G-CSF (Granulocyte Colony Stimulating Factor) Market Report: Trends, Forecast and Competitive Analysis to 2031
상품코드:1680583
리서치사:Lucintel
발행일:2025년 03월
페이지 정보:영문 150 Pages
라이선스 & 가격 (부가세 별도)
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한글목차
세계 G-CSF(과립구집락자극인자) 시장의 미래는 종양 질환, 혈액 질환, 성장호르몬 결핍, 만성질환 및 자가 면역 질환 시장에서의 기회로 인해 유망합니다. 세계 G-CSF(과립구집락자극인자) 시장은 2025년부터 2031년까지 3.2%의 CAGR로 2031년까지 약 107억 달러에 달할 것으로 예상됩니다. 이 시장의 주요 촉진요인은 암 발병률의 증가와 의료 비용의 증가입니다.
Lucintel은 유형별로는 캡슐이 예측 기간 동안 높은 성장세를 보일 것으로 예상하고 있습니다.
용도별로는 암 질환이 가장 높은 성장이 예상됩니다.
지역별로는 북미가 예측 기간 동안 가장 높은 성장세를 보일 것으로 예상됩니다.
G-CSF(과립구집락자극인자) 시장의 전략적 성장 기회
G-CSF(과립구집락자극인자) 시장은 몇 가지 전략적 성장 기회를 제시하고 있습니다. 다음 5가지가 가장 중요한 것으로 보입니다.
다양한 시장 성장 : 표적 G-CSF 제제는 의료 시스템 개선과 함께 암 발병률이 증가하고 있는 신흥국에서 큰 성장을 이룰 가능성이 높습니다. 이들 지역에서 바이오시밀러가 도입되면 시장 접근성과 수익이 증가할 것입니다.
병용요법 개발 : G-CSF의 최적 투여는 다른 암 치료제와 병용하여 달성할 수 있습니다. 이 전략은 G-CSF 투여만으로는 충분하지 않은 호중구감소증에 대한 해결책을 찾고 있는 의료진에게 도움이 될 수 있습니다.
R&D 투자 : R&D에 대한 추가 투자로 새로운 첨단 G-CSF 제제가 개발될 수 있습니다. 이러한 접근 방식은 환자의 변화하는 요구에 대응하고, 환자 순응도를 향상시킬 수 있습니다.
파트너십과 협업 : 생명공학 기업 및 연구기관과의 전략적 제휴는 새로운 G-CSF 제제의 효율적인 개발에 도움이 됩니다. 최첨단 기술과 새로운 아이디어를 도입하여 마케팅 전략을 강화하고 시장 성장에 박차를 가할 수 있습니다.
디지털 헬스 툴 활용 : G-CSF 치료 관리에 디지털 헬스 전략을 활용하면 치료 결과를 개선할 가능성이 높습니다. 또한, 만성질환 관리를 위해 조정된 원격의료 및 모바일 애플리케이션은 순응도를 개선하고 치료 효과를 향상시키는 데 도움이 될 수 있습니다.
이러한 전략적 성장 기회는 치료의 가용성을 높이고, 새로운 접근법을 자극하며, 환자의 건강 관리 계획을 개선함으로써 G-CSF(과립구 집락 자극 인자) 시장을 촉진할 수 있습니다. 따라서 이러한 추세는 G-CSF 분야의 시장 진입자들이 이 치열한 경쟁 시장에서 성공하기 위해 반드시 고려해야 할 사항입니다.
G-CSF(과립구집락자극인자) 시장 활성화 요인 및 과제
G-CSF(과립구집락자극인자) 시장의 성장은 여러 가지 촉진요인 및 과제에 의해 크게 영향을 받습니다. 이러한 요인은 이 시장에서 사업을 전개하려는 이해관계자들에게 매우 중요합니다.
G-CSF(과립구집락자극인자) 시장을 이끄는 요인은 다음과 같습니다:
암 발병률 증가 : G-CSF(과립구 집락 자극 인자) 시장 분화의 주요 원인은 화학요법 유발성 호중구감소증을 타겟으로 하는 G-CSF 치료제 시장을 증가시키는 암 인구의 증가입니다. 암 발병률이 증가함에 따라 효과적인 분석법 사용을 통해 환자에게 적절한 치료를 제공하는 데 중점을 두는 것이 필수적입니다.
