HERG Screening Market, By Type, By Ion Channel, By Testing Methods, By Application, By End User, By Country, and By Region - Industry Analysis, Market Size, Market Share & Forecast from 2024-2032
HERG Screening Market size was valued at USD 1,124.45 million in 2023, expanding at a CAGR of 10.9% from 2024 to 2032.
The HERG screening market, vital in drug development to assess compounds for cardiac safety, is driven by stringent drug safety regulations necessitating early cardiac risk identification, alongside a rising incidence of cardiac disorders globally. Advancements in drug discovery technologies and precision medicine further bolster demand for sophisticated HERG screening methods. However, challenges such as high equipment costs, data complexity, and ethical concerns around animal models restrict market growth. Opportunities lie in untapped emerging markets, continuous technological advancements enhancing screening efficiency, strategic collaborations between pharmaceutical entities, and screening providers driving innovation in HERG screening tailored for specific therapeutic areas.
HERG Screening Market- Market Dynamics
Rising Drug Innovation and Cardiovascular Disease Prevalence Driving the Market Growth
The HERG screening market is experiencing robust growth driven by increasing drug innovation and the rising prevalence of cardiovascular diseases. For instance, according to the World Health Organization (WHO), cardiovascular diseases remain the leading cause of death globally, with an estimated 17.9 million deaths annually. Additionally, the U.S. Food and Drug Administration (FDA) emphasizes the importance of cardiac safety assessments during drug development to mitigate adverse effects, highlighting the critical role of HERG screening. With pharmaceutical companies focusing on developing novel drugs and therapies, the demand for HERG screening services continues to escalate, ensuring safer and more effective treatments for cardiovascular conditions.
HERG Screening Market- Key Insights
As per the analysis shared by our research analyst, the global market is estimated to grow annually at a CAGR of around 10.9% over the forecast period (2024-2032)
Based on Type segmentation, Gene KCNH2 was predicted to show maximum market share in the year 2023
Based on Ion Channel segmentation, voltage-gated ion channel was the leading type in 2023
Based on Testing Methods segmentation, Automated Electrophysiology Systems was the leading type in 2023
Based on Application segmentation, Antiarrhythmic was the leading type in 2023
Based on end-user segmentation, Pharmaceutical Companies were the leading type in 2023
Based on region, North America was the leading revenue generator in 2023
HERG Screening Market- Segmentation Analysis:
The Global HERG Screening Market is segmented based on Type, ION Channel, Testing Methods, Application, End User, and Region.
The market is divided into two categories based on Type: Gene KCNH2 and mutant KCNH2. gene KCNH2 is highly preferred due to its relevance in assessing normal cardiac function and drug interactions. Mutant KCNH2 is secondary preferred, focusing on specific variants for targeted studies and drug response evaluations.
The market is divided into four categories based on ION Channel: Voltage-Gated Ion Channel, Ligand-Gated Ion Channel, Mechanosensitive, and Transient receptor potential. Voltage-gated ion channels are highly preferred due to their central role in cardiac function and drug-induced arrhythmia. Ligand-gated ion channels follow, important for specific drug interactions. Mechanosensitive and transient receptor potential channels are less commonly prioritized for cardiac safety assessments.
HERG Screening Market- Geographical Insights
North America dominates the market due to the presence of a well-established pharmaceutical industry and stringent regulatory standards emphasizing cardiac safety. The region is also characterized by substantial investments in research and development, particularly in innovative drug discovery. Europe follows closely, driven by similar regulatory frameworks and a significant focus on precision medicine. Asia Pacific showcases rapid growth potential attributed to increasing healthcare expenditure, expanding pharmaceutical sector, and rising awareness about drug safety. Emerging economies in this region, such as China and India, are witnessing growing adoption of HERG screening technologies fueled by advancements in healthcare infrastructure and a burgeoning demand for novel therapeutics. These geographical insights underscore the global reach and evolving landscape of the HERG screening market.
