세계의 아포토시스 어세이 시장(2023-2030년)

Global Apoptosis Assays Market - 2023-2030

US $ 4,350 ￦ 6,122,000

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한글목차

개요

아포토시스 어세이는 카스파제 활성화, 포스파티딜세린(PS)의 세포 표면 노출, DNA 단편화 등 프로그램된 세포 사멸과 관련된 세포 이벤트를 감지하고 정량화합니다. 세포사멸은 Annexin V, 카스파제, TUNEL DNA 단편화 분석을 통해 프로그램된 세포 사멸을 감지하고 평가합니다.

세포 기반 분석은 세포 사멸의 타임라인에 걸쳐 특정 세포 사멸 과정을 감지합니다. 세포 사멸 분석 키트 및 시약은 세포 수명주기의 자연스러운 부분인 프로그램된 세포 사멸을 조사하는 데 사용할 수 있습니다.

시장 역학

혁신적인 아포토시스 어세이 키트 증가가 시장 성장을 촉진할 것으로 예상됩니다.

아포토시스 어세이 키트는 아포토시스 세포, 괴사 세포 및 정상 세포를 동시에 모니터링하도록 설계되었습니다. 혁신적인 아포토시스 키트는 첨단 기술과 기술 절차를 제공하여 조사 시간을 단축시킵니다. 이러한 요인들은 키트에 대한 수요를 증가시켜 시장 성장을 주도하고 있습니다.

예를 들어 2022년 12월 9일, TransGen은 유세포 분석 또는 형광 현미경을 이용한 조기 세포 사멸 검출을 위해 서로 다른 프로브와 염료를 사용하는 4유형의 Annexin V 검사 키트를 발표했습니다. 이 키트는 조작이 간단하고 민감하고 특이적이어서 세포의 초기 세포 사멸을 감지하는 데 적합합니다.

또한 2022년 9월 20일, 나노라이브는 세포의 건강, 죽음, 세포사멸, 세포괴사를 라벨 없이 프로파일링하는 푸시 버튼식 자동화 솔루션인 LIVE 세포사멸 분석법을 판매했습니다. 머신러닝(ML) 알고리즘을 기반으로 세포 객체를 완전히 라벨 없이 생사를 분류하고, 세포사멸 세포와 괴사 세포를 구분합니다.

또한 새로운 치료제 증가와 첨단 치료법 개발을 위한 암 연구 증가가 시장 성장의 촉진요인으로 작용하고 있습니다.

연구개발에 필요한 높은 투자비용이 시장 성장의 걸림돌로 작용할 것으로 예상됨

항암제 개발 비용이 높으면 분석 비용에 영향을 미칠 수 있습니다. 신약 1종당 평균 연구개발비는 100만 달러 미만에서 200만 달러 이상으로 추정됩니다. 예를 들어 디누툭시맙은 소아위험성 신경모세포종 고형화 후 치료에 사용되는 약물로, 개발 비용은 2억 7,600만 달러에 달할 전망입니다. 이처럼 약물의 높은 개발 비용은 시장 성장에 영향을 미칠 수 있습니다.

목차

제1장 조사 방법과 조사 범위

제2장 정의와 개요

제3장 주요 요약

제4장 시장 역학

• 영향요인
  • 촉진요인
    • 혁신적인 아포토시스 어세이 키트의 증가
  • 억제요인
    • 연구개발에 필요한 고액의 투자
  • 기회
  • 영향 분석

제5장 산업 분석

• Porter's Five Forces 분석
• 공급망 분석
• 가격 분석
• 규제 분석
• 러시아·우크라이나 전쟁의 영향 분석
• DMI의 견해

제6장 COVID-19 분석

제7장 제품별

• 어세이 키트
  • DNA 단편화 어세이
  • Annexin V·세포 투과성 어세이
  • 미토콘드리아 어세이
• 시약
• 마이크로플레이트

제8장 탐지 기술별

• 유세포분석
• 세포 이미징·현미경
• 분광광도법
• 기타

제9장 용도별

• Drug Discovery·의약품 개발
• 임상·진단 용도
• 줄기세포 연구
• 기타

제10장 최종사용자별

• 병원·진단 연구소
• 제약·바이오테크놀러지 기업
• 학술·연구기관
• 기타

제11장 지역별

• 북미
  • 미국
  • 캐나다
  • 멕시코
• 유럽
  • 독일
  • 영국
  • 프랑스
  • 이탈리아
  • 스페인
  • 기타 유럽
• 남미
  • 브라질
  • 아르헨티나
  • 기타 남미
• 아시아태평양
  • 중국
  • 인도
  • 일본
  • 호주
  • 기타 아시아태평양
• 중동 및 아프리카