생명공학의 발전 : 새로운 G-CSF 제제 개발을 위해 생명공학 분야에서는 많은 기술 혁신이 이루어지고 있습니다. 새로운 제형과 투여 경로의 변화로 인해 치료가 더 효과적이고 더 많은 환자들이 치료를 지속할 수 있게 되면서 시장이 확대되고 있습니다.
호중구감소증 관리에 대한 인식 증가 : 호중구감소증 관리의 필요성에 대한 의료진과 Zulfiqar Ahmed 환자들의 인식이 높아지면서 G-CSF 사용이 증가하고 있습니다. 이 질환에 대한 환자 교육이 이루어지면서 환자들이 더 일찍 도움을 요청하고, 더 나은 결과를 얻을 수 있게 되었습니다.
지원적인 규제 프레임워크 : 규제 기관은 G-CSF의 신제품을 제조하고 승인받기 위해 기업과 전향적 또는 후향적으로 접촉하고 있습니다. 이러한 지원은 새로운 치료법의 시장 출시를 촉진합니다.
바이오시밀러의 혁신 : 바이오시밀러 제품이 G-CSF(과립구 집락 자극 인자) 시장에서 점유율을 계속 확대함에 따라 경쟁이 치열해지고 가격이 하락할 것입니다. 이로 인해 환자들은 G-CSF 요법을 더 쉽게 접할 수 있게 되고, 결과적으로 G-CSF 요법이 빠르게 확산될 수 있습니다.
G-CSF(과립구집락자극인자) 시장의 과제는 다음과 같습니다:
높은 개발 비용 : G-CSF 제제의 개발 및 상업화는 자본 집약적이기 때문에 추가 투자 및 기술 혁신에 대한 의욕을 떨어뜨릴 수 있습니다. 이러한 자본 집약적 산업에서 신규 진입 기업의 발목을 잡을 수 있습니다.
시장 포화 : 제네릭 의약품과 바이오시밀러의 보급은 차별화가 어려워지는 시장 포화로 이어질 수 있습니다. 이러한 경쟁 환경에서 살아남기 위해 기업들은 적극적으로 혁신을 도입해야 합니다.
규제상의 장애물 : G-CSF 제제의 신제품을 출시하고자 할 때, 규제 프로세스의 복잡성이 걸림돌이 될 수 있습니다. 안전성과 유효성에 대한 엄격한 규제는 제품 출시를 지연시키고 개발 비용을 증가시킬 수 있습니다.
G-CSF(과립구집락자극인자) 시장 동향은 암 발병률 증가, 생명공학 기술 발전, 바이오시밀러의 확대 등의 요인에 영향을 받고 있습니다. 그러나 높은 개발 비용, 시장 포화 상태, 복잡한 규제 등의 문제는 성장과 혁신을 제한할 수 있습니다. 이 지역의 이해관계자들은 시장 촉진요인을 활용하면서 이러한 문제를 해결해야 합니다. 이러한 힘이 G-CSF(과립구집락자극인자) 시장의 수요와 공급의 균형을 형성할 것으로 보입니다.
