세계의 TIL 요법 시장 : 적응증별, 주요 기업별, 주요 지역별 - 업계 동향과 세계 예측(-2035년)

Global TIL Therapies Market by Target Indication, Key Players and Key Geographical Regions : Industry Trends and Global Forecasts, Till 2035

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한글목차

세계의 TIL 요법 시장 규모는 2035년까지의 예측 기간 중 40%의 CAGR로 확대하며, 현재 8,700만 달러에서 2035년까지 50억 달러로 성장할 것으로 예측됩니다.

최근 종양침윤림프구(TIL) 기반 치료의 발전은 다양한 종양학 및 비종양학 질환의 치료에 대한 혁신적 치료의 잠재력을 부각시키고 있습니다. 암 특이적 항원에 미리 감작된 이 매우 특이적이고 유망한 세포 치료법은 암 치료에 혁명을 가져올 것으로 기대되고 있습니다. 현재 여러 지역에서 100개 이상의 TIL 치료 임상시험이 진행 중이며, TIL 치료의 임상적 이점과 치료 가능성을 지원하는 많은 증거를 바탕으로 여러 투자자들이 30개 임상시험에 27억 달러 이상을 투자하고 있습니다. 또한 임상적 성공은 현재 진행 중인 치료 개발 구상을 지원하기 위한 투자를 유치할 가능성이 높습니다. 유망한 임상시험 결과, 지속적인 기술 혁신의 속도, 투자자들의 충분한 재정적 지원에 힘입어 TIL 치료 시장은 예측 기간 중 큰 성장을 이룰 것으로 보입니다.

75개 이상의 TIL 기반 치료제가 다양한 암 질환의 치료를 위해 단독 또는 다른 약물과 병용하여 전임상/임상 개발의 다양한 단계에서 평가되고 있습니다.

현재 약 55명의 유명 대학 과학자들이 TIL 기반 임상 개발에 참여하고 있으며, 이들 KOL의 대부분은 주로 미국과 중국에 기반을 두고 있으며, 약 200개 기업이 다양한 유형의 세포 치료제를 제조하는 데 필요한 역량을 보유하고 있다고 주장하고 있습니다. 이러한 기업은 제품 개발의 여러 단계에 걸쳐 다양한 서비스를 제공하고 있으며, TIL 기반 치료제 개발에 대한 관심 증가는 최근 수년간 R&D 계약 증가를 통해 알 수 있습니다. T세포 면역치료의 잠재력을 본 여러 투자자들이 30건에 걸쳐 27억 달러를 투자했습니다.

세계의 TIL 요법 시장에 대해 조사했으며, 시장의 개요와 적응증별, 주요 기업별, 주요 지역별 동향 및 시장에 참여하는 기업의 개요 등을 제공하고 있습니다.

목차

제1장 서문

제2장 개요

제3장 서론

제4장 TIL 기반 치료법 : 시장 구도

제5장 임상시험의 분석

제6장 주요 업계 리더

제7장 TIL 기반 치료 프로파일

• 챕터 개요
• LN-144/Lifileucel(Iovance Biotherapeutics)
• LN-145(Iovance Biotherapeutics)
• ITIL-168(Instil Bio)
• LTX-315(Lytix Biopharma)

제8장 파트너십과 협업

제9장 자금조달과 투자 분석

제10장 특허 분석

제11장 사례 연구 : 세포치료 제조

제12장 원가분석

제13장 시장 예측과 기회 분석

제14장 기업 개요

• 챕터 개요
• Cellectis
• Cellular Biomedicine Group
• Iovance Biotherapeutics
• Lytix Biopharma
• Phio Pharmaceuticals

제15장 결론

제16장 이그제큐티브 인사이트

제17장 부록 I : 표 형식 데이터

제18장 부록 II : 기업 및 단체 리스트

KSA

영문 목차

영문목차

GLOBAL TIL THERAPIES MARKET: OVERVIEW

As per Roots Analysis, the global TIL therapy market is estimated to grow from USD 0.087 billion in the current year to USD 5 billion by 2035, at a CAGR of 40% during the forecast period, till 2035.