HERG Screening Market- Competitive Landscape:
Key companies such as Charles River Laboratories International Inc., Cyprotex PLC, Eurofins Scientific, and Cerep SA are prominent players offering comprehensive HERG screening services. These companies focus on leveraging advanced technologies like automated patch clamping and high-throughput screening to enhance efficiency and accuracy in cardiac safety assessments. Strategic partnerships and collaborations with pharmaceutical giants enable them to broaden their market reach and offer tailored solutions. Additionally, emerging players like Nanion Technologies and Sophion Bioscience are gaining traction with novel HERG screening platforms catering to diverse drug development needs. Furthermore, one notable instance of collaboration in the HERG screening market is the partnership between Charles River Laboratories International Inc. and AstraZeneca. This collaboration aimed to develop and validate a new cardiac safety testing panel, including HERG screening assays, to support drug discovery and development efforts.
Recent Developments:
In August 2023, Metrion Biosciences Limited was accepted into the UK GLP Compliance Monitoring Programme by the Medicines and Healthcare Products Regulatory Agency (MHRA). This allows the company to provide GLP-compliant hERG ion channel screening services worldwide.
In March 2020, Charles River Laboratories and Deciphex have partnered to co-develop deep learning-enabled pathology analytics. Charles River will exclusively offer Deciphex's Patholytix preclinical solution.
SCOPE OF THE REPORT
The scope of this report covers the market by its major segments, which include as follows:
GLOBAL HERG SCREENING MARKET KEY PLAYERS- DETAILED COMPETITIVE INSIGHTS
Aurora Biomed Inc.
Axion Biosystems
Cerep SA (a part of Eurofins Scientific)
Charles River Laboratories International, Inc.
Confluence Discovery Technologies
Cyprotex (a division of Evotec SE)
Cytocentrics AG
Eurofins Discovery
Icagen, Inc. (a division of Domain Therapeutics)
Metrion Biosciences Ltd.
MilliporeSigma (Merck KGaA)
Nanion Technologies GmbH
Ncardia
PerkinElmer, Inc.
SB Drug Discovery
Sophion Bioscience A/S
Others
GLOBAL HERG SCREENING MARKET, BY TYPE- MARKET ANALYSIS, 2019 - 2032
Gene KCNH2
Mutant KCNH2
GLOBAL HERG SCREENING MARKET, BY ION CHANNEL- MARKET ANALYSIS, 2019 - 2032
Voltage-Gated Ion Channel
Ligand-Gated Ion Channel
Mechanosensitive
Transient Receptor Potential
GLOBAL HERG SCREENING MARKET, BY TESTING METHODS- MARKET ANALYSIS, 2019 - 2032
Manual Patch Clamp Assay
Automated Electrophysiology Systems
In Silico Modeling
Binding Assays
GLOBAL HERG SCREENING MARKET, BY APPLICATION- MARKET ANALYSIS, 2019 - 2032
Antiarrhythmic
Antipsychotic
Antibiotic
Antimalarial
Antihistamine
GLOBAL HERG SCREENING MARKET, BY END USER- MARKET ANALYSIS, 2019 - 2032
Pharmaceutical Companies
Contract Research Organizations (CROs)
Academic and Research Institutions
GLOBAL HERG SCREENING MARKET, BY REGION- MARKET ANALYSIS, 2019 - 2032
North America
The U.S.
