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한글목차
주요 하이라이트 :
비소세포폐암의 TRP2 ADC 시장 규모는 2020년부터 2040년까지의 예측 기간 동안 상당한 CAGR을 나타낼 것으로 예측됩니다.
DelveInsight의 2024년 평가에 따르면, 주요 7개국 시장에서 비소세포폐암의 신규 발병 사례는 약 53만 7,700건이었습니다. 발병 인구 증가와 진단 기술의 진보로 이 수는 예측 기간(2025-2040년) 동안 증가할 것으로 예측됩니다.
주요 7개국 중에서 2024년 미국이 가장 많은 NSCLC 신규 발병 사례를 차지했습니다. 일본의 NSCLC 신규 발병수는 EU4·영국 및 미국에 비해 분명히 적은 상황입니다.
2024년 EU4 및 영국에서는 독일이 가장 많은 사례 수(약 57,000건)를 차지하고 스페인이 가장 적게(약 2만 6,600건) 되었습니다.
일본에서는 2024년에 약 12만 1,900건의 NSCLC 사례가 보고되었습니다.
2025년 6월, AstraZeneca는 DATROWAY가 미국에서 승인되었고 EGFR 돌연변이를 갖고 EGFR 표적 치료 및 백금 제형 기반 화학요법을 이미 받은 국소 진행 또는 전이성 NSCLC 성인 환자를 대상으로 사용할 수 있음을 발표했습니다.
또한 2025년 6월, 머크는 ASCO(American Society of Clinical Oncology)에서 데이터를 발표하고 sacituzumab govitecan이 기치 EGFR 변이 비편평 상피 NSCLC 환자에서 주효율(ORR), 무증악 생존기간(PFS), 전체 생존기간(OS)을 유의미하게 향상시켰다는 데이터를 발표했습니다.
이 보고서는 미국, EU4(독일, 프랑스, 이탈리아, 스페인), 영국, 일본의 비소세포폐암의 TRP2 ADC 시장 배경, 경쟁 구도, 시장 동향을 자세히 조사하고 분석합니다.
또한 본 보고서는 현재 치료의 실태, 신규 치료제의 동향, 각 치료제 시장 점유율, 2021년부터 2034년까지의 7MM(주요 7개 시장 : 미국, EU4, 영국, 일본)에 있어서 시장 규모의 현황 및 예측을 제공합니다. 또한 미충족 의료 수요에 대해서도 다루어 시장의 잠재성을 평가하고 최적의 사업 기회를 파악하기 위한 내용이 되고 있습니다.
대상 지역
미국
EU4(독일, 프랑스, 이탈리아, 스페인) 및 영국
일본
조사 기간 : 2021-2034년
조사 범위 :
주요 이벤트, 주요 요약, 표적 집단, 역학, 시장 예측, 환자 여정 및 다양한 바이오마커 검사율에 관한 정보
현재 및 신규 치료제의 종합적 개요, 대응 가능한 환자 집단에 대한 인사이트
비소세포폐암의 TRP2 ADC의 상세한 검토, 시장 규모 추이와 예측, 치료제별 시장 점유율, 상세한 전제조건, 근거
SWOT 분석, 전문가/KOL의 견해, 치료 선호 등에 의한 동향 이해 : 7MM에 있어서의 사업 전략의 책정이 우위
비소세포폐암의 TRP2 ADC 보고서 : 주요 강점
11년간 시장 예측
7MM 시장 예측 : 조사 범위
출시가 끝난 및 신규 치료제의 경쟁 환경
대상 환자군 규모
NSCLC 약제의 침투
주요 시장 예측의 전제조건
승인 및 신규 치료제 프로파일
의사의 견해/KOL의 견해
바이오마커 검사와 환자 여정
질적 분석(SWOT 및 분석가의 견해)
시장 규모 : 치료제별 및 적응증별
기존 및 미래 시장 기회
시장 규모 : 미충족 의료 수요
목차
제1장 중요한 인사이트
제2장 보고서 서문
제3장 비소세포폐암의 TROP2 ADC : 주요 요약
제4장 주요 사건
제5장 주요 7개국의 비소세포폐암의 TROP2 ADC 시장 : 개요
시장 점유율(%) 분포(2024년) : 치료제별
시장 점유율(%) 분포(2034년) : 치료제별
제6장 배경과 개요
제7장 비소세포폐암의 TROP2 ADC : 표적 집단
제8장 비소세포폐암의 TROP2 ADC : 시판 의약품
주요 기업
제품 설명
규제상의 이정표
기타 개발 활동
진행중인 임상 개발
안전성과 유효성
제9장 비소세포폐암의 TROP2 ADC : 신흥 약제
주요 기업
제품 설명
기타 개발 활동
임상 개발
안전성과 유효성
제10장 비소세포폐암의 TROP2 ADC : 주요 7개국 시장 분석
주요 조사 결과
시장 전망
예측의 전제조건
주요 7개국 시장 규모
미국
EU4 및 영국
일본
제11장 비소세포폐암의 TROP2 ADC : 미충족 수요(Unmet Needs)
제12장 SWOT 분석
제13장 KOL의 견해
제14장 시장 접근성 및 보험 적용
제15장 부록
제16장 Delveinsight의 제공 능력
제17장 면책사항
제18장 DelveInsight 정보
KTH
영문 목차
영문목차
Key Highlights:
The TROP2 ADCs in NSCLC Market Size is anticipated to grow with a significant CAGR during the study period (2020-2040).
Based on DelveInsight's assessment in 2024, the 7MM had approximately 537,700 incident cases of NSCLC. These are expected to rise due to the growing incident population and advancements in diagnostic capabilities during the forecast period (2025-2040).
Among the 7MM, the US accounted for the highest incident cases of NSCLC in 2024. Incident cases of NSCLC in Japan are significantly lower than in EU4, the UK, and the US.
In 2024, Germany had the highest number (~57,000) of NSCLC cases among the EU4 and the UK, while Spain had the lowest number (~26,600).
Japan accounted for approximately 121,900 cases of NSCLC in 2024.
In June 2025, AstraZeneca revealed that DATROWAY has been approved in the US to treat adult patients with locally advanced or metastatic EGFR-mutated NSCLC who have previously undergone EGFR-targeted therapy and platinum-based chemotherapy.
In June 2025, Merck shared data at the American Society of Clinical Oncology (ASCO) demonstrating that sacituzumab govitecan significantly enhanced response rates, progression-free survival (PFS), and overall survival (OS) compared to docetaxel in patients with previously treated EGFR-mutant nonsquamous NSCLC.
DelveInsight's "TROP2 ADCs in NSCLC Market Size, Target Population, Competitive Landscape and Market Forecast - 2040" report delivers an in-depth understanding of TROP2 ADCs in NSCLC, addressable patient pool, competitive landscape, and future market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the UK, and Japan.
The TROP2 ADCs in NSCLC market report provides insights around existing treatment practices in patients with TROP2 ADCs in NSCLC, approved (if any) and emerging TROP2 ADCs in NSCLC market size & market share of individual therapies, patient pool eligible for treatment with TROP2 ADCs in NSCLC, along with current and forecasted 7MM TROP2 ADCs in NSCLC market size from 2020-2040 by therapies and by indication. The report also covers current unmet needs and challenges while incorporating new classes in treatment paradigm, variations in accessibility and acceptability of new TROP2 ADCs in NSCLC in different geographies, along with insights on TROP2 ADCs in NSCLC pricing reimbursements to curate the best opportunities and assess the market's potential.
TROP2 ADCs in NSCLC Drugs Market Overview
This segment will provide detailed information beginning with the inhibitor journey from discovery of the mutation or protein expression to its entry into clinical development followed by its upcoming commercial potential in the TROP2 ADCs in NSCLC Drugs Market. This segment will dive into the different indications in TROP2 ADCs in NSCLC Market Size for which the inhibitor is being developed for, which would further give insights on the potential addressable patient population. Moreover, this segment will also give a brief overview around the existing treatment paradigm of the target indications.
TROP2 ADCs in NSCLC Clinical Trials
This section will give in depth information about the existing local and systemic options in the current treatment paradigm of all the potential indications, in which most of the pharmaceutical companies are actively evaluating their inhibitors. Potential of the emerging TROP2 ADCs in NSCLC Market Size in changing the current clinical practice guidelines is crucial to analyze especially when it comes to real world scenario.
It will also include the relevance and importance of incorporation of biomarker testing at varying stages of the disease. It is also important to understand that implementing such tests in routine clinical practice is not uniform in different countries due to issues such as cost, accessibility, reimbursement and non-recommendation in guidelines.
TROP2 ADCs in NSCLC Epidemiology Insights:
Based on DelveInsight's assessment in 2024, the 7MM had approximately 537,700 incident cases of NSCLC. These are expected to rise due to the growing incident population and advancements in diagnostic capabilities during the forecast period (2025-2040).
Among the 7MM, the US accounted for the highest incident cases of NSCLC in 2024. Incident cases of NSCLC in Japan are significantly lower than in EU4, the UK, and the US.
In 2024, Germany had the highest number (~57,000) of NSCLC cases among the EU4 and the UK, while Spain had the lowest number (~26,600).
Japan accounted for approximately 121,900 cases of NSCLC in 2024.
According to Kuo et al. (2025), TROP2 protein expression at any level was observed in 82% to 90% of NSCLC across sample sets; similar proportions of adenocarcinoma and squamous cell carcinoma expressed TROP2.
According to Ganti et al. (2021), from 2010 to 2017 (SEER [2018], the proportion of stage I at diagnosis increased from 24% to 29%, whereas the proportion of stage IV decreased from 48% to 44.1%.
TROP2 ADCs in NSCLC Drug Chapters
The TROP2 ADCs in NSCLC Drugs Market segment encloses a detailed analysis of marketed therapies and late-stage (Phase III and Phase II) therapies. It also helps understand the TROP2 ADCs in NSCLC Clinical Trial details, pharmacological action, agreements and collaborations related to TROP2 ADCs in NSCLC, their approval timelines, patent details, advantages and disadvantages, latest news and press releases.
TROP2 ADCs in NSCLC Marketed Drugs
The TROP2 ADCs in NSCLC marketed drug section will provide detailed drug profiles of already approved therapies. Information around clinical development activities, launch timing, regulatory milestones along with safety and efficacy data of the therapy will be included.
TROP2 ADCs in NSCLC Emerging Drugs
Apart from a comprehensive TROP2 ADCs in NSCLC Market Forecast competitive landscape in tabular form, the emerging drug chapters provides the product details and other development activities of the emerging TROP2 ADCs in NSCLC Market Size under the late and mid-stage of clinical development for various indications.
TRODELVY (sacituzumab govitecan): Gilead Sciences
TRODELVY (sacituzumab govitecan) is a first-in-class TROP2-directed ADC. It is intentionally designed with a proprietary hydrolyzable linker attached to SN-38, a topoisomerase I inhibitor payload. This unique combination delivers potent activity to TROP2-expressing cells and the microenvironment. TRODELVY is also being developed for potential investigational use in metastatic NSCLC.
Currently, TRODELVY is being evaluated in the Phase III EVOKE-03, in combination with KEYTRUDA for patients with metastatic NSCLC With PD-L1 Tumor Proportion Score (TPS) >=50%.
In January 2022, Gilead Sciences entered two clinical trial collaboration and supply agreements with Merck to evaluate the combination of Gilead's TROP2 targeting TRODELVY and Merck's anti-PD-1 therapy KEYTRUDA in first-line metastatic NSCLC.
Sacituzumab Tirumotecan: Merck and Kelun-Biotech
Sacituzumab tirumotecan, developed by Kelun-Biotech and licensed to Merck outside Greater China, is an investigational TROP2-targeting ADC composed of a monoclonal antibody, a topoisomerase I inhibitor payload, and a novel hydrolyzable linker. As of June 30, 2024, Merck is conducting 10 global Phase III trials and Phase II basket studies evaluating sacituzumab tirumotecan alone or in combination for various solid tumors, including NSCLC.
In June 2025, the data of sacituzumab tirumotecan, demonstrating statistically significant and clinically meaningful improvements in response rates and OS compared with docetaxel in previously treated patients with locally advanced or metastatic EGFR-mutant nonsquamous NSCLC, was presented by Merck at ASCO 2025.
In December 2024, the US FDA granted Breakthrough Therapy Designation (BTD) to sacituzumab tirumotecan for patients with advanced or metastatic nonsquamous NSCLC harboring EGFR mutations, whose disease progressed following a Tyrosine Kinase Inhibitor (TKI) and platinum-based chemotherapy.
DB-1305/BNT325: Dualitybio/BioNTech
DB-1305 (BNT325) is a novel TROP2-targeting ADC being co-developed by DualityBio and BioNTech. It is designed to deliver potent cytotoxic agents specifically to TROP2-expressing cancer cells, leveraging the overexpression of TROP2 in a wide range of solid tumors.
Currently, DB-1305/BNT325 is getting evaluated in the Phase II for the slid tumors including patients with NSCLC.
TROP2 ADCs in NSCLC Drug Class Insights
The TROP2 ADCs in NSCLC Drugs Market Insights section will provide comprehensive information on TROP2 ADCs in NSCLC as a class. This will include a broad overview of the class and its role in treating specific conditions. Insights may cover the historical clinical development of TROP2 ADCs in NSCLC, their mechanism of action, their subtypes and future commercial prospects. Additionally, the section will provide detailed information about current trends, challenges, and future prospects for this class of drugs.
