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Ankylosing Spondylitis Global Market Report 2025
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Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the spine and sacroiliac joints, causing inflammation in the joints and entheses, leading to pain, stiffness, and progressive loss of spinal mobility.

The main treatment modalities for ankylosing spondylitis include painkillers and non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), biological therapies, steroids, physical therapies, and surgery. Painkillers and NSAIDs are medications that inhibit the production of specific chemicals causing pain and swelling, aiming to relieve pain and reduce inflammation in AS treatment. Biologics, biosimilars, and small molecules are administered through various routes, including parenteral and oral, catering to both juvenile and adult populations. These treatments are employed by hospitals, clinics, research laboratories, and other end-users.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sharp rise in U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the healthcare sector, especially in the supply of essential medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are grappling with higher costs for imported surgical tools, imaging systems, and consumables like syringes and catheters, many of which have limited domestic substitutes. These escalating expenses are putting pressure on healthcare budgets, prompting some providers to delay equipment upgrades or pass increased costs on to patients. Furthermore, tariffs on raw materials and components are disrupting the manufacturing of vital drugs and devices, leading to supply chain delays. In response, the industry is adopting diversified sourcing strategies, expanding local production where feasible, and pushing for tariff exemptions on critical medical products.

The ankylosing spondylitis market research report is one of a series of new reports from The Business Research Company that provides ankylosing spondylitis market statistics, including ankylosing spondylitis industry global market size, regional shares, competitors with an ankylosing spondylitis market share, detailed ankylosing spondylitis market segments, market trends and opportunities, and any further data you may need to thrive in the ankylosing spondylitis industry. This ankylosing spondylitis market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The ankylosing spondylitis market size has grown strongly in recent years. It will grow from $5.9 billion in 2024 to $6.34 billion in 2025 at a compound annual growth rate (CAGR) of 7.5%. The growth in the historic period can be attributed to hla-b27 discovery, biologic treatments development, pain management approaches, patient advocacy and awareness, NSAIDS and disease modifying drugs.

The ankylosing spondylitis market size is expected to see strong growth in the next few years. It will grow to $8.68 billion in 2029 at a compound annual growth rate (CAGR) of 8.2%. The growth in the forecast period can be attributed to personalized medicine approach, novel biologics development, early intervention and screening, lifestyle and diet management, telemedicine and remote monitoring. Major trends in the forecast period include biosimilar availability, targeted pain therapies, patient-reported outcomes (pros) emphasis, community support programs, regenerative medicine exploration.

The forecast of 8.2% growth over the next five years reflects a slight reduction of 0.1% from the previous projection. This reduction is primarily due to the impact of tariffs between the US and other countries. Tariff barriers are expected to hamper the U.S. market by increasing the cost of Tumor Necrosis Factor-alphaTNF-alpha inhibitors and Interleukin (IL)-17 antagonists sourced from Switzerland and Germany, thereby reducing treatment efficacy for spinal inflammation and elevating rheumatology department expenditures. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.

The growing geriatric population is expected to drive the expansion of the ankylosing spondylitis market in the coming years. The geriatric population refers to the increasing proportion of elderly individuals resulting from changes in a population's age structure. This demographic shift has led to a rise in the number and proportion of people over the age of 60. Treatment and medication for ankylosing spondylitis play a crucial role in improving mobility and managing pain in elderly individuals affected by this condition. For example, in January 2023, the United Nations Department of Economic and Social Affairs (UN DESA), a US-based division of the UN Secretariat, reported that the global population of individuals aged 65 and older is projected to more than double, rising from 761 million in 2021 to 1.6 billion by 2050. As a result, the growing geriatric population is fueling the growth of the ankylosing spondylitis market.

The rising prevalence of autoimmune diseases is set to further boost the ankylosing spondylitis market. Autoimmune diseases encompass a wide range of disorders caused by abnormal immune responses, where the immune system mistakenly attacks and damages healthy cells, tissues, and organs. In the case of ankylosing spondylitis, the immune system incorrectly targets the body's own tissues, leading to inflammation and damage, particularly affecting the spine and pelvis. Genetic predisposition and environmental factors are key contributors to the development of this autoimmune condition. For instance, in September 2023, the IBD Clinical and Research Centre, a Canada-based organization focused on improving the lives of patients with Crohn's disease and ulcerative colitis, published the Impact of IBD Report 2023. The report revealed that with a prevalence rate of 825 per 100,000, over 320,000 Canadians had inflammatory bowel disease (IBD) in 2023, and this prevalence is expected to rise by 2.44% annually, with 1.1% of the population (470,000 Canadians) projected to be living with IBD by 2035. Consequently, the rising incidence of autoimmune diseases will drive the future growth of the ankylosing spondylitis market.