The market sizing and opportunity analysis has been segmented across the following parameters:

Target Indication

• Melanoma
• Head and Neck Carcinoma
• Chronic Lymphocytic Leukemia
• Sarcoma
• Hepatocellular Carcinoma
• Breast Cancer
• Acute Myeloid Leukemia
• Cervical Carcinoma

Key Geographical Regions

• North America
• Europe
• Asia-Pacific
• Middle East and North Africa
• Latin America
• Rest of the World

Key Players

GLOBAL TIL THERAPIES MARKET: GROWTH AND TRENDS

Recent advancements in modified tumor infiltrating lymphocytes (TIL)-based interventions highlight the potential of these innovative therapies for treating various oncological and non-oncological disorders. This highly specific and promising form of cell therapy, which is pre-sensitized to cancer specific antigens, is anticipated to revolutionize cancer treatment. It is worth noting that more than 100 clinical trials are currently underway to investigate TIL therapies across different geographies. Given the substantial evidence supporting the clinical advantages and therapeutic potential of TIL therapies, several investors have invested over USD 2.7 billion, across 30 instances. Moreover, clinical success is likely to draw in investments that are likely to support the ongoing and anticipated therapy development initiatives. Driven by the encouraging clinical trial results, ongoing pace of innovation and sufficient financial support from investors, the TIL therapy market is likely to witness significant growth during the forecast period.

GLOBAL TIL THERAPIES MARKET: KEY INSIGHTS

The report delves into the current state of the global TIL therapies market and identifies potential growth opportunities within the industry. Some key findings from the report include:

• Over 75 TIL-based therapies are being evaluated across different stages of preclinical / clinical development either as monotherapies or in combination with other drugs for the treatment of various oncological disorders.

• Both industry and non-industry players have demonstrated keen interest in the development of novel TIL-based therapies; further, melanoma emerged as the most popular target indication.
• Majority (56%) of industry players based in North America are actively undertaking efforts for the development / commercialization of TIL-based cell therapies; the industry is dominated by the presence of mid-sized players.
• Over the past decade, close to 95 clinical trials have been registered across different geographies for the evaluation of TIL-based therapies; extensive efforts are underway to improve the successive generations of such therapies.
• Close to 55 scientists from renowned universities are presently involved in the clinical development of TIL-based therapies; majority of these KOLs are primarily based in the US and China.
• Close to 200 players claim to have the required capabilities to manufacture different types of cell therapies; such firms also offer a wide range of services across different stages of product development.
• A growing interest in the development of TIL-based therapies is reflected from the increase in R&D agreements in the last few years; majority of the such deals were signed between players based in North America.
• Several investors, having realized the opportunity within this upcoming segment of T-cell immunotherapy, have invested USD 2.7 billion, across 30 instances.
• More than 165 patents have been filed / granted by various stakeholders in order to protect the intellectual property generated within this field.
• With a growing focus on the development pipeline and encouraging clinical results, the market is expected to witness an annualized growth rate of 40% in the next decade.

GLOBAL TIL THERAPIES MARKET: KEY SEGMENTS

Currently, Melanoma Occupies the Largest Share of the Global TIL Therapies Market

Based on the target indication, the market is segmented into melanoma, head and neck carcinoma, chronic lymphocytic leukemia, sarcoma, hepatocellular carcinoma, breast cancer, acute myeloid leukemia and cervical carcinoma. At present, melanoma holds the maximum share of the global TIL therapies market. This trend is unlikely to change in the near future.

North America Accounts for the Largest Share of the Market

Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America. Currently, North America captures the maximum share of the global TIL therapies market. It is worth highlighting that, over the years, the market in Europe is expected to grow at a higher CAGR.

