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Cough in Idiopathic Pulmonary Fibrosis (IPF) - Market Insights, Epidemiology, and Market Forecast - 2034
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Key Highlights:

DelveInsight's "Cough in Idiopathic pulmonary fibrosis (IPF) - Market Insights, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding of the Cough in IPF, historical and forecasted epidemiology and the Cough in IPF market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

The Cough in IPF market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Cough in IPF market size from 2020 to 2034. The report also covers current Cough in IPF treatment practices/algorithms and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered:

Study Period: 2020-2034.

Disease Understanding and Treatment Algorithm

Cough in IPF Overview

Chronic cough is prevalent in idiopathic pulmonary fibrosis (IPF), often presenting as the initial symptom and significantly impacting patients' lives. This persistent cough is associated with diminished quality of life, heightened rates of depression and anxiety, increased physiological impairment, and disease progression. While the complete understanding of its pathophysiology remains elusive, recent advancements shed light on its multifactorial nature.

The pathophysiology of chronic cough in IPF involves various factors, including alterations in mucous production and clearance, architectural distortion of lung tissues, and heightened sensitivity of the cough reflex. Patients with IPF may experience architectural changes in lung tissues, impairing their ability to produce and clear mucous effectively. Additionally, an increased sensitivity of the cough reflex contributes to the persistent nature of cough in IPF. The severity of cough symptoms is linked to a decline in overall health and is often indicative of disease progression.

Cough in IPF Diagnosis

The diagnosis of cough in IPF involves a comprehensive evaluation, including clinical assessment, pulmonary function tests (PFTs), and high-resolution computed tomography (HRCT) scans. In some cases, bronchoscopy may be utilized to examine the airways and collect samples for analysis. A multidisciplinary approach, collaboration among specialists, and the exclusion of other potential causes are integral.

Cough in IPF Treatment

Currently, there is no known approved treatment of cough in IPF. Therapies for cough in IPF can be divided into those that aim to suppress the cough reflex and those that specifically target the underlying pathology of IPF. Unfortunately, treatments aimed at suppressing the cough reflex have limited efficacy. The current treatment landscape consists of off-label therapies mainly classified as neuromodulating agents, corticosteroids, and other immunomodulatory agents. The lack of treatment and high frequency of cough in IPF severely impacts the quality of life of the patients.

Cough in IPF Epidemiology

As the market is derived using the patient-based model, the Cough in IPF epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Cases of IPF and Total Diagnosed Prevalent Cases of Cough in IPF, in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan, from 2020 to 2034.

As per DelveInsight's estimations, the total diagnosed prevalent cases of Cough in IPF in the 7MM were approximately 148 thousand cases in 2022 and are projected to increase during the forecast period.

Cough in IPF Drug Chapters

The drug chapter segment of the Cough in IPF report encloses a detailed analysis of Cough in IPF marketed drugs and late-stage (Phase III and Phase II) pipeline drugs. It also understands Cough in IPF clinical trial details, expressive pharmacological action, agreements and collaborations, approval, and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.

Emerging Drugs:

Orvepitant Maleate: NeRRe Therapeutics

Orvepitant Maleate, developed by NeRRe Therapeutics, is a novel, selective NK-1 receptor antagonist. It blocks substance P effects, reducing central neural hypersensitivity and addressing chronic cough through peripherally and centrally targeted mechanisms. After demonstrating proof of efficacy in patients with RCC or UCC, NeRRe is currently conducting Phase II trials to evaluate the effect of two doses of orvepitant in chronic cough with IPF.

Haduvio (nalbuphine ER): Trevi Therapeutics

Haduvio (nalbuphine ER) is under clinical development by Trevi Therapeutics and is currently in Phase II for cough in IPF treatment. Administered orally, it is an extended-release, mixed ?-opioid receptor agonist and µ-opioid receptor antagonist.

Note: Detailed emerging therapies assessment will be provided in the final report of Cough in IPF.

