세계 골이식편 및 골대체물 시장 규모는 2024년 34억 달러에 달했습니다. IMARC 그룹은 향후 2033년까지 52억 달러에 이를 것으로 예상했으며, 2025년부터 2033년까지 5%의 성장률(CAGR)을 나타낼 것으로 예측했습니다. 이 시장은 골관련 질환 증가, 이식편 재료의 급속한 기술 진보, 정형외과 수술 증가, 저침습(MI) 수술 수술에 대한 선호의 고조, 연구개발(R&D)에 있어서의 정부 지원 이니셔티브의 실시 등에 의해 역동적인 성장을 이루고 있습니다.
시장의 성장과 규모: 이 시장은 정형외과 수술과 고도의 골이식재에 대한 수요 증가, 노인 인구 증가, 급속한 기술진보, 골관련 질환 증가 등을 배경으로 안정된 성장을 이루고 있습니다.
주요 시장 성장 촉진요인: 시장 성장에 영향을 미치는 주요 촉진요인으로는 뼈와 관절 질환의 유병률 상승, 이식편 재료의 진보, 정형외과 수술 건수 증가, 저침습 수술(MIS)에 대한 선호가 높아지고, 정부에 의한 지원책의 실시 등이 있습니다.
주요 시장 동향 : 주요 시장 동향은 기존의 이식편에서 질병 전달 및 일관성에 대한 우려에서 합성 골 이식편, 생체적합성 골 이식편, 세포 기반 매트릭스를 사용하는 방향으로의 이동이 진행되는 것을 포함합니다. 게다가, 이식편 제조에서 3차원(3D) 프린팅과 나노기술의 통합이 시장 성장을 뒷받침하고 있습니다.
지리적 동향 : 북미는 고급 의료 인프라, 높은 의료비, 주요 시장 기업의 존재로 시장을 선도하고 있습니다. 다른 지역은 의료비 증가와 건강 관리 인프라 개선으로 큰 성장을 나타냅니다.
경쟁 구도 : 시장 특징은 연구 개발, 전략적 M&A, 세계 전개에 주력하는 주요 기업이 적극적으로 관여하고 있다는 것입니다. 또한 각 회사는 제품의 인지도와 보급률을 높이기 위해 마케팅 및 계몽 활동에 투자하고 있습니다.
과제와 기회: 시장은 엄격한 규제 환경, 첨단 이식 재료의 높은 비용, 특정 이식의 사용에 대한 윤리적 우려 등 다양한 과제에 직면하고 있습니다. 하지만 신흥국 시장에서 혁신적이고 효과적인 뼈 이식 솔루션에 대한 수요가 증가하고 개별화된 고급 이식 재료의 개발이 시장 성장의 새로운 기회를 창출하고 있습니다.
뼈와 관절 장애의 발생률 증가
골다공증, 골관절염, 척추 질환 등 골관절 질환의 유병률 상승은 시장 성장을 뒷받침하는 주요 요인 중 하나입니다. 이에 따라 척추 고정술, 관절 재건술, 외상 수술과 관련된 수술에 필수적이기 때문에 골이식편 및 골대체물을 포함한 효과적인 치료 옵션에 대한 수요 증가가 시장 성장을 뒷받침하고 있습니다. 게다가 관절장애의 영향을 받기 쉬운 노인 인구가 세계적으로 증가하고 있는 것도 시장 성장을 뒷받침하고 있습니다. 이와 함께 운동량의 감소나 영양불량 등의 라이프스타일 요인에 의한 뼈 및 관절장애의 이환율의 상승도 시장 성장에 기여하고 있습니다. 이 외에도 다양한 질병에 대한 인식과 진단률이 높아짐에 따라 골이식편 및 골대체물에 대한 수요 증가도 성장을 가속하는 요인으로 작용하고 있습니다.
