotechnology and pharmaceutical industries. Businesses feel compelled to bring new and better drugs to market for various conditions. Knock out mouse models are a must-have for preclinical evaluation and disease mechanism studies. This ongoing investment in drug development and discovery makes for a robust and consistent demand for these models, fueling growth and advancement in the market.

2. Gene Editing Technologies Advancements: The main driver is the ongoing development of gene editing technologies, especially CRISPR-Cas9. This has opened up a whole new way of producing knock out models, and the process now is quicker, more accurate, and cheaper. The technological advancements have alleviated a major bottleneck in research and enabled researchers to produce more intricate models, which in turn drives the market by increasing the capabilities and uses of knock out mice.

3. Increasing Demand for Personalized Medicine: Increasing demand for personalized and precision medicine is one of the key drivers. Personalized medicine depends on a comprehensive understanding of the genetic makeup of an individual and how it affects disease and treatment response. Patient-derived knock out mouse models are critical for testing and validating these personalized strategies. This trend is establishing a new, high-value use of knock out mice and is propelling their use in clinical research.

4. Increasing Chronic Diseases: The rising global incidence of chronic diseases like cancer, diabetes, and cardiovascular diseases is the key driver. All these diseases necessitate a large amount of research to find their underlying causes and new treatments. Knock out mice are employed to investigate the genetic origin of such conditions and to test for possible therapeutics. Increasing incidence of such diseases generates an ongoing demand for new research reagents, and hence for knock out mice.

5. Growth of Contract Research Organizations: The growth of the contract research organization sector is a major driver. Numerous pharmaceutical and biotechnology organizations are subcontracting their preclinical research to CROs to minimize costs as well as tap into specialized expertise. These CROs are heavy customers for knock out mouse models. This trend is compelling demand for both the models themselves and accompanying services, including breeding, phenotyping, and bespoke model creation, thus propelling market development.

Challenges in the knock out mouse model market are:

1. Ethical Issues and Regulatory Barriers: A major challenge is the ethical issues and strict regulatory guidelines around the use of animals in research. Public perception and animal welfare organizations may generate pressure to limit or eliminate animal testing. This necessitates a lengthy and complicated regulatory approval process for studies involving animals, which tends to delay the research and increase the expense. This ethical controversy and regulation serve as a significant restraint on the market.

2. High Model Generation and Maintenance Cost: The market is confronted with difficulty because of the high cost involved in the generation and maintenance of knock out mouse models. Establishing a new custom model is quite costly, and the constant expenses of sheltering, nourishing, and breeding a large mouse colony are out of reach for many research facilities. Such a high expenditure can be a threshold to entry for smaller laboratories and can restrict the scope of larger studies.

3. Lack of Predictive Accuracy and Complexity: The other major challenge is the complexity of disease modeling and the limitations of extrapolating predictions from mice to man. Although knock out mice are a valuable tool, they are not ideal models of human disease. The physiological differences between man and mouse can result in a lack of predictive accuracy, which is a cause of concern for drug developers. This complexity and potential for error pose a major challenge for the market.

The knock out mouse model market is witnessing dynamic growth, stimulated by the synergy of increased R&D expenditure and impressive technology developments. The trend in markets is favorably aided by increasing demand for personalized medicine and a shift in attention towards chronic disease studies. Yet, its full potential is threatened by the multifaceted challenges of ethical issues, high model costs, and the limitations inherent in animal models' ability to predict human outcomes.

List of Knock Out Mouse Model Companies

Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. With these strategies knock out mouse model companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the knock out mouse model companies profiled in this report include-

• Envigo
• GenOway
• Cyagen Biosciences
• Charles River Laboratories International
• TransGenic

Knock Out Mouse Model Market by Segment

The study includes a forecast for the global knock out mouse model market by type, application, and region.

