Necrotizing enterocolitis (NEC) is a severe, potentially life-threatening gastrointestinal disorder that primarily affects premature infants. It is characterized by inflammation and tissue death (necrosis) in the intestines, which can lead to complications such as perforation and infection. Common symptoms of NEC include feeding intolerance, abdominal bloating, vomiting, and changes in bowel movements.
The primary treatment options for necrotizing enterocolitis include total parenteral nutrition (TPN), gastrointestinal decompression, antimicrobial therapy, antifungal treatment, paracentesis, and other interventions. TPN provides essential nutrients directly into the bloodstream, allowing the intestines to rest and heal, which is particularly beneficial for infants with NEC. Diagnosis involves various laboratory tests and imaging techniques across multiple stages stage I (suspected NEC), stage II (definite NEC), and stage III (advanced NEC). These treatments are distributed through several channels, such as direct tender, hospital pharmacies, retail pharmacies, online pharmacies, and more, and are used in settings such as hospitals, neonatal intensive care units (NICUs), and specialty clinics.
The necrotizing enterocolitis market research report is one of a series of new reports from The Business Research Company that provides necrotizing enterocolitis market statistics, including the necrotizing enterocolitis industry global market size, regional shares, competitors with the necrotizing enterocolitis market share, detailed necrotizing enterocolitis market segments, market trends, and opportunities, and any further data you may need to thrive in the necrotizing enterocolitis industry. This necrotizing enterocolitis market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The necrotizing enterocolitis market size has grown strongly in recent years. It will grow from $4.83 billion in 2024 to $5.16 billion in 2025 at a compound annual growth rate (CAGR) of 6.8%. The growth observed during the historic period can be attributed to factors such as the rising incidence of necrotizing enterocolitis, growing populations, higher per capita income, increased government funding, and a rise in premature births.
The necrotizing enterocolitis market size is expected to see strong growth in the next few years. It will grow to $6.62 billion in 2029 at a compound annual growth rate (CAGR) of 6.4%. Looking ahead, the growth during the forecast period can be driven by factors such as increasing healthcare costs, the rising incidence and prevalence of ulcerative colitis (UC), the growing number of gastrointestinal diseases, the increase in geriatric and obese populations, and the expanding elderly demographic. Key trends expected in the forecast period include advancements in biomarker research for early NEC detection, progress in non-invasive testing methods, adoption of advanced monitoring systems, improvements in surgical techniques, and the development of targeted therapies.
The rising number of premature births is expected to drive the growth of the necrotizing enterocolitis (NEC) market. Premature births, or preterm births, occur when a baby is delivered before 37 weeks of gestation, compared to the typical 40-week term. The increase in premature births is attributed to maternal health conditions such as high blood pressure, diabetes, and infections, which elevate the risk of preterm labor, as well as lifestyle factors such as smoking, drug use, and poor nutrition. Premature infants are more vulnerable to necrotizing enterocolitis because their gastrointestinal systems are underdeveloped, making them more susceptible to inflammation and infection. For example, in January 2024, the Centers for Disease Control and Prevention reported that premature births account for 8.67% of all births in the U.S. annually. As a result, the rise in premature births is contributing to the growth of the NEC market.
Companies in the necrotizing enterocolitis market are focusing on developing innovative treatments to address the critical unmet needs for effective therapies in premature infants. One such solution is cell-free sterile biologic solutions, which are purified, sterile liquids containing bioactive molecules such as proteins, growth factors, and cytokines derived from cultured cells but without intact cells. These biologic solutions are designed to promote healing and reduce inflammation. For instance, in December 2023, Noveome Biotherapeutics, Inc., a U.S.-based biopharmaceutical company, received approval from the U.S. Food and Drug Administration to proceed with a Phase 1-2 clinical trial for ST266, a novel biologic targeting NEC in premature infants. This marks a significant advancement, as ST266 is expected to be the first major therapeutic development for NEC in over three decades, addressing a critical need given the high morbidity and mortality rates associated with the disease among vulnerable populations.
In January 2025, Siolta Therapeutics, a U.S.-based developer of novel live biotherapeutics for NEC, partnered with Cowellnex Co. to combat the disease in premature infants. This collaboration combines Siolta's expertise in microbial science with Cowellnex's strength in microbiome drug discovery. By leveraging Siolta's Precision Symbiotics Platform, the partnership aims to advance research and develop treatments for NEC in premature infants. Cowellnex Co. Ltd. is a biotechnology company focused on advancing microbiome drug discovery.
Major players in the necrotizing enterocolitis market are Abbott Laboratories, Astellas Pharma Inc., Mayo Foundation for Medical Education and Research, Cleveland Clinic, Boston Children's Hospital, Hollister Incorporated, UPMC Children's Hospital of Pittsburgh, Prolacta Bioscience Inc., Evolve BioSystems, Sigma-Tau Pharmaceuticals, Mead Johnson & Company LLC, Liminal BioSciences Inc., Noveome Biotherapeutics Inc., Infant Bacterial Therapeutics, Prometic Life Sciences Inc., Nexilico, Siolta Therapeutics, ProThera Biologics Inc., Plakous Therapeutics Inc., Chosen Diagnostics Inc.
North America was the largest region in the necrotizing enterocolitis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in necrotizing enterocolitis report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the necrotizing enterocolitis market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The necrotizing enterocolitis market consists of revenues earned by entities providing services such as neonatal intensive care, nutritional support, medical monitoring and support, and parental counseling and support. The market value includes the value of related goods sold by the service provider or included within the service offering. The necrotizing enterocolitis market also includes sales of feeding tubes, surgical instruments for resection, and anti-inflammatory drugs. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Necrotizing Enterocolitis Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on necrotizing enterocolitis market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
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Where is the largest and fastest growing market for necrotizing enterocolitis ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The necrotizing enterocolitis market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The market characteristics section of the report defines and explains the market.
The market size section gives the market size ($b) covering both the historic growth of the market, and forecasting its development.
The forecasts are made after considering the major factors currently impacting the market. These include:
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.
Market segmentations break down the market into sub markets.
The regional and country breakdowns section gives an analysis of the market in each geography and the size of the market by geography and compares their historic and forecast growth. It covers the growth trajectory of COVID-19 for all regions, key developed countries and major emerging markets.
The competitive landscape chapter gives a description of the competitive nature of the market, market shares, and a description of the leading companies. Key financial deals which have shaped the market in recent years are identified.
The trends and strategies section analyses the shape of the market as it emerges from the crisis and suggests how companies can grow as the market recovers.
Scope
Markets Covered:1) By Treatment: Total Parenteral Nutrition (TPN); Gastrointestinal Decompression; Antimicrobial Therapy; Antifungal Treatment; Paracentesis; Other Treatments
2) By Diagnosis: Laboratory Tests; Imaging Techniques
3) By Stage: Stage I (Suspected Necrotizing Enterocolitis); Stage II (Definite Necrotizing Enterocolitis); Stage III (Advanced Necrotizing Enterocolitis)
4) By Distribution Channel: Direct Tender; Hospital Pharmacy; Retail Pharmacy; Online Pharmacy; Other Distribution Channels
5) By End-User: Hospitals; Neonatal Intensive Care Units (NICUs); Specialty Clinics
Subsegments:
1) By Total Parenteral Nutrition (TPN): Standard TPN Formulations; Customized Or Individualized TPN Solutions; Lipid Emulsions for TPN; Protein And Amino Acid Supplements In TPN; Micronutrient And Electrolyte-Enhanced TPN
2) By Gastrointestinal Decompression: Nasogastric Tube (NG Tube) Decompression; Orogastric Tube Decompression; Surgical Gastrostomy for Decompression; Non-Surgical Decompression Techniques
4) By Antifungal Treatment: Systemic Antifungal Therapy; Prophylactic Antifungal Therapy For Preterm Infants; Combination Antifungal And Antibiotic Therapy For Severe NEC
5) By Paracentesis: Diagnostic Paracentesis; Therapeutic Paracentesis; Guided Paracentesis using Ultrasound Or Radiological Techniques
6) By Other Treatments: Probiotics And Prebiotics for NEC Prevention; Surgical Interventions; Stem Cell Therapy And Regenerative Medicine Approaches; Immunomodulatory Therapies; Supportive Care
Companies Mentioned: Abbott Laboratories; Astellas Pharma Inc.; Mayo Foundation for Medical Education and Research; Cleveland Clinic; Boston Children's Hospital
3. Necrotizing Enterocolitis Market Trends And Strategies
4. Necrotizing Enterocolitis Market - Macro Economic Scenario Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics And Covid And Recovery On The Market
5. Global Necrotizing Enterocolitis Growth Analysis And Strategic Analysis Framework
5.1. Global Necrotizing Enterocolitis PESTEL Analysis (Political, Social, Technological, Environmental and Legal Factors, Drivers and Restraints)
5.2. Analysis Of End Use Industries
5.3. Global Necrotizing Enterocolitis Market Growth Rate Analysis
5.4. Global Necrotizing Enterocolitis Historic Market Size and Growth, 2019 - 2024, Value ($ Billion)
5.5. Global Necrotizing Enterocolitis Forecast Market Size and Growth, 2024 - 2029, 2034F, Value ($ Billion)
5.6. Global Necrotizing Enterocolitis Total Addressable Market (TAM)
6. Necrotizing Enterocolitis Market Segmentation
6.1. Global Necrotizing Enterocolitis Market, Segmentation By Treatment, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Total Parenteral Nutrition (TPN)
Gastrointestinal Decompression
Antimicrobial Therapy
Antifungal Treatment
Paracentesis
Other Treatments
6.2. Global Necrotizing Enterocolitis Market, Segmentation By Diagnosis, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Laboratory Tests
Imaging Techniques
6.3. Global Necrotizing Enterocolitis Market, Segmentation By Stage, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Stage I (Suspected Necrotizing Enterocolitis)
Stage II (Definite Necrotizing Enterocolitis)
Stage III (Advanced Necrotizing Enterocolitis)
6.4. Global Necrotizing Enterocolitis Market, Segmentation By Distribution Channel, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Direct Tender
Hospital Pharmacy
Retail Pharmacy
Online Pharmacy
Other Distribution Channels
6.5. Global Necrotizing Enterocolitis Market, Segmentation By End-User, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Hospitals
Neonatal Intensive Care Units (NICUs)
Specialty Clinics
6.6. Global Necrotizing Enterocolitis Market, Sub-Segmentation Of Total Parenteral Nutrition (TPN), By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Standard TPN Formulations
Customized Or Individualized TPN Solutions
Lipid Emulsions for TPN
Protein And Amino Acid Supplements In TPN
Micronutrient And Electrolyte-Enhanced TPN
6.7. Global Necrotizing Enterocolitis Market, Sub-Segmentation Of Gastrointestinal Decompression, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Nasogastric Tube (NG Tube) Decompression
Orogastric Tube Decompression
Surgical Gastrostomy for Decompression
Non-Surgical Decompression Techniques
6.8. Global Necrotizing Enterocolitis Market, Sub-Segmentation Of Antimicrobial Therapy, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Broad-Spectrum Antibiotics
Gram-Positive Coverage Antibiotics
Gram-Negative Coverage Antibiotics
Combination Antibiotic Therapy
Prophylactic Antibiotic Strategies For High-Risk Neonates
6.9. Global Necrotizing Enterocolitis Market, Sub-Segmentation Of Antifungal Treatment, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Systemic Antifungal Therapy
Prophylactic Antifungal Therapy For Preterm Infants
Combination Antifungal And Antibiotic Therapy For Severe NEC
6.10. Global Necrotizing Enterocolitis Market, Sub-Segmentation Of Paracentesis, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Diagnostic Paracentesis
Therapeutic Paracentesis
Guided Paracentesis using Ultrasound Or Radiological Techniques
6.11. Global Necrotizing Enterocolitis Market, Sub-Segmentation Of Other Treatments, By Type, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
Probiotics And Prebiotics for NEC Prevention
Surgical Interventions
Stem Cell Therapy And Regenerative Medicine Approaches
Immunomodulatory Therapies
Supportive Care
7. Necrotizing Enterocolitis Market Regional And Country Analysis
7.1. Global Necrotizing Enterocolitis Market, Split By Region, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion
7.2. Global Necrotizing Enterocolitis Market, Split By Country, Historic and Forecast, 2019-2024, 2024-2029F, 2034F, $ Billion