목차
제1장 주요 요약
제2장 세계의 G-CSF(과립구집락자극인자) 시장 : 시장 역학
소개, 배경, 분류
공급망
업계 성장 촉진요인과 과제
제3장 2019년부터 2031년까지 시장 동향과 예측 분석
거시경제 동향(2019-2024년)과 예측(2025-2031년)
세계의 G-CSF(과립구집락자극인자) 시장 동향(2019-2024)과 예측(2025-2031)
유형별 : G-CSF(과립구집락자극인자) 시장
캡슐
정제
기타
용도별 : G-CSF(과립구집락자극인자) 세계 시장
종양성 질환
혈액질환
성장호르몬결핍증
만성질환 및 자가면역질환
기타
제4장 2019년부터 2031년까지 지역별 시장 동향과 예측 분석
지역별 : G-CSF(과립구집락자극인자) 시장
북미의 G-CSF(과립구집락자극인자) 시장
유럽의 G-CSF(과립구집락자극인자) 시장
아시아태평양의 G-CSF(과립구집락자극인자) 시장
기타 지역의 G-CSF(과립구집락자극인자) 시장
제5장 경쟁 분석
제품 포트폴리오 분석
운영 통합
Porter's Five Forces 분석
제6장 성장 기회와 전략 분석
성장 기회 분석
유형별 : 세계의 G-CSF(과립구집락자극인자) 시장 성장 기회
용도별 : 세계 G-CSF(과립구집락자극인자) 시장 성장 기회
지역별 : 세계의 G-CSF(과립구집락자극인자) 시장 성장 기회
세계의 G-CSF(과립구집락자극인자) 시장 최신 동향
전략 분석
신제품 개발
세계의 G-CSF(과립구집락자극인자) 시장 능력 확대
세계의 G-CSF(과립구집락자극인자) 시장 합병, 인수, 합작투자
인증과 라이선싱
제7장 주요 기업 개요
Amgen
Coherus Biosciences
Sandoz
Biocon/Mylan
Teva Pharmaceuticals
Chugai Pharma
Intalfarmaco
Pfizer
Sun Pharmaceutical Industries
BeyondSpring
ksm
영문 목차
영문목차
The future of the global G-CSF (granulocyte colony stimulating factor) market looks promising with opportunities in the oncological disease, blood disorder, growth hormone deficiencies, and chronic and autoimmune disorder markets. The global G-CSF (granulocyte colony stimulating factor) market is expected to reach an estimated $10.7 billion by 2031 with a CAGR of 3.2% from 2025 to 2031. The major drivers for this market are the increasing prevalence of cancer and rise in healthcare expenses.
Lucintel forecasts that, within the type category, the capsule is expected to witness higher growth over the forecast period.
Within the application category, oncological disease is expected to witness the highest growth.
In terms of regions, North America is expected to witness the highest growth over the forecast period.
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Emerging Trends in the G-CSF (Granulocyte Colony Stimulating Factor) Market
Numerous changes are being witnessed in the G-CSF (granulocyte colony stimulating factor) market, and these changes will help revolutionize the treatment model and market landscape. Five such trends are summarized below.
Increased Focus on Biosimilars: Competition in the G-CSF (granulocyte colony stimulating factor) market is being enhanced by the rise of biosimilars, resulting in lower prices and higher patient rates. With a couple of biosimilars already on the market, it is easier for healthcare providers to manage patients appropriately, which enhances adherence to treatment and improves overall health.
Personalized Medicine Approaches: A growing trend in personalized medicine is also affecting G-CSFs. Different patients presenting the same symptoms may have unique biological factors that should be considered. Therefore, the development of these new therapies becomes more targeted while limiting toxicity and enhancing the quality of life for patients.
Innovative Delivery Methods: New drug delivery systems, such as long-acting formulations and delivery via subcutaneous injection, are being introduced to increase compliance. These innovations also reduce the frequency of treatment, which is especially helpful for patients undergoing chemotherapy.
Regulatory Support and Guidance: Fundamental changes in medicine and health practices have led to regulations stipulating the use and administration of G-CSFs, enhancing care. Various guidelines also encourage monitoring, which is important in standardizing treatment practices among healthcare providers and ensuring that the necessary skills are available to treat patients optimally.
Integration of Digital Health Solutions: Digital health technologies, including telehealth and mobile applications for health management, are being adopted to assist in patient care during G-CSF therapy. These tools help improve patient adherence and control side effects through enhanced interactions with healthcare providers.
These trends are altering the G-CSF (granulocyte colony stimulating factor) market by spurring creativity, increasing the number of patients who can be treated, and improving treatment outcomes. To deliver patient care effectively in this expanding market, these factors will be crucial in determining and developing future therapeutic approaches.
Recent Developments in the G-CSF (Granulocyte Colony Stimulating Factor) Market
Within the G-CSF (granulocyte colony stimulating factor) market, there have been remarkable developments that address therapeutic efficacy and treatment parameters. Below are several noteworthy advancements in this field.
Launch of New Biosimilars: The entry of several biosimilars has resulted in fierce competition in the G-CSF (granulocyte colony stimulating factor) market, which has led to reduced prices and increased market penetration. This enables providers to offer more treatment options to patients without sacrificing quality.
