세계의 브루톤형 티로신 키나아제(BTK) 억제제 시장 보고서(2025년)
Bruton´s Tyrosine Kinase (BTK) Inhibitor Global Market Report 2025
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리서치사 : The Business Research Company
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한글목차

브루톤형 티로신키나아제(BTK) 억제제 시장 규모는 향후 몇 년 동안 급성장할 것으로 예상됩니다. 2029년에는 연평균 13.6%의 CAGR로 191억 8,000만 달러로 성장할 것입니다. 예측 기간의 성장은 자가면역질환 및 염증성 질환에서 BTK 억제제의 채택 확대, 승인된 치료제의 적응증 확대, 병용요법에 대한 관심 증가, 경구용 표적 치료제에 대한 선호도 증가, 세계 헬스케어 인프라 확대 등에 기인하는 것으로 보입니다. 이 기간의 주요 동향으로는 비공유결합형 BTK 억제제 설계의 발전, 가역적 및 선택적 결합 메커니즘의 혁신, 병용요법 최적화 기술, 내성 변이 경로를 타겟으로 한 개발, 경구용 제형 개선, 치료 모니터링을 위한 디지털 헬스 툴의 통합 등이 있습니다.

혈액학적 악성 종양의 유병률 증가는 브루톤형 티로신 키나아제(BTK) 억제제 시장의 향후 성장을 견인할 것으로 예상됩니다. 혈액학적 악성 종양은 혈액, 골수, 림프계에 발생하는 암으로 혈액세포와 면역세포의 기능에 영향을 미치는 백혈병, 림프종, 다발성 골수종 등의 질환이 포함됩니다. 전 세계적으로 고령화가 진행됨에 따라 이러한 혈액암 발병 위험이 높아지고 있습니다. BTK 억제제는 질병의 진행을 억제하고 암세포의 증식과 재발을 억제하여 환자를 돕고, 생존율을 연장하며, 이러한 질병의 유병률 증가에 기여합니다. 예를 들어, 호주에 기반을 둔 비영리단체인 Leukemia Foundation이 2023년 2월에 발표한 보고서에 따르면, 2022년부터 2035년까지 7,000명 이상의 어린이, 6,000명 이상의 젊은 성인, 10만 8,000명 이상의 25세에서 65세 사이의 성인이 주로 급성 림프아구성 백혈병, 급성 골수성 백혈병, 비호지킨림프종 등 혈액암으로 진단받는 것으로 추정됩니다. 그 결과, 혈액 악성종양 유병률의 증가는 BTK 억제제 시장의 확대를 뒷받침하고 있습니다.

BTK 억제제 시장의 주요 기업들은 치료 성과를 개선하기 위해 표적 치료제와 같은 의약품 개발 혁신에 집중하고 있습니다. 표적치료는 건강한 세포에 대한 피해를 최소화하면서 암세포나 질병 경로를 특이적으로 공격하도록 설계된 약물이나 물질을 사용합니다. 예를 들어, 2025년 7월 인도 제약사 글렌마크 파마슈티컬스(Glenmark Pharmaceuticals)는 인도 혈액암 환자를 위한 새로운 치료 옵션인 브루킨사(성분명: 자누브루티닙)를 발표하였습니다. 브루킨사는 인도에서 5가지 B세포 악성종양 치료제로 승인된 최초이자 유일한 BTK 억제제입니다. 이 약은 혈액과 림프절 모두에서 지속적으로 높은 BTK 점유율을 달성하고, 암성 B세포의 생존을 억제하는 효과를 높여 차세대 BTK 억제제로 주목받고 있습니다. 1세대 BTK 억제제에 비해 심장에 대한 부작용이 적고, 투약 중단율이 낮은 등 안전성 프로파일도 개선되었습니다. 또한, 내약성과 편의성에 따라 160mg을 1일 2회 또는 320mg을 1일 1회 복용할 수 있는 유연한 용량 옵션을 제공합니다.

목차

제1장 주요 요약

제2장 시장 특징

제3장 시장 동향과 전략

제4장 시장 : 금리, 인플레이션, 지정학, 무역 전쟁과 관세, 그리고 코로나와 회복이 시장에 미치는 영향을 포함한 거시경제 시나리오

제5장 세계의 성장 분석과 전략 분석 프레임워크

제6장 시장 세분화

제7장 지역별·국가별 분석

제8장 아시아태평양 시장

제9장 중국 시장

제10장 인도 시장

제11장 일본 시장

제12장 호주 시장

제13장 인도네시아 시장

제14장 한국 시장

제15장 서유럽 시장

제16장 영국 시장

제17장 독일 시장

제18장 프랑스 시장

제19장 이탈리아 시장

제20장 스페인 시장

제21장 동유럽 시장

제22장 러시아 시장

제23장 북미 시장

제24장 미국 시장

제25장 캐나다 시장

제26장 남미 시장

제27장 브라질 시장

제28장 중동 시장

제29장 아프리카 시장

제30장 경쟁 구도와 기업 개요

제31장 기타 주요 기업과 혁신적 기업

제32장 세계의 시장 경쟁 벤치마킹과 대시보드

제33장 주요 인수합병

제34장 최근의 시장 동향

제35장 시장 잠재력이 높은 국가, 부문, 전략

제36장 부록

KSM
영문 목차

영문목차

Bruton's tyrosine kinase (BTK) inhibitors are a class of drugs that block the activity of the BTK enzyme, which is crucial in B-cell signaling pathways. By inhibiting BTK, these medications help halt the growth and survival of malignant B-cells involved in certain blood cancers and autoimmune disorders.