Example Players in the Global TIL Therapies Market

• Iovance Biotherapeutics
• Bristol-Myers Squibb
• Instil Bio
• Lytix Biopharma
• CAR-T (Shanghai) Cell Biotechnology
• Incyte Corporation
• Prometheus Laboratories

GLOBAL TIL THERAPIES MARKET: RESEARCH COVERAGE

• Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the global TIL therapies market, focusing on key market segments, including [A] target indication, [B] key players and [C] key geographical regions.
• Market Landscape: A comprehensive evaluation of the overall market landscape of TIL therapy, considering various parameters, such as [A] type of developer, [B] phase of development, [C] therapeutic area, [D] key target indications, [E] source of T-cells, [F] route of administration, [G] dosing frequency, [H] target patient segment, [I] type of therapy and [J] developer landscape.
• Drug Profiles: In-depth profiles of mid- to late-stage clinical products (phase I/II or above), focusing on [A] overview of the therapy, [B] its mechanism of action, [C] dosage information, [D] details on the cost and sales information (wherever available), [E] a clinical development plan, and [F] clinical trial results.
• Company Profiles: In-depth profiles of key industry players in TIL therapy market, focusing on [A] company overviews, [B] product portfolio specific to TIL therapies [C] technology portfolio (if available), [D] recent developments related to TIL therapies and [E] the manufacturing capabilities of the companies.
• Clinical Trial Analysis: Examination of completed, ongoing, and planned clinical studies of various TIL therapies based on parameters like [A] trial registration year, [B] enrolled patient population, [C] trial status, [D] trial phase, [E] target patient segment, [F] type of sponsor / collaborator, [G] study design, [H] most active players (in terms of number of registered trials), [I] key focus areas and [J] geography.
• Key Opinion Leaders: An in-depth examination that emphasizes the key opinion leaders (KOLs) within this field includes an evaluation of various principal investigators overseeing clinical trials associated with TIL therapies. In addition, the chapter highlights the most prominent KOLs, based on third-party scoring criteria.
• Partnerships and Collaborations: An analysis of partnerships established in this sector, covering R&D agreements, license agreements (specific to technology platforms and product candidates), manufacturing agreements, clinical trial collaborations and others.
• Funding and Investment Analysis: A detailed evaluation of the investments made into companies having proprietary TIL therapies / technologies, encompassing venture capital financing, capital raised from IPOs and subsequent offerings, grants, and debt financing.
• Patent Analysis: Detailed analysis of various patents filed / granted related to tumor infiltrating lymphocytes based on [A] type of patent (granted and patent applications), [B] patent publication year, [C] geographical distribution, [D] type of player, [E] Cooperative Patent Classification (CPC) symbols, [F] emerging focus areas, [G] leading players (in terms of number of patents) and [H] patent benchmarking. It also includes a detailed patent valuation analysis.
• Case Study: A case study on manufacturing cell therapy products, highlighting the key challenges, and a detailed list of contract service providers and in-house manufacturers involved in this space.
• Cost Price Analysis: A comprehensive discussion on the various factors that are likely to influence the pricing of cell-based therapies. This includes an exploration of different models and approaches that pharmaceutical companies may consider while determining the prices of their lead therapy candidates that are likely to be marketed in the near future.

KEY QUESTIONS ANSWERED IN THIS REPORT

• How many companies are currently engaged in this market?
• Which are the leading companies in this market?
• What kind of partnership models are commonly adopted by industry stakeholders?
• What factors are likely to influence the evolution of this market?
• What is the current and future market size?
• What is the CAGR of this market?
• How is the current and future market opportunity likely to be distributed across key market segments?

REASONS TO BUY THIS REPORT

• The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
• Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
• The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.

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TABLE OF CONTENTS

1. PREFACE

• 1.1. Introduction
• 1.2. Key Market Insights
• 1.3. Scope of the Report
• 1.4. Research Methodology
• 1.5. Key Questions Answered
• 1.6. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION

• 3.1. Chapter Overview
• 3.2. Pillars of Cancer Therapy
• 3.3. Overview of Immunotherapies
• 3.4. Fundamentals of Cancer Immunotherapy
• 3.5. Classification of Cancer Immunotherapies
  • 3.5.1. By Mechanism of Action
  • 3.5.2. By Type of Target
  • 3.5.3. By Approach
  • 3.5.4. By Product Class
• 3.6. T-Cell Immunotherapies
  • 3.6.1. Historical Evolution
  • 3.6.2. Key Considerations for Developing T-Cell Immunotherapies
  • 3.6.3. Strategies Employed for the Redirection of T-Cells
  • 3.6.4. Manufacturing of Engineered T-Cells
  • 3.6.5. T-Cell Transduction and Transfection Methods
• 3.7. Tumor Infiltrating Lymphocyte (TIL)-based Cell Therapy
  • 3.7.1. Development History
  • 3.7.2. Development of TILs Therapy
• 3.8. Key Benefits and Roadblocks
• 3.9. Concluding Remarks

4. TIL-BASED THERAPIES: MARKET LANDSCAPE

• 4.1. Chapter Overview
• 4.2. TIL-based Therapies: Overall Market Landscape
  • 4.2.1. Analysis by Type of Developer
  • 4.2.2. Analysis by Phase of Development
  • 4.2.3. Analysis by Therapeutic Area
  • 4.2.4. Analysis by Key Target Indications
  • 4.2.5. Analysis by Source of T-Cells
  • 4.2.6. Analysis by Route of Administration
  • 4.2.7. Analysis by Dosing Frequency
  • 4.2.8. Analysis by Target Patient Segment
  • 4.2.9. Analysis by Type of Therapy
  • 4.2.10. Most Active Industry Players: Analysis by Number of TIL-based Therapies
  • 4.2.11. Most Active Non-Industry Players: Analysis by Number of TIL-based Therapies
• 4.3. TIL-based Therapies: Overall Developer Landscape
  • 4.3.1. Analysis by Year of Establishment
  • 4.3.2. Analysis by Company Size
  • 4.3.3. Analysis by Location of Headquarters

5. CLINICAL TRIAL ANALYSIS

• 5.1. Chapter Overview
• 5.2. Scope and Methodology
• 5.3. TIL-based Therapies: Clinical Trial Analysis
  • 5.3.1. Analysis by Trial Registration Year
  • 5.3.2. Analysis by Trial Registration Year and Enrolled Patient Population
  • 5.3.3. Analysis by Trial Status
  • 5.3.4. Analysis by Trial Registration Year and Trial Status
  • 5.3.5. Analysis by Trial Phase
  • 5.3.6. Analysis by Trial Phase and Enrolled Patient Population
  • 5.3.7. Analysis by Target Patient Segment
  • 5.3.8. Analysis by Type of Sponsor / Collaborator
  • 5.3.9. Analysis by Study Design
  • 5.3.10. Most Active Industry Players: Analysis by Number of Registered Trials
  • 5.3.11. Most Active Non-Industry Players: Analysis by Number of Registered Trials
  • 5.3.12. Word Cloud Analysis: Emerging Focus Areas
  • 5.3.13. Analysis of Clinical Trials by Geography
  • 5.3.14. Analysis of Enrolled Patient Population by Geography

6. KEY OPINION LEADERS

• 6.1. Chapter Overview
• 6.2. Assumptions and Key Parameters
• 6.3. Methodology
• 6.4. TIL-based Therapies: Key Opinion Leaders
  • 6.4.1. Analysis by Type of Organization
  • 6.4.2. Analysis by Affiliated Organization
  • 6.4.3. Analysis by Qualification
  • 6.4.4. Analysis by Geographical Location of KOLs
  • 6.4.5. KOL Activeness versus KOL Strength
  • 6.4.6. Most Prominent KOLs: Analysis by RA score
  • 6.4.7. Most Prominent KOLs: Comparison of RA Score and Third-Party Score

