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Atherosclerotic Cardiovascular Disease (ASCVD) - Market Insight, Epidemiology And Market Forecast - 2034
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Key Highlights:

DelveInsight's "Atherosclerotic Cardiovascular Disease (ASCVD) - Market Insights, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding of the Atherosclerotic Cardiovascular Disease (ASCVD), historical and forecasted epidemiology as well as the Atherosclerotic Cardiovascular Disease (ASCVD) market trends in the United States, EU4 and the UK (Germany, France, Italy, Spain) and the United Kingdom, and Japan.

The Atherosclerotic Cardiovascular Disease (ASCVD) market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Atherosclerotic Cardiovascular Disease (ASCVD) market size from 2020 to 2034. The Report also covers current Atherosclerotic Cardiovascular Disease (ASCVD) treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.

Geography Covered:

Study Period: 2020-2034

Disease Understanding and Treatment Algorithm

Atherosclerotic Cardiovascular Disease (ASCVD) Overview

ASCVD is a progressive and chronic condition that can affect various arteries throughout the body, including those supplying the heart (coronary arteries), brain (cerebral arteries), and legs (peripheral arteries). The most common manifestations of ASCVD include coronary artery disease (CAD), cerebrovascular disease (stroke), and peripheral arterial disease (PAD).

The development of ASCVD is influenced by a number of risk factors, such as poor diet, inactivity, cigarette use, obesity, family history, and alcohol abuse. The early stages of ASCVD are without symptoms, but later on as the artery narrows and blood flow is reduced, symptoms start to show. The type of artery that is affected and how much blood flow is impeded may also alter the symptoms. Angina, cold chills, dizziness, acute exhaustion, shortness of breath, and heart palpitations are a few typical symptoms.

Atherosclerotic Cardiovascular Disease (ASCVD) Diagnosis

In addition to symptoms, risk assessment is also used to make the diagnosis of ASCVD. Apolipoprotein E [APOE], LDLR, APOB, PCSK9, or LDLRAP1 genes; genotyping to study variations in contributing genes; and morphological examinations (ultrasonography, computed tomography, magnetic resonance imaging/angiography, or catheterization) are typically used to make a clinical diagnosis of ASCVD. Genetic testing, biomarker testing, and imaging can all be used to confirm an ASCVD diagnosis if a doctor has a suspicion. However, the cost and accessibility of genetic testing and biomarker testing may restrict their use.

Atherosclerotic Cardiovascular Disease (ASCVD) Treatment

Treatment strategies for Atherosclerotic Cardiovascular Disease occur at the population level but also engage individual adults to slow the development of ASCVD. Promoting a healthy lifestyle throughout life is the most important way to prevent ASCVD. Treatment other than lifestyle modification is based on pharmacotherapy and invasive procedures. A comprehensive patient-centered approach that addresses all aspects of a patient's lifestyle habits and estimated risk of a future ASCVD event is the first step in deciding where there may be a need for pharmacotherapy. For clinical ASCVD, revascularization procedures such as angioplasties and bypass are warranted, among others.

Atherosclerotic Cardiovascular Disease (ASCVD) Epidemiology

As the market is derived using a patient-based model, the Atherosclerotic Cardiovascular Disease (ASCVD) epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Cases of Atherosclerotic Cardiovascular Disease, (ASCVD), Gender-specific Diagnosed Prevalent Cases of Atherosclerotic Cardiovascular Disease (ASCVD), Age-specific Diagnosed Prevalent Cases of Atherosclerotic Cardiovascular Disease (ASCVD) and Comorbidity-specific Diagnosed Prevalent Cases of Atherosclerotic Cardiovascular Disease (ASCVD) in the 7MM covering, the United States, EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan from 2020 to 2034.

Atherosclerotic Cardiovascular Disease (ASCVD) Drug Chapters

The drug chapter segment of the Atherosclerotic Cardiovascular Disease (ASCVD) report encloses a detailed analysis of Atherosclerotic Cardiovascular Disease (ASCVD) off-label drugs and late-stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Atherosclerotic Cardiovascular Disease (ASCVD) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.

Marketed Drugs

LEQVIO (inclisiran): Novartis Pharmaceuticals Corporation

LEQVIO (inclisiran) is the pioneering and sole small-interfering RNA therapy designed to lower LDL cholesterol, a significant risk factor for ASCVD, a condition triggered by plaque accumulation in the arteries. It is administered by a healthcare professional through injections twice a year, with an initial dose and a follow-up dose after 3 months.

PRALUENT (alirocumab): Regeneron Pharmaceuticals/Sanofi

PRALUENT is a fully human monoclonal antibody that inhibits the binding of PCSK9 to the LDL receptor. Through inhibiting PCSK9, PRALUENT increases the number of available LDL receptors on the surface of liver cells to clear LDL, which lowers LDL cholesterol levels in the blood.

Emerging Drugs

Olpasiran (AMG 890): Amgen Inc.

Olpasiran (formerly AMG 890) is a small interfering RNA (siRNA) that lowers lipoprotein (a), also known as Lp (a). It is being investigated for treating ASCVD; the drug is administered subcutaneously as a solution. Currently, the company is recruiting for Phase III clinical trial to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with ASCVD and elevated lipoprotein (a).