Advancements in therapeutic options are a notable trend gaining traction in the ankylosing spondylitis market. Companies in the ankylosing spondylitis space are continuously innovating new therapeutic solutions to maintain their market presence. For instance, in April 2022, AbbVie Inc., a US-based biopharmaceutical company, announced the U.S. Food and Drug Administration's (FDA) approval of RINVOQ for treating adults with active ankylosing spondylitis (AS). This new oral treatment is intended for patients who have not responded to TNF blockers, providing significant improvements in symptoms such as back pain and physical function. Its rapid efficacy and positive safety profile from clinical trials make it a valuable addition to managing this chronic inflammatory condition, thereby expanding therapeutic options for patients.

Leading companies in ankylosing spondylitis are focusing on developing innovative drugs, such as those based on enzymatic and cellular assays, to treat moderately to severely active rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and non-radiographic axial spondylarthritis. Drugs developed using enzymatic and cellular assays are created and validated by testing their effects on specific enzymes or cell systems, allowing for more targeted and precise treatments. For example, in April 2022, AbbVie Inc. secured FDA approval for RINVOQ as a treatment for ankylosing spondylitis (AS). RINVOQ, a selective JAK inhibitor being investigated across multiple immune-mediated inflammatory conditions, demonstrates heightened inhibitory potency for JAK-1 over JAK-2, JAK-3, and TYK-2, based on enzymatic and cellular assay data.

In July 2023, Superior Biologics, Inc., a US-based specialty pharmacy and home infusion therapy service provider, and Coherus BioSciences, Inc. announced a national distribution agreement. This collaboration aims to distribute YUSIMRY, a biosimilar to Humira, across the US, offering patients an affordable and high-quality treatment for autoimmune conditions like ankylosing spondylitis, rheumatoid arthritis, and Crohn's disease. The partnership also helps employers reduce specialty drug costs by over 85%. Coherus BioSciences Inc. is a US-based biopharmaceutical company that provides YUSIMRY (adalimumab-aqvh), a biosimilar product for treating ankylosing spondylitis (AS).

Major companies operating in the ankylosing spondylitis market include Pfizer Inc., Johnson & Johnson Pvt. Ltd., Merck & Co. Inc., AbbVie Inc., Novartis AG, Bristol-Myers Squibb, Eli Lilly and Company, Gilead Sciences Inc., Boehringer Ingelheim International GmbH, Amgen Inc., Cedars-Sinai, Viatris Inc., Astellas Pharma Inc., AstraZeneca plc, UCB Inc., Cipla Inc., Zydus Lifesciences Limited, Celltrion Inc., Hetero Labs Ltd., UCSF Health, Janssen Biotech Inc., Reliance Life Sciences Pvt. Ltd.

North America was the largest region in the ankylosing spondylitis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the ankylosing spondylitis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

The countries covered in the ankylosing spondylitis market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The ankylosing spondylitis market consists of sales of nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs (DMARDs), tumor necrosis factor (TNF) inhibitors, interleukin inhibitors, and corticosteroids. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Ankylosing Spondylitis Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on ankylosing spondylitis market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for ankylosing spondylitis ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The ankylosing spondylitis market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.

Scope

Table of Contents

1. Executive Summary

2. Ankylosing Spondylitis Market Characteristics

3. Ankylosing Spondylitis Market Trends And Strategies

4. Ankylosing Spondylitis Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market

5. Global Ankylosing Spondylitis Growth Analysis And Strategic Analysis Framework

6. Ankylosing Spondylitis Market Segmentation

7. Ankylosing Spondylitis Market Regional And Country Analysis

8. Asia-Pacific Ankylosing Spondylitis Market

9. China Ankylosing Spondylitis Market

10. India Ankylosing Spondylitis Market

11. Japan Ankylosing Spondylitis Market

12. Australia Ankylosing Spondylitis Market

13. Indonesia Ankylosing Spondylitis Market

14. South Korea Ankylosing Spondylitis Market

15. Western Europe Ankylosing Spondylitis Market

16. UK Ankylosing Spondylitis Market

17. Germany Ankylosing Spondylitis Market

18. France Ankylosing Spondylitis Market

19. Italy Ankylosing Spondylitis Market

20. Spain Ankylosing Spondylitis Market

21. Eastern Europe Ankylosing Spondylitis Market

22. Russia Ankylosing Spondylitis Market

23. North America Ankylosing Spondylitis Market

24. USA Ankylosing Spondylitis Market

25. Canada Ankylosing Spondylitis Market

26. South America Ankylosing Spondylitis Market

27. Brazil Ankylosing Spondylitis Market

28. Middle East Ankylosing Spondylitis Market

29. Africa Ankylosing Spondylitis Market

30. Ankylosing Spondylitis Market Competitive Landscape And Company Profiles

31. Ankylosing Spondylitis Market Other Major And Innovative Companies

32. Global Ankylosing Spondylitis Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Ankylosing Spondylitis Market

34. Recent Developments In The Ankylosing Spondylitis Market

35. Ankylosing Spondylitis Market High Potential Countries, Segments and Strategies

36. Appendix

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