파킨슨병 시장 - 시장 인사이트, 역학, 시장 예측(2034년)
Parkinson´s Disease Market Insight, Epidemiology And Market Forecast - 2034
상품코드 : 1605438
리서치사 : DelveInsight
발행일 : On Demand Report
페이지 정보 : 영문 318 Pages
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한글목차

2023년 주요 7개국에서 파킨슨병 진단을 받은 파킨슨병 유병자 수는 약 271만 8,000명입니다. 이 중 미국이 45%, 일본이 9%, 독일이 18%를 차지합니다.

주요 7개국의 파킨슨병 시장 규모는 2023년 약 32억 1,800만 달러에 달했습니다. 이 시장은 2024년부터 2034년까지 예측 기간 동안 상당한 CAGR로 성장할 것으로 예상됩니다.

제약회사들은 더 나은 치료법을 개발하기 위해 적극적으로 노력하고 있습니다. 후기 단계의 치료제로는 Supernus Pharmaceutical과 Britannia Pharmaceutical의 SPN-830(아포몰핀 주입 펌프), AbbVie의 tavapadon, Pharma Two B의 P2B001(서방형 프라미펙솔 및 라사길린), 타나베미쓰비시제약/NeuroDerm의 ND0612(레보도파/카르비도파), Annovis Bio의 Buntanetap/ANVS402/ANVS401 등이 있습니다.

파킨슨 재단에 따르면 파킨슨 병은 신경 퇴행성 질환으로 주로 흑질이라고 불리는 뇌의 특정 영역에있는 도파민 생성(도파민 성) 뉴런을 주로 침범하는 신경 퇴행성 질환입니다. 파킨슨병은 시간이 지남에 따라 진행되기 때문에 단계에 따라 증상이 어떻게 진행되는지, 그리고 다음 단계에 어떤 증상이 나타날지 예측할 수 있습니다. 일반적으로 파킨슨병은 5단계, 즉 1기, 2기, 3기, 4기, 5기, 6기, 7기, 8기, 9기로 나뉩니다.

파킨슨병은 진단이 어려운 질환입니다. 대신 병력, 증상, 신체 검사, 신경학적 검사, 경우에 따라서는 추가 검사의 조합을 바탕으로 진단하는 것이 일반적이며, MRI는 다른 원인을 배제하기 위해서만 사용되기도 합니다. 뇌의 도파민 농도를 평가하는 영상 검사 DaTscan은 진단을 확정하는 데 도움이 될 수 있습니다. 또한 경두개 도플러 초음파, PET, 단광자 방출 컴퓨터 단층촬영(SPECT), 형태학적 MRI, 트랙토그래피, 기능적 MRI, 관류 영상 등 신경영상 검사의 발전으로 특발성 파킨슨병과 다른 파킨슨병을 감별하는 데 활용되고 있습니다. 도파민 수송체 리간드를 이용한 PET 및 SPECT와 같은 방사성 핵종 영상은 도파민 대사 및 결핍을 평가할 수 있는 가장 좋은 접근법입니다.

치료에는 레보도파 제제, MAO-B 억제제, COMT 억제제, 아만타딘, 항콜린제 등의 약리학적 접근과 운동요법, 물리치료, 작업치료, 언어치료 등의 비약리학적 접근이 있습니다. 뇌심부자극요법이나 레보도파-카르비도파 경장 현탁액 치료와 같은 접근법은 약물 내성 떨림, 약물 중단 시 증상 악화, 이상운동증 환자에게 도움이 될 수 있습니다.

파킨슨병의 관리는 증상 완화를 통해 파킨슨병 환자의 삶의 질을 개선하는 것을 목표로 합니다. 미국 FDA의 승인을 받은 약물로는 XADAGO, DUOPA/DUODOPA, INBRIJA, ONGENTYS 등이 있으며, 파킨슨병의 운동 증상 및 비운동 증상 치료에도 사용되고 있습니다.