Knock Out Mouse Model Market by Type [Value from 2019 to 2031]:

• Constitutive Knockout Mouse
• Conditional Knockout Mouse
• Protein Function Knockout Mouse

Knock Out Mouse Model Market by Application [Value from 2019 to 2031]:

• Hospital
• Laboratory
• Others

Country Wise Outlook for the Knock Out Mouse Model Market

The knock out mouse model market is a vital part of contemporary biomedical research, being an invaluable instrument for uncovering the function of genes and mechanisms of disease. Developments have been pushed forward in recent times by a convergence of sophisticated genetic engineering strategies, an expanding emphasis on personalized medicine, and the rising sophistication of therapeutic research. The market is evolving with a shift toward more sophisticated models, such as conditional and humanized mice, which provide a more accurate representation of human disease. This evolution is enabling researchers to accelerate drug discovery and develop more targeted and effective treatments for a wide range of diseases.

• United States: United States market for knock out mouse models is a world leader, backed by huge government and private investments in biomedical research. Current trends revolve around the universal adoption of CRISPR-Cas9 technology, which has optimized gene editing to be quicker, more accurate, and less expensive. There is also a strong shift towards outsourcing the generation and breeding of models to specialist contract research organizations. This market is underpinned by a robust pharmaceutical and biotechnology sector, with a special emphasis on oncology and rare disease research.
• China: China's knock out mouse model market is growing strongly, driven by high government investment in life sciences and a growing domestic biotechnology industry. Recent advances have included an emphasis on establishing large-scale mouse model repositories and an emphasis on innovative gene editing technologies. Chinese firms are providing a vast variety of custom mouse models at affordable prices, increasing accessibility to the technology. The industry also witnesses growth in partnerships between universities and private companies aimed at advancing research and development.
• Germany: The German knock out mouse model market is distinguished by a robust academic research base and a stringent quality and ethical animal care standard. Recent advances are towards the generation of highly specific and physiologically relevant conditional knock out models to evaluate gene function in a spatiotemporal fashion. German scientists also lead the way in applying these models to advanced disease fields such as neurodegeneration and immunology. The industry enjoys a mature network of research establishments and robust regulatory system to guarantee high-standard research.
• India: The Indian knock out mouse model industry is a growth-emerging market, fostered by expanding investment in life sciences R&D and a developing contract research sector. Recent trends are aiming for enhanced access to superior quality mouse models and local expertise in genetic engineering. The market is experiencing increased collaboration between Indian and overseas companies to tap expertise and technology. This expansion is further assisted by a huge reservoir of experienced scientific experts and an increasing emphasis on drug development and discovery.
• Japan: Japan's knock out mouse model market is highly advanced in terms of technology and is extremely innovative in nature, with a special emphasis on accuracy and high-level model usage. Recent advancements have seen a tendency towards the utilization of humanized mouse models for the study of immunology and infectious diseases. Japanese scientists also dominate the use of knock out mice in stem cell and regenerative medicine research. The industry is backed by a solid platform of industrial and academic research, with industry leaders heavily investing in R&D to create new-generation animal models and associated services.

Features of the Global Knock Out Mouse Model Market

• Market Size Estimates: Knock out mouse model market size estimation in terms of value ($B).
• Trend and Forecast Analysis: Market trends (2019 to 2024) and forecast (2025 to 2031) by various segments and regions.
• Segmentation Analysis: Knock out mouse model market size by type, application, and region in terms of value ($B).
• Regional Analysis: Knock out mouse model market breakdown by North America, Europe, Asia Pacific, and Rest of the World.
• Growth Opportunities: Analysis of growth opportunities in different type, application, and regions for the knock out mouse model market.
• Strategic Analysis: This includes M&A, new product development, and competitive landscape of the knock out mouse model market.

Analysis of competitive intensity of the industry based on Porter's Five Forces model.

This report answers following 11 key questions:

• Q.1. What are some of the most promising, high-growth opportunities for the knock out mouse model market by type (constitutive knockout mouse, conditional knockout mouse, and protein function knockout mouse), application (hospital, laboratory, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
• Q.2. Which segments will grow at a faster pace and why?
• Q.3. Which region will grow at a faster pace and why?
• Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
• Q.5. What are the business risks and competitive threats in this market?
• Q.6. What are the emerging trends in this market and the reasons behind them?
• Q.7. What are some of the changing demands of customers in the market?
• Q.8. What are the new developments in the market? Which companies are leading these developments?
• Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
• Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?
• Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?

Table of Contents

1. Executive Summary

2. Market Overview

• 2.1 Background and Classifications
• 2.2 Supply Chain

3. Market Trends & Forecast Analysis

• 3.2 Industry Drivers and Challenges
• 3.3 PESTLE Analysis
• 3.4 Patent Analysis
• 3.5 Regulatory Environment

4. Global Knock Out Mouse Model Market by Type

• 4.1 Overview
• 4.2 Attractiveness Analysis by Type
• 4.3 Constitutive Knockout Mouse: Trends and Forecast (2019-2031)
• 4.4 Conditional Knockout Mouse: Trends and Forecast (2019-2031)
• 4.5 Protein Function Knockout Mouse: Trends and Forecast (2019-2031)

5. Global Knock Out Mouse Model Market by Application

• 5.1 Overview
• 5.2 Attractiveness Analysis by Application
• 5.3 Hospital: Trends and Forecast (2019-2031)
• 5.4 Laboratory: Trends and Forecast (2019-2031)
• 5.5 Others: Trends and Forecast (2019-2031)

6. Regional Analysis

• 6.1 Overview
• 6.2 Global Knock Out Mouse Model Market by Region

7. North American Knock Out Mouse Model Market

• 7.1 Overview
• 7.2 North American Knock Out Mouse Model Market by Type
• 7.3 North American Knock Out Mouse Model Market by Application
• 7.4 United States Knock Out Mouse Model Market
• 7.5 Mexican Knock Out Mouse Model Market
• 7.6 Canadian Knock Out Mouse Model Market

8. European Knock Out Mouse Model Market

• 8.1 Overview
• 8.2 European Knock Out Mouse Model Market by Type
• 8.3 European Knock Out Mouse Model Market by Application
• 8.4 German Knock Out Mouse Model Market
• 8.5 French Knock Out Mouse Model Market
• 8.6 Spanish Knock Out Mouse Model Market
• 8.7 Italian Knock Out Mouse Model Market
• 8.8 United Kingdom Knock Out Mouse Model Market

9. APAC Knock Out Mouse Model Market

• 9.1 Overview
• 9.2 APAC Knock Out Mouse Model Market by Type
• 9.3 APAC Knock Out Mouse Model Market by Application
• 9.4 Japanese Knock Out Mouse Model Market
• 9.5 Indian Knock Out Mouse Model Market
• 9.6 Chinese Knock Out Mouse Model Market
• 9.7 South Korean Knock Out Mouse Model Market
• 9.8 Indonesian Knock Out Mouse Model Market

10. ROW Knock Out Mouse Model Market

• 10.1 Overview
• 10.2 ROW Knock Out Mouse Model Market by Type
• 10.3 ROW Knock Out Mouse Model Market by Application
• 10.4 Middle Eastern Knock Out Mouse Model Market
• 10.5 South American Knock Out Mouse Model Market
• 10.6 African Knock Out Mouse Model Market

11. Competitor Analysis

• 11.1 Product Portfolio Analysis
• 11.2 Operational Integration
• 11.3 Porter's Five Forces Analysis
  • Competitive Rivalry
  • Bargaining Power of Buyers
  • Bargaining Power of Suppliers
  • Threat of Substitutes
  • Threat of New Entrants
• 11.4 Market Share Analysis

12. Opportunities & Strategic Analysis

• 12.1 Value Chain Analysis
• 12.2 Growth Opportunity Analysis
  • 12.2.1 Growth Opportunities by Type
  • 12.2.2 Growth Opportunities by Application
• 12.3 Emerging Trends in the Global Knock Out Mouse Model Market
• 12.4 Strategic Analysis
  • 12.4.1 New Product Development
  • 12.4.2 Certification and Licensing
  • 12.4.3 Mergers, Acquisitions, Agreements, Collaborations, and Joint Ventures

13. Company Profiles of the Leading Players Across the Value Chain

• 13.1 Competitive Analysis
• 13.2 Envigo
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.3 GenOway
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.4 Cyagen Biosciences
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.5 Charles River Laboratories International
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.6 TransGenic
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing

14. Appendix

• 14.1 List of Figures
• 14.2 List of Tables
• 14.3 Research Methodology
• 14.4 Disclaimer
• 14.5 Copyright
• 14.6 Abbreviations and Technical Units
• 14.7 About Us
• 14.8 Contact Us