전당뇨병 : 시장 인사이트, 역학, 시장 예측(2034년)
Prediabetes - Market Insight, Epidemiology, and Market Forecast - 2034
상품코드 : 1886148
리서치사 : DelveInsight
발행일 : On Demand Report
페이지 정보 : 영문 200 Pages
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한글목차

중요한 하이라이트

전당뇨병 시장 전망

적절한 생활습관 관리 외에도, 전당뇨병 환자들은 약리학적 개입, 즉 인슐린 효과를 강화하고 결국 제2형 당뇨병으로의 진행을 막을 수 있는 당내성 장애(IGT)를 제한하는 대체 접근법을 선택해야 합니다.

메트포르민은 항고혈당제로, 기당뇨 또는 제2형 당뇨병 환자의 기초 및 식후 혈장 포도당 수치를 낮춤으로써 포도당 내성을 개선합니다. 비승인 용도로 처방될 수 있습니다. 메트포르민은 간 포도당 생성을 감소시키고, 장에서의 포도당 흡수를 억제하며, 말초 포도당 흡수 및 이용을 증가시켜 인슐린 감수성을 향상시킵니다. 치료에 사용되는 또 다른 약물군은 경구 복용하는 GLP-1 유사체로, 동일한 수준의 고혈당을 유발하는 정맥 내 포도당 투여 대비 2-3배 높은 혈장 인슐린 반응을 제공합니다.

다음 약물군은 DPP-IV 억제제, 즉 빌다글립틴으로, DPP-4의 촉매 부위에 공유 결합하여 장기간 효소 억제를 유발하는 방식으로 작용합니다. 마지막으로 알파-글루코시다제 억제제(전분 차단제라고도 함)는 식후 혈당 수치를 낮추는 데 도움을 주는 항당뇨병 약물입니다.

전당뇨병 치료제 파이프라인은 그다지 탄탄하지 않으며 중요한 주력 후보 치료제가 부족합니다. 새로운 치료법은 semaglutide(Novo Nordisk), APH-012(Aphaia Pharma) 등을 포함합니다.

본 보고서에서는 전당뇨의 주요 7개 시장(미국, 독일, 스페인, 이탈리아, 프랑스, 영국, 일본)에 대한 조사 분석을 실시하고, 각국 시장 규모와 예측, 각 치료법 시장 점유율, 현재의 치료법, 미충족 필요 등의 정보를 제공합니다.

목차

제1장 중요한 지견

제2장 보고서 개요

제3장 전당뇨병의 주요 요약

제4장 전당뇨의 중요한 사건

제5장 역학과 시장 예측 조사 방법

제6장 전당뇨병 : 시장 개요

제7장 질병 배경과 개요 : 전당뇨병

제8장 치료와 가이드라인

제9장 역학과 환자 인구

제10장 환자 여정

제11장 시판 중인 약품

제12장 신약

제13장 전당뇨병 : 시장 규모

제14장 전당뇨의 미충족 요구

제15장 전당뇨의 SWOT 분석

제16장 전당뇨병에 대한 KOL의 견해

제17장 시장 진입과 보험급여

제18장 부록

제19장 DelveInsight의 서비스 내용

제20장 면책사항

제21장 DelveInsight 정보

HBR
영문 목차

영문목차

Key Highlights:

DelveInsight's "Prediabetes - Market Insight, Epidemiology and Market Forecast - 2034" report delivers an in-depth analysis of Prediabetes epidemiology, market, and clinical development in Prediabetes. In addition to this, the report provides historical and forecasted epidemiology and market data as well as a detailed analysis of the Prediabetes market trends in the United States, EU4 (Germany, France, Italy, and Spain ) and the United Kingdom, and Japan.

Prediabetes market report provides real-world prescription pattern analysis, emerging drugs assessment, market share, and uptake/adoption pattern of individual therapies, as well as historical and forecasted Prediabetes market size from 2020 to 2034 in 7MM. The report also covers current Prediabetes treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's underlying potential.

Geography Covered:

Prediabetes Understanding and Treatment Algorithm

Prediabetes Overview

Prediabetes is a widespread and often silent metabolic condition in which blood sugar levels are elevated above the normal range but not yet high enough for a type 2 diabetes diagnosis. Some lifestyle and genetic factor including obesity, family history of type 2 diabetes sedentary lifestyles, obesity, a family history of the disease, and other genetic and lifestyle variables. Since there are frequently no obvious symptoms, many people are unaware that they have it. Among the symptoms that could be present are increased hunger, weariness, impaired vision, and thirst. By leading a healthy lifestyle, you can avoid prediabetes and the development of type 2 diabetes.

Prediabetes Diagnosis

Most adults start having their diabetes screened at age 35, but if a patient is overweight or has other risk factors, doctors typically advise getting examined earlier. There are three types of testing: haemoglobin A1c, which has values between 5.7% and 6.4%; oral glucose tolerance test, which is less common than other tests, with the exception of pregnancy; and fasting plasma glucose (FPG), whose levels between 100 and 125 mg/dL indicate prediabetes. Since prediabetes frequently has no symptoms, early detection is essential. The diagnosis is typically confirmed by repeat testing on a different day.

Prediabetes Treatment

Changes to one's lifestyle can help prevent or postpone the development of type 2 diabetes. Eating a balanced diet low in added sugars and refined carbs, exercising, decreasing 5-7% of body weight, and consuming nutritious, high-fiber foods. By making these adjustments, the chance of getting diabetes can be decreased by over 50%. Although they have shown promise in clinical trials, newer drugs including as GLP-1 receptor agonists (e.g., tirzepatide, semaglutide) are not yet FDA-approved specifically for prediabetes.