이 보고서는 주요 7개국 파킨슨병 시장을 조사하여 시장 개요와 함께 역학, 환자 동향, 새로운 치료법, 2034년까지의 시장 규모 예측, 미충족 의료 수요 등을 제공합니다.

목차

제1장 중요한 인사이트

제2장 보고서 소개

제3장 파킨슨병 시장 개요

제4장 파킨슨병 역학과 시장 조사 방법

제5장 파킨슨병 주요 요약

제6장 중요한 사건

제7장 질환 배경과 개요

제8장 역학과 환자 인구

제9장 환자 동향

제10장 출시된 치료제

제11장 새로운 약제 프로파일

제12장 파킨슨병 : 시장 분석

제13장 주요 오피니언 리더의 견해

제14장 SWOT 분석

제15장 미충족 수요

제16장 시장 접근과 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight 소개

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영문 목차

영문목차

Key Highlights:

DelveInsight's "Parkinson's disease - Market Insights, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding of the Parkinson's disease, historical and forecasted epidemiology as well as the Parkinson's disease market trends in the United States, EU4 and the UK (Germany, France, Italy, Spain) and the United Kingdom, and Japan.

The Parkinson's disease market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Parkinson's disease market size from 2020 to 2034. The Report also covers current Parkinson's disease treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.

Geography Covered:

Study Period: 2020-2034

Disease Understanding and Treatment Algorithm

Parkinson's disease Overview

According to the Parkinson's Foundation, Parkinson's disease is a neurodegenerative disorder that affects predominately dopamine-producing (dopaminergic) neurons in a specific area of the brain called the substantia nigra. Because Parkinson's disease develops over time, various stages help identify how symptoms have progressed and what should be expected next. Generally, there are five stages of Parkinson's disease: Stage I, Stage II, Stage III, Stage IV, and Stage V.

Parkinson's disease diagnosis

Diagnosing Parkinson's disease can be challenging, as there is no definitive test for the condition. Instead, the diagnosis is typically based on a combination of medical history, symptoms, physical and neurological examinations, and sometimes additional tests. MRI may be used only to exclude other causes. DaTscan, an imaging test, can assist in confirming the diagnosis by assessing dopamine levels in the brain. Additionally, advancements in neuroimaging studies, including transcranial Doppler ultrasonography, PET, single-photon emission computed tomography (SPECT), morphometric MRI studies, tractography, functional MRI, and perfusion imaging, are being used to differentiate idiopathic Parkinson's disease from other parkinsonian disorders. Radionuclide imaging modalities like PET and SPECT, using a dopamine transporter ligand, have become the best approach to assess dopamine metabolism and deficiency.

Parkinson's disease treatment

Treatment involves pharmacologic approaches, typically with levodopa preparations prescribed with or without other medications, MAO-B inhibitors, COMT inhibitors, amantadine, and anticholinergics, and non-pharmacologic approaches (such as exercise, physical, occupational, and speech therapies). Approaches such as deep brain stimulation and treatment with levodopa-carbidopa enteral suspension can help individuals with medication-resistant tremors, worsening symptoms when the medication wears off, and dyskinesia.

The management of Parkinson's disease aims at improving the quality of life for individuals affected by the condition with symptomatic relief. There are several medications approved by the US FDA such as, XADAGO, DUOPA/DUODOPA, INBRIJA, ONGENTYS, and others are also being used to treat motor and non-motor symptoms associated with Parkinson's disease.

Parkinson's Disease Epidemiology

As the market is derived using a patient-based model, the Parkinson's disease epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by, Total Diagnosed Prevalent Cases of Parkinson's Disease, Gender-specific Diagnosed Prevalent Cases of Parkinson's Disease, Age-specific Diagnosed Prevalent Cases of Parkinson's Disease, Stage-specific Diagnosed Prevalent Cases of Parkinson's Disease, Diagnosed Prevalent Cases of Psychosis due to Parkinson's Disease, and Diagnosed Prevalent Cases of MCI due to Parkinson's Disease in the 7MM covering, the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2020 to 2034.

Parkinson's Disease Drug Chapters

The drug chapter segment of the Parkinson's disease report encloses a detailed analysis of Parkinson's disease off-label drugs and late-stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Parkinson's disease clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.

Marketed Drugs

CREXONT (carbidopa and levodopa) ER capsules: Amneal Pharmaceuticals

CREXONT is a novel oral formulation of carbidopa/levodopa (CD/LD) that combines immediate-release (IR) granules and extended-release (ER) pellets. This prescription medication is used to treat Parkinson's disease, Parkinson's disease caused by brain infection or inflammation, and Parkinson's disease-like symptoms resulting from carbon monoxide or manganese poisoning in adults. The ER beads in CREXONT consist of levodopa (LD), coated with a sustained-release polymer for slow drug release, a mucoadhesive polymer to ensure the granules remain at the absorption site longer, and an enteric coating to prevent premature disintegration in the stomach. This formulation is distinct from RYTARY (carbidopa/levodopa) extended-release capsules, Amneal's extended-release CD/LD treatment for Parkinson's disease approved by the US FDA in 2015.

In February 2024, Amneal Pharmaceuticals entered into an exclusive licensing agreement with Zambon Biotech for IPX203 (CREXONT) in the European Union.

In August 2024, the US FDA approved CREXONT extended-release capsules for the treatment of Parkinson's disease.

Emerging Drugs

SPN-830 (apomorphine infusion device): Supernus Pharmaceutical/Britannia Pharmaceuticals

SPN-830 (apomorphine infusion device) is an investigational apomorphine infusion device under review for the continuous treatment of motor fluctuations (OFF episodes) in Parkinson's disease patients that are not adequately controlled with oral levodopa and one or more adjunct Parkinson's disease medications. SPN-830 is an SC formulation of apomorphine delivered continuously through a portable electronic infusion pump under the skin for 14-18 h. The target infusion rate ranged between 3 mg and 8 mg per h. The thin, small needle applied underneath the skin is usually placed on the abdomen or upper thigh. Such administration has the potential to be less invasive, with fewer injection sites, and is more convenient than Supernus Pharmaceutical's already approved product APOKYN, which mimics the action of dopamine in the brain, is intended to reduce off periods on demand, and is administered under the skin.

In April 2024, the US FDA issued a complete response letter (CRL) for Supernus Pharmaceuticals' NDA for SPN-830.

Additionally, in August 2024, Supernus Pharmaceuticals resubmitted its NDA for the apomorphine infusion device (SPN-830) to provide continuous treatment for motor fluctuations (OFF episodes) in Parkinson's disease.

Parkinson's Disease Market Outlook

Parkinson's disease is a progressively worsening neurodegenerative disorder with an unclear cause and pathogenesis. Its global burden is increasing, driven by aging populations and environmental factors. Classic symptoms include motor issues like bradykinesia, rigidity, tremors, and postural instability, along with non-motor symptoms such as depression, cognitive impairment, and autonomic disturbances, which significantly affect quality of life. Diagnosing Parkinson's is challenging due to symptom overlap with other movement disorders, with imaging like PET scans aiding in diagnosis.

While no curative therapy exists, various pharmacological and non-pharmacological treatments are used to manage symptoms. Carbidopa/levodopa remains the most effective treatment, with new formulations like CREXONT (approved in August 2024) and RYTARY (approved in 2015) offering symptom relief. DUOPA, a carbidopa/levodopa enteral suspension, and HARUROPI TAPE (ropinirole HCL), a transdermal patch, provide additional options, though innovations have been limited.

The Parkinson's disease treatment landscape faces significant unmet needs, particularly for curative and disease-modifying therapies. Better motor symptom control, especially for tremors, gait, balance, and psychosis treatment, remains a critical challenge.

Nevertheless, a plethora of medications is under development. These include drugs that specifically target a-synuclein pathology, widely considered to be the driver of neurodegeneration in Parkinson's disease. These drugs offer hope for disease-modifying agents in the short- to medium-term future. In combination with several regenerative approaches, including stem cells and gene therapies, therapeutics for Parkinson's disease are likely to see significant advances over the coming years, with several novel, effective options likely to become available in the foreseeable future.

