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Congenital Adrenal Hyperplasia Global Market Report 2025
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Congenital adrenal hyperplasia (CAH) is a group of inherited disorders that impact adrenal gland function due to enzyme deficiencies, primarily 21-hydroxylase. Management involves hormone replacement therapy to regulate cortisol and aldosterone levels, suppress excess androgen production, and address symptoms such as electrolyte imbalances and abnormal physical development.

The main types of CAH are classic and non-classic congenital adrenal hyperplasia. Classic CAH is a genetic disorder mainly caused by 21-hydroxylase deficiency, resulting in cortisol deficiency, excess androgen production, and potential aldosterone loss. Diagnosis and treatment take place across various healthcare settings, including hospitals, specialty clinics, ambulatory surgical centers, and research institutes.

The congenital adrenal hyperplasia market research report is one of a series of new reports from The Business Research Company that provides congenital adrenal hyperplasia market statistics, including the congenital adrenal hyperplasia industry global market size, regional shares, competitors with the congenital adrenal hyperplasia market share, detailed congenital adrenal hyperplasia market segments, market trends, and opportunities, and any further data you may need to thrive in the congenital adrenal hyperplasia industry. This congenital adrenal hyperplasia market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The congenital adrenal hyperplasia market size has grown strongly in recent years. It will grow from $0.47 billion in 2024 to $0.50 billion in 2025 at a compound annual growth rate (CAGR) of 7.3%. The growth during the historic period can be credited to the rising prevalence of congenital adrenal hyperplasia, increased adoption of corticosteroid therapies, growing healthcare expenditure, a heightened focus on pediatric care, and expanding government initiatives and reimbursement policies.

The congenital adrenal hyperplasia market size is expected to see strong growth in the next few years. It will grow to $0.66 billion in 2029 at a compound annual growth rate (CAGR) of 7.1%. The growth in the forecast period can be credited to the rising demand for personalized medicine, an increasing incidence of genetic disorders, growing research on congenital adrenal hyperplasia treatments, higher healthcare investments, and the expanding use of telemedicine in managing the condition. Key trends include advancements in healthcare infrastructure, progress in molecular diagnostics, the development of enzyme replacement therapies, the creation of long-acting corticosteroid formulations, and improvements in genetic screening.

The increasing demand for gene therapy is expected to drive the growth of the congenital adrenal hyperplasia market in the coming years. Gene therapy is a medical technique that involves modifying or manipulating an individual's genes to treat or prevent disease. The rising demand for gene therapy is fueled by advancements in genetic research and biotechnology, enabling more precise and targeted treatments for genetic disorders, cancers, and other chronic diseases. Congenital adrenal hyperplasia (CAH), which results from genetic mutations affecting adrenal hormone production, is a key area for gene therapy, offering opportunities for targeted genetic interventions to correct underlying defects and restore normal hormone function. For example, in April 2024, the American Society of Gene and Cell Therapy (ASGCT), a US-based professional membership organization, reported that out of 1,023 gene therapies in development for rare diseases, eight of the top 10 targeted oncological conditions. Additionally, the second quarter of 2024 saw a 25% increase in gene therapy trials, with 76 new studies initiated. This growing demand for gene therapy is contributing to the expansion of the congenital adrenal hyperplasia market.

Leading companies in the congenital adrenal hyperplasia market are focusing on developing innovative treatments such as CRF1 receptor antagonists to regulate cortisol production and reduce adrenal androgen excess. CRF1 receptor antagonists are drugs that block the corticotropin-releasing factor 1 (CRF1) receptor, helping to regulate the body's stress response and control excessive adrenal androgen production in conditions such as CAH. For instance, in December 2024, Neurocrine Biosciences, Inc., a US-based biopharmaceutical company, received FDA approval for crenessity (crinecerfont), the first new treatment for congenital adrenal hyperplasia in 70 years. This oral medication functions as a selective antagonist of corticotropin-releasing factor type 1 receptors, helping to regulate excess adrenocorticotropic hormone (ACTH) and adrenal androgens while allowing for lower glucocorticoid doses. Approval was based on data from the CAHtalyst Phase 3 studies, which demonstrated significant efficacy in reducing androgen levels. Crenessity is expected to be available soon, representing a major advancement in CAH management.