Prediabetes Epidemiology

The Prediabetes epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented as total prevalent cases of prediabetes, total diagnosed prevalent cases of prediabetes, age-specific cases of prediabetes, gender-specific cases of prediabetes, and total treated cases of prediabetes in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain), and the United Kingdom, and Japan from 2020 to 2034.

Prediabetes Drug Chapters

The drug chapter segment of the Prediabetes report encloses a detailed analysis of Prediabetes emerging pipeline drugs. It also deep dives into Prediabetes's pivotal clinical trial details, recent and expected market approvals, patent details, the latest news, and recent deals and collaborations.

Emerging Drugs

Semaglutide: Novo Nordisk

Novo Nordisk is investigating semaglutide 2.4 mg subcutaneous injection in subjects with obesity and prediabetes. It is essentially a GLP-1 receptor agonist. Currently the drug is in Phase III trial.

APH-012: Aphaia Pharma

APH-012 is being evaluated by Aphaia Pharma in a Phase II trial to evaluate its ability to improve glucose tolerance in participants with prediabetes with a pathological Oral Glucose Tolerance Test (OGTT) after 6 weeks of APH-012 administration.

The prevalence of prediabetes and unknown diabetes increases steadily with male sex, age, and body mass index.

Drug Class Insights

GLP-1 receptor agonist

GLP-1 receptor agonists are a class of medications that mimic the action of glucagon-like peptide-1 (GLP-1), an incretin hormone released from the gut in response to food. They enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety, thereby improving blood glucose control and supporting weight loss. These drugs are widely used in type 2 diabetes and obesity treatment. Common GLP-1 receptor agonists include semaglutide (OZEMPIC, WEGOVY). They are typically administered via subcutaneous injection (weekly or daily), although oral semaglutide is also available. According to clinical research, GLP-1 agonists can dramatically reduce fasting glucose and HbA1c in prediabetic people, which may postpone or even stop the onset of Type 2 diabetes. But the common side effects associated with the GLP-1 receptor agonists include nausea, vomiting, diarrhea, and sometimes pancreatitis or gallbladder issues.

Prediabetes Market Outlook

Apart from proper lifestyle management, prediabetic patients need to opt for several pharmacological interventions, i.e., an alternative approach, enhancing insulin impact, and limiting Impaired Glucose Tolerance (IGT) that will eventually obstruct the progression toward T2D.

Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients who are having prediabetes or T2D by lowering both basal and postprandial plasma glucose. It can be prescribed off-label. Metformin decreases hepatic glucose production, intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Another class of drugs used for the treatment includes GLP-1 analogues that are consumed orally and provide two- to three-fold greater plasma insulin response compared to the same level of hyperglycemia enhanced by intravenous glucose.

The next class of medication includes DPP-IV inhibitors, i.e., vildagliptin that works by binding covalently to the catalytic site of DPP-4, eliciting prolonged enzyme inhibition. Lastly, alpha-glucosidase inhibitors, sometimes referred to as starch blockers, are antidiabetic medicines that help to reduce postmeal blood-glucose levels.

The pipeline of prediabetes is not so robust and lacks essential key players. Some of the emerging therapies include semaglutide (Novo Nordisk), APH-012 (Aphaia Pharma), and others.

Prediabetes drug uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2025-2034, which depends on the competitive landscape, safety, and efficacy data, along with the order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.

Prediabetes Pipeline Development Activities

The report provides insights into different therapeutic candidates in the emerging stages. It also analyses key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Prediabetes therapies.

KOL Views

To keep up with the real-world scenario in emerging market trends, we take opinions from Key Industry leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts were contacted for insights on the evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake, along with challenges related to accessibility, including Medical/scientific writers, Professors, and Others.

DelveInsight's analysts connected with 20+ KOLs to gather insights; however, interviews were conducted with 10+ KOLs in the 7MM. Centers such as University of Bari, Virginia Mason Medical Center, etc., were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or prediabetes market trends.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of gaps in disease diagnosis, patient awareness, physician acceptability, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

In efficacy, the trial's primary and secondary outcome measures are evaluated; for instance, in event-free survival, one of the most important primary outcome measures is event-free survival and overall survival.

Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Market Access and Reimbursement

Reimbursement may be referred to as the negotiation of a price between a manufacturer and a payer that allows the manufacturer access to the market. It is provided to reduce the high costs and make the essential drugs affordable. Health technology assessment (HTA) plays an important role in reimbursement decision-making and recommending the use of a drug. These recommendations vary widely throughout the seven major markets, even for the same drug. In the US healthcare system, both Public and Private health insurance coverage are included. Also, Medicare and Medicaid are the largest government-funded programs in the US. The major healthcare programs, including Medicare, Medicaid, Health Insurance Program (CHIP), and the state and federal health insurance marketplaces, are overseen by the Centers for Medicare & Medicaid Services (CMS). Other than these, Pharmacy Benefit Managers (PBMs) and third-party organizations that provide services and educational programs to aid patients are also present.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Report:

Prediabetes Report Insights

Prediabetes Report Key Strengths

Prediabetes Report Assessment

FAQs:

Reason to Buy:

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary of Prediabetes

4. Key Events of Prediabetes

5. Epidemiology and Market Forecast Methodology

6. Prediabetes: Market Overview at a Glance

7. Disease Background and Overview: Prediabetes

8. Treatment and Guidelines

9. Epidemiology and Patient Population

10. Patient Journey

11. Marketed Drugs

12. Emerging Drugs

13. Prediabetes: Market Size

14. Unmet Needs of Prediabetes

15. SWOT Analysis of Prediabetes

16. KOL Views of Prediabetes

17. Market Access and Reimbursement

18. Appendix

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

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