¼¼°èÀÇ ROS-1 ¾ïÁ¦Á¦ ½ÃÀå : ´ë»ó ȯÀÚ Áý´Ü, °æÀï ±¸µµ, ½ÃÀå ¿¹Ãø(-2034³â)
ROS Proto-oncogene 1 (ROS-1) Inhibitors -Target Population, Competitive Landscape, and Market Forecast-2034
»óǰÄÚµå : 1745756
¸®¼­Ä¡»ç : DelveInsight Business Research LLP
¹ßÇàÀÏ : On Demand Report
ÆäÀÌÁö Á¤º¸ : ¿µ¹® 120 Pages
 ¶óÀ̼±½º & °¡°Ý (ºÎ°¡¼¼ º°µµ)
US $ 7,950 £Ü 10,900,000
PDF (Single User License) help
PDF º¸°í¼­¸¦ 1¸í¸¸ ÀÌ¿ëÇÒ ¼ö ÀÖ´Â ¶óÀ̼±½ºÀÔ´Ï´Ù. Àμ⠰¡´ÉÇϸç Àμ⹰ÀÇ ÀÌ¿ë ¹üÀ§´Â PDF ÀÌ¿ë ¹üÀ§¿Í µ¿ÀÏÇÕ´Ï´Ù.
US $ 11,925 £Ü 16,350,000
PDF (2-3 User License) help
PDF º¸°í¼­¸¦ µ¿ÀÏ »ç¾÷Àå¿¡¼­ 3¸í±îÁö ÀÌ¿ëÇÒ ¼ö ÀÖ´Â ¶óÀ̼±½ºÀÔ´Ï´Ù. Àμ⠰¡´ÉÇϸç Àμ⹰ÀÇ ÀÌ¿ë ¹üÀ§´Â PDF ÀÌ¿ë ¹üÀ§¿Í µ¿ÀÏÇÕ´Ï´Ù.
US $ 15,900 £Ü 21,800,000
PDF (Site License) help
PDF º¸°í¼­¸¦ µ¿ÀÏ »ç¾÷ÀåÀÇ ¸ðµç ºÐÀÌ ÀÌ¿ëÇÒ ¼ö ÀÖ´Â ¶óÀ̼±½ºÀÔ´Ï´Ù. Àμ⠰¡´ÉÇϸç Àμ⹰ÀÇ ÀÌ¿ë ¹üÀ§´Â PDF ÀÌ¿ë ¹üÀ§¿Í µ¿ÀÏÇÕ´Ï´Ù.
US $ 23,850 £Ü 32,700,000
PDF (Global License) help
PDF º¸°í¼­¸¦ µ¿ÀÏ ±â¾÷ÀÇ ¸ðµç ºÐÀÌ ÀÌ¿ëÇÒ ¼ö ÀÖ´Â ¶óÀ̼±½ºÀÔ´Ï´Ù. Àμ⠰¡´ÉÇϸç Àμ⹰ÀÇ ÀÌ¿ë ¹üÀ§´Â PDF ÀÌ¿ë ¹üÀ§¿Í µ¿ÀÏÇÕ´Ï´Ù.


¤± Add-on °¡´É: °í°´ÀÇ ¿äû¿¡ µû¶ó ÀÏÁ¤ÇÑ ¹üÀ§ ³»¿¡¼­ CustomizationÀÌ °¡´ÉÇÕ´Ï´Ù. ÀÚ¼¼ÇÑ »çÇ×Àº ¹®ÀÇÇØ Áֽñ⠹ٶø´Ï´Ù.
¤± º¸°í¼­¿¡ µû¶ó ÃֽŠÁ¤º¸·Î ¾÷µ¥ÀÌÆ®ÇÏ¿© º¸³»µå¸³´Ï´Ù. ¹è¼Û±âÀÏÀº ¹®ÀÇÇØ Áֽñ⠹ٶø´Ï´Ù.

Çѱ۸ñÂ÷

º» º¸°í¼­¿¡¼­´Â ¹Ì±¹, EU 4°³±¹(µ¶ÀÏ, ÇÁ¶û½º, ÀÌÅ»¸®¾Æ, ½ºÆäÀÎ), ¿µ±¹, ÀϺ»¿¡¼­ÀÇ ROS-1 ¾ïÁ¦Á¦ ½ÃÀåÀ» Á¶»çÇßÀ¸¸ç,, ½ÃÀå ¹è°æ, ½ÃÀå µ¿Çâ, ±âÁ¸ ¾à ¹× ½ÅÈï¾àÀÇ °³¿ä, °æÀï ±¸µµ, ½ÃÀå Á¡À¯À², ȯÀÚ¼ö, ½ÃÀå ±Ô¸ð ÃßÀÌ¿Í ¿¹Ãø, ¹ÌÃæÁ· ÀÇ·á ¼ö¿ä, ½ÃÀå Á¢±Ù°ú »óȯ µ¿Çâ µîÀ» Á¤¸®Çß½À´Ï´Ù

