Affinity chromatography is a highly specific separation method employed to isolate particular molecules from a complex mixture through distinct biological interactions. This technique is based on the selective binding between a target molecule and a complementary partner that is immobilized on a solid matrix.
The primary products used in affinity chromatography include resins or gels, columns, magnetic beads, reagents and consumables, and accessories. Resins or gels contain ligands that bind specifically to target molecules, enabling the process of separation and purification. Various approaches are utilized, such as immobilized metal affinity chromatography, protein A, G, or L affinity chromatography, bio-specific affinity chromatography, among others, and are applied in biomolecule purification and chromatographic separation. This technique is employed by diverse end users, such as pharmaceutical and biotechnology firms, research centers, and academic institutions.
The affinity chromatography market research report is one of a series of new reports from The Business Research Company that provides affinity chromatography market statistics, including affinity chromatography industry global market size, regional shares, competitors with a affinity chromatography market share, detailed affinity chromatography market segments, market trends and opportunities, and any further data you may need to thrive in the affinity chromatography industry. This affinity chromatography market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The affinity chromatography market size has grown strongly in recent years. It will grow from $3.44 billion in 2024 to $3.68 billion in 2025 at a compound annual growth rate (CAGR) of 7.0%. The growth during the historic period can be attributed to the rising demand for protein purification, advancements in personalized medicine, increased investments in academic and industrial R&D, greater adoption of monoclonal antibodies, and the expansion of proteomics and genomics research.
The affinity chromatography market size is expected to see strong growth in the next few years. It will grow to $4.76 billion in 2029 at a compound annual growth rate (CAGR) of 6.6%. The growth in the forecast period can be attributed to the expansion of the biopharmaceutical industry, rising demand for gene and cell therapies, an increase in biosimilar production, growing focus on continuous bioprocessing, and stricter regulatory requirements for biologics purity. Key trends expected during this period include integration with single-use technologies, a move toward automation and high-throughput screening, the creation of innovative ligands and resins, applications in diagnostics and biomarker discovery, and the extension of use into non-biopharmaceutical sectors.
The increasing demand for biopharmaceuticals is anticipated to drive the growth of the affinity chromatography market in the coming years. Biopharmaceuticals are therapeutic products derived from biological sources, such as living cells or organisms, and are used to treat, prevent, or diagnose various diseases. This demand is growing primarily because biopharmaceuticals provide highly targeted and effective treatments for complex conditions like cancer and autoimmune disorders, leading to improved patient outcomes where conventional drugs often prove inadequate. Affinity chromatography plays a critical role by enabling the precise and efficient purification of complex biomolecules, including antibodies and proteins, which is essential for producing high-quality biopharmaceuticals. For example, in July 2024, the UK Department for Science, Innovation, and Technology reported that the U.S. leads the global biopharmaceutical sector, with companies investing approximately $96 billion in R&D in 2023, representing over 20% of their total sales. The sector also generated significant economic value, with $25 billion in exports and $26 billion in R&D from predominantly foreign-owned firms in 2022. As a result, the growing demand for biopharmaceuticals is set to accelerate the expansion of the affinity chromatography market.
Leading companies in the affinity chromatography market are concentrating on the development of advanced technologies, such as next-generation affinity chromatography units, to enable faster, more flexible, and efficient antibody purification in laboratory environments. These innovations mark a significant advancement in purification systems by offering improved specificity, scalability, and automation, often featuring novel ligands and enhanced resin materials to address the evolving needs of biopharmaceutical research and manufacturing. For example, in October 2024, Sartorius, a Germany-based pharmaceutical company, introduced the Sartobind Rapid A Lab, a Protein A affinity chromatography unit. This unit incorporates the fastest available Protein A matrix, significantly boosting productivity and transforming antibody purification. Tailored for research scientists, it offers a plug-and-play benchtop system that supports rapid cycling without requiring buffer degassing. Its membrane design resists clogging and maintains stable backpressure, ensuring consistent performance with syringes, pumps, or chromatography systems across up to 100 purification cycles. Throughout its consumable lifespan, it can deliver up to 17 times more antibody yield than traditional resin-based columns.
In July 2024, Repligen, a US-based life sciences company, acquired Tantti Laboratory Inc. for an undisclosed sum. Through this acquisition, Repligen gains access to Tantti's macroporous chromatography beads, which are used in the purification of viral vectors, viruses, nucleic acids, and other advanced modalities. The acquisition is intended to strengthen and expand Repligen's portfolio in the rapidly growing area of new modality bioprocessing. Tantti Laboratory Inc. is a Taiwan-based manufacturer of affinity chromatography products.
Major players in the affinity chromatography market are Thermo Fisher Scientific, Merck KGaA, Asahi Kasei Medical Co. Ltd., GE Healthcare Life Sciences, MilliporeSigma, Lonza Group Ltd., Agilent Technologies, Cytiva, Sartorius AG, Tosoh Bioscience, Waters Corporation, Bio-Rad Laboratories, Pall Corporation, Promega Corporation, Biotage, Horizon Discovery, KNAUER Wissenschaftliche Gerate GmbH, BioWorks Inc., BIA Separation, JNC Corporation.
North America was the largest region in the affinity chromatography market in 2024. The regions covered in affinity chromatography report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the affinity chromatography market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The affinity chromatography market consists of revenues earned by entities by providing services such as custom ligand development, column packing and preparation, protein purification services, and process optimization. The market value includes the value of related goods sold by the service provider or included within the service offering. The affinity chromatography market also includes sales of chromatography media and supports, elution buffers, affinity tags, and labeling kits. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Affinity Chromatography Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on affinity chromatography market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
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Where is the largest and fastest growing market for affinity chromatography ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The affinity chromatography market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The market characteristics section of the report defines and explains the market.