The primary categories of BTK inhibitors include first-generation, second-generation, and third-generation drugs. First-generation BTK inhibitors are the initial group of therapies designed to block BTK and treat blood cancers by preventing cancer cell proliferation. These drugs are administered through various routes, including oral, intravenous, and subcutaneous methods. Their applications span multiple conditions such as chronic lymphocytic leukemia (CLL), follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, small lymphocytic lymphoma (SLL), Waldenstrom macroglobulinemia, other selective B-cell malignancies, chronic graft-versus-host disease, and more. They are used by a range of end users including hospitals, specialty clinics, research laboratories, pharmacies, and others.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

The bruton's tyrosine kinase (BTK) inhibitor market research report is one of a series of new reports from The Business Research Company that provides bruton's tyrosine kinase (BTK) inhibitor market statistics, including bruton's tyrosine kinase (BTK) inhibitor industry global market size, regional shares, competitors with a bruton's tyrosine kinase (BTK) inhibitor market share, bruton's tyrosine kinase (BTK) inhibitor market segments, market trends and opportunities, and any further data you may need to thrive in the bruton's tyrosine kinase (BTK) inhibitor industry. This bruton's tyrosine kinase (BTK) inhibitor market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The bruton's tyrosine kinase (BTK) inhibitor market size has grown rapidly in recent years. It will grow from $10.12 billion in 2024 to $11.52 billion in 2025 at a compound annual growth rate (CAGR) of 13.8%. The growth during the historic period can be attributed to increasing unmet medical needs in oncology, higher success rates in clinical trials, greater awareness among healthcare professionals, the expanding use of targeted small molecules, and more frequent inclusion in treatment guidelines.

The bruton's tyrosine kinase (BTK) inhibitor market size is expected to see rapid growth in the next few years. It will grow to $19.18 billion in 2029 at a compound annual growth rate (CAGR) of 13.6%. The projected growth in the forecast period can be attributed to increasing adoption of BTK inhibitors in autoimmune and inflammatory diseases, rising label expansions for approved treatments, growing interest in combination therapy approaches, a preference for oral targeted medications, and the expansion of healthcare infrastructure worldwide. Key trends during this period include advancements in the design of non-covalent BTK inhibitors, innovations in reversible and selective binding mechanisms, technologies that optimize combination therapies, developments targeting resistance mutation pathways, improvements in oral delivery formulations, and the integration of digital health tools for therapy monitoring.

The rising prevalence of hematological malignancies is expected to drive growth in the Bruton's tyrosine kinase (BTK) inhibitor market moving forward. Hematological malignancies are cancers that originate in the blood, bone marrow, or lymphatic system and include diseases such as leukemia, lymphoma, and multiple myeloma, which impact blood and immune cell functions. An aging global population contributes to a higher risk of developing these blood cancers, as the likelihood of such diseases increases with age. BTK inhibitors assist patients by controlling disease progression, reducing cancer cell growth and relapse, thereby extending survival rates and contributing to an increased prevalence of these conditions. For example, a report by the Leukemia Foundation, an Australia-based non-profit organization, published in February 2023, estimates that between 2022 and 2035, over 7,000 children, 6,000 young adults, and 108,000 adults aged 25-65 will be diagnosed with blood cancers, primarily acute lymphoblastic leukemia, acute myeloid leukemia, and non-Hodgkin lymphoma. As a result, the growing prevalence of hematological malignancies is supporting the expansion of the BTK inhibitor market.

Leading companies in the BTK inhibitor market are focusing on drug development innovations like targeted therapy to improve treatment outcomes. Targeted therapy involves using drugs or substances designed to specifically attack cancer cells or disease pathways while minimizing harm to healthy cells. For instance, in July 2025, Glenmark Pharmaceuticals Ltd., an India-based pharmaceutical company, introduced Brukinsa (zanubrutinib), a new treatment option for Indian patients with blood cancers. Brukinsa is the first and only BTK inhibitor approved in India for treating five types of B-cell malignancies. It stands out as a next-generation BTK inhibitor by achieving sustained high-level BTK occupancy in both blood and lymph nodes, enhancing its effectiveness at inhibiting cancerous B-cell survival. The drug has an improved safety profile with fewer cardiac side effects and lower discontinuation rates compared to first-generation BTK inhibitors. It also offers flexible dosing options, allowing patients to take either 160 mg twice daily or 320 mg once daily based on tolerance and convenience.