Obicetrapib (TA-8995): NewAmsterdam Pharma

Obicetrapib is a novel, selective CETP inhibitor that potently decreases low-density lipoprotein-cholesterol (LDL-C) as well as increases high-density lipoprotein-cholesterol (HDL-C) and the number of ApoA1-containing lipoproteins. The drug candidate is designed to be administered orally. Currently, the company is recruiting for Phase III clinical trials to evaluate the effect of obicetrapib on the risk of major adverse cardiovascular events (MACE), including cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke, or non-elective coronary revascularization.

Atherosclerotic Cardiovascular Disease (ASCVD) Market Outlook

The treatment of Atherosclerotic Cardiovascular Disease (ASCVD) focuses on reducing cardiovascular risk and managing the underlying atherosclerosis. Lifestyle modifications, including a heart-healthy diet, regular physical activity, smoking cessation, and weight management, are fundamental in controlling risk factors such as hypertension, diabetes, and hyperlipidemia.

Pharmacological therapy is also crucial; statins are the first-line treatment to lower low-density lipoprotein cholesterol (LDL-C), with high-intensity statins recommended for high-risk patients. For those with statin intolerance or inadequate response, non-statin therapies like ezetimibe or PCSK9 inhibitors may be added. Antiplatelet therapy, typically aspirin, is prescribed to prevent thrombotic events in patients with established ASCVD. Blood pressure control, using antihypertensives like ACE inhibitors or ARBs, is essential in reducing cardiovascular complications. In cases of acute coronary syndrome or significant coronary artery stenosis, revascularization procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) may be necessary.

Ongoing monitoring and patient education on adherence to treatment and lifestyle changes are vital for long-term management of ASCVD.

Atherosclerotic Cardiovascular Disease (ASCVD) Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to launch in the market during 2020-2034. For example, MK-0616 in the US is expected to be launched by 2027 with a peak share of 1.20%. MK-0616 is anticipated to take 7 years to peak with a medium uptake.

Atherosclerotic Cardiovascular Disease (ASCVD) Pipeline Development Activities

The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Atherosclerotic Cardiovascular Disease (ASCVD) emerging therapies.

KOL Views

To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Atherosclerotic Cardiovascular Disease (ASCVD) evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Rollins School of Public Health, Emory University, Atlanta, Georgia; Department of Epidemiology and Health Monitoring, Robert Koch Institute; Cardiovascular Prevention Institute, Paris; Teikyo Academic Research Center, Teikyo University, Itabashi-ku, Tokyo, and others

Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Atherosclerotic Cardiovascular Disease (ASCVD) market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Market Access and Reimbursement

The high cost of therapies for the treatment is a major factor restraining the growth of the global drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Report:

Atherosclerotic Cardiovascular Disease (ASCVD) Report Insights

Atherosclerotic Cardiovascular Disease (ASCVD) Report Key Strengths

Atherosclerotic Cardiovascular Disease (ASCVD) Report Assessment

Key Questions:

Market Insights

Epidemiology Insights

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies

Reasons to Buy:

Frequently Asked Questions:

1. What is the forecast period covered in the report?

The Atherosclerotic Cardiovascular Disease (ASCVD) Epidemiology and Market Insight report for the 7MM covers the forecast period from 2024 to 2034, providing a projection of market dynamics and trends during this timeframe.

2. Who are the key players in the Atherosclerotic Cardiovascular Disease (ASCVD) market?

The Atherosclerotic Cardiovascular Disease (ASCVD) market is quite robust. The major layers are Merck Sharp & Dohme Corp, NewAmsterdam Pharma, Amgen Inc., and others which are currently developing drugs for the treatment of Atherosclerotic Cardiovascular Disease (ASCVD).

3. How is the market size estimated in the forecast report?

The market size is estimated through data analysis, statistical modeling, and expert opinions. It may consider factors such as prevalent cases, treatment costs, revenue generated, and market trends.

4. What is the key driver of the Atherosclerotic Cardiovascular Disease (ASCVD) market?

The increase in diagnosed prevalent cases of Atherosclerotic Cardiovascular Disease (ASCVD) and the launch of emerging therapies are attributed to be the key drivers for increasing the Atherosclerotic Cardiovascular Disease (ASCVD) market.

5. What is the expected impact of emerging therapies or advancements in Atherosclerotic Cardiovascular Disease (ASCVD) treatment on the market?

Introducing new therapies, advancements in diagnostic techniques, and innovations in treatment approaches can significantly impact the Atherosclerotic Cardiovascular Disease (ASCVD) treatment market. Market forecast reports may provide analysis and predictions regarding the potential impact of these developments.

6. Does the report provide insights into the competitive landscape of the market?

The market forecast report may include information on the competitive landscape, profiling key market players, their product offerings, partnerships, and strategies, and helping stakeholders understand the competitive dynamics of the Atherosclerotic Cardiovascular Disease (ASCVD) market.

Table of Contents

1. Key Insights

2. Report Introduction

3. Atherosclerotic Cardiovascular Disease (ASCVD) Market Overview by Therapies

4. Methodology of ASCVD Epidemiology and Market

5. Executive Summary of Atherosclerotic Cardiovascular Disease (ASCVD)

6. Key Events

7. Disease Background and Overview: ASCVD

8. Epidemiology and Patient Population

9. Patient Journey

10. Marketed Drugs

11. Emerging Drugs

12. ASCVD: Market Analysis

13. Key Opinion Leaders' Views

14. SWOT Analysis

15. Unmet Needs

16. Market Access and Reimbursement

17. Appendix

18. Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

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