급속한 기술 발달
뼈 이식에 사용되는 생체 재료의 발전은 시장 성장을 뒷받침하는 주요 요인입니다. 이에 따라 뼈의 재생과 치유를 효율적으로 돕는 인산칼슘 세라믹, 생체활성 유리, 각종 폴리머 등의 합성 재료와 생체 적합성 재료의 개발이 시장 성장을 뒷받침하고 있습니다. 이러한 재료는 질병 전파 위험 감소, 안정적인 품질, 특정 임상 요구에 맞는 재료 특성의 조정 능력 등 몇 가지 장점이 있습니다. 게다가 3차원(3D) 프린팅과 같은 첨단 기술이 널리 통합되어 수술 결과를 개선하면서 환자의 해부학적 구조와 완벽하게 일치하는 맞춤형 이식편을 만들 수 있게 되면 시장 성장이 촉진될 것으로 예상됩니다. 이에 더해 뼈이식재에 나노기술을 급속히 활용함으로써 자연의 골구조를 보다 충실히 모방하여 골전도성과 생체적합성을 향상시키는 것이 시장 성장을 자극하고 있습니다.
정형외과 수술 증가
스포츠 외상과 사고 증가, 노인 인구 증가로 인해 세계 정형외과 수술의 건수가 증가하고 있는 것이 시장 성장을 가속하는 주요 요인이 되고 있습니다. 또한 척추 고정술, 사지 구제 수술, 재건 수술 등의 수술로 골이식편 및 골대체물의 이용이 증가하고 있는 것도 시장 성장에 밝은 전망을 가져오고 있습니다. 이와 함께 당뇨병이나 류마티스 관절염과 같은 근골격계에 영향을 미치는 만성질환의 유병률 상승으로 인한 정형외과 수술 증가가 시장 성장을 뒷받침하고 있습니다. 이와는 별도로 새로운 수술 수술의 등장과 수술 적응의 확대 등 정형외과 수술의 다양화가 진행되고 있는 것도 시장의 성장에 기여하고 있습니다.
낮은 침습(MI) 수술에 대한 선호도 증가
외과적 외상 경감, 입원 기간 단축, 회복 시간 단축 등 다양한 이점이 있기 때문에 환자와 외과의사 사이에서 저침습 수술(MIS)에 대한 선호가 높아지고 있는 것이 성장을 가속하는 요인으로 작용하고 있습니다. 또한 저침습 수술에 적합한 골이식 제품의 개발과 채용이 동종이식편, 탈회골 매트릭스, 합성이식편 수요를 촉진하여 시장 성장을 크게 뒷받침하고 있습니다. 게다가 보다 정밀하고 효율적인 수술을 가능하게 하는 수술 기구와 영상 기술의 급속한 진보도 성장을 가속하는 요인으로 작용하고 있습니다. 이에 따라 수술의 효율성과 성공률을 높이기 위해 뼈 이식재에 적합한 특수 MIS 도구의 개발이 시장 성장을 가속하고 있습니다.
정부에 의한 지원책의 실시
골이식편 및 골대체물의 연구개발(R&D)에 대한 정부기관이나 헬스케어 조직에 의한 지원 증가는 시장 성장을 가속하는 주요 요인입니다. 여기에는 혁신적인 뼈 이식 솔루션 개발을 지원하는 자금 지원, 보조금, 신제품 및 첨단 제품의 규제 승인 촉진 등이 포함됩니다. 게다가 기술 혁신과 임상 결과의 개선으로 이어지는 연구기관과 업계 기업의 협력 관계 증가가 시장 성장의 원동력이 되고 있습니다. 이에 따라 신제품의 유효성과 안전성을 검증하기 위한 임상시험과 연구를 위한 플랫폼을 제공하는 민관 파트너십 증가가 시장의 성장을 가속하고 있습니다. 이 외에도 신제품 승인 프로세스를 간소화하고 신제품 개발과 관련된 시간과 비용을 크게 줄이는 정책 구현이 시장 성장에 기여합니다.
The global bone graft and substitutes market size reached USD 3.4 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 5.2 Billion by 2033, exhibiting a growth rate (CAGR) of 5% during 2025-2033. The market is experiencing robust growth, driven by the rising incidence of bone-related disorders, rapid technological advancements in graft materials, increasing incidences of orthopedic surgeries, growing preference for minimally invasive (MI) surgical techniques, and the implementation of supportive governmental initiatives in research and development (R&D).
Market Growth and Size: The market is witnessing stable growth, driven by the rising demand for orthopedic surgeries and advanced bone graft materials, growing geriatric population, rapid technological advancements, and the increasing incidences of bone-related diseases.
Major Market Drivers: Key drivers influencing the market growth include the rising prevalence of bone and joint disorders, advancements in graft materials, increasing number of orthopedic surgeries, growing preference for minimally invasive surgeries (MIS), and implementation of supportive government initiatives.