Canada
Europe
Germany
France
Italy
Spain
United Kingdom
Russia
Netherlands
Sweden
Poland
Rest of Europe
Asia Pacific
India
China
South Korea
Japan
Australia
Thailand
Indonesia
Philippines
Rest of APAC
Latin America
Brazil
Mexico
Argentina
Colombia
Rest of LATAM
The Middle East and Africa
Saudi Arabia
United Arab Emirates
Israel
Turkey
Algeria
Egypt
Rest of MEA
Table of Contents
1.HERG Screening Market Overview
1.1.Study Scope
1.2.Market Estimation Years
2.Executive Summary
2.1.Market Snippet
2.1.1.HERG Screening Market Snippet by Type
2.1.2.HERG Screening Market Snippet by Ion Channel
2.1.3.HERG Screening Market Snippet by Testing Methods
2.1.4.HERG Screening Market Snippet by Application
2.1.5.HERG Screening Market Snippet by End User
2.1.6.HERG Screening Market Snippet by Country
2.1.7.HERG Screening Market Snippet by Region
2.2.Competitive Insights
3.HERG Screening Key Market Trends
3.1.HERG Screening Market Drivers
3.1.1.Impact Analysis of Market Drivers
3.2.HERG Screening Market Restraints
3.2.1.Impact Analysis of Market Restraints
3.3.HERG Screening Market Opportunities
3.4.HERG Screening Market Future Trends
4.HERG Screening Industry Study
4.1.PEST Analysis
4.2.Porter's Five Forces Analysis
4.3.Growth Prospect Mapping
4.4.Regulatory Framework Analysis
5.HERG Screening Market: COVID-19 Impact Analysis
5.1.Pre-COVID-19 Impact Analysis
5.2.Post-COVID-19 Impact Analysis
5.2.1.Top Performing Segments
5.2.2.Marginal Growth Segments
5.2.3.Top Looser Segments
5.2.4.Marginal Loss Segments
6.HERG Screening Market Landscape
6.1.HERG Screening Market Share Analysis, 2023
6.2.Breakdown Data, by Key Manufacturer
6.2.1.Established Players' Analysis
6.2.2.Emerging Players' Analysis
7.HERG Screening Market - By Type
7.1.Overview
7.1.1.Segment Share Analysis, By Type, 2023 & 2032 (%)
7.1.2.Gene KCNH2
7.1.3.Mutant KCNH2
8.HERG Screening Market - By Ion Channel
8.1.Overview
8.1.1.Segment Share Analysis, By Ion Channel, 2023 & 2032 (%)
8.1.2.Voltage-Gated Ion Channel
8.1.3.Ligand-Gated Ion Channel
8.1.4.Mechanosensitive
8.1.5.Transient receptor potential
9.HERG Screening Market - By Testing Methods
9.1.Overview
9.1.1.Segment Share Analysis, By Testing Methods, 2023 & 2032 (%)
9.1.2.Manual Patch Clamp Assay
9.1.3.Automated Electrophysiology Systems
9.1.4.In Silico Modeling
9.1.5.Binding Assays
10.HERG Screening Market - By Application
10.1.Overview
10.1.1.Segment Share Analysis, By Application, 2023 & 2032 (%)
10.1.2.Antiarrhythmic
10.1.3.Antipsychotic
10.1.4.Antibiotic
10.1.5.Antimalarial
10.1.6.Antihistamine
11.HERG Screening Market - By End User
11.1.Overview
11.1.1.Segment Share Analysis, By End User, 2023 & 2032 (%)
11.1.2.Pharmaceutical Companies
11.1.3.Contract Research Organizations (CROs)
11.1.4.Academic and Research Institutions
12.HERG Screening Market- By Geography
12.1.Introduction
12.1.1.Segment Share Analysis, By Geography, 2023 & 2032 (%)
12.2.North America
12.2.1.Overview
12.2.2.HERG Screening Key Manufacturers in North America
12.2.3.North America Market Size and Forecast, By Country, 2019 - 2032 (US$ Million)
12.2.4.North America Market Size and Forecast, By Type, 2019 - 2032 (US$ Million)
12.2.5.North America Market Size and Forecast, By Ion Channel, 2019 - 2032 (US$ Million)
12.2.6.North America Market Size and Forecast, By Testing Methods, 2019 - 2032 (US$ Million)
12.2.7.North America Market Size and Forecast, By Application, 2019 - 2032 (US$ Million)
12.2.8.North America Market Size and Forecast, By End User, 2019 - 2032 (US$ Million)