In November 2022, Neurocrine Biosciences, Inc. expanded its portfolio by acquiring Diurnal Group Limited for an undisclosed amount. This acquisition aims to strengthen Neurocrine's presence in hormone therapeutics, accelerate the development of Diurnal's products, and enhance its market position in the UK for chronic endocrine diseases. Diurnal Group Limited, a UK-based biotech company, specializes in developing and commercializing hormone therapeutics for the treatment of chronic endocrine disorders, including congenital adrenal hyperplasia, adrenal insufficiency, hypogonadism, and hypothyroidism.

Major players in the congenital adrenal hyperplasia market are Pfizer Inc., Sanofi S.A., Thermo Fisher Scientific Inc., Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Eton Pharmaceuticals Inc, Teva Pharmaceutical Industries, Macleods Pharmaceuticals, H. Lundbeck A/S, Neurocrine Biosciences Inc., BridgeBio Pharma Inc, Regenxbio Inc., Millendo Therapeutics Inc., Applied Therapeutics, Inc., OMass Therapeutics Limited, ViennaLab Diagnostics GmbH, EffRx Pharmaceuticals SA, Adrenas Therapeutics Inc, HBM Alpha Therapeutics, Spruce Biosciences Inc., and Crinetics Pharmaceuticals Inc.

North America was the largest region in the congenital adrenal hyperplasia market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in congenital adrenal hyperplasia report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the congenital adrenal hyperplasia market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The congenital adrenal hyperplasia market consists of revenues earned by entities by providing services such as telemedicine and remote monitoring, diagnostic testing services, hormone replacement therapy (HRT) services, and surgical interventions. The market value includes the value of related goods sold by the service provider or included within the service offering. The congenital adrenal hyperplasia market also includes sales of glucocorticoids, mineralocorticoids, and adrenal androgens. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Congenital Adrenal Hyperplasia Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on congenital adrenal hyperplasia market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for congenital adrenal hyperplasia ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The congenital adrenal hyperplasia market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Congenital Adrenal Hyperplasia Market Characteristics

3. Congenital Adrenal Hyperplasia Market Trends And Strategies

4. Congenital Adrenal Hyperplasia Market - Macro Economic Scenario Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics And Covid And Recovery On The Market

5. Global Congenital Adrenal Hyperplasia Growth Analysis And Strategic Analysis Framework

6. Congenital Adrenal Hyperplasia Market Segmentation

7. Congenital Adrenal Hyperplasia Market Regional And Country Analysis

8. Asia-Pacific Congenital Adrenal Hyperplasia Market

9. China Congenital Adrenal Hyperplasia Market

10. India Congenital Adrenal Hyperplasia Market

11. Japan Congenital Adrenal Hyperplasia Market

12. Australia Congenital Adrenal Hyperplasia Market

13. Indonesia Congenital Adrenal Hyperplasia Market

14. South Korea Congenital Adrenal Hyperplasia Market

15. Western Europe Congenital Adrenal Hyperplasia Market

16. UK Congenital Adrenal Hyperplasia Market

17. Germany Congenital Adrenal Hyperplasia Market

18. France Congenital Adrenal Hyperplasia Market

19. Italy Congenital Adrenal Hyperplasia Market

20. Spain Congenital Adrenal Hyperplasia Market

21. Eastern Europe Congenital Adrenal Hyperplasia Market

22. Russia Congenital Adrenal Hyperplasia Market

23. North America Congenital Adrenal Hyperplasia Market

24. USA Congenital Adrenal Hyperplasia Market

25. Canada Congenital Adrenal Hyperplasia Market

26. South America Congenital Adrenal Hyperplasia Market

27. Brazil Congenital Adrenal Hyperplasia Market

28. Middle East Congenital Adrenal Hyperplasia Market

29. Africa Congenital Adrenal Hyperplasia Market

30. Congenital Adrenal Hyperplasia Market Competitive Landscape And Company Profiles

31. Congenital Adrenal Hyperplasia Market Other Major And Innovative Companies

32. Global Congenital Adrenal Hyperplasia Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Congenital Adrenal Hyperplasia Market

34. Recent Developments In The Congenital Adrenal Hyperplasia Market

35. Congenital Adrenal Hyperplasia Market High Potential Countries, Segments and Strategies

36. Appendix

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