TROP2 ADCs in NSCLC Market Outlook
This section will include details on changing TROP2 ADCs in NSCLC market dynamics post initiation of clinical development activities of the inhibitor. It will also provide a detailed summary and comparison of all the therapies being developed by leading players in this space. This section will highlight the advantages of one therapy over the other after assessment based on parameters such as data availability in the form of safety and efficacy, number of patients enrolled in each trial, and trial's inclusion criteria. There will be a Key focus on the importance of development and need for the commercial success of these targeted therapies to achieve treatment goals that physicians and patients are looking for. It will also sum up all the early stage players active in this space.
TROP2 ADCs in NSCLC Drugs Market Uptake
This section focuses on the TROP2 ADCs in NSCLC Drugs Market Uptake rate of potential TROP2 ADCs in NSCLC already launched and expected to be launched in the market during 2020-2040, which depends on the competitive landscape, safety, efficacy data, and order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.
TROP2 ADCs in NSCLC Pipeline Development Activities
The TROP2 ADCs in NSCLC Market report provides insights into TROP2 ADCs clinical trials within Phase III and Phase II stages. It also analyzes key players involved in developing targeted therapeutics.
TROP2 ADCs in NSCLC Pipeline Development Activities
The TROP2 ADCs in NSCLC Market report covers information on collaborations, acquisitions and mergers, licensing, and patent details for TROP2 ADCs in NSCLC.
KOL Views
To keep up with current and future market trends, we incorporate Key physicians, Therapy Area Researcher's, and other Industry Experts' opinions working in the domain through primary research to fill in the data gaps and validate our secondary research. 25+ Key Opinion Leaders (KOLs) were contacted for insights on TROP2 ADCs in NSCLC' incorporation in the evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, drug uptake, along with challenges related to accessibility.
TROP2 ADCs in NSCLC Qualitative Analysis
We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Analyst views. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the analyst's discretion and assessment of the cost analysis and existing and evolving treatment landscape.
TROP2 ADCs in NSCLC Market Access and Reimbursement
This section will include TROP2 ADCs in NSCLC market insights around the standard HTA pricing, recent reformations in 2024 and modifications in reimbursement process in the 7MM. For example, In the United States, a multi payer model exists when it comes to drug pricing regime, which is currently undergoing significant changes, with recent federal legislation, such as the Prescription Drug Pricing Reform provisions of the Inflation Reduction Act, significantly altering the pricing regime under certain federal programs. Whereas in Germany, the market access differs from the systems followed in many other countries as no pricing and reimbursement approval is required during launch of a new therapy.
Moreover, this section will also provide details on reimbursement of approved therapy, if any.
Scope of the TROP2 ADCs in NSCLC Market Report
The TROP2 ADCs in NSCLC Market report covers a segment of key events, an executive summary, target patient pool, epidemiology and TROP2 ADCs in NSCLC market forecast, information around patient journey and varying biomarker testing rates
Additionally, an all-inclusive account of the current and emerging therapies drug chapters, insights on TROP2 ADCs in NSCLC addressable patient pool
A detailed review of the TROP2 ADCs in NSCLC market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report
The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, and treatment preferences that help in shaping and driving the 7MM TROP2 ADCs in NSCLC market.
TROP2 ADCs in NSCLC Market Size of Inhibitors by therapies and indication will be provided
TROP2 ADCs in NSCLC Report Key Strengths
11 Years TROP2 ADCs in NSCLC Market Forecast
The 7MM Coverage for TROP2 ADCs in NSCLC Market Forecast
TROP2 ADCs in NSCLC Competitive Landscape of current and emerging therapies
TROP2 ADCs in NSCLC Total Addressable patient population
TROP2 ADCs in NSCLC Drugs Uptake
Key TROP2 ADCs in NSCLC Market Forecast Assumptions
TROP2 ADCs in NSCLC Approved and Emerging therapy Profiles
Physician's perspectives/KOL opinions
Biomarker testing and Patient journey
Qualitative Analysis (SWOT and Analyst Views)
TROP2 ADCs in NSCLC Market Size by therapy and indication
Existing and Future Market Opportunity
TROP2 ADCs in NSCLC Unmet Needs
FAQs:
What was the TROP2 ADCs in NSCLC total market size, the market size by therapies, market share (%) distribution in 2020, and what would it look like by 2040? What are the contributing factors for TROP2 ADCs in NSCLC market growth?