Cough in IPF Market Outlook

Cough, a predominant and distressing symptom in IPF, significantly compromises patients' quality of life, prompting a pressing need for effective interventions tailored to this aspect of the disease. Despite approved therapies for IPF, there is not an established treatment specifically targeting the associated cough.

Current therapeutic strategies for IPF-related cough fall into two categories: those suppressing the cough reflex and those targeting IPF pathology. Yet, agents like dextromethorphan and opioids exhibit limited efficacy and systemic side effects, hindering widespread use. Traditional IPF medications, pirfenidone and nintedanib, mainly focus on disease progression without extensive studies on managing IPF-related cough.

The IPF-related cough treatment market emphasizes the need for targeted therapies. Ongoing research in neuromodulating agents, immunomodulators, and behavior-based therapies holds promise, but comprehensive studies are needed to develop effective treatments, enhancing the quality of life for those affected by this challenging symptom.

The market for Cough in IPF is expected to experience positive growth with the approval of potential drugs like Orvepitant Maleate and Haduvio (nalbuphine ER).

Cough in IPF Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to launch in the market during 2020-2034. For example, Haduvio (nalbuphine ER) in the US is expected to be launched by 2028.

Further detailed analysis of emerging therapies drug uptake in the report…

Cough in IPF Pipeline Development Activities

The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Cough in IPF emerging therapies.

KOL Views

To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Cough in IPF evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Albert Einstein College of Medicine, New York; Keck School of Medicine, University of Southern California, Los Angeles; Ruhrlandklinik, University Hospital Essen, Essen, Germany; Louis Pradel Hospital, Hospices Civils de Lyon, France; University of Milano Bicocca, Italy; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK; Graduate School of Medicine, Kyoto University, Kyoto, Japan, and others.

DelveInsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Cough in IPF market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Market Access and Reimbursement

The high cost of therapies for the treatment is a major factor restraining the growth of the global drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Report:

Cough in IPF Report Insights

Cough in IPF Report Key Strengths

Cough in IPF Report Assessment

Key Questions:

Market Insights

Epidemiology Insights

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies

Reasons to Buy:

Frequently Asked Questions:

1. What is the forecast period covered in the report?

The Cough in IPF Epidemiology and Market Insight report for the 7MM covers the forecast period from 2023 to 2034, providing a projection of market dynamics and trends during this timeframe.

2. Who are the key players in the Cough in IPF market?

The Cough in IPF emerging market has few drugs. The major key players developing therapies for cough in IPF are Trevi Therapeutics, NeRRe Therapeutics, and others.

3. How is the market size estimated in the forecast report?

The market size is estimated through data analysis, statistical modeling, and expert opinions. It may consider factors such as prevalent cases, treatment costs, revenue generated, and market trends.

4. What is the key driver of the Cough in IPF market?

The increase in diagnosed prevalent cases of Cough in IPF and the launch of emerging therapies are attributed to be the key drivers for increasing Cough in IPF market.

5. What is the expected impact of emerging therapies or advancements in Cough in IPF treatment on the market?

Introducing new therapies, advancements in disease understanding and diagnostic techniques, and innovations in treatment approaches can significantly impact the Cough in IPF treatment market. Market forecast reports may provide analysis and predictions regarding the potential impact of these developments.

6. Does the report provide insights into the competitive landscape of the market?

The market forecast report may include information on the competitive landscape, profiling key market players, their product offerings, partnerships, and strategies, and helping stakeholders understand the competitive dynamics of the Cough in IPF market.

Table of Contents

1. Key Insights

2. Report Introduction

3. Cough in Idiopathic pulmonary fibrosis (IPF) Market Overview at a Glance

4. Epidemiology and Market Methodology of Cough in IPF

5. Executive Summary of Cough in IPF

6. Key Events

7. Disease Background and Overview

8. Epidemiology and Patient Population

9. Patient Journey

10. Emerging Therapies

11. Cough in IPF: Market Analysis

12. Key Opinion Leaders' Views

13. SWOT Analysis

14. Unmet Needs

15. Market Access and Reimbursement

16. Appendix

17. DelveInsight Capabilities

18. Disclaimer

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