In December 2024, Innovent Biologics Inc., a China-based biopharmaceutical firm, entered a partnership with Eli Lilly and Company to commercialize and distribute Jaypirca (pirtobrutinib) in mainland China. This collaboration enables Innovent to expand its oncology portfolio and utilize its commercial infrastructure to market and distribute Jaypirca, the first and only approved non-covalent BTK inhibitor for patients with relapsed or refractory mantle cell lymphoma. Eli Lilly, a US-based pharmaceutical company, retains responsibility for Jaypirca's research and development as well as post-market medical affairs.

Major players in the bruton's tyrosine kinase (BTK) inhibitor market are Johnson & Johnson Inc., F. Hoffmann-La Roche Ltd, Merck & Co. Inc., AbbVie Inc., Novartis International AG, Sanofi S.A., Bristol-Myers Squibb Company, AstraZeneca PLC, Eli Lilly and Company, Gilead Sciences Inc., Biogen Inc., Incyte Corporation, Ono Pharmaceutical Co Ltd., BeOne Medicines Inc., Nurix Therapeutics Inc., InnoCare Pharma Limited, Carna Biosciences Inc., Aptose Biosciences Inc., TG Therapeutics Inc., and Everest Medicines Limited.

North America was the largest region in the bruton's tyrosine kinase (BTK) inhibitor market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in bruton's tyrosine kinase (BTK) inhibitor report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the bruton's tyrosine kinase (BTK) inhibitor market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The bruton's tyrosine kinase (BTK) inhibitor market consists of sales of ibrutinib, acalabrutinib, zanubrutinib, spebrutinib, and evobrutinib. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Bruton's Tyrosine Kinase (BTK) Inhibitor Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on bruton's tyrosine kinase (btk) inhibitor market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for bruton's tyrosine kinase (btk) inhibitor ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The bruton's tyrosine kinase (btk) inhibitor market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.

Scope

Table of Contents

1. Executive Summary

2. Bruton's Tyrosine Kinase (BTK) Inhibitor Market Characteristics

3. Bruton's Tyrosine Kinase (BTK) Inhibitor Market Trends And Strategies

4. Bruton's Tyrosine Kinase (BTK) Inhibitor Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market

5. Global Bruton's Tyrosine Kinase (BTK) Inhibitor Growth Analysis And Strategic Analysis Framework

6. Bruton's Tyrosine Kinase (BTK) Inhibitor Market Segmentation

7. Bruton's Tyrosine Kinase (BTK) Inhibitor Market Regional And Country Analysis

8. Asia-Pacific Bruton's Tyrosine Kinase (BTK) Inhibitor Market

9. China Bruton's Tyrosine Kinase (BTK) Inhibitor Market

10. India Bruton's Tyrosine Kinase (BTK) Inhibitor Market

11. Japan Bruton's Tyrosine Kinase (BTK) Inhibitor Market

12. Australia Bruton's Tyrosine Kinase (BTK) Inhibitor Market

13. Indonesia Bruton's Tyrosine Kinase (BTK) Inhibitor Market

14. South Korea Bruton's Tyrosine Kinase (BTK) Inhibitor Market

15. Western Europe Bruton's Tyrosine Kinase (BTK) Inhibitor Market

16. UK Bruton's Tyrosine Kinase (BTK) Inhibitor Market

17. Germany Bruton's Tyrosine Kinase (BTK) Inhibitor Market

18. France Bruton's Tyrosine Kinase (BTK) Inhibitor Market

19. Italy Bruton's Tyrosine Kinase (BTK) Inhibitor Market

20. Spain Bruton's Tyrosine Kinase (BTK) Inhibitor Market

21. Eastern Europe Bruton's Tyrosine Kinase (BTK) Inhibitor Market

22. Russia Bruton's Tyrosine Kinase (BTK) Inhibitor Market

23. North America Bruton's Tyrosine Kinase (BTK) Inhibitor Market

24. USA Bruton's Tyrosine Kinase (BTK) Inhibitor Market

25. Canada Bruton's Tyrosine Kinase (BTK) Inhibitor Market

26. South America Bruton's Tyrosine Kinase (BTK) Inhibitor Market

27. Brazil Bruton's Tyrosine Kinase (BTK) Inhibitor Market

28. Middle East Bruton's Tyrosine Kinase (BTK) Inhibitor Market

29. Africa Bruton's Tyrosine Kinase (BTK) Inhibitor Market

30. Bruton's Tyrosine Kinase (BTK) Inhibitor Market Competitive Landscape And Company Profiles

31. Bruton's Tyrosine Kinase (BTK) Inhibitor Market Other Major And Innovative Companies

32. Global Bruton's Tyrosine Kinase (BTK) Inhibitor Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Bruton's Tyrosine Kinase (BTK) Inhibitor Market

34. Recent Developments In The Bruton's Tyrosine Kinase (BTK) Inhibitor Market

35. Bruton's Tyrosine Kinase (BTK) Inhibitor Market High Potential Countries, Segments and Strategies

36. Appendix

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