Which drug is going to be the largest contributor by 2040?
What is the market access and reimbursement scenario of TROP2 ADCs in NSCLC?
What are the pricing variations among different geographies?
How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitations of existing therapies?
Patient acceptability in terms of preferred treatment options as per real-world scenarios?
Reasons to Buy the TROP2 ADCs in NSCLC Market Forecast Report:
The TROP2 ADCs in NSCLC Market report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the TROP2 ADCs in NSCLC Market.
Understand the existing TROP2 ADCs in NSCLC market opportunities and future trends in varying geographies
Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
Highlights of access and reimbursement policies of approved therapies, barriers to accessibility of expensive off-label therapies, and patient assistance programs.
To understand Key Opinion Leaders' perspectives around the accessibility and acceptability of emerging treatment options along with unmet need of current therapies
Details on report methodology, top indications covered, market assumptions, patient journey and KOLs to strengthen the pharmaceutical companies' development and launch strategy.
Table of Contents
1. Key Insights
2. Report Introduction
3. Executive Summary of TROP2 ADCs in NSCLC
4. Key Events
5. TROP2 ADCs in NSCLC Market Overview At A Glance
5.1. Market Share (%) Distribution of TROP2 ADCs in NSCLC By Therapy in 2025
5.2. Market Share (%) Distribution of TROP2 ADCs in NSCLC By Therapy in 2040
6. Background And Overview
7. TROP2 ADCs in NSCLC Target Population
8. TROP2 ADCs in NSCLC Marketed Drugs
8.1. Key Competitors
8.2. Company 1: Product 1
8.2.1. Product Description
8.2.2. Regulatory Milestones
8.2.3. Other Developmental Activities
8.2.4. Ongoing Clinical Development
8.2.5. Safety and Efficacy
8.3. Company 2: Product 2
8.3.1. Product Description
8.3.2. Regulatory Milestones
8.3.3. Other Developmental Activities
8.3.4. Ongoing Clinical Development
8.3.5. Safety and Efficacy
9. TROP2 ADCs in NSCLC Emerging Drugs
9.1. Key Competitors
9.2. Company 1: Product 1
9.2.1. Product Description
9.2.2. Other Development Activities
9.2.3. Clinical Development
9.2.3.1. Clinical Trials Information
9.2.4. Safety and Efficacy
9.3. Company 2: Product 2
9.3.1. Product Description
9.3.2. Other Development Activities
9.3.3. Clinical Development
9.3.3.1. Clinical Trials Information
9.3.4. Safety and Efficacy
10. TROP2 ADCs in NSCLC: The 7MM Analysis
10.1. Key Findings
10.2. TROP2 ADCs in NSCLC Market Outlook
10.3. Key Market Forecast Assumptions
10.4. Total Market Size of TROP2 ADCs in NSCLC in the 7MM
10.4.1. Market Size of TROP2 ADCs in NSCLC By Therapies In the 7MM
10.4.2. Market Size of TROP2 ADCs in NSCLC By Indication In the 7MM
10.6. TROP2 ADCs in NSCLC United States Market Size
10.6.1. Total Market Size of TROP2 ADCs in NSCLC in the United States
10.6.2. Market Size of TROP2 ADCs in NSCLC By Therapies in the United States
10.7. TROP2 ADCs in NSCLC EU4 and the UK Market Size
10.7.1. Total Market Size of TROP2 ADCs in NSCLC in EU4 and the UK
10.7.2. Market Size of TROP2 ADCs in NSCLC By Therapies in EU4 and the UK
10.8. TROP2 ADCs in NSCLC Japan Market Size
10.8.1. Total Market Size of TROP2 ADCs in NSCLC in Japan
10.8.2. Market Size of TROP2 ADCs in NSCLC By Therapies in Japan
11. TROP2 ADCs in NSCLC Unmet Needs
12. SWOT Analysis
13. KOL Views
14. TROP2 ADCs in NSCLC Market Access and Reimbursement
14.1. United States
14.1.1. Centre for Medicare & Medicaid Services (CMS)
14.2. EU4 and the UK
14.2.1. Germany
14.2.2. France
14.2.3. Italy
14.2.4. Spain
14.2.5. United Kingdom
14.3. Japan
14.3.1. MHLW
15. Appendix
15.1. Bibliography
15.2. Report Methodology
16. Delveinsight Capabilities
17. Disclaimer
18. About DelveInsight
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