ÀÌ º¸°í¼´Â ´Ù¹ß¼º °æÈÁõ(MS) ½ÃÀåÀ» Á¶»çÇßÀ¸¸ç, °æ±¸¿ë Áúȯ Á¶Àý ¿ä¹ý(DMT)ÀÇ ¼èÅð¿Í º¸´Ù È¿°úÀûÀÎ Ä¡·á¹ýÀÇ µîÀå¿¡ ÃÊÁ¡À» ¸ÂÃß¾î ´Ù¹ß¼º °æÈÁõ(MS) Ä¡·áÀÇ ÇöÀç¿Í ¹Ì·¡¸¦ Á¾ÇÕÀûÀ¸·Î ºÐ¼®ÇÕ´Ï´Ù.
º¸°í¼¿¡¼ ´Ù·é ÁÖ¿ä ºê·£µå
- Mavenclad(cladribine)
- Ocrevus (ocrelizumab)
- masitinib
- Gilenya(fingolimod)
- Mayzent(siponimod)
- Kesimpta (ofatumumab)
- Tecfidera(dimethyl fumarate)
- Zeposia(ozanimod)
- Ponvory(ponesimod)
|
- tolebrutinib
- Vumerity(diroximel fumarate)
- Tysabri (natalizumab)
- Briumvi(ublituximab)
- fenebrutinib
- remibrutinib
- Aubagio(teriflunomide)
- vidofludimus calcium
- frexalimab
|
±â¾÷
- Novartis
- Roche
- Sanofi
- AB Science
- Bristol Myers Squibb
- Biogen
- Neuraxpharm
|
- TG Therapeutics
- Vanda
- Merck Group
- Immunic
- ImmuNext
- Juvise Pharmaceuticals
|
¸ñÂ÷
ÁÖ¿ä ¿ä¾à
Ä¡·á ¾Ë°í¸®Áò
Á¶»ç ¸ñÀû
- Ãâ½Ã ÀǾàǰ
- Oral disease-modifying therapies
- Second-generation sphingosine modulators
- Mavenclad (cladribine; Merck Group)
- Tysabri (natalizumab; Biogen)
- Anti-CD20 monoclonal antibodies
- ÆÄÀÌÇÁ¶óÀÎ ÀǾàǰ
- Masitinib(AB Science)
- Tolebrutinib(Sanofi)
- Fenebrutinib(Roche)
- Remibrutinib(Novartis)
- Vidofludimus calcium(IMU-838, Immunic)
- Frexalimab(Sanofi/ImmuNext)
- MS¿¡ÀÇ Á¶±â ´Ü°è Á¢±Ù
ºÎ·Ï
LSH
This report provides a comprehensive analysis of the current and future landscape of multiple sclerosis (MS) therapies, focusing on the decline of oral disease-modifying therapies (DMTs) and the rise of higher-efficacy treatments. It examines the market dynamics of key therapies like Zeposia, Mavenclad, and Tysabri, and explores the potential of emerging treatments such as masitinib and tolebrutinib.
Key questions answered:
- 1. What events are impacting the uptake of oral DMTs?
- 2. How are therapies perceived by the medical community in terms of efficacy, tolerability, and ease of administration?
- 3. Which recently completed or ongoing clinical trials have the greatest potential to affect prescribing trends?
- 4. What will DMTs need to show to become the treatment of choice in specific therapy lines?
- 5. How will the use of each current and pipeline DMT change in the future in terms of line of therapy and preference?
- 6. What will pipeline products need to show in terms of efficacy and tolerability to compete with current therapies?
- 7. Which pipeline products are the most promising, and how will they impact current market players?
- 8. How will the treatment landscape for MS evolve in the future for each patient segment and line of therapy?
Key brands covered in this report:
- Mavenclad (cladribine)
- Ocrevus (ocrelizumab)
- masitinib
- Gilenya (fingolimod)
- Mayzent (siponimod)
- Kesimpta (ofatumumab)
- Tecfidera (dimethyl fumarate)
- Zeposia (ozanimod)
- Ponvory (ponesimod)
|
- tolebrutinib
- Vumerity (diroximel fumarate)
- Tysabri (natalizumab)
- Briumvi (ublituximab)
- fenebrutinib
- remibrutinib
- Aubagio (teriflunomide)
- vidofludimus calcium
- frexalimab
|
Companies:
- Novartis
- Roche
- Sanofi
- AB Science
- Bristol Myers Squibb
- Biogen
- Neuraxpharm
|
- TG Therapeutics
- Vanda
- Merck Group
- Immunic
- ImmuNext
- Juvise Pharmaceuticals
|
Table of Contents
Executive summary
Treatment algorithm
Research objectives
- Marketed drugs
- Oral disease-modifying therapies
- Second-generation sphingosine modulators
- Mavenclad (cladribine; Merck Group)
- Tysabri (natalizumab; Biogen)
- Anti-CD20 monoclonal antibodies
- Pipeline drugs
- Masitinib (AB Science)
- Tolebrutinib (Sanofi)
- Fenebrutinib (Roche)
- Remibrutinib (Novartis)
- Vidofludimus calcium (IMU-838; Immunic)
- Frexalimab (Sanofi/ImmuNext)
- Earlier-stage approaches for MS
Appendix
- KOL details
- KOLs from North America
- KOLs from Europe