ÁÖ¿ä ÇÏÀ̶óÀÌÆ® :

ROS-1 ¾ïÁ¦Á¦ º¸°í¼­ : ÀλçÀÌÆ®

ROS-1 ¾ïÁ¦Á¦ º¸°í¼­ : ÁÖ¿ä °­Á¡

ROS-1 ¾ïÁ¦Á¦ º¸°í¼­ : Æò°¡

¸ñÂ÷

Á¦1Àå Áß¿äÇÑ ÀλçÀÌÆ®

Á¦2Àå º¸°í¼­ ¼Ò°³

Á¦3Àå ROS1 ¾ïÁ¦Á¦: ½ÃÀå °³¿ä

Á¦4Àå ROS1 ¾ïÁ¦Á¦: ÁÖ¿ä ¿ä¾à

Á¦5Àå ROS1 ¾ïÁ¦Á¦: ¿ªÇÐ ¹× ½ÃÀå Á¶»ç ¹æ¹ý

Á¦6Àå ROS1 ¾ïÁ¦Á¦: Áß¿äÇÑ »ç°Ç

Á¦7Àå ROS1 ¾ïÁ¦Á¦: ¹è°æ ¹× °³¿ä

Á¦8Àå ÁÖ¿ä 7°³±¹¿¡¼­ÀÇ ROS1 ¾ïÁ¦Á¦ÀÇ ¿ªÇаú ȯÀÚ Àα¸

Á¦9Àå Á¶»ó½Ã¾à

Á¦10Àå ½ÅÈï¾à

Á¦11Àå ROS1 ¾ïÁ¦Á¦: ÁÖ¿ä 7°³±¹ ºÐ¼®

Á¦12Àå KOL(Key Opinion Leader)ÀÇ °ßÇØ

Á¦13Àå ROS1 ¾ïÁ¦Á¦: SWOT ºÐ¼®

Á¦14Àå ROS1 ¾ïÁ¦Á¦: ¹ÌÃæÁ· ¿ä±¸

Á¦15Àå ½ÃÀå Á¢±Ù°ú »óȯ

Á¦16Àå ºÎ·Ï

Á¦17Àå DelveInsightÀÇ ¼­ºñ½º ³»¿ë

Á¦18Àå ¸éÃ¥»çÇ×

Á¦19Àå DelveInsight Á¤º¸

JHS
¿µ¹® ¸ñÂ÷

¿µ¹®¸ñÂ÷

Key Highlights:

DelveInsight's "ROS Proto-oncogene 1 (ROS-1) Inhibitors -Target Population, Competitive Landscape, and Market Forecast-2034" report delivers an in-depth understanding of the ROS-1 inhibitor, historical and Competitive Landscape, and ROS-1 inhibitor market trends in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.

The ROS-1 inhibitor market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM ROS-1 inhibitor market size from 2020 to 2034. The report also covers current ROS-1 inhibitor treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.

Geography Covered:

Study Period: 2020-2034

ROS Proto-oncogene 1 (ROS-1) Inhibitors Understanding

ROS Proto-oncogene 1 (ROS-1) Inhibitor Overview

ROS-1 inhibitors are TKIs that specifically target the ROS-1 protein, which is often activated in certain types of cancers, particularly NSCLC. ROS-1 (Receptor tyrosine kinase) is a pivotal transmembrane receptor protein tyrosine kinase that regulates several cellular processes like apoptosis, survival, differentiation, proliferation, cell migration, and transformation. Other than NSCLC, it plays an important role in different malignancies, including glioblastoma, CRC, gastric adenocarcinoma, inflammatory myofibroblastic tumors, ovarian cancer, and others. ROS-1 inhibitor is a substance that blocks the activity of an abnormal protein called ROS-1 fusion protein, which is found in some types of cancer cells. Blocking the ROS-1 fusion protein may help keep cancer cells that have it from growing and spreading. Some ROS-1 inhibitors are used to treat cancer. They are a type of targeted therapy. All ROS-1 inhibitors are multi-kinase inhibitors that can inhibit Anaplastic Lymphoma Kinase (ALK), Mesenchymal Epithelial Transition (MET), and other kinases in addition to ROS. ROS-1 kinase inhibitors primarily affect the kinase domain of ROS-1.

Seventy-seven Conventional kinases can be classified into DFG-in (active, type I) and DFG-out (inactive, type II) kinases, depending on the domain conformation.

