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Normothermic Machine Perfusion Global Market Report 2025
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Normothermic machine perfusion is a preservation method where organs are kept at normal body temperature (around 37°C) and provided with oxygenated blood or perfusate to replicate physiological conditions. This technique supports improved organ viability, functional assessment, and extended preservation time before transplantation.

The primary products in normothermic machine perfusion include portable and stationary normothermic machines. Portable devices are compact, mobile systems designed to preserve donor organs at a body temperature of around 37°C during transportation. These machines function using various advanced technologies, such as mechanical circulation, oxygenation systems, and monitoring systems. Major applications include organ preservation, transplantation, and research and development, with use spanning hospitals, ambulatory surgery centers (ASCs), specialty clinics, and other healthcare settings.

The normothermic machine perfusion market research report is one of a series of new reports from The Business Research Company that provides normothermic machine perfusion market statistics, including the normothermic machine perfusion industry global market size, regional shares, competitors with the normothermic machine perfusion market share, detailed normothermic machine perfusion market segments, market trends, and opportunities, and any further data you may need to thrive in the normothermic machine perfusion industry. This normothermic machine perfusion market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The normothermic machine perfusion market size has grown rapidly in recent years. It will grow from $1.28 billion in 2024 to $1.49 billion in 2025 at a compound annual growth rate (CAGR) of 16.5%. Growth during the historic period was driven by rising organ demand, better preservation outcomes, an increase in donor age and use of marginal organs, regulatory support, growing investments in medical technologies, and the need to minimize cold ischemia time.

The normothermic machine perfusion market size is expected to see rapid growth in the next few years. It will grow to $2.73 billion in 2029 at a compound annual growth rate (CAGR) of 16.2%. Growth in the forecast period is expected to result from higher demand for marginal donor organ utilization, improved transplant success rates with NMP, an increase in clinical trials and regulatory approvals, rising investments in organ preservation technologies, and broader adoption in emerging economies. Key trends projected for the forecast period include the use of AI-powered monitoring, device miniaturization, integration with telemedicine platforms, application to marginal and DCD (donation after circulatory death) organs, development of multi-organ perfusion systems, and advancements in biocompatible materials.

The growing demand for organ transplantation is expected to drive the expansion of the normothermic machine perfusion market. Organ transplantation involves replacing a malfunctioning or diseased organ with a healthy one from a donor. The increasing need for transplants is fueled by the rising prevalence of end-stage organ failure, often due to chronic diseases, as well as advancements in surgical techniques and immunosuppressive therapies. Normothermic machine perfusion plays a critical role in preserving and reviving donor organs by maintaining them at body temperature with oxygenated blood or a perfusate until they are transplanted. For example, in January 2024, the U.S. Department of Health & Human Services reported that 46,632 organ transplants were performed in 2023, marking an 8.7% increase over 2022. This growing demand for organ transplants is driving market growth for normothermic machine perfusion.

Key players in the normothermic machine perfusion market are concentrating on establishing advanced research facilities to foster innovation, enhance organ preservation technologies, and improve transplant outcomes. Expanding these facilities boosts the capacity for organ preservation, research, and clinical application, which in turn enhances both transplant success rates and availability. For example, in May 2024, OrganOx Ltd., a UK-based medical equipment company, opened a new 18,000 sq. ft. research and development facility in Oxford. This expansion is aimed at advancing innovation and fostering partnerships, building on the success of its Metra device, which has improved liver transplant outcomes worldwide. The company remains optimistic about advancing both scientific and clinical innovations through technology to better address organ failure.

In March 2025, OrganOx Ltd. partnered with ProCure On Demand Ltd. to enhance donor liver recovery and evaluation for transplantation. By combining OrganOx's normothermic machine perfusion system with ProCure's skilled surgical team and extensive service network, the collaboration aims to provide flexible, comprehensive solutions tailored to the specific needs of transplant centers, ultimately improving transplant efficiency and patient outcomes. ProCure On Demand is a U.S.-based healthcare company specializing in human organ transplantation.

Major players in the normothermic machine perfusion market are CVS Health Corporation, Medtronic plc, Tandem Diabetes Care Inc., Fluent Medical Inc., TransMedics Inc., XENIOS AG, RVL Pharmaceuticals plc, Xvivo Perfusion AB, LifePort Inc., Lifeline Scientific Inc., Organ Recovery Systems Inc., Bridge to Life Ltd., OrganOx Limited, Paragonix Technologies Inc., SurgiCor LLC, Waters Medical Systems LLC, InnovaHealth Partners LP, Prescient Surgical Inc., Vascular Insights LLC, and Lung Bioengineering Inc.

North America was the largest region in the normothermic machine perfusion market in 2024. The regions covered in normothermic machine perfusion report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the normothermic machine perfusion market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The normothermic machine perfusion market includes revenues earned by entities by providing services such as organ viability assessment, logistics and transport solutions, and organ repair and reconditioning. The market value includes the value of related goods sold by the service provider or included within the service offering. The normothermic machine perfusion market also includes sales of perfusion systems, kits, bioreactors, sensors, and monitoring systems. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Normothermic Machine Perfusion Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on normothermic machine perfusion market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for normothermic machine perfusion ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The normothermic machine perfusion market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Normothermic Machine Perfusion Market Characteristics

3. Normothermic Machine Perfusion Market Trends And Strategies

4. Normothermic Machine Perfusion Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market

5. Global Normothermic Machine Perfusion Growth Analysis And Strategic Analysis Framework

6. Normothermic Machine Perfusion Market Segmentation

7. Normothermic Machine Perfusion Market Regional And Country Analysis

8. Asia-Pacific Normothermic Machine Perfusion Market

9. China Normothermic Machine Perfusion Market

10. India Normothermic Machine Perfusion Market

11. Japan Normothermic Machine Perfusion Market

12. Australia Normothermic Machine Perfusion Market

13. Indonesia Normothermic Machine Perfusion Market

14. South Korea Normothermic Machine Perfusion Market

15. Western Europe Normothermic Machine Perfusion Market

16. UK Normothermic Machine Perfusion Market

17. Germany Normothermic Machine Perfusion Market

18. France Normothermic Machine Perfusion Market

19. Italy Normothermic Machine Perfusion Market

20. Spain Normothermic Machine Perfusion Market

21. Eastern Europe Normothermic Machine Perfusion Market

22. Russia Normothermic Machine Perfusion Market

23. North America Normothermic Machine Perfusion Market

24. USA Normothermic Machine Perfusion Market

25. Canada Normothermic Machine Perfusion Market

26. South America Normothermic Machine Perfusion Market

27. Brazil Normothermic Machine Perfusion Market

28. Middle East Normothermic Machine Perfusion Market

29. Africa Normothermic Machine Perfusion Market

30. Normothermic Machine Perfusion Market Competitive Landscape And Company Profiles

31. Normothermic Machine Perfusion Market Other Major And Innovative Companies

32. Global Normothermic Machine Perfusion Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Normothermic Machine Perfusion Market

34. Recent Developments In The Normothermic Machine Perfusion Market

35. Normothermic Machine Perfusion Market High Potential Countries, Segments and Strategies

36. Appendix

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