제12장 경쟁 구도

• 경쟁 시나리오
• 시장 현황/점유율 분석
• M&A 분석

제13장 기업 개요

• Thermo Fisher Scientific Inc.
  • 기업 개요
  • 제품 포트폴리오와 설명
  • 재무 개요
  • 주요 동향
• Elabscience Biotechnology Inc.
• Bio-Rad Laboratories
• Merck KGaA
• Molecular Devices, LLC.
• Becton, Dickinson, and Company
• Bio-Techne Corporation.
• Promega Corporation.
• BPS Bioscience Inc.
• Agilent Technologies, Inc.

제14장 부록

KSA

영문 목차

영문목차

Overview

Apoptosis assay detects and quantifies the cellular events associated with programmed cell death, including caspase activation, cell surface exposure of phosphatidylserine (PS), and DNA fragmentation. Cellular apoptosis assays to detect programmed cell death using Annexin V, Caspase, and TUNEL DNA fragmentation assays.

Cell-based assays detect specific cell death processes across the apoptotic timeline. Apoptosis assay kits and reagents are available for investigations in programmed cell death, a natural part of the cell's life cycle.

Market Dynamics

Increase in the innovative apoptotic assay kits is expected to drive the market growth

Apoptosis Assay Kit is designed to monitor apoptotic, necrotic, and healthy cells simultaneously. Innovative apoptosis kits offer advanced technologies and technological procedures, which reduces the time in research studies. Thus, these factors increase the demand for the kits, which drives the market growth.

For instance, on December 9, 2022, TransGen introduced 4 Annexin V testing kits with different probes and dyes for early apoptosis detection using flow cytometry or fluorescence microscopy. These kits are easy to operate, highly sensitive and specific, and are suitable for detecting early apoptosis of the cells.

Additionally, on September 20, 2022, Nanolive marketed the LIVE Cell Death Assay, a push button, automated solution for profiling cell health, death, apoptosis, and necrosis, label-free. Based on a machine learning (ML) algorithm, it classifies cellular objects completely label-free as living or dead, distinguishing apoptotic and necrotic cells.

Additionally, the increase in novel therapeutics and the increase in the number of cancer research for developing advanced treatments act as driving factors of the market growth.

High investments required in research and development are expected to hamper the market growth

Higher costs of developing a cancer drug can impact the cost of the assays. It is estimated that the average R&D cost per new drug ranges from less than $1 Million to more than $2 Million per drug. For instance, Dinutuximab, a drug used for post-consolidation therapy for childhood-risk neuroblastoma, costs $276 million to develop. Thus, the high cost of developing a drug can affect the market growth.

Segment Analysis

The global apoptosis market is segmented based on product, detection technology, application, end-user, and region.

Flow cytometry holds the largest market share in the global apoptosis assays market

The flow cytometry segment holds a significant position in the apoptosis assay market share due to the efficiency of the technique over the other methods. It is one of the most popular and versatile applications for studying apoptosis. It offers the ability to study large numbers of cells individually rather than in a mixed population, examining simultaneously the expression of many proteins like cell-specific markers and indicators of apoptosis.

It has wide applications in the pharmaceutical industry because it provides a way to understand the drug's mechanism of action in the drug discovery process. To stratify a better target for patients, it is necessary to understand the mechanism of drug action, which flow cytometry does.

On June 3, 2022, BD launched an advanced flow cytometry system that sorts cells based on their inner workings. The new BD FACSDiscover S8 Cell Sorter features the breakthrough BD cell view image technology.

Additionally, it has a variety of applications in research and development. Flow Cytometry detects changes in the plasma and mitochondrial membranes, caspase activity, nuclear condensation, and fragmentation as possible indicators of apoptosis. Flow cytometry allows the study of all aspects of apoptosis, from induction via surface receptors, to late stages where DNA fragmentation occurs. Thus, the above factors allow the usage of a flow cytometer in apoptosis studies. Thus, flow cytometry holds a significant market share.

