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Histone Deacetylase Inhibitors Global Market Report 2025
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Histone deacetylase inhibitors are compounds that disrupt the function of histone deacetylases, which are enzymes responsible for removing acetyl groups from histone proteins. This disruption can lead to increased acetylation of histones, resulting in a more relaxed chromatin structure and changes in gene expression.

Histone deacetylase inhibitors are mainly classified into Class I, Class II, Class III, and other types. Histone deacetylases are a group of enzymes that remove acetyl groups from histone proteins, causing chromatin condensation and transcriptional repression. These inhibitors can be administered orally, via injection, and are available through hospital pharmacies, online pharmacies, retail pharmacies, among others. They are useful in various fields such as oncology and neurology, with end users including hospitals, home care settings, specialty clinics, and other facilities.

The histone deacetylase inhibitors market research report is one of a series of new reports from The Business Research Company that provides histone deacetylase inhibitors with a histone deacetylase inhibitors market share, detailed histone deacetylase inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the histone deacetylase inhibitors industry. This histone deacetylase inhibitors market research report delivers a complete perspective on everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The histone deacetylase inhibitors market size has grown strongly in recent years. It will grow from $1.2 billion in 2024 to $1.3 billion in 2025 at a compound annual growth rate (CAGR) of 8.2%. The growth in the historic period can be attributed to regulatory support and fast-track approvals, the growing prevalence of cancer, increased funding for cancer research, the expansion of therapeutic applications, and increased expenditure on healthcare infrastructure.

The histone deacetylase inhibitors market size is expected to see strong growth in the next few years. It will grow to $1.77 billion in 2029 at a compound annual growth rate (CAGR) of 7.9%. The growth in the forecast period can be attributed to growing investment in biotechnology, the growing elderly population, favorable regulatory approvals and faster drug approval processes, improved drug delivery systems, and the expansion of therapeutic applications. Major trends in the forecast period include the integration of wearable devices to monitor patient health, innovations in nanotechnology and drug delivery methods, advances in identifying and validating biomarkers, artificial intelligence (AI) and machine learning, and next-generation sequencing.

The rising incidence of cancer is expected to drive the growth of the histone deacetylase inhibitors market. This increase in cancer cases is largely due to factors such as aging populations, higher exposure to risk factors such as tobacco, diet, and environmental pollutants, and advancements in diagnostic techniques that lead to earlier and more frequent detection. Histone deacetylase inhibitors treat cancer by altering chromatin structure, which activates tumor suppressor genes and suppresses oncogenes, causing cell cycle arrest and apoptosis in cancer cells. For example, in February 2024, the World Health Organization predicted that approximately 35 million new cancer cases would occur in 2050, a 77% increase from the estimated 20 million cases in 2022. Thus, the growing incidence of cancer is boosting the histone deacetylase inhibitors market.

Major companies in the histone deacetylase inhibitors market are focusing on developing innovative product formulations, such as oral histone deacetylase (HDAC) inhibitors, to provide more treatment options and enhance patient convenience and compliance. An oral HDAC inhibitor is a drug taken by mouth that targets HDAC enzymes involved in gene regulation and can be used to treat various diseases, including cancer and inflammatory conditions. For instance, in March 2024, Italfarmaco S.p.A., an Italian pharmaceutical company, received FDA approval for Duvyzat (givinostat), an oral HDAC inhibitor, for treating Duchenne muscular dystrophy (DMD) in patients aged 6 years and older. Duvyzat mitigates muscle damage by reducing inflammation and fibrosis while promoting muscle fiber regeneration, slowing the progression of muscle deterioration associated with DMD. This approval was based on the pivotal phase 3 EPIDYS trial, which showed that patients on Duvyzat had a statistically significant decrease in the time to complete the four-stair climb assessment compared to placebo.

