개요
세계의 3D 하이드로겔 배양 시장은 2023년에 15억 8,000만 달러에 달하며, 2024-2031년 예측 기간 중 CAGR 13.5%로 성장하며, 2031년에는 43억 6,000만 달러에 달할 것으로 예측됩니다.
3D 하이드로겔 세포배양은 자연 세포 외 환경을 시뮬레이션하는 3차원(3D) 하이드로겔 매트릭스에서 세포를 배양하는 첨단 방법입니다. 하이드로겔은 가교된 친수성 고분자 네트워크로, 구조적 무결성을 유지하면서 다량의 물을 흡수할 수 있습니다.
이 기술에서 세포는 하이드로겔 매트릭스 내에 이식되어 생체 조직에서와 마찬가지로 3차원적으로 주변 환경과 상호 작용할 수 있습니다. 이 설정은 기존의 2차원(2D) 세포배양보다 생리학적으로 더 적합한 모델이며, 생체 내에서 일어나는 세포와 세포외기질(ECM)의 복잡한 상호 작용을 보다 정확하게 반영합니다.
3차원 세포배양에 사용되는 하이드로겔은 콜라겐, 피브린, 알긴산과 같은 천연 소재나 폴리에틸렌글리콜(PEG), 폴리아크릴아미드와 같은 합성 소재에서 조달할 가능성이 있습니다. 이러한 하이드로겔은 구성, 경도 및 다공성을 변경하여 특정 조직 특성을 재현하도록 맞춤화할 수 있습니다. 이러한 적응성은 암 연구, 줄기세포 연구, 조직 공학, 신약 개발 등 다양한 연구 및 의료 분야에서 매우 중요합니다.
촉진요인
기술의 발전
세계 3D 하이드로겔 배양 시장 수요는 여러 가지 요인에 의해 주도되고 있습니다. 주요 요인 중 하나는 기술 발전입니다. 특히 JellaGel Hydrogel과 같은 제품의 등장으로 하이드로겔 제형과 그 용도의 혁신은 3D 하이드로겔 배양 시장의 확대에 매우 중요한 역할을 하고 있습니다. 해파리 콜라겐으로 만든 JellaGel Hydrogel은 포유류가 아닌 다른 재료에 대한 연구자들에게 세포배양에 있으며, 안정적이고 일관성 있는 재료에 대한 수요 증가에 대응할 수 있는 새로운 대안을 제공합니다.
또한 이 업계의 주요 기업은 3D 하이드로겔 배양 시장의 성장을 가속하는 연구개발 활동과 제품 출시에 더욱 집중하고 있습니다. 예를 들어 2024년 6월 인도과학연구원(IISc) 생물공학부(BE) 연구진은 포유류 폐 환경을 충실하게 재현한 혁신적인 3D 하이드로겔 배양 시스템을 개발했습니다.
또한 2023년 6월에는 새로운 생체적합성 하이드로겔 수지가 출시되어 바이오프린팅 분야에서 매우 중요한 순간이 될 것이며, 복잡한 고해상도 생체 구조물을 제작할 수 있는 능력이 강화된 새로운 시대를 열게 될 것입니다. 이 혁신적인 수지는 2광자 중합(2PP)을 촉진하는 최첨단 3D 프린팅 기술로, 마이크로에서 메조 스케일까지 정밀한 구조물을 제작할 수 있습니다.
억제요인
높은 제조 비용, 제한된 원자재 가용성, 엄격한 규제 요건 등의 요인이 시장을 저해할 것으로 예상됩니다.
Overview
The global 3D hydrogel culture market reached US$ 1.58 billion in 2023 and is expected to reach US$ 4.36 billion by 2031 growing with a CAGR of 13.5% during the forecast period 2024-2031.
3D hydrogel cell culture is an advanced method for cultivating cells within a three-dimensional (3D) hydrogel matrix that simulates the natural extracellular environment. Hydrogels are networks of cross-linked, hydrophilic polymers capable of absorbing significant amounts of water while retaining their structural integrity.
In this technique, cells are embedded within the hydrogel matrix, enabling them to interact with their surroundings in all three dimensions, akin to their behavior in living tissues. This setup offers a more physiologically relevant model than traditional two-dimensional (2D) cell cultures, as it more accurately reflects the intricate interactions between cells and their extracellular matrix (ECM) that occur in vivo.
The hydrogels used for 3D cell culture can be sourced from natural materials such as collagen, fibrin, and alginate, or they can be synthetic, like polyethylene glycol (PEG) and polyacrylamide. These hydrogels can be customized to replicate specific tissue characteristics by modifying their composition, stiffness, and porosity. This adaptability is crucial for various applications in research and medicine, including cancer studies, stem cell research, tissue engineering, and drug discovery.