Geographical Penetration

North America is expected to hold a significant position in the global apoptosis assays market share

An increase in the development of anticancer drugs in the region is expected to hold the region in the dominant market share. Apoptosis assays elucidate the cell death-related events during tumor cell killing by anti-cancer drugs. Apoptosis assays are available for single and multi-time point analysis as well as real-time live-cell imaging. Many anticancer drugs are designed to kill cells by inducing apoptosis.

The increase in the number of cancer cases is influencing the development and launches of new drugs, thus increasing the region's market share. For instance, according to the American Cancer Society, it is estimated that 1.9 million new cancer cases have been diagnosed and 609,360 cancer deaths in the United States in 2022. Thus, increasing the development of drugs for the treatment of cancer.

An increase in the development and approvals of anticancer drugs increases apoptosis studies to evaluate the mechanism of the drug. For instance, on September 2, 2022, the FDA approved durvalumab in combination with gemcitabine and cisplatin for adult patients with locally advanced or metastatic biliary tract cancer. Thus, the number of anticancer drug approvals is expected to hold the region in the dominant position in the apoptosis assays market

COVID-19 Impact Analysis

COVID-19 has impacted the growth of the apoptosis assays market. The shift of focus to research and developing novel products for treating COVID-19 has created a negative impact on the apoptosis assays market growth. The delay in approvals of the kits has also affected the market growth. The delay in drug discovery has also impacted the apoptosis assays market.

Market Segmentation

By Product

• Assay Kits
  • Caspase assays
  • DNA Fragmentation Assays
  • Annexin V and Cell Permeability Assays

• Mitochondrial Assays
  • Reagents
  • Microplates

By Detection Technology

• Flow Cytometry
• Cell Imaging and Microscopy
• Spectrophotometry
• Others

By Application

• Drug Discovery and Development
• Clinical and Diagnostic Applications
• Stem Cell Research
• Others

By End-User

• Hospital & Diagnostic Laboratories
• Pharmaceutical & Biotechnology Companies
• Academic & Research Institutes
• Others

By Region

• North America
  • U.S.
  • Canada
  • Mexico

• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Rest of Europe

• South America
  • Brazil
  • Argentina
  • Rest of South America

• Asia-Pacific
  • China
  • India
  • Japan
  • Australia
  • Rest of Asia-Pacific

• Middle East and Africa

Competitive Landscape

The global apoptosis assays market is fragmented, with the presence of many local and international players. Thermo Fisher Scientific Inc., Elabscience Biotechnology Inc., Bio-Rad Laboratories, Merck KGaA, Molecular Devices, LLC., Becton, Dickinson, and Company, Bio-Techne Corporation., Promega Corporation., BPS Bioscience Inc., and Agilent Technologies, Inc. are the leading companies with a significant market share.

Why Purchase the Report?

• To visualize the global apoptosis assays market segmentation based on product, detection technology, application, end-user, and region, as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development.
• Excel data sheet with numerous data points of apoptosis assays market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.

The global apoptosis assays market report would provide approximately 59 tables, 70 figures, and 186 Pages.

Target Audience 2023

• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies

Table of Contents

1. Methodology and Scope

• 1.1. Research Methodology
• 1.2. Research Objective and Scope of the Report

2. Definition and Overview

3. Executive Summary

• 3.1. Snippet by Product
• 3.2. Snippet by Detection Technology
• 3.3. Snippet by Application
• 3.4. Snippet by End-User
• 3.5. Snippet by Region

4. Dynamics

• 4.1. Impacting Factors
  • 4.1.1. Drivers
    • 4.1.1.1. Increase in the innovative apoptotic assay kits
  • 4.1.2. Restraints
    • 4.1.2.1. High investments required in research and developments
  • 4.1.3. Opportunity
  • 4.1.4. Impact Analysis

5. Industry Analysis

• 5.1. Porter's Five Force Analysis
• 5.2. Supply Chain Analysis
• 5.3. Pricing Analysis
• 5.4. Regulatory Analysis
• 5.5. Russia-Ukraine War Impact Analysis
• 5.6. DMI Opinion

6. COVID-19 Analysis

• 6.1. Analysis of COVID-19
  • 6.1.1. Scenario Before COVID
  • 6.1.2. Scenario During COVID
  • 6.1.3. Scenario Post COVID
• 6.2. Pricing Dynamics Amid COVID-19
• 6.3. Demand-Supply Spectrum
• 6.4. Government Initiatives Related to the Market During Pandemic
• 6.5. Manufacturers Strategic Initiatives
• 6.6. Conclusion