Key Market Trends: The key market trends involve the ongoing shift towards using synthetic and biocompatible bone graft substitutes and cell-based matrices due to concerns over disease transmission and consistency in traditional grafts. Additionally, the integration of three-dimensional (3D) printing and nanotechnology in graft manufacturing is bolstering the market growth.
Geographical Trends: North America leads the market due to its advanced healthcare infrastructure, high healthcare spending, and the presence of major key market players. Other regions are also showing significant growth, fueled by increasing healthcare expenditure and improvements in healthcare infrastructure.
Competitive Landscape: The market is characterized by the active involvement of key players who are focusing on research and development (R&D), strategic mergers and acquisitions, and global expansion. Furthermore, companies are investing in marketing and educational efforts to increase product awareness and adoption.
Challenges and Opportunities: The market faces various challenges, such as stringent regulatory environments, high cost of advanced graft materials, and ethical concerns regarding the use of certain grafts. However, growing demand for innovative and effective bone graft solutions in emerging markets and the development of personalized and advanced graft materials are creating new opportunities for the market growth.
Increasing incidence of bone and joint disorders
The rising prevalence of bone and joint disorders, such as osteoporosis, osteoarthritis, and spinal disorders, is one of the major factors boosting the market growth. In line with this, the growing demand for effective treatment options, including bone grafts and substitutes, as they are crucial in surgeries related to spinal fusions, joint reconstruction, and trauma surgeries, is favoring the market growth. Moreover, the increasing geriatric population across the globe, who are susceptible to joint disorders is propelling the market growth. Along with this, the rising incidence of bone and joint disorders due to lifestyle factors, including reduced physical activity and poor nutrition, is also contributing to the market growth. Besides this, the heightened demand for bone grafts and substitutes due to the growing awareness and diagnosis rates of various conditions is acting as a growth-inducing factor.
Rapid technological advancements
The rising advancements in biomaterials that are used for bone grafting are major factors bolstering the market growth. In line with this, the development of synthetic and biocompatible materials, such as calcium phosphate ceramics, bioactive glasses, and various polymers that efficiently aid in bone regeneration and healing, is providing a thrust to the market growth. They offer several advantages, such as reduced risk of disease transmission, consistent quality, and the ability to tailor the material properties to specific clinical needs. Moreover, the widespread integration of advanced technologies like three-dimensional (3D) printing that enable the creation of customized grafts that perfectly match the patient's anatomy while improving surgical outcomes is anticipated to drive the market growth. Besides this, the rapid utilization of nanotechnology in bone grafting materials to mimic the natural bone structure more closely, offering improved osteoconduction and biocompatibility, is stimulating the market growth.
Increasing cases of orthopedic surgeries
The increasing number of orthopedic surgeries performed across the globe due to the rising prevalence of sports injuries, accidents, and the growing geriatric population, is a major factor propelling the market growth. Moreover, the increasing utilization of bone grafts and substitutes in procedures such as spinal fusion, limb salvage surgeries, and reconstructive surgeries is creating a positive outlook for the market growth. Along with this, the escalation in orthopedic surgeries due to the rising prevalence of chronic diseases that affect the musculoskeletal system, like diabetes and rheumatoid arthritis, is bolstering the market growth. Apart from this, the heightened diversification of orthopedic procedures, including the advent of new surgical techniques and the expansion of surgical indications, are contributing to the market growth.
Growing preference for minimally invasive (MI) surgical procedures
The increasing preference for minimally invasive surgeries (MIS) among patients and surgeons due to its various benefits, such as reduced surgical trauma, shorter hospital stays, and faster recovery times, is acting as a growth-inducing factor. Moreover, the development and adoption of bone grafting products suitable for minimally invasive applications, propelling the demand for allografts, demineralized bone matrices, and synthetic grafts, is providing a considerable boost to the market growth. Additionally, rapid advancements in surgical instruments and imaging technologies, which allow for more precise and efficient surgeries, are acting as a growth-inducing factor. In line with this, the development of specialized MIS tools that are compatible with bone graft materials to enhance the efficiency and success rates of the procedures is fostering the market growth.
Implementation of supportive government initiatives
The increasing support by government bodies and healthcare organizations for research and development (R&D) in bone grafts and substitutes is a major factor fueling the market growth. It includes funding, grants, and facilitation of regulatory approvals for new and advanced products, aiding the development of innovative bone grafting solutions. Moreover, the growing collaboration between research institutions and industry players, leading to technological innovations and improved clinical outcomes, is providing an impetus to the market growth. In line with this, the rising public-private partnerships that provide a platform for clinical trials and studies to validate the efficacy and safety of new products are enhancing the market growth. Apart from this, the imposition of policies that streamline the approval process for new products, significantly reducing the time and cost associated with developing new products, is contributing to the market growth.
Allografts
Machined Allografts
Demineralized Bone Matrix (DBMs)
Bone Graft Substitutes
Bone Morphogenic Proteins (BMPs)
Synthetic Bone Grafts
Cell-based Matrices
Others
Allografts accounts for the majority of the market share
Allografts hold the largest market share as they are extensively used in various orthopedic procedures due to their osteoconductive and osteoinductive properties. They are favored in complex surgeries, such as spinal fusion, due to their ability to mimic natural bone structure and promote new bone growth. Moreover, allografts are available in various forms, including fresh, freeze-dried, and demineralized bone matrices, catering to a wide range of clinical needs. Besides this, the rising preference for allografts due to their effectiveness in facilitating bone healing, thus reducing the risk of patient morbidity associated with autograft harvesting is acting as growth-inducing factors.
Bone graft substitutes comprise synthetic materials or biologically derived products that are used as alternatives to traditional bone grafts. They include ceramics, polymers, and composite materials designed to provide a scaffold for bone growth and reduce the need for autografts or allografts. Moreover, their consistent quality and the elimination of risks related to disease transmission or immune rejection are enhancing the market growth.
Cell-based matrices involve the use of living cells combined with scaffolding materials to promote bone regeneration. They are seeded with a patient's cells or donor cells, making them highly biocompatible and effective in enhancing the bone healing process. Moreover, the widespread integration of stem cell technology and tissue engineering in cell-based matrices is driving the market growth.
Spinal Fusion
Trauma
Joint Reconstruction
Foot and Ankle
Dental Bone Grafting
Craniomaxillofacial
Others
Spinal fusion holds the largest share in the industry
Spinal fusion represents the largest segment in the market, driven by the increasing prevalence of spinal disorders, such as degenerative disc disease, scoliosis, and spinal stenosis. Bone grafts and substitutes are essential in spinal fusion surgeries for facilitating the fusion of two or more vertebrae to stabilize the spine and alleviate pain. Moreover, the effectiveness of bone grafts in promoting bone growth and healing is creating a positive outlook for the market growth. Besides this, the increasing utilization of demineralized bone matrices, along with synthetic bone graft substitutes in spinal fusion surgeries, due to their osteoconductive properties and ability to integrate with the patient's bone, is supporting the market growth.
Trauma surgeries involve the use of bone grafts and substitutes in the treatment of fractures and bone defects resulting from accidents, injuries, or surgeries. They help in supporting bone healing, especially in cases of complex fractures or where bone loss has occurred. Moreover, the continuous development of high-strength and biocompatible graft materials that provide structural support and enhance the natural healing process, is fueling the market growth.
Joint reconstruction surgeries, such as hip or knee replacements, often require bone grafts for better integration of implants and restoration of joint function. They help fill bone voids and promote bone ingrowth around prosthetic components to ensure the stability and longevity of the implants. Furthermore, the increasing incidence of joint disorders and the growing geriatric population are contributing to the market growth.
In foot and ankle surgeries, bone grafts are used for reconstructive procedures, treating deformities, and healing of fractures. Moreover, the growing demand for specific types of grafts that can conform to the complex anatomy of the foot and ankle, providing structural support and promoting bone regeneration, is boosting the market growth. Besides this, the rising number of sports-related injuries and conditions like arthritis are favoring the market growth.
Dental bone grafting utilizes grafts to augment the jawbone and support dental implants, especially in cases of bone loss due to periodontal disease or tooth extraction. Along with this, the growing utilization of dental bone grafts owing to the increasing popularity of dental implants for missing teeth is stimulating the market growth. Besides this, rapid advancements in graft materials that ensure better integration and stability of the implants are enhancing the market growth.
Craniomaxillofacial involves the application of bone grafts in surgeries related to the skull, face, and jaws. They are essential in reconstructive surgeries, trauma recovery, and congenital disability repairs. Moreover, the development of customized graft solutions that can adapt to the complex geometries of facial bones, ensuring functional and aesthetic outcomes, is propelling the market growth.
Hospitals
Surgical Centres
Clinics
Others
Hospitals represents the leading market segment
Hospitals represent the largest segment due to their comprehensive healthcare services, including advanced surgical procedures that require bone grafts and substitutes. Moreover, they are equipped with advanced facilities and a wide range of medical specialties, making them the preferred choice for complex surgeries, such as spinal fusion, joint reconstruction, and trauma-related procedures. Besides this, the widespread availability of skilled surgeons, multidisciplinary teams, and advanced post-operative care in hospitals is contributing to the market growth. Additionally, hospitals have the infrastructure to support the storage and handling of various types of bone grafts, including those that require specific storage conditions.
Surgical centres are known for procedures that require bone grafting but do not necessitate the extensive resources of a hospital. They include certain types of dental bone grafting, minor joint repairs, and some cosmetic and reconstructive surgeries. Moreover, the heightened focus on minimally invasive (MI) techniques, which reduce patient recovery time and resource utilization, is boosting the market growth.
Clinics include specialized orthopedic and dental clinics that cater to specific procedures that involve bone grafting, such as dental implant placement or minor orthopedic corrections. They provide targeted and specialized care in a more personalized and accessible setting. Additionally, the rising growth in specialized clinics, along with advancements in outpatient surgical techniques, is bolstering the market growth.
North America
Europe
Asia Pacific
Middle East and Africa
Latin America
North America leads the market, accounting for the largest bone graft and substitutes market share
The market research report has also provided a comprehensive analysis of all the major regional markets, which include North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. According to the report, North America accounted for the largest market share.
North America holds the largest market share, due to the high prevalence of bone-related disorders, advanced healthcare infrastructure, and the presence of key market players in the region. In line with this, the increasing number of orthopedic procedures, including spinal fusion and joint reconstruction surgeries, driving the demand for bone grafts and substitutes, is boosting the market growth. Additionally, the rising medical research and innovation, with substantial investments in developing advanced graft materials and surgical techniques, is fueling the market growth. Along with this, the increasing healthcare expenditure and the presence of well-established healthcare systems is contributing to the market growth.
The Europe's market for bone graft and substitutes is driven by factors, such as the growing geriatric population, increasing incidences of osteoporosis and other bone-related conditions, and the adoption of advanced medical technologies. Along with this, the well-developed healthcare system and the presence of some of the leading players in the medical device industry, is fueling the market growth.
The Asia Pacific region is experiencing rapid growth in the market, attributed to the increasing healthcare expenditure, growing awareness of advanced medical treatments, and an expanding geriatric population. Moreover, the rising number of orthopedic procedures due to the growing middle class and improvements in healthcare infrastructure, is also acting as growth-inducing factors.
In Latin America, the market for bone graft and substitutes is growing steadily, driven by the gradual improvement in healthcare infrastructure and increasing accessibility to advanced medical treatments. Besides this, the increasing prevalence of chronic diseases that affect bone health, coupled with a growing focus on healthcare modernization, is strengthening the market growth.
The market in the Middle East and Africa is evolving due to the improving healthcare infrastructure and increasing government initiatives to modernize healthcare services. Along with this, the widespread adoption of advanced medical technologies, including bone grafts and substitutes, in the region is creating a positive outlook for the market growth.
The major players are engaged in various strategic initiatives to strengthen their market position and respond to the evolving medical needs in orthopedics. They are investing in research and development (R&D) to innovate and improve their product offerings by focusing on developing advanced materials that are more biocompatible, osteoconductive, and osteoinductive. Besides this, the leading firms are emphasizing creating synthetic and hybrid grafts that combine the benefits of natural bone tissue with the versatility and safety of synthetic materials. Moreover, they are expanding their reach through mergers and acquisitions, partnerships with healthcare providers, and collaborations with research institutions to enhance their technological capabilities and market access.
The market research report has provided a comprehensive analysis of the competitive landscape. Detailed profiles of all major companies have also been provided. Some of the key players in the market include:
Zimmer Biomet Dental
DePuy Synthes
Wright Medical Technology
Medtronic Plc.
Stryker Corporation
NuVasive Inc.
Arthrex Inc.
Integra LifeSciences
Baxter International Inc.
Musculoskeletal Transplant Foundation
Bacterin International Holdings
SeaSpine
LifeNet Health