Advancements in Long-Acting Formulations: Novel long-acting G-CSF formulations are gaining traction, requiring administration at longer intervals. These modifications increase patient compliance, especially for those undergoing chemotherapy, improving convenience and adherence rates.
Integration of Telehealth Solutions: Patients undergoing G-CSF therapy benefit from remote monitoring and consultations through telehealth platforms. This promotes patient participation and facilitates the timely enhancement of care.
Clinical Trials for New Indications: New trials are investigating the use of G-CSF for patients with severe infections or autoimmune diseases. The expanded application of G-CSF could address unmet medical needs in various patient populations.
Regulatory Approvals for Combination Therapies: New application regions for G-CSF have approved combination therapy protocols, suggesting that consolidating treatment strategies could improve outcomes, particularly in complicated clinical situations, and provide clinicians with a wider range of treatment options.
These changes are contributing to positive developments in the G-CSF (granulocyte colony stimulating factor) market, enhancing treatment accessibility, improving patient adherence, and broadening treatment options. As these trends continue, they will play an increasingly important role in shaping the future of the G-CSF (granulocyte colony stimulating factor) market.
Strategic Growth Opportunities for G-CSF (Granulocyte Colony Stimulating Factor) Market
The G-CSF (granulocyte colony stimulating factor) market presents several strategic growth opportunities. The following five appear to be the most critical.
Diverse Market Growth: Targeted G-CSF products are likely to experience significant growth in developing countries, where cancer incidence is rising alongside improvements in healthcare systems. The introduction of biosimilars in these regions will increase market access and revenue.
Development of Combination Therapies: The optimal administration of G-CSF can be achieved by combining it with other oncological drugs. This strategy will benefit healthcare professionals seeking solutions for neutropenia, which often requires more than just G-CSF administration.
Investment in Research and Development: Further investment in R&D could lead to the development of new and advanced G-CSF products. This approach will address the changing needs of patients and improve compliance.
Partnerships and Collaborations: Strategic collaborations with biotech companies and research organizations will help efficiently develop novel G-CSF products. Shared efforts can enhance marketing strategies by incorporating cutting-edge technologies and new ideas, spurring market growth.
Utilization of Digital Health Tools: The use of digital health strategies in managing G-CSF therapy is likely to improve therapeutic outcomes. Telemedicine and mobile applications tailored for chronic illness management will also help improve compliance and enhance the effectiveness of treatment.
These strategic growth opportunities can boost the G-CSF (granulocyte colony stimulating factor) market by increasing treatment availability, stimulating new approaches, and improving healthcare planning for patients. Therefore, these trends are essential for market participants in the G-CSF sector to consider for success in this competitive market.
G-CSF (Granulocyte Colony Stimulating Factor) Market Driver and Challenges
The growth of G-CSF (granulocyte colony stimulating factor) market is largely affected by numerous drivers and most of the challenges. These factors are very critical to the stakeholders who wish to operate in this market.
The factors responsible for driving the G-CSF(granulocyte colony stimulating factor) market include:
Rising Cancer Incidence: The main source of differentiation for G-CSF (granulocyte colony stimulating factor) market is the increasing cancer population which increases the market of the G-CSF therapies such as the ones targeting chemotherapy-induced neutropenia. Because of the rising incidences of cancer, the focus on providing proper care to the patients through the use of effective assays is becoming essential.
Advancements in Biotechnology: There are many technological innovations in the biotechnology field for the development of novel G-CSF products. New formulations and change in the routes of administration make treatments more effective and more patients adhere to therapy thus widening the market.
Growing Awareness of Neutropenia Management: There is an increase in the healthcare providers' and Zulfiqar Ahmed patients' appreciation regarding the need to manage neutropenia thereby increasing the use of G-CSF. Education is upon patients in relation to the disease which encourages them to seek help very early on thus getting better results.
Supportive Regulatory Frameworks: Regulatory bodies are in contact with firms either prospectively or retrospectively encouraging them to undertake processes of making new G-CSF products and getting them approved- this validates and creates a desideratum for development. This support expedites the introduction into the market of new medicinal treatments.