The market size section gives the market size ($b) covering both the historic growth of the market, and forecasting its development.
The forecasts are made after considering the major factors currently impacting the market. These include:
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.
Market segmentations break down the market into sub markets.
The regional and country breakdowns section gives an analysis of the market in each geography and the size of the market by geography and compares their historic and forecast growth. It covers the growth trajectory of COVID-19 for all regions, key developed countries and major emerging markets.
The competitive landscape chapter gives a description of the competitive nature of the market, market shares, and a description of the leading companies. Key financial deals which have shaped the market in recent years are identified.
The trends and strategies section analyses the shape of the market as it emerges from the crisis and suggests how companies can grow as the market recovers.
Scope
Markets Covered:1) By Product: Resins Or Gels; Columns; Magnetic Beads; Reagents And Consumables; Accessories
2) By Technique: Immobilized Metal Affinity Chromatography; Protein A Or G Or L Affinity Chromatography; Bio-Specific Affinity Chromatography; Other Techniques
3) By Application: Biomolecule Purification; Chromatographic Separation
4) By End User: Pharmaceutical And Biotechnology Companies; Research Institutes; Academic Institutions
Subsegments:
1) By Resins Or Gels: Agarose-Based resins; Polystyrene-Based resins; Silica-Based resins; Sepharose-Based gels; Dextran-Based resins; Cellulose-Based resins
3) By Magnetic Beads: Streptavidin-Coated Beads; Protein A Or G Or L-Coated Beads; Ni-NTA Magnetic Beads; Glutathione Magnetic Beads; Custom Ligand-Conjugated Beads
4) By Reagents And Consumables: Ligands; Elution Buffers; Binding Buffers; Wash Buffers; Coupling Reagents
5) By Accessories: Tubing And Connectors; Frits And Filters; Column Holders; Sample Loops; Flow Restrictors
Companies Mentioned: Thermo Fisher Scientific; Merck KGaA; Asahi Kasei Medical Co. Ltd.; GE Healthcare Life Sciences; MilliporeSigma
Regions: Asia-Pacific; Western Europe; Eastern Europe; North America; South America; Middle East; Africa
Time series: Five years historic and ten years forecast.
Data: Ratios of market size and growth to related markets, GDP proportions, expenditure per capita,
Data segmentations: country and regional historic and forecast data, market share of competitors, market segments.
Sourcing and Referencing: Data and analysis throughout the report is sourced using end notes.
Delivery format: PDF, Word and Excel Data Dashboard.
Table of Contents
1. Executive Summary
2. Affinity Chromatography Market Characteristics
3. Affinity Chromatography Market Trends And Strategies
4. Affinity Chromatography Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market
5. Global Affinity Chromatography Growth Analysis And Strategic Analysis Framework
5.1. Global Affinity Chromatography PESTEL Analysis (Political, Social, Technological, Environmental and Legal Factors, Drivers and Restraints)
5.2. Analysis Of End Use Industries
5.3. Global Affinity Chromatography Market Growth Rate Analysis
5.4. Global Affinity Chromatography Historic Market Size and Growth, 2019 - 2024, Value ($ Billion)
5.5. Global Affinity Chromatography Forecast Market Size and Growth, 2024 - 2029, 2034F, Value ($ Billion)
5.6. Global Affinity Chromatography Total Addressable Market (TAM)
6. Affinity Chromatography Market Segmentation
6.1. Global Affinity Chromatography Market, Segmentation By Product, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Resins Or Gels
Columns
Magnetic Beads
Reagents And Consumables
Accessories
6.2. Global Affinity Chromatography Market, Segmentation By Technique, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Immobilized Metal Affinity Chromatography
Protein A Or G Or L Affinity Chromatography
Bio-Specific Affinity Chromatography
Other Techniques
6.3. Global Affinity Chromatography Market, Segmentation By Application, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Biomolecule Purification
Chromatographic Separation
6.4. Global Affinity Chromatography Market, Segmentation By End User, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Pharmaceutical And Biotechnology Companies
Research Institutes
Academic Institutions
6.5. Global Affinity Chromatography Market, Sub-Segmentation Of Resins Or Gels, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Agarose-Based Resins
Polystyrene-Based Resins
Silica-Based Resins
Sepharose-Based Gels
Dextran-Based Resins
Cellulose-Based Resins
6.6. Global Affinity Chromatography Market, Sub-Segmentation Of Columns, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Pre-Packed Columns
Empty Columns
Mini-Spin Columns
Gravity Flow Columns
High-Performance Columns
6.7. Global Affinity Chromatography Market, Sub-Segmentation Of Magnetic Beads, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Streptavidin-Coated Beads
Protein A Or G Or L-Coated Beads
Ni-NTA Magnetic Beads
Glutathione Magnetic Beads
Custom Ligand-Conjugated Beads
6.8. Global Affinity Chromatography Market, Sub-Segmentation Of Reagents And Consumables, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Ligands
Elution Buffers
Binding Buffers
Wash Buffers
Coupling Reagents
6.9. Global Affinity Chromatography Market, Sub-Segmentation Of Accessories, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Tubing And Connectors
Frits And Filters
Column Holders
Sample Loops
Flow Restrictors
7. Affinity Chromatography Market Regional And Country Analysis
7.1. Global Affinity Chromatography Market, Split By Region, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
7.2. Global Affinity Chromatography Market, Split By Country, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion