세계의 메틸말론산혈증(MMA) 시장 보고서(2025년)
Methylmalonic Acidemia (MMA) Global Market Report 2025
상품코드 : 1730949
리서치사 : The Business Research Company
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한글목차

메틸말론산혈증(MMA) 시장 규모는 향후 수년간 강력한 성장이 전망됩니다. 2029년에는 CAGR 5.8%로 성장할 전망이며, 125억 달러로 성장이 예측됩니다. 예측 기간에 전망되는 성장은 신생아 스크리닝 프로그램 확대, 헬스케어 전문가 의식 향상, 유전자 치료 진보, 희귀 질환 연구에 대한 투자 증가, 전문적 치료의 가용성 향상 등의 요인에 의해 초래됩니다. 이 기간에 예상되는 주요 동향으로는 유전자 편집 기술 진보, 조기 발견을 위한 진단 기술 강화, 효소 보충 요법 진보, 정밀 의료 접근법 채택, 신생아 유전자 스크리닝 프로그램 실시 확대 등이 있습니다.

대사성 질환과 비타민 결핍증의 유병률 증가는 메틸말론산혈증(MMA) 시장의 성장을 가속할 것으로 예측됩니다. 대사장애는 신체가 특정 영양소를 처리하거나 에너지를 생산하거나 세포 내 화학반응을 조절하는 데 어려움을 겪는 상태입니다. 비타민 결핍증은 신체가 제대로 기능하기에 충분한 특정 비타민이 부족해 생깁니다. 대사 이상이나 비타민 결핍증의 증가는 식생활의 혼란, 앉기 쉬운 생활, 스트레스 레벨의 고조가 주된 원인이 되고 있습니다. 가공식품, 설탕, 건강하지 않은 지방이 많고 필수 영양소가 부족하기 쉬운 현대의 식생활은 비타민과 미네랄의 결핍을 조장하고 있습니다. 이러한 대사 이상이나 비타민 부족, 특히 비타민 B12의 결핍은, 메틸말로닐-CoA의 대사를 저해해, 메틸말론산의 축적이나 MMA의 악화로 이어집니다. 예를 들어 2024년 11월 미국 국립보건연구소는 비타민B12 결핍증 유병률이 4.6%에서 5.2%로 상승했고, 2023년 3분기부터 4분기 사이 507개 사례가 추가됐다고 보고했습니다. 그 결과 대사성 질환이나 비타민 결핍증 발생률 증가가 MMA 시장 확대에 박차를 가하고 있습니다.

MMA 시장의 주요 기업은 MMA의 유전적 원인을 표적으로 하고, 이를 앓고 있는 환자의 독성 대사산물의 축적을 억제하기 위해 효소 기능을 강화함으로써 치료 성과를 개선하기 위해 mRNA 기반 치료법 등의 혁신적인 솔루션의 개발에 주력하고 있습니다. mRNA 기반 치료법은 메신저 RNA를 사용하여 유전성 질환을 포함한 질병의 치료에 도움이 되는 특정 단백질을 생산하도록 세포에 지시합니다. 예를 들어 2024년 6월 미국 제약 및 바이오 기술 기업 모더나는 FDA로부터 mRNA-3705를 START 시험 프로그램에 포함하는 승인을 획득했습니다. 이 치료제는 프로피온산혈증에 대한 mRNA-3927 프로그램에서도 채택되고 있는 Moderna 독자적인 지질 나노입자(LNP) 시스템을 사용하고 있습니다. FDA는 mRNA-3705에 희귀병용의약품, 패스트트랙, 희귀소아질환 지정을 부여하여 개발과 임상의 진척을 촉진하고 있습니다.

목차

제1장 주요 요약

제2장 시장 특징

제3장 시장 동향 및 전략

제4장 시장-거시경제 시나리오 금리, 인플레이션, 지정학, 신형 코로나 바이러스 감염의 영향과 회복이 시장에 미치는 영향을 포함한 거시경제 시나리오

제5장 세계의 성장 분석 및 전략 분석 프레임워크

제6장 시장 세분화

제7장 지역별 및 국가별 분석

제8장 아시아태평양 시장

제9장 중국 시장

제10장 인도 시장

제11장 일본 시장

제12장 호주 시장

제13장 인도네시아 시장

제14장 한국 시장

제15장 서유럽 시장

제16장 영국 시장

제17장 독일 시장

제18장 프랑스 시장

제19장 이탈리아 시장

제20장 스페인 시장

제21장 동유럽 시장

제22장 러시아 시장

제23장 북미 시장

제24장 미국 시장

제25장 캐나다 시장

제26장 남미 시장

제27장 브라질 시장

제28장 중동 시장

제29장 아프리카 시장

제30장 경쟁 구도 및 기업 프로파일

제31장 기타 주요 기업 및 혁신 기업

제32장 세계 시장 경쟁 벤치마킹 및 대시보드

제33장 주요 인수합병(M&A)

제34장 최근 시장 동향

제35장 시장의 잠재력이 높은 국가, 부문 및 전략

제36장 부록

AJY
영문 목차

영문목차

Methylmalonic acidemia (MMA) is a rare inherited metabolic disorder in which the body is unable to effectively break down certain proteins and fats due to a deficiency in the enzyme methylmalonyl-CoA mutase or a related coenzyme, vitamin B12. The severity of MMA symptoms can vary, but they often include vomiting, lethargy, poor feeding, developmental delay, seizures, and failure to thrive.

The primary indications for methylmalonic acidemia (MMA) include acidosis, ketosis, hyperammonemia, hypoglycemia, hyperglycemia, neutropenia, and other related conditions. Acidosis refers to an excess of acid in the blood, resulting in a lower-than-normal pH level. There are various types of disorders associated with MMA, such as homocystinuria, isolated methylmalonic acidurias, and combined methylmalonic aciduria. These treatments and interventions are available through different distribution channels, including hospitals, pharmacies, clinics, and other outlets.

The methylmalonic acidemia (MMA) market research report is one of a series of new reports from The Business Research Company that provides methylmalonic acidemia (MMA) market statistics, including the methylmalonic acidemia (MMA) industry global market size, regional shares, competitors with the methylmalonic acidemia (MMA) market share, detailed methylmalonic acidemia (MMA) market segments, market trends, and opportunities, and any further data you may need to thrive in the methylmalonic acidemia (MMA) industry. This methylmalonic acidemia (MMA) market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The methylmalonic acidemia (MMA) market size has grown strongly in recent years. It will grow from $9.39 billion in 2024 to $9.97 billion in 2025 at a compound annual growth rate (CAGR) of 6.2%. The growth observed in the historical period can be attributed to factors such as the rising incidence of metabolic disorders and vitamin deficiencies, increased healthcare spending, greater health consciousness, a higher prevalence of genetic disorders, and growing demand from various end-user industries.

The methylmalonic acidemia (MMA) market size is expected to see strong growth in the next few years. It will grow to $12.50 billion in 2029 at a compound annual growth rate (CAGR) of 5.8%. The growth projected for the forecast period is driven by factors such as the expansion of newborn screening programs, increased awareness among healthcare professionals, advancements in gene therapy, growing investments in rare disease research, and improved availability of specialized treatments. Key trends expected during this period include advancements in gene editing technologies, enhanced diagnostic techniques for early detection, progress in enzyme replacement therapies, the adoption of precision medicine approaches, and the growing implementation of newborn genetic screening programs.

The rising prevalence of metabolic disorders and vitamin deficiencies is expected to drive the growth of the methylmalonic acidemia (MMA) market. Metabolic disorders are conditions where the body struggles to process certain nutrients, produce energy, or regulate chemical reactions within cells. Vitamin deficiencies occur when the body lacks enough specific vitamins to function properly. The increase in metabolic disorders and vitamin deficiencies is largely attributed to poor diets, sedentary lifestyles, and heightened stress levels. Modern diets, which are often rich in processed foods, sugars, and unhealthy fats while lacking essential nutrients, contribute to deficiencies in vitamins and minerals. These metabolic disorders and vitamin deficiencies, especially vitamin B12 deficiency, disrupt methylmalonyl-CoA metabolism, leading to the buildup of methylmalonic acid and worsening MMA. For example, in November 2024, the National Institutes of Health reported that the prevalence of vitamin B12 deficiency rose from 4.6% to 5.2%, adding 507 cases between the third and fourth quarters of 2023. As a result, the growing incidence of metabolic disorders and vitamin deficiencies is fueling the expansion of the MMA market.

Leading companies in the MMA market are focusing on developing innovative solutions, such as mRNA-based therapies, to improve treatment outcomes by targeting the genetic causes of MMA and enhancing enzyme function to reduce the accumulation of toxic metabolites in affected individuals. mRNA-based therapies use messenger RNA to instruct cells to produce specific proteins that help treat diseases, including genetic disorders. For example, in June 2024, Moderna, Inc., a US-based pharmaceutical and biotechnology company, received FDA approval to include mRNA-3705 in the START pilot program, a significant advancement for rare disease treatments. mRNA-3705 is an investigational therapy for MMA caused by MUT deficiency, designed to restore the missing enzyme using mRNA technology. The therapy uses Moderna's proprietary lipid nanoparticle (LNP) system, also employed in the mRNA-3927 program for propionic acidemia. The FDA has granted mRNA-3705 orphan drug, fast track, and rare pediatric disease designations, expediting its development and clinical progress.

In October 2022, Alexion Pharmaceuticals, a US-based biopharmaceutical company, acquired LogicBio Therapeutics for approximately $68.2 million. This acquisition aims to accelerate Alexion's growth in genomic medicines by utilizing unique technology, a talented rare disease research team, and expertise in preclinical development. LogicBio Therapeutics, Inc. is a US-based biotechnology company specializing in gene-editing and gene therapy solutions for rare genetic diseases, including MMA.

Major players in the methylmalonic acidemia (mma) market are Moderna Inc., Lonza Group Ltd., Alexion Pharmaceuticals Inc., PTC Therapeutics Inc., Ironwood Pharmaceuticals Inc., Wockhardt Limited, Spectrum Chemical Manufacturing Corp., Asklepios BioPharmaceutical Inc. (AskBio), Selecta Biosciences Inc., BTG International Inc., BridgeBio Pharma Inc., VectivBio Holding AG, Supriya Lifescience Ltd., Recordati Rare Diseases Inc., Agios Pharmaceuticals Inc., AdvaCare Pharma USA LLC, LogicBio Therapeutics Inc., HemoShear Therapeutics LLC, Manus Aktteva Biopharma LLP, Deccan Nutraceuticals Pvt. Ltd.

North America was the largest region in the methylmalonic acidemia (MMA) market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in methylmalonic acidemia (MMA) report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the methylmalonic acidemia (MMA) market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The methylmalonic acidemia (MMA) market consists of revenues earned by entities by providing services such as medical management, dietary support, and vitamin and medication therapy. The market value includes the value of related goods sold by the service provider or included within the service offering. The methylmalonic acidemia market includes sales of hydroxocobalamin, vitamin B12 tablets, other pharmaceutical and therapeutic products, dietary products, and diagnostic tools. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Methylmalonic Acidemia (MMA) Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on methylmalonic acidemia (mma) market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for methylmalonic acidemia (mma) ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The methylmalonic acidemia (mma) market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Methylmalonic Acidemia (MMA) Market Characteristics

3. Methylmalonic Acidemia (MMA) Market Trends And Strategies

4. Methylmalonic Acidemia (MMA) Market - Macro Economic Scenario Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics And Covid And Recovery On The Market

5. Global Methylmalonic Acidemia (MMA) Growth Analysis And Strategic Analysis Framework

6. Methylmalonic Acidemia (MMA) Market Segmentation

7. Methylmalonic Acidemia (MMA) Market Regional And Country Analysis

8. Asia-Pacific Methylmalonic Acidemia (MMA) Market

9. China Methylmalonic Acidemia (MMA) Market

10. India Methylmalonic Acidemia (MMA) Market

11. Japan Methylmalonic Acidemia (MMA) Market

12. Australia Methylmalonic Acidemia (MMA) Market

13. Indonesia Methylmalonic Acidemia (MMA) Market

14. South Korea Methylmalonic Acidemia (MMA) Market

15. Western Europe Methylmalonic Acidemia (MMA) Market

16. UK Methylmalonic Acidemia (MMA) Market

17. Germany Methylmalonic Acidemia (MMA) Market

18. France Methylmalonic Acidemia (MMA) Market

19. Italy Methylmalonic Acidemia (MMA) Market

20. Spain Methylmalonic Acidemia (MMA) Market

21. Eastern Europe Methylmalonic Acidemia (MMA) Market

22. Russia Methylmalonic Acidemia (MMA) Market

23. North America Methylmalonic Acidemia (MMA) Market

24. USA Methylmalonic Acidemia (MMA) Market

25. Canada Methylmalonic Acidemia (MMA) Market

26. South America Methylmalonic Acidemia (MMA) Market

27. Brazil Methylmalonic Acidemia (MMA) Market

28. Middle East Methylmalonic Acidemia (MMA) Market

29. Africa Methylmalonic Acidemia (MMA) Market

30. Methylmalonic Acidemia (MMA) Market Competitive Landscape And Company Profiles

31. Methylmalonic Acidemia (MMA) Market Other Major And Innovative Companies

32. Global Methylmalonic Acidemia (MMA) Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Methylmalonic Acidemia (MMA) Market

34. Recent Developments In The Methylmalonic Acidemia (MMA) Market

35. Methylmalonic Acidemia (MMA) Market High Potential Countries, Segments and Strategies

36. Appendix

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