Innovation of Biosimilars: As biosimilar products continue to gain a larger share in the G-CSF (granulocyte colony stimulating factor) market, competition heats up and prices decline. This makes it easier for patients to undergo G-CSF which in turn brings about the fast uptake of G-CSF therapy methods into practice.
Challenges in the G-CSF (granulocyte colony stimulating factor) market are:
High Development Costs: Developing and commercializing a G-CSF product is capital-intensive, which may discourage further investment and innovation. In such a capital-heavy industry, this may deter new market players.
Market Saturation: The proliferation of generics and biosimilars may lead to market saturation, where differentiation becomes difficult. Organizations must actively introduce innovations to survive in this competitive environment.
Regulatory Hurdles: The complexity of regulatory processes sometimes interferes with the ability of companies to launch new G-CSF products. Strict safety and efficacy regulations may delay product availability in the market and inflate development costs.
The G-CSF (granulocyte colony stimulating factor) market trends are influenced by factors such as increasing cancer incidences, technological advances in biotechnology, and the growing range of biosimilars. However, issues like high development costs, market saturation, and complex regulations could limit growth and innovation. Stakeholders in the region will need to address these challenges while capitalizing on market drivers. These forces will shape the balance between supply and demand in the G-CSF (granulocyte colony stimulating factor) market.
List of G-CSF (Granulocyte Colony Stimulating Factor) Companies
Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. Through these strategies G-CSF (granulocyte colony stimulating factor) companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the G-CSF (granulocyte colony stimulating factor) companies profiled in this report include-
Amgen
Coherus Biosciences
Sandoz
Biocon/Mylan
Teva Pharmaceuticals
Chugai Pharma
Intalfarmaco
Pfizer
Sun Pharmaceutical Industries
BeyondSpring
G-CSF (Granulocyte Colony Stimulating Factor) by Segment
The study includes a forecast for the global G-CSF (granulocyte colony stimulating factor) market by type, application, and region.
G-CSF (Granulocyte Colony Stimulating Factor) Market by Type [Analysis by Value from 2019 to 2031]:
Capsule
Tablet
Others
G-CSF (Granulocyte Colony Stimulating Factor) Market by Application [Analysis by Value from 2019 to 2031]:
Oncological Disease
Blood Disorder
Growth Hormone Deficiencies
Chronic and Autoimmune Disorder
Others
G-CSF (Granulocyte Colony Stimulating Factor) Market by Region [Analysis by Value from 2019 to 2031]:
North America
Europe
Asia Pacific
The Rest of the World
Country Wise Outlook for the G-CSF (Granulocyte Colony Stimulating Factor) Market
The Granulocyte Colony Stimulating Factor (G-CSF) market is expected to grow rapidly due to factors such as advancements in biotechnology, increasing awareness of neutropenia management, and the rising demand for cancer therapeutics. G-CSF plays a crucial role in boosting neutrophil counts, which is vital for chemotherapy patients and those suffering from various blood diseases. Drug formulation innovations and regulatory improvements in countries like the USA, China, Germany, India, and Japan are enhancing patient care and treatment outcomes.
USA: G-CSF formulations such as pegfilgrastim have found widespread use in the U.S. among oncology patients due to the rise in chemotherapy-induced neutropenia. Several G-CSF biosimilars have been approved by the FDA, increasing market competition and availability. Recent clinical trials are exploring new methods of administration, including subcutaneous injections, to improve patient convenience. Additionally, there is a growing focus on individualized treatment plans that enhance the effectiveness of G-CSF therapies.
China: The G-CSF (granulocyte colony stimulating factor) market in China is expanding rapidly due to the increasing number of cancer patients and the aging population. To support the research and manufacturing of G-CSF drugs, the government has implemented favorable policies, leading to an increase in the number of new biosimilars on the market. New strategies have been introduced to ensure the safe use of G-CSF in cancer patients, while local pharmaceutical companies are collaborating with global biotech firms to improve product access.
Germany: Germany is making significant strides in G-CSF therapies, with ongoing efforts to develop advanced delivery systems and formulations. Recent studies focus on improving treatment plans to achieve the desired outcomes while minimizing toxicity. The country has also seen a rise in biosimilar development, which is likely to improve access to treatment and lower costs for patients. Regulatory bodies are actively advocating for best practices in G-CSF use, helping standardize care for oncology patients.