The current emerging pipeline is robust, late-stage drugs expected to enter the Parkinson's disease market during the forecast period include Supernus Pharmaceuticals/Britannia Pharmaceuticals' SPN-830 (apomorphine infusion pump), AbbVie's tavapadon, Pharma Two B's P2B001 (extended-release pramipexole and rasagiline), and Mitsubishi Tanabe Pharma Corporation (NeuroDerm)'s ND0612 (levodopa/carbidopa), among others. The approval of these therapies could significantly impact market dynamics, although their success rates remain uncertain.

Parkinson's Disease Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to launch in the market during 2020-2034. For example, SPN-830 in the US is expected to be launched by 2025 with a peak share of 2.50%. Tavapadon is anticipated to take 7 years to peak with a medium uptake.

Parkinson's Disease Pipeline Development Activities

The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Parkinson's disease emerging therapies.

KOL Views

To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Parkinson's disease evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Parkinson's Foundation, Miami, US; Stanford University, US; Pacific Health Research and Education Institute, Honolulu, HI US; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Germany; Sante publique France, French Public Health Agency, Saint-Maurice, France; Sante publique France, French Public Health Agency, Saint-Maurice, France; Universitario Central de Asturias, Spain; and Department of Neurology, The Jikei University Katsushika Medical Center, Tokyo, Japan.

Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Parkinson's disease market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Market Access and Reimbursement

The high cost of therapies for the treatment is a major factor restraining the growth of the global drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Report:

Parkinson's disease Report Insights

Parkinson's Disease Report Key Strengths

Parkinson's Disease Report Assessment

Key Questions:

Market Insights

Epidemiology Insights

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies

Reasons to Buy:

Frequently Asked Questions:

1. What is the forecast period covered in the report?

The Parkinson's Disease Epidemiology and Market Insight report for the 7MM covers the forecast period from 2024 to 2034, providing a projection of market dynamics and trends during this timeframe.

2. Who are the key players in the Parkinson's Disease market?

The Parkinson's Disease market is quite robust. The major players are Supernus Pharmaceuticals, Britannia Pharmaceuticals, AbbVie , Pharma Two B, Mitsubishi Tanabe Pharma Corporation, NeuroDerm and others which are currently developing drugs for the treatment of Parkinson's disease.

3. How is the market size estimated in the forecast report?

The market size is estimated through data analysis, statistical modeling, and expert opinions. It may consider factors such as prevalent cases, treatment costs, revenue generated, and market trends.

4. What is the key driver of the Parkinson's Disease market?

The increase in diagnosed prevalent cases of Parkinson's Disease and the launch of emerging therapies are attributed to be the key drivers for increasing the Parkinson's disease market.

5. What is the expected impact of emerging therapies or advancements in Parkinson's Disease treatment on the market?

Introducing new therapies, advancements in diagnostic techniques, and innovations in treatment approaches can significantly impact the Parkinson's disease treatment market. Market forecast reports may provide analysis and predictions regarding the potential impact of these developments.

6. Does the report provide insights into the competitive landscape of the market?

The market forecast report may include information on the competitive landscape, profiling key market players, their product offerings, partnerships, and strategies, and helping stakeholders understand the competitive dynamics of the Parkinson's Disease market.

Table of Contents

1. Key Insights

2. Report Introduction

3. Parkinson's disease Market Overview at a Glance

4. Methodology of Parkinson's disease Epidemiology and Market

5. Executive Summary of Parkinson's Disease

6. Key Events

7. Disease Background and Overview

8. Epidemiology and Patient Population

9. Patient Journey

10. Marketed Therapies

11. Emerging Drug Profiles

12. Parkinson's disease: Market Analysis

13. Key Opinion Leaders' Views

14. SWOT Analysis

15. Unmet Needs

16. Market Access and Reimbursement

17. Appendix

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

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