In January 2024, Bristol Myers Squibb, a US-based pharmaceutical company, acquired Mirati Therapeutics Inc. for an undisclosed amount. This acquisition aims to significantly strengthen and diversify Bristol Myers' oncology portfolio, which includes the lung cancer medicine KRAZATI (adagrasib) and a leading KRAS and KRAS-enabling program with two Phase 1 candidates. The goal is to accelerate the development and delivery of innovative cancer treatments and enhance Bristol Myers' long-term growth in oncology. Mirati Therapeutics Inc. is a US-based targeted oncology company specializing in developing cancer therapeutics and histone deacetylase inhibitors.

Major companies operating in the histone deacetylase inhibitors market are Merck & Co. Inc., AstraZeneca plc, Novartis AG, Eisai Co. Ltd., Aurobindo Pharma Limited, Karyopharm Therapeutics Inc., Syndax Pharmaceuticals Inc., MEI Pharma Inc., Italfarmaco S.p.A., Tokyo Chemical Industry Co. Ltd., InvivoGen Corp., Huya Bioscience International LLC, Crystal Genomics Inc., Spectrum Pharmaceuticals Inc., Curis Inc., Celgene Corporation, Celleron Therapeutics, Medivir AB, Onxeo SA, Regenacy Pharmaceuticals Inc., Shenzhen Chipscreen Biosciences Co. Ltd., Wellness Pharma International LLC, Forum Pharmaceuticals Inc., Midatech Pharma PLC

North America was the largest region in the histone deacetylase inhibitors market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the histone deacetylase inhibitors market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

The countries covered in the histone deacetylase inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The histone deacetylase inhibitors market consists of sales of bioinformatics tools, cell culture systems, laboratory equipment, and diagnostic devices. The market value includes the value of related goods sold by the service provider or included within the service offering. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

Histone Deacetylase Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.

This report focuses on histone deacetylase inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.

Reasons to Purchase

Where is the largest and fastest growing market for histone deacetylase inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The histone deacetylase inhibitors market global report from the Business Research Company answers all these questions and many more.

The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.

The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.

Scope

Table of Contents

1. Executive Summary

2. Histone Deacetylase Inhibitors Market Characteristics

3. Histone Deacetylase Inhibitors Market Trends And Strategies

4. Histone Deacetylase Inhibitors Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Covid And Recovery On The Market

5. Global Histone Deacetylase Inhibitors Growth Analysis And Strategic Analysis Framework

6. Histone Deacetylase Inhibitors Market Segmentation

7. Histone Deacetylase Inhibitors Market Regional And Country Analysis

8. Asia-Pacific Histone Deacetylase Inhibitors Market

9. China Histone Deacetylase Inhibitors Market

10. India Histone Deacetylase Inhibitors Market

11. Japan Histone Deacetylase Inhibitors Market

12. Australia Histone Deacetylase Inhibitors Market

13. Indonesia Histone Deacetylase Inhibitors Market

14. South Korea Histone Deacetylase Inhibitors Market

15. Western Europe Histone Deacetylase Inhibitors Market

16. UK Histone Deacetylase Inhibitors Market

17. Germany Histone Deacetylase Inhibitors Market

18. France Histone Deacetylase Inhibitors Market

19. Italy Histone Deacetylase Inhibitors Market

20. Spain Histone Deacetylase Inhibitors Market

21. Eastern Europe Histone Deacetylase Inhibitors Market

22. Russia Histone Deacetylase Inhibitors Market

23. North America Histone Deacetylase Inhibitors Market

24. USA Histone Deacetylase Inhibitors Market

25. Canada Histone Deacetylase Inhibitors Market

26. South America Histone Deacetylase Inhibitors Market

27. Brazil Histone Deacetylase Inhibitors Market

28. Middle East Histone Deacetylase Inhibitors Market

29. Africa Histone Deacetylase Inhibitors Market

30. Histone Deacetylase Inhibitors Market Competitive Landscape And Company Profiles

31. Histone Deacetylase Inhibitors Market Other Major And Innovative Companies

32. Global Histone Deacetylase Inhibitors Market Competitive Benchmarking And Dashboard

33. Key Mergers And Acquisitions In The Histone Deacetylase Inhibitors Market

34. Recent Developments In The Histone Deacetylase Inhibitors Market

35. Histone Deacetylase Inhibitors Market High Potential Countries, Segments and Strategies

36. Appendix

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