India: The G-CSF (granulocyte colony stimulating factor) market in India is growing due to the increasing incidence of cancer and improved healthcare access. Neutropenic patients now have more treatment options as affordable G-CSF biosimilars become available. Campaigns to raise awareness of chemotherapy side effect management among healthcare providers are gaining traction. Additionally, efforts by Indian pharmaceutical companies, along with potential collaborations with international organizations, are accelerating the development of novel G-CSF formulations.
Japan: Japan's G-CSF (granulocyte colony stimulating factor) market is focused on drug development with the support of advanced technologies. New long-acting G-CSF formulations that require less frequent administration are improving patient adherence to treatment. Additionally, the regulatory environment is becoming more favorable for biosimilars, speeding up their approval process. Clinical studies are increasingly focused on tailoring G-CSF therapy to specific patient conditions, which is expected to enhance treatment efficacy for cancer patients.
Features of the Global G-CSF (Granulocyte Colony Stimulating Factor) Market
Market Size Estimates: G-CSF (granulocyte colony stimulating factor) market size estimation in terms of value ($B).
Trend and Forecast Analysis: Market trends (2019 to 2024) and forecasts (2025 to 2031) by various segments and regions.
Segmentation Analysis: G-CSF (granulocyte colony stimulating factor) market size by type, application, and region in terms of value ($B).
Regional Analysis: G-CSF (granulocyte colony stimulating factor) market breakdown by North America, Europe, Asia Pacific, and Rest of the World.
Growth Opportunities: Analysis of growth opportunities in different type, application, and regions for the G-CSF (granulocyte colony stimulating factor) market.
Strategic Analysis: This includes M&A, new product development, and competitive landscape of the G-CSF (granulocyte colony stimulating factor) market.
Analysis of competitive intensity of the industry based on Porter's Five Forces model.
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This report answers following 11 key questions:
Q.1. What are some of the most promising, high-growth opportunities for the G-CSF (granulocyte colony stimulating factor) market by type (capsule, tablet, and others), application (oncological disease, blood disorder, growth hormone deficiencies, chronic and autoimmune disorder, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
Q.2. Which segments will grow at a faster pace and why?
Q.3. Which region will grow at a faster pace and why?
Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
Q.5. What are the business risks and competitive threats in this market?
Q.6. What are the emerging trends in this market and the reasons behind them?
Q.7. What are some of the changing demands of customers in the market?
Q.8. What are the new developments in the market? Which companies are leading these developments?
Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?
Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?
2.1: Introduction, Background, and Classifications
2.2: Supply Chain
2.3: Industry Drivers and Challenges
3. Market Trends and Forecast Analysis from 2019 to 2031
3.1. Macroeconomic Trends (2019-2024) and Forecast (2025-2031)
3.2. Global G-CSF (Granulocyte Colony Stimulating Factor) Market Trends (2019-2024) and Forecast (2025-2031)
3.3: Global G-CSF (Granulocyte Colony Stimulating Factor) Market by Type
3.3.1: Capsule
3.3.2: Tablet
3.3.3: Others
3.4: Global G-CSF (Granulocyte Colony Stimulating Factor) Market by Application
3.4.1: Oncological Disease
3.4.2: Blood Disorder
3.4.3: Growth Hormone Deficiencies
3.4.4: Chronic and Autoimmune Disorder
3.4.5: Others
4. Market Trends and Forecast Analysis by Region from 2019 to 2031
4.1: Global G-CSF (Granulocyte Colony Stimulating Factor) Market by Region
4.2: North American G-CSF (Granulocyte Colony Stimulating Factor) Market
4.2.1: North American Market by Type: Capsule, Tablet, and Others
4.2.2: North American Market by Application: Oncological Disease, Blood Disorder, Growth Hormone Deficiencies, Chronic and Autoimmune Disorder, and Others
4.3: European G-CSF (Granulocyte Colony Stimulating Factor) Market
4.3.1: European Market by Type: Capsule, Tablet, and Others
4.3.2: European Market by Application: Oncological Disease, Blood Disorder, Growth Hormone Deficiencies, Chronic and Autoimmune Disorder, and Others