ROS Proto-oncogene 1 Inhibitor Epidemiology

The ROS-1 inhibitors epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented as total cases in selected indications for ROS-1 inhibitors, total eligible patient pool for ROS-1 inhibitors in selected indications, total treated cases in selected indications for ROS-1 inhibitors in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain), and the United Kingdom, and Japan from 2020 to 2034.

ROS Proto-oncogene 1 Inhibitor Drug Chapters

The drug chapter segment of the ROS-1 inhibitor reports encloses a detailed analysis of ROS-1 inhibitor-marketed drugs and mid and late-stage pipeline drugs. It also helps understand the ROS-1 inhibitor's clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Marketed Drugs

AUGTYRO (repotrectinib): Bristol Myers Squibb

AUGTYRO is an oral prescription medicine developed by Bristol Myers Squibb. It is a kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic ROS-1-positive NSCLC and adult and pediatric patients 11 years of age and older with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion and are locally advanced or metastatic or where surgical resection is likely to result in severe morbidity or has progressed following treatment or have no satisfactory alternative therapy.

In November 2023, the FDA approved AUGTYRO for the treatment of adult patients with locally advanced or metastatic ROS-1-positive NSCLC. In June 2024, the FDA announced its accelerated approval for the treatment of adult and pediatric patients 12 years of age and older with solid tumors that have an NTRK gene fusion, are locally advanced or metastatic, or where surgical resection is likely to result in severe morbidity, and have progressed following treatment or have no satisfactory alternative therapy. The approval is received based on the trial TRIDENT-1. In September 2024, AUGTYRO was approved in Japan for the treatment of ROS-1 fusion gene-positive unresectable advanced or recurrent NSCLC.

ROZLYTREK (enrectinib): GENENTECH

ROZLYTREK is an oral prescription medicine developed by Genentech. It is used to treat adults with NSCLC that has spread to other parts of the body and is caused by an abnormal ROS-1 gene. It is also used to treat adults and children 1 month of age and older with solid tumors (cancer) that are caused by certain abnormal NTRK genes and have spread or if surgery to remove their cancer is likely to cause severe complications.

ROZLYTREK (entrectinib) was approved for ROS-1-positive metastatic NSCLC by the FDA in August 2019, the European Commission (EC) in August 2020 for treatment-naive patients, and in Japan in February 2020 for unresectable, advanced, or metastatic ROS-1 fusion-positive NSCLC.

Emerging Drugs

DOVBLERON (taletrectinib): Nuvation Bio/Innovent Biologics/Daiichi Sankyo/Nippon Kayaku

Taletrectinib is an oral, potent, central nervous system-active, and selective, next-generation ROS-1 inhibitor specifically designed for the treatment of patients with advanced ROS-1-positive NSCLC. The US FDA previously granted taletrectinib Breakthrough Therapy Designation (BRD) for the treatment of patients with locally advanced or metastatic ROS-1 positive NSCLC who either have or have not previously been treated with ROS-1 TKIs, and Orphan Drug Designation (ODD) for the treatment of patients with ROS-1 positive NSCLC and other NSCLC indications. Nuvation Bio has initiated an Expanded Access Program (EAP) for taletrectinib in the US for the treatment of patients with locally advanced or metastatic ROS-1-positive NSCLC when no comparable or satisfactory alternative therapy options are available.

Zidesamtinib (NVL-520): Nuvalent

Zidesamtinib is a novel brain-penetrant ROS-1-selective inhibitor created to overcome several limitations observed with currently available therapies. Zidesamtinib received BTD from the US FDA for the treatment of patients with ROS-1-positive metastatic NSCLC who have been previously treated with two or more ROS-1 TKIs. The Phase II portion of the ARROS-1 Phase I/II (NCT05118789) clinical trial of zidesamtinib for patients with advanced ROS-1-positive NSCLC and other solid tumors is now enrolling.

In April 2025, Nuvalent announced the publication of a manuscript in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, which supports the rational molecular design of zidesamtinib, its novel and selective ROS-1 inhibitor.

Drug Class Insights

The ROS-1 NSCLC current market is mainly dominated by TKIs such as XALKORI at present and is anticipated to be dominated by AUGTYRO, Taletrectinib, and NVL-520 by 2034. XALKORI is a tyrosine kinase receptor inhibitor, targeting the ALK or ROS-1 kinases (proteins), which turn on the ALK or ROS-1 gene, thus preventing the expression of oncogenic fusion proteins from activating gene expression. AUGTYRO is a next-generation TKI known for its efficient ability to cross the blood-brain barrier. Another emerging drug, which is taletrectinib, functions as a comprehensive inhibitor targeting TRK and ROS-1 with selectivity. Taletrectinib has demonstrated activity against the challenging ROS-1 solvent-front mutation G2032R.

ROS Proto-oncogene 1 Inhibitor Market Outlook

The market for ROS-1 inhibitors is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with different types of cancers, the growing awareness of ROS 1 inhibitors, and the increasing number of ROS-1 inhibitors that are under clinical trials and filed for approval by various companies.