7. By Product

• 7.1. Introduction
  • 7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
  • 7.1.2. Market Attractiveness Index, By Product
• 7.2. Assay Kits *
  • 7.2.1. Introduction
  • 7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
  • 7.2.3. DNA Fragmentation Assays
  • 7.2.4. Annexin V and Cell Permeability Assays
  • 7.2.5. Mitochondrial Assays
• 7.3. Reagents
• 7.4. Microplates

8. By Detection Technology

• 8.1. Introduction
  • 8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 8.1.2. Market Attractiveness Index, By Application
• 8.2. Flow Cytometry *
  • 8.2.1. Introduction
  • 8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
• 8.3. Cell Imaging and Microscopy
• 8.4. Spectrophotometry
• 8.5. Others

9. By Application

• 9.1. Introduction
  • 9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 9.1.2. Market Attractiveness Index, By Application
• 9.2. Drug Discovery and Development *
  • 9.2.1. Introduction
  • 9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
• 9.3. Clinical and Diagnostic Applications
• 9.4. Stem Cell Research
• 9.5. Others

10. By End-User

• 10.1. Introduction
  • 10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
  • 10.1.2. Market Attractiveness Index, By End-User
• 10.2. Hospital & Diagnostic Laboratories *
  • 10.2.1. Introduction
  • 10.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
• 10.3. Pharmaceutical & Biotechnology Companies
• 10.4. Academic & Research Institutes
• 10.5. Others

11. By Region

• 11.1. Introduction
  • 11.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
  • 11.1.2. Market Attractiveness Index, By Region
• 11.2. North America
  • 11.2.1. Introduction
  • 11.2.2. Key Region-Specific Dynamics
  • 11.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
  • 11.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
  • 11.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 11.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
  • 11.2.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
    • 11.2.7.1. U.S.
    • 11.2.7.2. Canada
    • 11.2.7.3. Mexico
• 11.3. Europe
  • 11.3.1. Introduction
  • 11.3.2. Key Region-Specific Dynamics
  • 11.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
  • 11.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
  • 11.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 11.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
  • 11.3.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
    • 11.3.7.1. Germany
    • 11.3.7.2. UK
    • 11.3.7.3. France
    • 11.3.7.4. Italy
    • 11.3.7.5. Spain
    • 11.3.7.6. Rest of Europe
• 11.4. South America
  • 11.4.1. Introduction
  • 11.4.2. Key Region-Specific Dynamics
  • 11.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
  • 11.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
  • 11.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 11.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
  • 11.4.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
    • 11.4.7.1. Brazil
    • 11.4.7.2. Argentina
    • 11.4.7.3. Rest of South America
• 11.5. Asia-Pacific
  • 11.5.1. Introduction
  • 11.5.2. Key Region-Specific Dynamics
  • 11.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
  • 11.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
  • 11.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 11.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
  • 11.5.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
    • 11.5.7.1. China
    • 11.5.7.2. India
    • 11.5.7.3. Japan
    • 11.5.7.4. Australia
    • 11.5.7.5. Rest of Asia-Pacific
• 11.6. Middle East and Africa
  • 11.6.1. Introduction
  • 11.6.2. Key Region-Specific Dynamics
  • 11.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
  • 11.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
  • 11.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
  • 11.6.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User

12. Competitive Landscape

• 12.1. Competitive Scenario
• 12.2. Market Positioning/Share Analysis
• 12.3. Mergers and Acquisitions Analysis

13. Company Profiles

• 13.1. Thermo Fisher Scientific Inc. *
  • 13.1.1. Company Overview
  • 13.1.2. Product Portfolio and Description
  • 13.1.3. Financial Overview
  • 13.1.4. Key Developments
• 13.2. Elabscience Biotechnology Inc.
• 13.3. Bio-Rad Laboratories
• 13.4. Merck KGaA
• 13.5. Molecular Devices, LLC.
• 13.6. Becton, Dickinson, and Company
• 13.7. Bio-Techne Corporation.
• 13.8. Promega Corporation.
• 13.9. BPS Bioscience Inc.
• 13.10. Agilent Technologies, Inc.

LIST NOT EXHAUSTIVE

14. Appendix

• 14.1. About Us and Services
• 14.2. Contact Us

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