Market Dynamics: Drivers
Technological advancements
The demand for the global 3D hydrogel culture market is driven by multiple factors. One of the primary factors is the technological advancements. Innovations in hydrogel formulations and their applications, particularly with the emergence of products like JellaGel Hydrogel, are playing a pivotal role in the expansion of the 3D hydrogel culture market. JellaGel, made from jellyfish collagen, provides researchers with a novel non-mammalian alternative that meets the growing demand for reliable and consistent materials in cell culture.
Moreover, key players in the industry more focus on R&D activities and product launches that would drive this 3D hydrogel culture market growth. For instance, in June 2024, researchers from the Department of Bioengineering (BE) at the Indian Institute of Science (IISc) developed an innovative 3D hydrogel culture system that closely replicates the mammalian lung environment.
Also, in June 2023, the launch of a new biocompatible hydrogel resin represents a pivotal moment in the field of bioprinting, marking the beginning of a new era characterized by enhanced capabilities in creating complex, high-resolution bio-structures. This innovative resin facilitates 2-photon polymerization (2PP), a cutting-edge 3D printing technology that allows for the precise fabrication of structures ranging from the micro- to mesoscale.
Restraints
Factors such as high production costs, limited availability of raw materials, and stringent regulatory requirements, are expected to hamper the market.
The global 3D hydrogel culture market is segmented based on product, application, end-user, and region.
The scaffold based segment accounted for approximately 52.1% of the global 3D hydrogel culture market share
The scaffold based segment is expected to hold the largest market share over the forecast period. Scaffold-based 3D hydrogel cell cultures utilize scaffolds to provide essential physical support for cells, enabling them to aggregate, proliferate, and migrate effectively. Traditionally, cells have been cultured on extracellular matrix (ECM) proteins in two-dimensional (2D) environments; however, this approach often fails to accurately replicate the complexities of the in vivo environment.
scaffold-based 3D hydrogel cultures allow cells to be embedded within a supportive matrix, which means that the characteristics of the scaffold material can significantly influence cellular behavior. Therefore, it is crucial to select the most appropriate scaffold for your specific application to ensure it aligns well with the requirements of drug screening and development processes.
Moreover, key player's strategies such as partnerships & collaborations, and research activities would drive this segment growth in the 3D hydrogel culture market. For instance, in April 2022, Cell Guidance Systems Ltd, a company specializing in the control, manipulation, and monitoring of cells both in vitro and in vivo, partnered with Manchester BIOGEL, a biotechnology firm focused on designing and manufacturing 3D synthetic peptide hydrogels, to introduce PODS-PeptiGels. This new kit integrates the advantages of two innovative cell culture technologies: synthetic peptide hydrogels (PeptiGels) and a selection of sustained-release growth factors (PODS). The collaboration aims to provide researchers with a reproducible and highly adaptable environment for 3D cell culture, enhancing experimental flexibility and reliability.
Similarly, in a research publication in Frontiers in May 2022, scaffold-based 3D hydrogel cultures, 3D bioprinting, and ECM-based bioinks present promising opportunities for replicating native tissue architectures, but several significant challenges persist. To fully realize the potential of this technology and enable its application in clinical environments, it is crucial to tackle these issues through dedicated research and interdisciplinary collaboration. This approach will help transform healthcare and enhance the quality of life for patients.
North America accounted for approximately 44.6% of the global 3D hydrogel culture market share
North America region is expected to hold the largest market share over the forecast period owing to the growing prevalence of chronic diseases, including diabetes, cardiovascular conditions, and obesity, which has led to an increased demand for effective treatment solutions. Hydrogel-based products are being increasingly adopted for their therapeutic advantages in addressing these issues, especially in areas like wound care and drug delivery systems.
Moreover, in this region, a major number of key player's presence, well-advanced healthcare infrastructure, strong investment in research and development, favorable regulatory environment, and technological advancements help to propel this 3D hydrogel culture market growth. For instance, in December 2021, Inventia Life Science, an Australian specialist in 3D bioprinting, successfully closed a Series B funding round, raising $25 million (USD).
This funding was led by Blackbird Ventures and supported by long-time investor Skip Capital, bringing the company's total funding to $32 million. With this new capital, Inventia Life Science plans to accelerate the rollout of its flagship product, the RASTRUM 3D bioprinter. A key focus of this expansion will be in the U.S. market, where Inventia sees significant potential. The company estimates that the biomedical research and drug discovery sector in the U.S. is worth over $40 billion, indicating a substantial opportunity for their technology.
The major global 3D hydrogel culture market players include Corning Incorporated, Thermo Fisher Scientific, Inc., Lonza., Merck KGaA, Advanced BioMatrix, 3D Biotek LLC., PromoCell GmbH, Avantor, Inc., MIMETAS, and CN Bio Innovations Ltd, among others.
The global 3D hydrogel culture market report would provide approximately 62 tables, 56 figures, and 182 pages.
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