ROS-1 inhibitors demonstrate the highest efficacy in treating NSCLC, whether these are established therapies with regulatory approval or emerging treatments. ROS-1 inhibitors have revolutionized the management of NSCLC, representing a pivotal therapeutic approach. Established treatments such as ROZLYTREK and ZYKADIA (off-label) have demonstrated significant efficacy in ROS-1-positive NSCLC, with expanded indications spanning various disease stages. Additionally, experimental drugs like Zidesamtinib (NVL-520) offer potential effects by inhibiting ROS-1, addressing metastatic solid tumors. With ongoing clinical trials and regulatory advancements, the market outlook for ROS-1 inhibitors is promising, fostering continued innovation and progress in prostate cancer therapeutics. This evolution holds the potential to improve patient outcomes and redefine standards of care in NSCLC management globally.

Several key players, including Genentech, Pfizer, Bristol Myers Squibb, Nuvalent, and others, are involved in developing drugs for ROS-1 inhibitors for various indications such as NSCLC, breast cancer, and others. Overall, this is an exciting new class of agents with great potential for development. The maturation of current studies over the next few years will lead to a better understanding of ROS-1 inhibitors and define their role in the therapy of cancer.

ROS Proto-oncogene 1 Inhibitor Drugs Uptake

This section focuses on the uptake rate of potential approved and emerging ROS-1 inhibitors expected to be launched in the market during 2025-2034.

ROS Proto-oncogene 1 Inhibitor Pipeline Development Activities

The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I and analyzes key players involved in developing targeted therapeutics.

The presence of numerous drugs under different stages is expected to generate immense opportunity for ROS-1 inhibitors market growth over the forecasted period.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for ROS-1 inhibitor therapies.

KOL Views

To keep up with current and future market trends, we take Industry Experts' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on ROS-1 inhibitors' evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, drug uptake, along challenges related to accessibility.

DelveInsight's analysts connected with 20+ KOLs to gather insights; however, interviews were conducted with 10+ KOLs in the 7MM. Centers such as Baptist Health Medical Group and others.

Their opinion helps understand and validate current and emerging therapy treatment patterns or ROS-1 inhibitor market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Market Access and Reimbursement

Reimbursement may be referred to as the negotiation of a price between a manufacturer and payer that allows the manufacturer access to the market. It is provided to reduce the high costs and make the essential drugs affordable. Health technology assessment (HTA) plays an important role in reimbursement decision-making and recommending the use of a drug. These recommendations vary widely throughout the seven major markets, even for the same drug.

In the US healthcare system, both Public and Private health insurance coverage are included. Also, Medicare and Medicaid are the largest government-funded programs in the US. The major healthcare programs including Medicare, Medicaid, the Children's Health Insurance Program (CHIP), and the state and federal health insurance marketplaces are overseen by the Centers for Medicare & Medicaid Services (CMS). Other than these, Pharmacy Benefit Managers (PBMs), and third-party organizations that provide services, and educational programs to aid patients are also present.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

The abstract list is not exhaustive, will be provided in the final report

Key Updates on ROS-1 Inhibitor

Scope of the Report:

ROS-1 Inhibitor Report Insights

ROS-1 Inhibitor Report Key Strengths

ROS-1 Inhibitor Report Assessment

Key Questions:

Reasons to buy:

Table of Contents

1. Key Insights

2. Report Introduction

3. ROS Proto-oncogene 1 Inhibitor Market Overview at a Glance

4. Executive Summary of ROS Proto-oncogene 1 Inhibitor

5. Epidemiology and Market Methodology of ROS Proto-oncogene 1 Inhibitor

6. Key Events of ROS Proto-oncogene 1 Inhibitor

7. Background and Overview of ROS Proto-oncogene 1 Inhibitor

8. Epidemiology and Patient Population of ROS Proto-oncogene 1 Inhibitor in 7MM

9. Marketed Drugs

10. Emerging Therapies of ROS Proto-oncogene 1 Inhibitor

11. ROS Proto-oncogene 1 Inhibitor: 7MM Analysis

12. Key Opinion Leaders' Views

13. SWOT Analysis of ROS Proto-oncogene 1 Inhibitor

14. Unmet Needs of ROS Proto-oncogene 1 Inhibitor

15. Market Access and Reimbursement

16. Appendix

17. DelveInsight Capabilities

18. Disclaimer

19. About DelveInsight

(ÁÖ)±Û·Î¹úÀÎÆ÷¸ÞÀÌ¼Ç 02-2025-2992 kr-info@giikorea.co.kr
¨Ï Copyright Global Information, Inc. All rights reserved.
PC¹öÀü º¸±â