7. TIL-BASED THERAPY PROFILES

• 7.1. Chapter Overview
• 7.2. LN-144 / Lifileucel (Iovance Biotherapeutics)
  • 7.2.1. Therapy Overview
  • 7.2.2. Clinical Trial Information
  • 7.2.3. Clinical Trial Endpoints
  • 7.2.4. Clinical Trial Results
  • 7.2.5. Estimated Sales Revenues
• 7.3. LN-145 (Iovance Biotherapeutics)
  • 7.3.1. Therapy Overview
  • 7.3.2. Clinical Trial Information
  • 7.3.3. Clinical Trial Endpoints
  • 7.3.4. Clinical Trial Results
  • 7.3.5. Estimated Sales Revenues
• 7.4. ITIL-168 (Instil Bio)
  • 7.4.1. Therapy Overview
  • 7.4.2. Clinical Trial Information
  • 7.4.3. Clinical Trial Endpoints
  • 7.4.4. Clinical Trial Results
  • 7.4.5. Estimated Sales Revenues
• 7.5. LTX-315 (Lytix Biopharma)
  • 7.5.1. Therapy Overview
  • 7.5.2. Clinical Trial Information
  • 7.5.3. Clinical Trial Endpoints
  • 7.5.4. Clinical Trial Results
  • 7.5.5. Estimated Sales Revenues

8. PARTNERSHIPS AND COLLABORATIONS

• 8.1. Chapter Overview
• 8.2. Partnership Models
• 8.3. TIL-based Therapies: Partnerships and Collaborations
  • 8.3.1. Analysis by Year of Partnership
  • 8.3.2. Analysis by Type of Partnership
  • 8.3.3. Analysis by Year of Partnership and Type of Partnership
  • 8.3.4. Analysis by Type of Partner
  • 8.3.5. Most Popular Products: Analysis by Number of Partnerships
  • 8.3.6. Most Active Industry Players: Analysis by Number of Partnerships
  • 8.3.7. Most Active Non-Industry Players: Analysis by Number of Partnerships
  • 8.3.8. Analysis by Geography
    • 8.3.8.1. Intercontinental and Intracontinental Agreements
    • 8.3.8.2. International and Local Deals

9. FUNDING AND INVESTMENT ANALYSIS

• 9.1. Chapter Overview
• 9.2. Type of Funding
• 9.3. TIL-based Therapies: Funding and Investment Analysis
  • 9.3.1. Analysis by Year of Investment
  • 9.3.2. Analysis by Amount Invested
  • 9.3.3. Analysis by Type of Funding
  • 9.3.4. Analysis by Type of Investor
  • 9.3.5. Most Active Players: Analysis by Number of Instances
  • 9.3.6. Most Active Investors: Analysis by Amount Invested
  • 9.3.7. Analysis of Amount Invested by Geography
  • 9.3.8. Most Active Investors: Analysis by Number of Funding Instances

10. PATENT ANALYSIS

• 10.1. Chapter Overview
• 10.2. Scope and Methodology
• 10.3. TIL-based Therapies: Patent Analysis
  • 10.3.1. Analysis by Patent Publication Year
  • 10.3.2. Analysis By Patent Application Year
  • 10.3.3. Analysis by Geography
  • 10.3.4. Analysis by Type of Player
  • 10.3.5. Analysis by CPC Symbols
  • 10.3.6. Word Cloud Analysis: Emerging Focus Areas
  • 10.3.7. Leading Players: Analysis by Number of Patents
  • 10.3.8. TIL-based Therapies: Patent Benchmarking
  • 10.3.9. Analysis By Patent Characteristics
  • 10.3.10. TIL-based Therapies: Patent Valuation

11. CASE STUDY: CELL THERAPY MANUFACTURING

• 11.1. Chapter Overview
• 11.2. Overview of Cell Therapy Manufacturing
• 11.3. Cell Therapy Manufacturing Models
  • 11.3.1. Centralized Manufacturing Model
  • 11.3.2. Decentralized Manufacturing Model
• 11.4. Scalability of Cell Therapy Manufacturing Processes
  • 11.4.1. Scale-Up
  • 11.4.2. Scale-Out
• 11.5. Types of Cell Therapy Manufacturers
• 11.6. Key Challenges Related to Manufacturing of Cell Therapies
• 11.7. Important Factors for Cell Therapy Manufacturing
  • 11.7.1. Characterization
  • 11.7.2. Cost of Goods
• 11.8. Automation of Cell Therapy Manufacturing Process
• 11.9. Cell Therapy Manufacturing Supply Chain
• 11.10. Comparison of Player Having In-House Capabilities and Contract Manufacturers
• 11.11. Regulatory Landscape
• 11.12. Future Perspectives

12. COST PRICE ANALYSIS

• 12.1. Chapter Overview
• 12.2. Factors Contributing to the High Price of Cell / Gene Therapies
• 12.3. Pricing Models for T-Cell Immunotherapies
  • 12.3.1. Based on Associated Costs
  • 12.3.2. Based on Availability of Competing Products
  • 12.3.3. Based on Patient Segment
  • 12.3.4. Based on Opinions of Industry Experts
• 12.4. Reimbursement related Considerations for T-Cell Immunotherapies

13. MARKET FORECAST AND OPPORTUNITY ANALYSIS

• 13.1. Chapter Overview
• 13.2. Scope and Limitations
• 13.3. Key Assumptions and Forecast Methodology
• 13.4. Global TIL-Based Therapies Market, since 2022
  • 13.4.1. TIL-based Therapies Market: Analysis by Target Indication
  • 13.4.2. TIL-based Therapies Market: Analysis by Key Players
  • 13.4.3. TIL-based Therapies Market: Analysis by Key Geographical Regions
  • 13.4.4. Product Wise Sales Forecast
    • 13.4.4.1. Lifileucel / LN-144 (Iovance Biotherapeutics)
      • 13.4.4.1.1. Sales Forecast (USD Million)
      • 13.4.4.1.2. Net Present Value (USD Million)
      • 13.4.4.1.3. Value Creation Analysis
    • 13.4.4.2. LN-145 (Iovance Biotherapeutics)
      • 13.4.4.2.1. Sales Forecast (USD Million)
      • 13.4.4.2.2. Net Present Value (USD Million)
      • 13.4.4.2.3. Value Creation Analysis
    • 13.4.4.3. LTX-315 and TILs (Lytix Biopharma)
      • 13.4.4.3.1. Sales Forecast (USD Million)
      • 13.4.4.3.2. Net Present Value (USD Million)
      • 13.4.4.3.3. Value Creation Analysis
    • 13.4.4.4. TILs (Prometheus Laboratories)
      • 13.4.4.4.1. Sales Forecast (USD Million)
      • 13.4.4.4.2. Net Present Value (USD Million)
      • 13.4.4.4.3. Value Creation Analysis
    • 13.4.4.5. Donor Lymphocyte Infusion (Incyte)
      • 13.4.4.5.1. Sales Forecast (USD Million)
      • 13.4.4.5.2. Net Present Value (USD Million)
      • 13.4.4.5.3. Value Creation Analysis
    • 13.4.4.6. ITIL-168 (Instil Bio)
      • 13.4.4.6.1. Sales Forecast (USD Million)
      • 13.4.4.6.2. Net Present Value (USD Million)
      • 13.4.4.6.3. Value Creation Analysis
    • 13.4.4.7. IOV-2001 (Iovance Biotherapeutics)
      • 13.4.4.7.1. Sales Forecast (USD Million)
      • 13.4.4.7.2. Net Present Value (USD Million)
      • 13.4.4.7.3. Value Creation Analysis
    • 13.4.4.8. TILs (CAR-T (Shanghai) Cell Biotechnology)
      • 13.4.4.8.1. Sales Forecast (USD Million)
      • 13.4.4.8.2. Net Present Value (USD Million)
      • 13.4.4.8.3. Value Creation Analysis
    • 13.4.4.9. TILs (Bristol-Myers Squibb)
      • 13.4.4.9.1. Sales Forecast (USD Million)
      • 13.4.4.9.2. Net Present Value (USD Million)
      • 13.4.4.9.3. Value Creation Analysis

14. COMPANY PROFILES

• 14.1. Chapter Overview
• 14.2. Cellectis
• 14.3. Cellular Biomedicine Group
• 14.4. Iovance Biotherapeutics
• 14.5. Lytix Biopharma
• 14.6. Phio Pharmaceuticals

15. CONCLUDING REMARKS

16. EXECUTIVE INSIGHTS

17. APPENDIX I: TABULATED DATA

18. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS

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